AiPD: Autoinhibited Protein Database

Gene name	Ddx18
Protein name	ATP-dependent RNA helicase DDX18
Names	DEAD box protein 18
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:66942
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

46-171 (Predicted disordered autoinhibitory region) PR

46-171 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8K363-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs220329601	11	R>K	No	EVA
rs3388493705	24	N>S	No	EVA
rs3388497190	24	N>Y	No	EVA
rs3388493649	27	L>M	No	EVA
rs30774248	30	T>A	No	EVA
rs30774249	36	S>T	No	EVA
rs233618055	69	Q>E	No	EVA
rs3388493235	112	K>R	No	EVA
rs30775150	139	E>D	No	EVA
rs3388497231	163	A>*	No	EVA
rs3388491864	163	A>D	No	EVA
rs3388494639	195	I>N	No	EVA
rs3388494266	208	D>G	No	EVA
rs3388497182	236	F>L	No	EVA
rs3388497191	322	I>N	No	EVA
rs3388492437	381	D>Y	No	EVA
rs3388494833	477	R>S	No	EVA
rs3388494615	547	K>I	No	EVA
rs3388495255	555	L>Q	No	EVA
rs3388493776	577	I>L	No	EVA
rs3388491808	634	Q>*	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	ATP-dependent RNA helicase DEAD-box, conserved site	321 - 329	IPR000629
domain	Helicase, C-terminal	389 - 559	IPR001650
domain	DEAD/DEAH box helicase domain	193 - 364	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	188 - 393	IPR014001
domain	Domain of unknown function DUF4217	550 - 613	IPR025313
domain	DDX18/Has1, DEAD-box helicase domain	180 - 377	IPR044773

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus, nucleolus Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.

Name	Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q03532	HAS1	ATP-dependent RNA helicase HAS1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q4FZF3	Ddx49	Probable ATP-dependent RNA helicase DDX49	Mus musculus (Mouse)	PR
Q8K4L0	Ddx54	ATP-dependent RNA helicase DDX54	Mus musculus (Mouse)	PR
Q9CWX9	Ddx47	Probable ATP-dependent RNA helicase DDX47	Mus musculus (Mouse)	PR
Q9CWT6	Ddx28	Probable ATP-dependent RNA helicase DDX28	Mus musculus (Mouse)	PR
Q91VR5	Ddx1	ATP-dependent RNA helicase DDX1	Mus musculus (Mouse)	PR
Q6ZPL9	Ddx55	ATP-dependent RNA helicase DDX55	Mus musculus (Mouse)	PR
Q9ESV0	Ddx24	ATP-dependent RNA helicase DDX24	Mus musculus (Mouse)	PR
P60843	Eif4a1	Eukaryotic initiation factor 4A-I	Mus musculus (Mouse)	PR
P10630	Eif4a2	Eukaryotic initiation factor 4A-II	Mus musculus (Mouse)	PR
Q569Z5	Ddx46	Probable ATP-dependent RNA helicase DDX46	Mus musculus (Mouse)	PR
Q0DBS1	Os06g0535100	Putative DEAD-box ATP-dependent RNA helicase 51	Oryza sativa subsp japonica (Rice)	PR
Q9FFQ1	RH31	DEAD-box ATP-dependent RNA helicase 31	Arabidopsis thaliana (Mouse-ear cress)	PR
O80792	RH33	Putative DEAD-box ATP-dependent RNA helicase 33	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LIH9	RH51	DEAD-box ATP-dependent RNA helicase 51	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SB89	RH27	DEAD-box ATP-dependent RNA helicase 27	Arabidopsis thaliana (Mouse-ear cress)	PR