Q8K337
PR
Gene name |
Inpp5b |
Protein name |
Type II inositol 1,4,5-trisphosphate 5-phosphatase |
Names |
Inositol polyphosphate-5-phosphatase B, Phosphoinositide 5-phosphatase, 5PTase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:16330 |
EC number |
3.1.3.36: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8K337
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2KIG | NMR | - | A | 1-156 | PDB |
| AF-Q8K337-F1 | Predicted | AlphaFoldDB |
61 variants for Q8K337
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388710429 | 3 | Q>H | No | EVA | |
| rs3388697418 | 7 | I>N | No | EVA | |
| rs3388705049 | 36 | L>F | No | EVA | |
| rs3388712978 | 62 | I>F | No | EVA | |
| rs3388712692 | 79 | F>C | No | EVA | |
| rs3388717236 | 100 | Q>H | No | EVA | |
| rs3388705368 | 115 | G>C | No | EVA | |
| rs3388712961 | 119 | R>I | No | EVA | |
| rs3388699347 | 122 | L>P | No | EVA | |
| rs3388715495 | 140 | E>D | No | EVA | |
| rs258555119 | 142 | E>K | No | EVA | |
| rs27569320 | 148 | T>R | No | EVA | |
| rs228479457 | 153 | D>H | No | EVA | |
| rs3388708857 | 166 | P>Q | No | EVA | |
| rs244670005 | 173 | A>P | No | EVA | |
| rs214072899 | 177 | G>E | No | EVA | |
| rs27569319 | 178 | S>G | No | EVA | |
| rs3388699397 | 178 | S>N | No | EVA | |
| rs27569317 | 219 | H>Y | No | EVA | |
| rs3394712083 | 225 | R>I | No | EVA | |
| rs27569316 | 230 | L>R | No | EVA | |
| rs3388710463 | 242 | D>E | No | EVA | |
| rs3388708798 | 243 | W>R | No | EVA | |
| rs226516197 | 259 | V>G | No | EVA | |
| rs215749350 | 262 | V>L | No | EVA | |
| rs27553892 | 281 | P>L | No | EVA | |
| rs3388697452 | 303 | R>H | No | EVA | |
| rs3388711857 | 304 | S>P | No | EVA | |
| rs3388710412 | 307 | V>L | No | EVA | |
| rs3388699328 | 320 | K>* | No | EVA | |
| rs3388712947 | 322 | G>A | No | EVA | |
| rs234123379 | 329 | R>K | No | EVA | |
| rs3388711447 | 393 | F>L | No | EVA | |
| rs3388708865 | 396 | T>S | No | EVA | |
| rs3388708745 | 429 | L>F | No | EVA | |
| rs3388703338 | 478 | N>I | No | EVA | |
| rs3388711852 | 523 | L>M | No | EVA | |
| rs3388704974 | 542 | K>R | No | EVA | |
| rs27553830 | 545 | E>Q | No | EVA | |
| rs3388712680 | 573 | E>V | No | EVA | |
| rs3388699346 | 617 | S>C | No | EVA | |
| rs3388711846 | 675 | R>W | No | EVA | |
| rs3388711884 | 681 | N>K | No | EVA | |
| rs3388712950 | 685 | M>V | No | EVA | |
| rs3388717234 | 718 | W>C | No | EVA | |
| rs3388711866 | 726 | G>V | No | EVA | |
| rs27553789 | 766 | E>D | No | EVA | |
| rs3388705391 | 771 | Y>C | No | EVA | |
| rs3388711501 | 820 | R>M | No | EVA | |
| rs3388699381 | 844 | A>V | No | EVA | |
| rs250583060 | 874 | Q>H | No | EVA | |
| rs215534666 | 876 | C>R | No | EVA | |
| rs3388708860 | 905 | S>N | No | EVA | |
| rs3388705423 | 920 | I>V | No | EVA | |
| rs227763350 | 921 | L>S | No | EVA | |
| rs3394536588 | 930 | V>A | No | EVA | |
| rs3394712795 | 931 | F>I | No | EVA | |
| rs3394786789 | 932 | N>K | No | EVA | |
| rs3394805459 | 933 | Y>* | No | EVA | |
| rs3388704976 | 948 | N>D | No | EVA | |
| rs13468788 | 993 | L>P | No | EVA |
No associated diseases with Q8K337
6 regional properties for Q8K337
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rho GTPase-activating protein domain | 821 - 993 | IPR000198 |
| domain | Inositol polyphosphate-related phosphatase | 343 - 644 | IPR000300 |
| domain | Endonuclease/exonuclease/phosphatase | 350 - 629 | IPR005135 |
| domain | INPP5B, PH domain | 1 - 147 | IPR031896 |
| domain | OCRL1/INPP5B, INPP5c domain | 345 - 638 | IPR037793 |
| domain | Inositol polyphosphate 5-phosphatase OCRL, RhoGAP | 772 - 990 | IPR047078 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.36 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endoplasmic reticulum-Golgi intermediate compartment | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| phagocytic vesicle membrane | The lipid bilayer surrounding a phagocytic vesicle. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| inositol-1,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. |
| inositol-polyphosphate 5-phosphatase activity | Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| metal ion binding | Binding to a metal ion. |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| flagellated sperm motility | The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| inositol phosphate dephosphorylation | The process of removing a phosphate group from any mono- or polyphosphorylated inositol. |
| phosphatidylinositol dephosphorylation | The process of removing one or more phosphate groups from a phosphatidylinositol. |
| regulation of protein processing | Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VDS5 | RhoGAP92B | Rho GTPase-activating protein 92B | Drosophila melanogaster (Fruit fly) | PR |
| Q9NRR6 | INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV | Homo sapiens (Human) | PR |
| Q92835 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Homo sapiens (Human) | PR |
| Q9Y3L3 | SH3BP1 | SH3 domain-binding protein 1 | Homo sapiens (Human) | PR |
| P32019 | INPP5B | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Homo sapiens (Human) | PR |
| Q9ES52 | Inpp5d | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Mus musculus (Mouse) | PR |
| Q8K2H3 | Fam13b | Protein FAM13B | Mus musculus (Mouse) | PR |
| P55194 | Sh3bp1 | SH3 domain-binding protein 1 | Mus musculus (Mouse) | PR |
| Q8BYW1 | Arhgap25 | Rho GTPase-activating protein 25 | Mus musculus (Mouse) | PR |
| Q6NVF0 | Ocrl | Inositol polyphosphate 5-phosphatase OCRL | Mus musculus (Mouse) | PR |
| P97573 | Inpp5d | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQSVAIQET | LVEGEYCVIA | VQGVLCKGDS | RQSRLLGLVR | YRLENDAQEH | ALFLYTHRRM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AITGDDVSLD | QIVPLSKDFM | LEEVSPDGEL | YILGSDVTVQ | LNTAELKLVF | QLPFGSHTRT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLQEVARACP | GFDPETRDPE | FEWLSRHTCA | EPDAESPKPR | EWNSDPGTRS | GFAPIGGSRH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSRNARRGLE | DVLPRGPGYI | LLWGGAAEEP | EFLLAEEMHE | GGPVRGRRPL | AGRRDEALEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ADWEMSAGGG | SRERDCAGVS | NVDSSRPNGR | GPDQPSGARC | PEKPENSLTR | QNKSKSDMSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KVRSATVTVS | DKAHILSVQK | FGLRDTIVRS | HLVQKEENYT | YIQNFRFFVG | TYNVNGQSPK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ECLRPWLSHS | ALAPDVYCVG | FQELDLSKEA | FFFHDTPKEE | EWFKAVSESL | HPDAKYAKVK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FVRLVGIMLL | LYVKQEHAAY | ISEVEAETVG | TGIMGRMGNK | GGVAIRFQLH | NTSICVVNSH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LAAHTEEYER | RNQDYRDICS | RMQFPQVDPS | QPPLTINKHD | VILWLGDLNY | RIEELDVGKV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KKLVEEKAFQ | TLYAHDQLKI | QVAARTIFDG | FTEGEITFQP | TYKYDTGSDD | WDTSEKCRAP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AWCDRILWKG | KNITQLSYQS | HMALKTSDHK | PVSSVFDIGV | RVVNEELYRK | TLEEIVRSLD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KMENANIPSV | TLSKREFCFE | NVKYMQLQTE | SFTIHNSQVP | CQFEFINKPD | EESYCKQWLT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ARPSKGFLLP | DSHVEIELEL | FVNKSTATKL | NSGKDTIEDI | LVLHLERGKD | YFLSVSGNYL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PSCFGSPIHT | LCYMREPILD | LPLKTVSDLT | LMSVQTADDR | SQLENPMEIP | KELWMMVDYL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YRNAVQQEDL | FQQPGLRPEF | DHIRDCLDTG | MIDQLCANNH | SVAEALLLFL | ESLPEPVICY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SAYHSCLECS | GNYAASKQII | LTLPSFHKNV | FNYLMAFLQE | LLKNSANNHL | DENILASIFG |
| 970 | 980 | 990 | |||
| SLLLRNPARH | QKLDMAEKKK | AQEFIHQFLC | GPL |