Q8K2H4
SS
Gene name |
Acap1 (Centb1, Kiaa0050) |
Protein name |
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
Names |
Centaurin-beta-1 , Cnt-b1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:216859 |
EC number |
|
Protein Class |
|
Descriptions
ACAP1 (ArfGAP with coiled-coil, ankyrin repeat, and PH domains protein 1) is an ARF6 GAP that acts as a key component of a defined clathrin complex for endocytic recycling. A flexible linker region between the GAP and ANK domains acts to obstruct cargo binding, with a key residue within this region (Ser-554) regulating this obstruction. The excision of the linker region results in promoting cargo binding and integrin recycling.
Autoinhibitory domains (AIDs)
Target domain |
403-525 (GAP domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K2H4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K2H4-F1 | Predicted | AlphaFoldDB |
34 variants for Q8K2H4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3402465193 | 86 | S>R | No | EVA | |
| rs3389170952 | 90 | K>T | No | EVA | |
| rs3389168923 | 158 | A>V | No | EVA | |
| rs3402360173 | 163 | R>P | No | EVA | |
| rs3401749561 | 166 | Y>D | No | EVA | |
| rs51339993 | 177 | V>I | No | EVA | |
| rs3401782969 | 178 | N>S | No | EVA | |
| rs3401782995 | 226 | N>WA* | No | EVA | |
| rs3401749577 | 239 | E>* | No | EVA | |
| rs3402376359 | 240 | Q>H | No | EVA | |
| rs3402438299 | 241 | R>M | No | EVA | |
| rs3389175196 | 250 | L>I | No | EVA | |
| rs3402382320 | 283 | W>C | No | EVA | |
| rs3401749578 | 284 | S>C | No | EVA | |
| rs3402539302 | 284 | S>T | No | EVA | |
| rs3389172702 | 298 | Q>L | No | EVA | |
| rs3389175182 | 320 | C>S | No | EVA | |
| rs3389184712 | 329 | F>L | No | EVA | |
| rs3389109259 | 331 | V>L | No | EVA | |
| rs217136871 | 383 | A>S | No | EVA | |
| rs3389170961 | 384 | P>R | No | EVA | |
| rs257928035 | 394 | G>R | No | EVA | |
| rs3389143423 | 414 | V>M | No | EVA | |
| rs47070859 | 488 | R>Q | No | EVA | |
| rs3389168918 | 500 | S>C | No | EVA | |
| rs3389178866 | 545 | K>E | No | EVA | |
| rs3389184708 | 581 | H>N | No | EVA | |
| rs1131733267 | 598 | V>A | No | EVA | |
| rs3402360275 | 600 | W>S | No | EVA | |
| rs1135353883 | 601 | V>I | No | EVA | |
| rs3389166328 | 618 | N>I | No | EVA | |
| rs3389143458 | 654 | G>W | No | EVA | |
| rs3389135260 | 710 | E>K | No | EVA | |
| rs230289785 | 738 | H>Y | No | EVA |
No associated diseases with Q8K2H4
5 regional properties for Q8K2H4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Arf GTPase activating protein | 405 - 527 | IPR001164 |
| domain | Pleckstrin homology domain | 265 - 362 | IPR001849 |
| repeat | Ankyrin repeat | 576 - 671 | IPR002110-1 |
| repeat | Ankyrin repeat | 672 - 702 | IPR002110-2 |
| domain | BAR domain | 5 - 238 | IPR004148 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| recycling endosome membrane | The lipid bilayer surrounding a recycling endosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O97902 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| A5PK26 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| A1Z7A6 | Asap | ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein | Drosophila melanogaster (Fruit fly) | SS |
| O43150 | ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | SS |
| Q8TDY4 | ASAP3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Homo sapiens (Human) | SS |
| Q9ULH1 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15027 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15057 | ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
| Q5U464 | Asap3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q7SIG6 | Asap2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | SS |
| Q9QWY8 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q6ZQK5 | Acap2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | PR |
| Q1AAU6 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| Q9C6C3 | AGD2 | ADP-ribosylation factor GTPase-activating protein AGD2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SMX5 | AGD4 | ADP-ribosylation factor GTPase-activating protein AGD4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVKLDFEEC | LKDSPRFRAS | IELVETEVSE | LETRLEKLLK | LGSCLLESGQ | HYLAAGRAFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGICDLARLG | PPEPMMAECL | EKFTVSLNHK | LDSHAELLDA | TQHTLQQQIQ | TLVKEGLRGF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| REARRDFWRG | AENLEAALTH | NAEVPRRRVQ | EAEEAGTALR | TARAGYRSRA | LDYALQVNVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDKRKFDIME | FVLRLVEAQA | TYFQQGHEEL | NRLAQYRKEL | GTQLHNLVLN | SARQKRDMEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RHVLLKQKEL | GGEEPEPSLK | EGPSGLVMEG | HLFKRASNAF | KTWSRRWFTI | QNNQLVYQKK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YKDPVTVVVD | DLRLCTVKLC | PDSERRFCFE | VVSTSKSCFL | QADSERLLQL | WVSAVQSSIA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SAFSQAHLEN | SPRGPGQVSG | YHAPGSAATL | ACGGAARGRE | SGGVGQVAAQ | VQSVDGNAQC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CDCREPAPEW | ASINLGVTLC | IQCSGIHRSL | GVHFSKVRSL | TLDSWEPELV | KLMCELGNVI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| INQIYEARVE | AMAVKKPGPS | CSRQEKEAWI | HAKYVEKKFL | TKLPEIRGRR | GGRGPPRGHP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PVPPKPPIRP | HSGIVRSKSE | CPSDDMGSLH | PGALLFQAAG | HPPSLPTMAD | ALAHGADVNW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VNVGQGNATP | LIRATAANSL | LACEFLLQNG | ANVNQADSAG | RGPLHHATIL | GHTGLACLFL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KRGADLGARD | TEGRDPLTIA | METTNADIVT | LLRLAKMREA | EAAQGQAGDE | TYLDIFRDFS |
| 730 | |||||
| LMASDDPEKL | SRRSHDLHTL |