Q8K2H3
Gene name |
Fam13b (Fam13b1) |
Protein name |
Protein FAM13B |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:225358 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K2H3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K2H3-F1 | Predicted | AlphaFoldDB |
37 variants for Q8K2H3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389492645 | 47 | D>V | No | EVA | |
| rs3389492655 | 71 | E>K | No | EVA | |
| rs3389458795 | 177 | F>L | No | EVA | |
| rs3389507965 | 199 | R>D | No | EVA | |
| rs3389507927 | 201 | M>R | No | EVA | |
| rs31607620 | 264 | V>A | No | EVA | |
| rs228775953 | 275 | D>E | No | EVA | |
| rs220690512 | 290 | A>T | No | EVA | |
| rs3389489139 | 319 | D>E | No | EVA | |
| rs3389458786 | 327 | N>I | No | EVA | |
| rs3389458786 | 327 | N>S | No | EVA | |
| rs3389505076 | 334 | L>V | No | EVA | |
| rs3389492650 | 338 | C>Y | No | EVA | |
| rs3389471928 | 383 | E>K | No | EVA | |
| rs3389492988 | 389 | S>N | No | EVA | |
| rs3389489112 | 389 | S>R | No | EVA | |
| rs3389492577 | 391 | G>S | No | EVA | |
| rs3389493029 | 416 | E>D | No | EVA | |
| rs242005980 | 429 | C>Y | No | EVA | |
| rs212798740 | 444 | T>I | No | EVA | |
| rs3408309142 | 475 | A>T | No | EVA | |
| rs3389486203 | 490 | R>K | No | EVA | |
| rs3389505091 | 491 | S>A | No | EVA | |
| rs3389452073 | 531 | P>L | No | EVA | |
| rs3389492586 | 538 | A>S | No | EVA | |
| rs3408454561 | 577 | N>K | No | EVA | |
| rs3389501070 | 624 | R>P | No | EVA | |
| rs3389471920 | 671 | V>I | No | EVA | |
| rs3389501026 | 675 | Y>C | No | EVA | |
| rs3389486230 | 676 | D>V | No | EVA | |
| rs3408578647 | 680 | L>I | No | EVA | |
| rs3389441310 | 701 | R>C | No | EVA | |
| rs3407358005 | 706 | L>* | No | EVA | |
| rs242351917 | 752 | L>S | No | EVA | |
| rs3389501017 | 803 | E>K | No | EVA | |
| rs3389505065 | 838 | L>H | No | EVA | |
| rs3389492973 | 846 | D>E | No | EVA |
No associated diseases with Q8K2H3
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VDS5 | RhoGAP92B | Rho GTPase-activating protein 92B | Drosophila melanogaster (Fruit fly) | PR |
| Q9Y3L3 | SH3BP1 | SH3 domain-binding protein 1 | Homo sapiens (Human) | PR |
| P32019 | INPP5B | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Homo sapiens (Human) | PR |
| P55194 | Sh3bp1 | SH3 domain-binding protein 1 | Mus musculus (Mouse) | PR |
| Q8K337 | Inpp5b | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Mus musculus (Mouse) | PR |
| Q8BYW1 | Arhgap25 | Rho GTPase-activating protein 25 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRKSSSPSLS | NCNSDLASKI | FGIPLDELQQ | GGHPDNEVPF | IVRHVVDYIE | EHGGLEQQGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FQVNGNAETV | EWLRQRYDSG | EEVDLVKEAD | VPSAISLLRF | FLQELPEPVI | PGSLHIHLLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSQDYNNEDE | FGRKLRFLLQ | QLPPVNYSLL | KFLCRFLANV | ASHHEEIWSA | NSLAAVFGPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VFHIYTDVED | MKEQEIVSRI | MAGLLENYYE | FFENEEEDFS | SNDLSSITEQ | VNELSEEEEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DEKLEHIEEL | PEEGVEKSAG | MPEVLQLRMT | ENLLDSDSVT | ASTRIDAAAA | TTTNASDGNI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KCSKPVAGTT | ADNEVMQQDF | VFEDQKNNES | VGILLEPCSD | HGDSEDGCPE | RKEYLLCDSD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLPHLILDSS | SKIRDLNANT | ELEVTEGQSV | GVQGEAACIQ | IAQLDLKNVS | DGDKWEEPFP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AFKSWQEDCE | SGEAQLSPQA | ARMTHHPLGE | DCPPVLSHRS | LDFGQSQRFL | HDPEALDFSS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KALSFTRIRR | SSFSSKDEKR | EDRTPYQLVK | KLQKKIRQFE | EQFERERNSK | PSYSDIAANP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KVLKWMTELT | KLRKQIKDAK | HKNSDGEFAP | QTRPRSNTLP | KSFGSSLDHE | DGESEGEPRV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IQKEKTPSKE | ATLELITKRL | KENRAERHLP | EDIKKMTKDH | LIEEKTSLQK | SLLYYESQHG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RPVTREERHI | VKPLYDRYRL | VKQMLTRASI | TPVLGSPSTK | RRGQMLQPII | EGETAHFFEE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IKEEEEDGVS | LSSELGDILS | TSVHTQSSLE | NLESDAEENQ | EKLARDLCLS | STRAASVPEL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LEQLWKARAE | KKKLRKMLRE | FEEAFYQQNG | RNAQKEDRVP | VLEEYKEYKR | IKAKLRLLEV |
| 850 | |||||
| LISKQDSSKS | I |