Q8K2C8
PR
Gene name |
Gpat4 |
Protein name |
Glycerol-3-phosphate acyltransferase 4 |
Names |
GPAT4, 1-acylglycerol-3-phosphate O-acyltransferase 6, 1-AGP acyltransferase 6, 1-AGPAT 6, Acyl-CoA:glycerol-3-phosphate acyltransferase 4, Lysophosphatidic acid acyltransferase zeta, LPAAT-zeta, Testis spermatogenesis apoptosis-related protein 7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:102247 |
EC number |
2.3.1.15: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K2C8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K2C8-F1 | Predicted | AlphaFoldDB |
23 variants for Q8K2C8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3398818697 | 21 | V>A | No | EVA | |
| rs3388976313 | 28 | V>I | No | EVA | |
| rs3388976375 | 38 | V>M | No | EVA | |
| rs3388973212 | 54 | F>V | No | EVA | |
| rs3388969702 | 95 | I>N | No | EVA | |
| rs3388953527 | 120 | R>Q | No | EVA | |
| rs3388976768 | 129 | D>G | No | EVA | |
| rs3388978683 | 130 | E>V | No | EVA | |
| rs3388957383 | 158 | L>M | No | EVA | |
| rs261575186 | 196 | M>I | No | EVA | |
| rs3388947200 | 212 | H>Y | No | EVA | |
| rs3388976844 | 231 | Y>H | No | EVA | |
| rs3388957402 | 234 | R>M | No | EVA | |
| rs3388973128 | 291 | E>D | No | EVA | |
| rs3388957430 | 300 | L>Q | No | EVA | |
| rs3398893431 | 345 | V>G | No | EVA | |
| rs3398343145 | 346 | Y>* | No | EVA | |
| rs3398823235 | 347 | P>T | No | EVA | |
| rs3388929171 | 370 | T>M | No | EVA | |
| rs3388976797 | 375 | M>T | No | EVA | |
| rs3388974179 | 405 | R>K | No | EVA | |
| rs3388976801 | 443 | S>I | No | EVA | |
| rs3388973214 | 449 | N>S | No | EVA |
No associated diseases with Q8K2C8
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.15 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. |
| sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity | Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| acyl-CoA metabolic process | The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. |
| CDP-diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. |
| diacylglycerol metabolic process | The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. |
| fatty acid metabolic process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
| glandular epithelial cell maturation | The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. |
| lactation | The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. |
| lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| mammary gland development | The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. |
| phosphatidylcholine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
| regulation of multicellular organism growth | Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. |
| triglyceride biosynthetic process | The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. |
| triglyceride metabolic process | The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A3FPG8 | GPAT4 | Glycerol-3-phosphate acyltransferase 4 | Bos taurus (Bovine) | PR |
| Q5ZLL8 | GPAT3 | Glycerol-3-phosphate acyltransferase 3 | Gallus gallus (Chicken) | PR |
| Q8NF37 | LPCAT1 | Lysophosphatidylcholine acyltransferase 1 | Homo sapiens (Human) | PR |
| Q86UL3 | GPAT4 | Glycerol-3-phosphate acyltransferase 4 | Homo sapiens (Human) | PR |
| Q8C0N2 | Gpat3 | Glycerol-3-phosphate acyltransferase 3 | Mus musculus (Mouse) | PR |
| Q6NVG1 | Lpcat4 | Lysophospholipid acyltransferase LPCAT4 | Mus musculus (Mouse) | PR |
| Q3TFD2 | Lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Mus musculus (Mouse) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6PBN5 | aup1 | Lipid droplet-regulating VLDL assembly factor AUP1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| A3KGT9 | agpat9l | Glycerol-3-phosphate acyltransferase 3-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFLLLPFDSL | IVNLLGISLT | VLFTLLLVFI | IVPAIFGVSF | GIRKLYMKTL | LKIFAWATLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MERGAKERNH | QLYKPYTNGI | IAKDPTSLEE | EIKEIRRSGS | SKALDKTPEF | ELSDIFYFCR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGMETIMDDE | VTKRFSAEEL | ESWNLLSRTN | YNFQYISLRL | TILWGLGVLI | RYCFLLPLRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALAFTGIGLL | VVGTTMVGYL | PNGRFKEFLS | KHVHLMCYRI | CVRALTAIIT | YHNRKNRPRN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GGICVANHTS | PIDVIILASD | GYYAMVGQVH | GGLMGVIQRA | MVKACPHVWF | ERSEVKDRHL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VAKRLTEHVQ | DKSKLPILIF | PEGTCINNTS | VMMFKKGSFE | IGATVYPVAI | KYDPQFGDAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WNSSKYGMVT | YLLRMMTSWA | IVCSVWYLPP | MTREKDEDAV | QFANRVKSAI | ARQGGLVDLL |
| 430 | 440 | 450 | |||
| WDGGLKREKV | KDTFKEEQQK | LYSKMIVGNH | EDRSRS |