Q8K1Y2

SS
Gene name
Prkd3 (Prkcn)
Protein name
Serine/threonine-protein kinase D3
Names
Protein kinase C nu type, nPKC-nu
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:75292
EC number
2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

Protein kinase D (PKD) is a member of Ser/Thr kinases and plays a major role in Golgi function and organization. The PH domain within the PKD may autoinhibit the function of the PKD.

Autoinhibitory domains (AIDs)

416-532 (PH domain) SS

Target domain

575-831 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

718-740 (Activation loop from InterPro)

Target domain

575-831 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8K1Y2

Entry ID Method Resolution Chain Position Source
AF-Q8K1Y2-F1 Predicted AlphaFoldDB

3 variants for Q8K1Y2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs241386634 13 S>P No Ensembl
rs224432625 18 T>S No Ensembl
rs227209410 416 T>A No Ensembl

No associated diseases with Q8K1Y2

10 regional properties for Q8K1Y2

Type Name Position InterPro Accession
domain Protein kinase domain 575 - 831 IPR000719
domain Pleckstrin homology domain 416 - 534 IPR001849
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 154 - 205 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 271 - 321 IPR002219-2
active_site Serine/threonine-protein kinase, active site 694 - 706 IPR008271
binding_site Protein kinase, ATP binding site 581 - 604 IPR017441
domain Diacylglycerol/phorbol-ester binding 152 - 166 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 168 - 177 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 298 - 309 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 310 - 322 IPR020454-4

Functions

Description
EC Number 2.7.11.13 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Membrane
  • Translocation to the cell membrane is required for kinase activation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

1 GO annotations of biological process

Name Definition
protein kinase D signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15139 PRKD1 Serine/threonine-protein kinase D1 Homo sapiens (Human) EV
Q9BZL6 PRKD2 Serine/threonine-protein kinase D2 Homo sapiens (Human) SS
O94806 PRKD3 Serine/threonine-protein kinase D3 Homo sapiens (Human) SS
Q62101 Prkd1 Serine/threonine-protein kinase D1 Mus musculus (Mouse) SS
Q8BZ03 Prkd2 Serine/threonine-protein kinase D2 Mus musculus (Mouse) SS
Q5XIS9 Prkd2 Serine/threonine-protein kinase D2 Rattus norvegicus (Rat) SS
Q9WTQ1 Prkd1 Serine/threonine-protein kinase D1 Rattus norvegicus (Rat) SS
O45818 dkf-2 Serine/threonine-protein kinase dkf-2 Caenorhabditis elegans SS
10 20 30 40 50 60
MSANNSPPSA QKSVFPATVS AVLPAPSPCS SPKTGLSARL SNGSFSAPSL TNSRGSVHTV
70 80 90 100 110 120
SFLLQIGLTR ESVTIEAQEL SLSAVKDLVC SIVYQKFPEC GFFGMYDKIL LFRHDMNSEN
130 140 150 160 170 180
ILQLITSADE IHEGDLVEVV LSALATVEDF QIRPHALYVH SYKAPTFCDY CGEMLWGLVR
190 200 210 220 230 240
QGLKCEGCGL NYHKRCAFKI PNNCSGVRKR RLSNVSLPGP GLSVPRPLQP ECVPLLSEES
250 260 270 280 290 300
HTHQEPSKRI PSWSGRPIWM EKMVMCRVKV PHTFAVHSYG RPTICQYCKR LLKGLFRQGM
310 320 330 340 350 360
QCKDCKFNCH KRCASKVPRD CLGEVTFNGE PCSVGTDADM PMDIDSSDVN SDGSRGLDDS
370 380 390 400 410 420
EEPSPPEDKM FFLDPTDLDV ERDEETVKTI SPSTSNNIPL MRVVQSIKHT KRRSSTVVKE
430 440 450 460 470 480
GWMVHYTSRD NLRKRHYWRL DSKCLTLFQN ESGSKYYKEI PLSEILRVSS PQDFTSISQG
490 500 510 520 530 540
SNPHCFEIIT DTVVYFVGEN NGSSSHNPVL AATGVGLDVA QSWEKAIRQA LMPVTPQASV
550 560 570 580 590 600
CTSPGQGKDH NLATSISVSN CQVQENVDIS SVYQIFADEV LGSGQFGIVY GGKHRKTGRD
610 620 630 640 650 660
VAIKVIDKMR FPTKQESQLR NEVAILQNLH HPGIVNLECM FETPERVFVV MEKLHGDMLE
670 680 690 700 710 720
MILSSEKSRL PERITKFMVT QILVALRNLH FKNIVHCDLK PENVLLASAE PFPQVKLCDF
730 740 750 760 770 780
GFARIIGEKS FRRSVVGTPA YLAPEVLRSK GYNRSLDMWS VGVIVYVSLS GTFPFNEDED
790 800 810 820 830 840
INDQIQNAAF MYPPNPWREI SSEAIDLINN LLQVKMRKRY SVDKSLSHPW LQDYQTWLDL
850 860 870 880
REFETRIGER YITHESDDAR WEIHAYTHNL EYPKHFIMAP NPDDMEEDP