Q8K0D0

PR
Gene name
Cdk17 (Pctaire2, Pctk2)
Protein name
Cyclin-dependent kinase 17
Names
Cell division protein kinase 17, PCTAIRE-motif protein kinase 2, Serine/threonine-protein kinase PCTAIRE-2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:237459
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-207 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

330-353 (Activation loop from InterPro)

Target domain

192-473 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8K0D0

Entry ID Method Resolution Chain Position Source
AF-Q8K0D0-F1 Predicted AlphaFoldDB

17 variants for Q8K0D0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3400868310 30 T>A No EVA
rs3389128837 72 R>S No EVA
rs3389063289 135 R>L No EVA
rs3401629623 150 D>A No EVA
rs3400314408 156 G>V No EVA
rs3401486646 157 Y>C No EVA
rs3401741198 159 E>Q No EVA
rs3389125581 172 M>L No EVA
rs3389133709 215 E>D No EVA
rs3401260495 232 P>H No EVA
rs3389133713 420 D>Y No EVA
rs3389095661 427 F>S No EVA
rs3389121169 435 L>P No EVA
rs51284152 471 V>M No EVA
rs46279653 478 P>A No EVA
rs46279653 478 P>S No EVA
rs3389116144 506 S>Y No EVA

No associated diseases with Q8K0D0

3 regional properties for Q8K0D0

Type Name Position InterPro Accession
domain Protein kinase domain 192 - 473 IPR000719
active_site Serine/threonine-protein kinase, active site 309 - 321 IPR008271
binding_site Protein kinase, ATP binding site 198 - 221 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of transcription involved in G1/S transition of mitotic cell cycle Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00526 CDK3 Cyclin-dependent kinase 3 Homo sapiens (Human) PR
O94921 CDK14 Cyclin-dependent kinase 14 Homo sapiens (Human) PR
Q96Q40 CDK15 Cyclin-dependent kinase 15 Homo sapiens (Human) PR
Q00537 CDK17 Cyclin-dependent kinase 17 Homo sapiens (Human) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
Q8R3L8 Cdk8 Cyclin-dependent kinase 8 Mus musculus (Mouse) PR
Q8BWD8 Cdk19 Cyclin-dependent kinase 19 Mus musculus (Mouse) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q3TZA2 Cdkl4 Cyclin-dependent kinase-like 4 Mus musculus (Mouse) PR
Q8CEQ0 Cdkl1 Cyclin-dependent kinase-like 1 Mus musculus (Mouse) PR
Q8BLF2 Cdkl3 Cyclin-dependent kinase-like 3 Mus musculus (Mouse) PR
Q9QUK0 Cdkl2 Cyclin-dependent kinase-like 2 Mus musculus (Mouse) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
O35831 Cdk17 Cyclin-dependent kinase 17 Rattus norvegicus (Rat) PR
Q5Z754 CDKF-1 Cyclin-dependent kinase F-1 Oryza sativa subsp japonica (Rice) PR
Q9S713 STN7 Serine/threonine-protein kinase STN7, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
A4IIW7 cdk14 Cyclin-dependent kinase 14 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q1RLU9 cdk15 Cyclin-dependent kinase 15 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEESSSKDNE PIVKNGRPPT SHSVHSFLHQ
70 80 90 100 110 120
YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN LKMGSDGESD QASGTSSDEV
130 140 150 160 170 180
QSPTGVCLRN RIHRRISMED LNKRLSLPAD IRIPDGYLEK LQISSPPFDQ PMSRRSRRAS
190 200 210 220 230 240
LSEIGFGKME TYIKLEKLGE GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS
250 260 270 280 290 300
LLKDLKHANI VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG
310 320 330 340 350 360
LAYCHRRKVL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV TLWYRPPDVL
370 380 390 400 410 420
LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL IFRLLGTPSQ ETWPGVSSND
430 440 450 460 470 480
EFKNYNFPKY KPQPLINHAP RLDSEGIELI TKFLQYESKK RVPAEEAMKH VYFRSLGPRI
490 500 510 520
HALPESVSIF SLKEIQLQKD PGFRNSSYPE TGHGKNRRQS MLF