Q8JHJ2

PR
Gene name
ddx55
Protein name
ATP-dependent RNA helicase DDX55
Names
DEAD box protein 55
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

445-560 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8JHJ2

Entry ID Method Resolution Chain Position Source
AF-Q8JHJ2-F1 Predicted AlphaFoldDB

No variants for Q8JHJ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8JHJ2

No associated diseases with Q8JHJ2

6 regional properties for Q8JHJ2

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 169 - 177 IPR000629
domain Helicase, C-terminal 241 - 405 IPR001650
domain DEAD/DEAH box helicase domain 33 - 212 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 28 - 237 IPR014001
domain RNA helicase, DEAD-box type, Q motif 9 - 37 IPR014014
domain Domain of unknown function DUF4217 402 - 465 IPR025313

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL08 DDX55 ATP-dependent RNA helicase DDX55 Bos taurus (Bovine) PR
Q5ZLN8 DDX55 ATP-dependent RNA helicase DDX55 Gallus gallus (Chicken) PR
Q8NHQ9 DDX55 ATP-dependent RNA helicase DDX55 Homo sapiens (Human) PR
Q6ZPL9 Ddx55 ATP-dependent RNA helicase DDX55 Mus musculus (Mouse) PR
P34640 ZK512.2 Probable ATP-dependent RNA helicase DDX55 homolog Caenorhabditis elegans PR
Q9FVV4 RH55 DEAD-box ATP-dependent RNA helicase 55 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MENITDGKWG SLPVKLHDNI LQTLKELGFT YMTPVQSACI PLFMSNKDVA AEAVTGSGKT
70 80 90 100 110 120
LAFVIPALEI LLKREEKLKK MQVGALIITP TRELAMQISE VMGRFLQGFP QFTQILLIGG
130 140 150 160 170 180
SNPIEDVEKL KTQGANIIIA TPGRLEDMFR RKADGLDLAT AVKSLDVLVL DEADRLLDMG
190 200 210 220 230 240
FEASLNTILG YLPKQRRTGL FSATQTQELE KLVRAGLRNP VRITVKEKGV AASSVQKTPA
250 260 270 280 290 300
KLSNYYTMCR AEEKFNTLVA FLRQHKHEKQ LVFFSTCACV EYFGKALEVL VKNVSIHCIH
310 320 330 340 350 360
GKMKHKRNKI FADFRALKSG ILVCTDVMAR GIDIPEVNWV LQYDPPSSAS SFVHRCGRTA
370 380 390 400 410 420
RIGNQGNALV FLLPMEESYV NFLSINQKCP LQSFSSVKDV VDVLPKLKAM ALGDRAMFEK
430 440 450 460 470 480
GMRAFVSYVQ AYAKHECSLI FRIKDLDFAA LARGFALLRL PKMPELRGKT FPDFKAEAID
490 500 510 520 530 540
TDTIRFKDKN REKQRQKWLA EQKEKEVPLR KNFIKNKAWS KQKIKKDRKK KRLPKAKLDQ
550 560 570 580 590
DSDAAEEDLN ELMNDTRLLK KLKKGKITEE DFDKQMSSTD KHKPAGIDSS DGD