Q8JH55
Gene name |
hoxb8b (hoxa8) |
Protein name |
Homeobox protein Hox-B8b |
Names |
Homeobox protein Hox-A8 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:30420 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8JH55
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8JH55-F1 | Predicted | AlphaFoldDB |
No variants for Q8JH55
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8JH55 | |||||
No associated diseases with Q8JH55
5 regional properties for Q8JH55
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 143 - 207 | IPR001356 |
| conserved_site | Homeobox protein, antennapedia type, conserved site | 134 - 139 | IPR001827 |
| conserved_site | Homeobox, conserved site | 178 - 201 | IPR017970 |
| domain | Homeobox domain, metazoa | 167 - 178 | IPR020479-1 |
| domain | Homeobox domain, metazoa | 182 - 201 | IPR020479-2 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P23459 | HOXD8 | Homeobox protein Hox-D8 | Gallus gallus (Chicken) | PR |
| A2T6Z0 | HOXB1 | Homeobox protein Hox-B1 | Pan troglodytes (Chimpanzee) | SS |
| P10105 | lab | Homeotic protein labial | Drosophila melanogaster (Fruit fly) | EV |
| P31268 | HOXA7 | Homeobox protein Hox-A7 | Homo sapiens (Human) | SS |
| P49639 | HOXA1 | Homeobox protein Hox-A1 | Homo sapiens (Human) | SS |
| P14653 | HOXB1 | Homeobox protein Hox-B1 | Homo sapiens (Human) | SS |
| P09022 | Hoxa1 | Homeobox protein Hox-A1 | Mus musculus (Mouse) | SS |
| O08656 | Hoxa1 | Homeobox protein Hox-A1 | Rattus norvegicus (Rat) | SS |
| A2D649 | HOXB1 | Homeobox protein Hox-B1 | Macaca mulatta (Rhesus macaque) | SS |
| Q28IU6 | hoxd1 | Homeobox protein Hox-D1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| F1Q4R9 | meox1 | Homeobox protein MOX-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSYFVNSLF | TKFKGGDSLR | SNYYDCPSYT | PDLGGRPSVL | YGHNTGSAFQ | HAAQFPDFYH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HGTSSFPHAS | YQQTPCAVAY | PGDATGNILG | QDGLQKQSFF | GAPDSDFTQF | GDCNLKVSGI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RDDLESAEPC | TAQLFPWMRP | QATGRRRGRQ | TYSRYQTLEL | EKEFLFNPYL | TRKRRIEVSH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALALTERQVK | IWFQNRRMKW | KKEHNKDKFP | SSKAEQEEIE | RERQEGSQVS | EKHTSGEEDS |
| EASSNSK |