Q8JH47

PR
Gene name
cdk8
Protein name
Cyclin-dependent kinase 8
Names
Cell division protein kinase 8, Mediator complex subunit cdk8, Mediator of RNA polymerase II transcription subunit cdk8
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

322-464 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

172-198 (Activation loop from InterPro)

Target domain

21-335 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8JH47

Entry ID Method Resolution Chain Position Source
AF-Q8JH47-F1 Predicted AlphaFoldDB

No variants for Q8JH47

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8JH47

No associated diseases with Q8JH47

3 regional properties for Q8JH47

Type Name Position InterPro Accession
domain Protein kinase domain 21 - 335 IPR000719
active_site Serine/threonine-protein kinase, active site 147 - 159 IPR008271
binding_site Protein kinase, ATP binding site 27 - 52 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39073 SSN3 Meiotic mRNA stability protein kinase SSN3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9VT57 Cdk8 Cyclin-dependent kinase 8 Drosophila melanogaster (Fruit fly) PR
Q9BWU1 CDK19 Cyclin-dependent kinase 19 Homo sapiens (Human) PR
P49336 CDK8 Cyclin-dependent kinase 8 Homo sapiens (Human) PR
Q8BWD8 Cdk19 Cyclin-dependent kinase 19 Mus musculus (Mouse) PR
Q8R3L8 Cdk8 Cyclin-dependent kinase 8 Mus musculus (Mouse) PR
Q6P3N6 cdk8 Cyclin-dependent kinase 8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q1RLU9 cdk15 Cyclin-dependent kinase 15 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6AXJ9 cdkl1 Cyclin-dependent kinase-like 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
A8WIP6 cdk20 Cyclin-dependent kinase 20 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGYDFKVKLT GERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDRDYA LKQIEGTGIS
70 80 90 100 110 120
MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP
130 140 150 160 170 180
LQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLS
190 200 210 220 230 240
NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED
250 260 270 280 290 300
IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH
310 320 330 340 350 360
KVKPDSKAFH LLQKLLTMDP IRRITSEQAM QDPYFLEEPL PTSDVFAGCQ IPYPKREFLT
370 380 390 400 410 420
EEEPEDKADK KNQQQQQGNN HTNGAGHTGN PDNSHAQGPP LKKVRVVPPT ATSSGLIMTS
430 440 450 460
DYQRSNPHAA YQNPGPSTSL PQSSMGYSST SQQPPQYSHQ THRY