AiPD: Autoinhibited Protein Database

Q8IWK6

Gene name	ADGRA3
Protein name	Adhesion G protein-coupled receptor A3
Names	G-protein coupled receptor 125
Species	Homo sapiens (Human)
KEGG Pathway	hsa:166647
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

918-989 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

918-989 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8IWK6

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8IWK6-F1	Predicted				AlphaFoldDB

1149 variants for Q8IWK6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV002547533 RCV001351661 CA2874388 rs770123865	50	R>G	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001326962 RCV002546205 rs1717464188	132	K>E	Inborn genetic diseases [ClinVar]	Yes	ClinVar dbSNP
RCV001054664 rs144574896 CA2874254 RCV002553778	157	R>Q	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001297717 rs1018423478 CA93527755 RCV002538493	208	T>A	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV001236596 CA2874020 RCV003166465 rs142865840	388	G>R	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV002546227 RCV001327649 rs372207735 CA2873921	520	R>H	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs201873439 RCV001051868 RCV002553268 CA2873914	527	A>D	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV002547547 rs140116910 RCV001352062 CA2873723	722	I>V	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001069998 CA2873644 rs149451001 RCV000787837	798	L>F	Retinitis pigmentosa Retinitis pigmentosa (rp) [ClinVar, Ensembl]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001257836 rs562486549 CA2873602 RCV001035179	835	S>C	Autosomal recessive retinitis pigmentosa [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs145912220 CA2873593 RCV001294870 RCV002538445	858	A>V	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs542362755 CA2873488 RCV002546108 RCV001323834	962	L>M	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs768003943 RCV001037558 CA2873477 RCV002551388	977	S>Y	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001071029 rs370347164 RCV002554616 CA2873410	1078	N>S	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001233926 rs766112442 RCV002563238 CA2873366	1152	K>Q	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2873365 rs201521604 RCV002540183 RCV000899118	1153	M>T	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
RCV002563795 CA356472339 RCV001233246 CA2873358 rs776705989	1161	Q>H	Inborn genetic diseases [ClinVar]	Yes	ClinGen ExAC TOPMed gnomAD ClinVar dbSNP
rs760737507 RCV002546225 RCV001327491 CA2873320	1222	R>G	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2873289 rs142653146 RCV002563179 RCV001230188	1277	Q>R	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs147716223 CA2873269 RCV001041833 RCV002552504	1303	G>C	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA356508018 rs1320585612	4	P>R		No	ClinGen TOPMed
rs1244956451 CA356508016	5	G>R		No	ClinGen TOPMed
TCGA novel	6	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001322895 rs1719643978	7	R>G		No	ClinVar dbSNP
rs886775748 CA94061047	7	R>Q		No	ClinGen TOPMed gnomAD
rs1259148815 CA356507999	8	R>W		No	ClinGen gnomAD
rs1336498787 CA356507979	11	A>G		No	ClinGen TOPMed gnomAD
rs1336498787 CA356507978	11	A>V		No	ClinGen TOPMed gnomAD
rs1312106646 CA356507975	12	Q>*		No	ClinGen TOPMed gnomAD
CA356507977 rs1312106646	12	Q>K		No	ClinGen TOPMed gnomAD
rs1451093446 CA356507972	12	Q>R		No	ClinGen gnomAD
rs1415861816 CA356507964	13	P>Q		No	ClinGen TOPMed gnomAD
CA356507967 rs1334222250	13	P>S		No	ClinGen gnomAD
rs1167244986 CA356507958	14	P>L		No	ClinGen TOPMed
CA356507959 rs1167244986	14	P>R		No	ClinGen TOPMed
rs186892593 CA2874405	18	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2874404 rs781095724	21	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1039926602 CA94061045	22	L>F		No	ClinGen TOPMed
CA94061046 rs899791062	22	L>S		No	ClinGen TOPMed
CA356507918 rs1188365810	22	L>V		No	ClinGen TOPMed gnomAD
rs946612775 CA94061044	23	A>V		No	ClinGen TOPMed gnomAD
CA356507900 rs1227413593	25	L>P		No	ClinGen TOPMed
CA356507899 rs1227413593	25	L>R		No	ClinGen TOPMed
rs1318494279 CA356507897	26	A>P		No	ClinGen TOPMed
rs1302418626 CA356507893	26	A>V		No	ClinGen TOPMed gnomAD
CA356507878 rs1367175682	29	G>A		No	ClinGen TOPMed gnomAD
CA94061042 rs990259194	30	G>D		No	ClinGen TOPMed
CA2874402 rs751553781	31	G>C		No	ClinGen ExAC TOPMed gnomAD
CA356507870 rs751553781	31	G>R		No	ClinGen ExAC TOPMed gnomAD
CA94061041 rs751553781	31	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1410509997 CA356507850	34	G>A		No	ClinGen TOPMed
CA356507845 rs924625895	35	G>A		No	ClinGen TOPMed
CA94061040 RCV001314498 rs924625895	35	G>D		No	ClinGen ClinVar TOPMed dbSNP
rs1156517825 CA356507842	36	A>P		No	ClinGen TOPMed gnomAD
rs777241546 CA356507833	37	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1217227687 CA356507837	37	A>P		No	ClinGen TOPMed
CA2874400 rs777241546	37	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1212942592 CA356507819	40	P>S		No	ClinGen TOPMed
CA94061035 rs764874814	41	A>G		No	ClinGen ExAC TOPMed gnomAD
rs752306317 CA2874398	41	A>S		No	ClinGen ExAC gnomAD
CA2874397 rs764874814	41	A>V		No	ClinGen ExAC TOPMed gnomAD
CA356507809 rs1404505008	42	G>A		No	ClinGen gnomAD
COSM3661036 CA2874395 rs555110508	42	G>C	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA356507808 rs1404505008	42	G>D		No	ClinGen gnomAD
CA356507811 rs555110508	42	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767966248 CA2874394	44	K>M		No	ClinGen ExAC gnomAD
rs774948198 CA2874393	44	K>N		No	ClinGen ExAC gnomAD
rs1479146029 CA356507787	45	H>Q		No	ClinGen TOPMed gnomAD
CA94061034 rs1017054129	45	H>R		No	ClinGen TOPMed
CA2874391 rs768819559	46	D>H		No	ClinGen ExAC TOPMed gnomAD
CA356507785 rs768819559	46	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA2874389 rs775802126	47	G>E		No	ClinGen ExAC gnomAD
CA2874390 rs763133957	47	G>R		No	ClinGen ExAC gnomAD
CA94061032 rs1029272421	48	R>Q		No	ClinGen TOPMed
rs1433867534 CA356507764	50	R>Q		No	ClinGen TOPMed
rs1291221163 CA356507754	52	A>P		No	ClinGen TOPMed gnomAD
rs1230522457 CA356507743	54	R>G		No	ClinGen gnomAD
rs1276990030 CA356507733	55	A>E		No	ClinGen TOPMed gnomAD
rs1336948214 CA356507734	55	A>S		No	ClinGen gnomAD
rs1276990030 CA356507731	55	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	56	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356507725 rs1284317363 RCV001314492	56	A>V		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA2874386 rs780815306	57	G>A		No	ClinGen ExAC gnomAD
CA2874387 rs537261703	57	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770806145 CA2874385	60	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1450022332 CA356507696	61	G>V		No	ClinGen TOPMed
rs746870825 CA2874384	62	K>R		No	ClinGen ExAC TOPMed gnomAD
rs777717582 CA2874383	63	V>A		No	ClinGen ExAC
rs1426064016 CA356507643	69	E>V		No	ClinGen gnomAD
rs1189623947 CA356507638	70	L>F		No	ClinGen gnomAD
rs752216538 CA2874381	71	A>T		No	ClinGen ExAC gnomAD
CA94061030 rs1039661126	71	A>V		No	ClinGen TOPMed
CA356507629 rs569805222	72	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs569805222 CA2874380	72	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA94061029 rs140236262	72	Q>R		No	ClinGen ESP TOPMed gnomAD
CA356507617 rs1577395984	74	L>V		No	ClinGen Ensembl
RCV001327684 CA2874377 rs374728383	75	P>S		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1280982513 CA356507603	76	P>L		No	ClinGen gnomAD
CA2874376 rs558030696	77	D>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1368115045 CA356507592	78	T>I		No	ClinGen gnomAD
rs1405482095 CA356507580	80	P>R		No	ClinGen gnomAD
CA356507582 rs1439982796	80	P>S		No	ClinGen gnomAD
rs1399501600 CA356507573	81	N>I		No	ClinGen gnomAD
rs1399501600 CA356507575	81	N>S		No	ClinGen gnomAD
rs1577395945 CA356507566	82	R>P		No	ClinGen Ensembl
rs1347234888 CA356507561	83	T>M		No	ClinGen TOPMed gnomAD
rs1347234888 CA356507559	83	T>R		No	ClinGen TOPMed gnomAD
rs1360352632 CA356481272	90	N>K		No	ClinGen gnomAD
TCGA novel	93	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs114456992 CA2874326	94	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel rs1717941331 RCV001352575	94	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinVar NCI-TCGA dbSNP
TCGA novel	95	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs921364290 CA93538175	95	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA356481218 rs1164624337	98	N>S		No	ClinGen gnomAD
CA356481217 rs1164624337	98	N>T		No	ClinGen gnomAD
rs774095509 CA2874323	99	G>D		No	ClinGen ExAC gnomAD
CA2874322 rs768622040	100	S>*		No	ClinGen ExAC gnomAD
rs1577369846 CA356481200	101	F>S		No	ClinGen Ensembl
rs976832762 CA93538164	108	E>G		No	ClinGen TOPMed
TCGA novel	108	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1717939254 RCV001298179	109	R>S		No	ClinVar dbSNP
rs1218545395 CA356481141	110	L>S		No	ClinGen gnomAD
CA2874298 rs775315372	111	D>V		No	ClinGen ExAC gnomAD
COSM261138 rs776366061 CA2874295	113	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA356480542 rs1329833064	114	N>S		No	ClinGen gnomAD
rs917865116 CA93534126	116	L>I		No	ClinGen Ensembl
rs1404795712 CA356480520	117	I>S		No	ClinGen gnomAD
CA356480482 rs1176537336	122	P>L		No	ClinGen gnomAD
rs1313844190 CA356480458	126	W>*		No	ClinGen TOPMed
rs1464214027 CA356480439	129	S>A		No	ClinGen gnomAD
CA93531996 COSM109240 rs140443154	140	R>*	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1165791849 RCV001340893	140	R>L		No	ClinVar dbSNP
rs1165791849 COSM1054562 CA356480055	140	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA2874263 rs114686229 RCV000886519	141	I>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1267974089 CA356480038	141	I>M		No	ClinGen Ensembl
TCGA novel	142	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356480024 rs1193139320	143	C>G		No	ClinGen gnomAD
rs142690763 RCV001204902 CA2874261	145	N>D		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1560326080 CA356479997	145	N>S		No	ClinGen Ensembl
CA356479587 rs1242101958	147	D>N		No	ClinGen TOPMed
rs542014008 CA2874259 RCV001326662	148	I>V		No	ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD
CA356479546 rs1560326065	150	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	152	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA93531987 rs376845643	152	L>V		No	ClinGen ESP
CA2874256 rs61736472 RCV001049332	154	N>S		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs903166194 CA93531980	155	L>V		No	ClinGen Ensembl
CA2874255 rs147434497	157	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
COSM733696 rs1218443503 CA356479045	159	N>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs753760901 CA2874242	159	N>S		No	ClinGen ExAC gnomAD
CA356479042 rs114895475	160	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2874241 rs114895475	160	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs994379710 CA93529060	161	S>L		No	ClinGen Ensembl
rs1163248487 CA356479021	163	N>Y		No	ClinGen TOPMed
CA356478959 rs1374833161	166	S>Y		No	ClinGen gnomAD
CA2874238 rs767092568	167	S>A		No	ClinGen ExAC gnomAD
RCV001244106 rs1716874572	169	S>A		No	ClinVar dbSNP
CA356478912 rs1577354487	170	Q>R		No	ClinGen Ensembl
rs774010326 CA2874236	171	G>E		No	ClinGen ExAC gnomAD
CA356478885 rs1459802329	172	T>I		No	ClinGen TOPMed
CA356478826 rs759901739	177	A>G		No	ClinGen ExAC TOPMed gnomAD
rs147262995 CA2874235	177	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs759901739 CA2874234	177	A>V		No	ClinGen ExAC TOPMed gnomAD
rs771331276 CA2874232	178	S>L		No	ClinGen ExAC gnomAD
rs1177298597 CA356478783	180	R>Q		No	ClinGen gnomAD
rs773134595 CA2874230	180	R>W		No	ClinGen ExAC gnomAD
CA356478773 rs1315357669	181	S>Y		No	ClinGen gnomAD
TCGA novel	185	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2874199 RCV001297892 rs771978768	187	E>Q		No	ClinGen ClinVar ExAC dbSNP gnomAD
RCV001345305 rs1716782628	188	Y>S		No	ClinVar dbSNP
rs1290029021 CA356478545	189	L>V		No	ClinGen gnomAD
CA356478535 rs1490143852	190	L>F		No	ClinGen gnomAD
rs546772345 CA2874198	191	C>F		No	ClinGen 1000Genomes ExAC
CA356478509 rs1292210374	194	N>D		No	ClinGen gnomAD
rs1455788291 CA356478505	194	N>T		No	ClinGen gnomAD
rs1223419576 CA356478497	195	I>T		No	ClinGen gnomAD
CA2874197 rs376148471	196	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1462380144 CA356478481	198	M>L		No	ClinGen TOPMed
rs951469992 CA93527789	199	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs191604615 CA2874195	200	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA2874196 rs191604615	200	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA2874194 rs147390035	200	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2874193 rs769648494	204	E>K		No	ClinGen ExAC gnomAD
CA2874192 rs761890075	205	K>R		No	ClinGen ExAC TOPMed gnomAD
rs542554708 CA2874191	206	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA93527758 rs964191258	207	I>L		No	ClinGen TOPMed
RCV001349368 CA2874189 rs149598012	208	T>M		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs141210874 CA2874186 RCV001305016	210	R>Q		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA2874187 rs575529822	210	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs1346605672 CA356478385	213	R>G		No	ClinGen TOPMed gnomAD
rs1217019843 CA356478374	214	C>S		No	ClinGen gnomAD
RCV001327516 CA356478371 rs1264172149	214	C>W		No	ClinGen ClinVar TOPMed dbSNP
rs907724711 CA93527733	217	P>H		No	ClinGen gnomAD
rs907724711 CA356478352	217	P>L		No	ClinGen gnomAD
rs766605600 CA2874185	222	A>T		No	ClinGen ExAC gnomAD
CA93527718 rs930614453	224	P>R		No	ClinGen Ensembl
CA2874182 rs750838186	225	V>I		No	ClinGen ExAC gnomAD
CA356478306 rs750838186	225	V>L		No	ClinGen ExAC gnomAD
CA356478296 rs1168152504	226	T>I		No	ClinGen gnomAD
CA2874180 rs762476240	227	G>S		No	ClinGen ExAC TOPMed gnomAD
rs368999398 CA356478289	228	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2874178 rs368999398	228	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA356478275 rs1266596617	230	Q>*		No	ClinGen gnomAD
CA356478268 rs1194184746	231	E>K		No	ClinGen gnomAD
rs775809391 CA2874176	234	T>S		No	ClinGen ExAC gnomAD
rs181385852 CA2874148	236	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1252063250 CA356478234	236	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
RCV001339526 CA2874147 rs560712931	237	P>L		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs902854483 CA93526367	238	P>L		No	ClinGen gnomAD
CA356477719 rs1175800415	240	E>Q		No	ClinGen gnomAD
CA2874145 rs771512345	242	P>L		No	ClinGen ExAC gnomAD
CA356477644 rs1441926176	243	S>F		No	ClinGen TOPMed
TCGA novel	244	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2874142 rs754627253	245	Y>C		No	ClinGen ExAC gnomAD
rs141526104 CA2874140	246	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA93526359 rs914286200	247	T>I		No	ClinGen Ensembl
CA2874138 rs148364573	250	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2874137 rs145174089	251	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2874136 rs758890185	251	R>H		No	ClinGen ExAC TOPMed gnomAD
CA356477523 COSM1728373 rs758890185	251	R>L	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2874134 rs200120620	253	V>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1463183942 CA356477461	254	V>G		No	ClinGen gnomAD
rs986688317 CA93526347	255	F>S		No	ClinGen TOPMed
rs939413784 CA93526344	258	D>N		No	ClinGen TOPMed gnomAD
CA356477393 rs1167723845	259	S>G		No	ClinGen gnomAD
TCGA novel	259	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs562864844 CA2874133 CA356477382	259	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs754083729 CA2874132	264	C>F		No	ClinGen ExAC gnomAD
rs1244343882 CA356477352	264	C>S		No	ClinGen gnomAD
rs1467675518 CA356477345	265	M>V		No	ClinGen gnomAD
CA356477324 rs1253044060	268	Y>H		No	ClinGen gnomAD
CA2874131 rs766122065	269	I>T		No	ClinGen ExAC gnomAD
CA2874130 rs760467942	270	D>G		No	ClinGen ExAC TOPMed gnomAD
CA356477303 rs1214945769	271	Q>E		No	ClinGen gnomAD
CA2874129 rs773047692	272	D>G		No	ClinGen ExAC gnomAD
CA2874127 rs372445132 CA356477283	273	M>I		No	ClinGen ESP ExAC gnomAD
CA2874128 rs375429759	273	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs200853804 CA93526309	280	D>G		No	ClinGen 1000Genomes TOPMed gnomAD
rs1186805080 CA356477226	281	G>E		No	ClinGen gnomAD
CA356477221 rs1328363462	282	R>K		No	ClinGen gnomAD
CA356477220 rs1328363462	282	R>T		No	ClinGen gnomAD
rs1410950421 CA356477192	286	T>N		No	ClinGen gnomAD
rs138542858 CA2874122	287	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2061699 CA2874120 RCV000952893	289	S>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2874118 rs758909833	291	G>D		No	ClinGen ExAC TOPMed gnomAD
CA356477156 rs1019095837	292	I>L		No	ClinGen TOPMed
rs1019095837 CA93526273	292	I>V		No	ClinGen TOPMed
CA2874117 rs201250338	296	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	297	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149071206 CA2874116	297	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA93526272 rs1012984343	298	M>V		No	ClinGen Ensembl
CA356477082 rs1560319199	302	C>S		No	ClinGen Ensembl
CA356477079 rs1348533415	302	C>Y		No	ClinGen gnomAD
CA356477072 rs1236595571	303	S>C		No	ClinGen gnomAD
rs755046461 CA2874115	303	S>P		No	ClinGen ExAC gnomAD
CA93526262 rs753993728	305	I>F		No	ClinGen ExAC TOPMed gnomAD
CA2874113 rs766572844	305	I>M		No	ClinGen ExAC gnomAD
CA2874114 rs753993728	305	I>V		No	ClinGen ExAC TOPMed gnomAD
CA356477056 rs1443161336	306	A>E		No	ClinGen TOPMed gnomAD
rs1443161336 CA356477055	306	A>G		No	ClinGen TOPMed gnomAD
CA356482814 rs1208066767	311	I>T		No	ClinGen TOPMed
CA93529142 rs367781640	313	N>K		No	ClinGen ESP
CA356482801 rs1159226684	313	N>S		No	ClinGen gnomAD
RCV001207220 rs1716480565	316	A>D		No	ClinVar dbSNP
CA2874090 rs144997202 RCV001042433	316	A>P		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs144997202 CA2874091	316	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2874089 rs756306946	317	G>E		No	ClinGen ExAC gnomAD
rs750665555 CA2874088	318	S>A		No	ClinGen ExAC TOPMed gnomAD
rs757003096 CA356482769	319	T>A		No	ClinGen ExAC TOPMed gnomAD
rs548920791 CA93529117	319	T>I		No	ClinGen 1000Genomes
CA2874086 rs757003096	319	T>P		No	ClinGen ExAC TOPMed gnomAD
rs1045072095 CA93529112	322	W>*		No	ClinGen Ensembl
rs751453660 CA2874085	323	G>D		No	ClinGen ExAC gnomAD
CA2874084 rs763921566	324	C>Y		No	ClinGen ExAC gnomAD
rs1007105687 CA93529088	326	V>F		No	ClinGen TOPMed
rs763054287 CA2874083	327	Q>*		No	ClinGen ExAC gnomAD
rs775111076 CA2874082	330	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2874081 RCV001067375 rs150340074	330	R>H		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001044534 CA2874080 rs140303157	331	G>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs776179924 CA2874079	333	N>D		No	ClinGen ExAC gnomAD
rs772414820 CA2874078	333	N>I		No	ClinGen ExAC
rs1380838808 RCV001246318	334	T>M		No	ClinVar dbSNP
CA356482670 rs1380838808	334	T>R		No	ClinGen gnomAD
CA2874076 rs774838047	336	T>N		No	ClinGen ExAC gnomAD
rs1560316934 CA356482629	341	V>I		No	ClinGen Ensembl
rs1168073178 CA356482607	344	S>G		No	ClinGen gnomAD
CA356482604 rs1427630925	344	S>N		No	ClinGen gnomAD
CA356482599 RCV001212008 rs1448310207	345	S>P		No	ClinGen ClinVar TOPMed dbSNP
CA2874074 rs749843781	346	A>T		No	ClinGen ExAC gnomAD
rs1042158327 CA93529044	348	Y>C		No	ClinGen TOPMed
CA356482570 rs1294703932	349	C>S		No	ClinGen TOPMed
COSM3825687 rs147843055 CA2874072 RCV000923226 COSM1239012	350	P>L	oesophagus large_intestine breast [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs757554862 CA2874069	353	R>S		No	ClinGen ExAC gnomAD
CA356482539 rs1469092660	354	V>L		No	ClinGen TOPMed gnomAD
rs1469092660 CA356482541	354	V>M		No	ClinGen TOPMed gnomAD
rs1225707325 CA356482534	355	V>L		No	ClinGen gnomAD
RCV001297284 rs1307282344 CA356482510	358	K>T		No	ClinGen ClinVar dbSNP gnomAD
rs758392440 CA2874066	361	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1198602965 CA356482484	362	R>G		No	ClinGen TOPMed
rs1716406956 RCV001210860	364	P>L		No	ClinVar dbSNP
CA2874040 rs764372193	364	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	365	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001237326 CA2874039 rs200053006	366	T>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs866442647 CA93528030	368	A>S		No	ClinGen Ensembl
rs770277871 CA2874037	368	A>V		No	ClinGen ExAC gnomAD
rs776553108 CA2874035	369	G>A		No	ClinGen ExAC gnomAD
CA2874036 rs186079507	369	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778147136 CA2874032	371	T>I		No	ClinGen ExAC gnomAD
rs747944751 CA2874030	372	A>T		No	ClinGen ExAC gnomAD
CA356482396 rs1289761104	374	L>P		No	ClinGen gnomAD
CA356482374 rs1407221276	377	T>M		No	ClinGen TOPMed
rs535789557 RCV001236608 CA2874026	378	R>Q		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA2874027 rs147674998 RCV001060811	378	R>W		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA356482365 rs1313662497	379	N>S		No	ClinGen TOPMed
rs749982044 CA2874024	380	T>P		No	ClinGen ExAC gnomAD
rs1363480860 CA356482358	380	T>S		No	ClinGen gnomAD
rs1377478870 CA356482352	381	H>R		No	ClinGen TOPMed
rs1453057207 CA356482345	382	G>D		No	ClinGen gnomAD
CA2874022 rs567943236	386	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
CA356482309 rs1474458118	387	P>L		No	ClinGen gnomAD
rs1393588101 CA356482282	391	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA356482285 rs1374772747	391	Q>R		No	ClinGen TOPMed
CA93527951 rs904397261	393	E>K		No	ClinGen TOPMed
rs759913509 CA2874019	395	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1271007842 COSM3132826 CA356482232 COSM3825686	398	R>H	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
RCV001305342 rs770852914 CA2874017	399	R>I		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs537910946 CA93527940	401	D>G		No	ClinGen 1000Genomes TOPMed gnomAD
CA356482186 rs1269694285	405	F>C		No	ClinGen gnomAD
rs1231054427 CA356482174	407	A>T		No	ClinGen gnomAD
rs148523163 CA2874016	408	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA2874015 rs190663255	408	D>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs892565695 CA93527927	409	D>E		No	ClinGen TOPMed gnomAD
CA2874013 rs748422868	411	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA356482137 rs1381776989	412	S>F		No	ClinGen gnomAD
rs774236322 RCV001237435 CA2874012	413	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA2874011 rs144734405	413	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs748536522 CA93527916	416	Y>C		No	ClinGen TOPMed gnomAD
CA356482097 rs1417357563 COSM311557	418	N>S	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
RCV001069208 rs1417357563	418	N>T		No	ClinVar dbSNP
CA356482092 rs1337010283	419	D>N		No	ClinGen Ensembl
rs915267698 CA93527914	420	V>I		No	ClinGen TOPMed
CA2874009 rs780050247	423	V>D		No	ClinGen ExAC gnomAD
CA93527904 rs989876254	424	L>I		No	ClinGen Ensembl
CA356482053 rs1371909802	425	Y>C		No	ClinGen gnomAD
rs1193094611 CA356482030	428	N>Y		No	ClinGen gnomAD
rs1196119946 CA356481998	430	M>I		No	ClinGen gnomAD
RCV001201416 rs1272053856 CA356482002	430	M>L		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs768277348 CA2873993	431	P>L		No	ClinGen ExAC gnomAD
rs1344234186 CA356481993	431	P>S		No	ClinGen gnomAD
CA2873992 rs749092609	432	L>P		No	ClinGen ExAC gnomAD
CA93527325 rs185049428	434	L>F		No	ClinGen 1000Genomes TOPMed gnomAD
CA356481975 rs1275704907	434	L>H		No	ClinGen gnomAD
CA356481974 rs1275704907	434	L>P		No	ClinGen gnomAD
rs775212347 CA2873991	436	N>D		No	ClinGen ExAC TOPMed gnomAD
CA2873990 rs769737129	437	A>V		No	ClinGen ExAC TOPMed gnomAD
rs780634313 CA93527292	438	V>L		No	ClinGen ExAC TOPMed gnomAD
rs780634313 CA2873988	438	V>M		No	ClinGen ExAC TOPMed gnomAD
CA2873987 rs756794895	440	T>R		No	ClinGen ExAC gnomAD
rs758044902 CA2873985	442	R>L		No	ClinGen ExAC gnomAD
rs758044902 CA2873984 COSM1429170	442	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2873983 rs754227219	443	Q>H		No	ClinGen ExAC gnomAD
CA2873981 rs756669320	446	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1191940597 CA356481902	447	Y>S		No	ClinGen TOPMed
CA93527226 rs1042820988	448	T>I		No	ClinGen TOPMed gnomAD
CA356481898 rs1483906456	448	T>P		No	ClinGen gnomAD
rs750997181 CA2873980	453	N>T		No	ClinGen ExAC gnomAD
rs767636238 CA2873979	455	S>A		No	ClinGen ExAC gnomAD
rs761996323 CA2873978	456	D>G		No	ClinGen ExAC gnomAD
CA356481840 rs1279121520	457	K>E		No	ClinGen gnomAD
TCGA novel	457	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873976 rs764369233	458	M>I		No	ClinGen ExAC TOPMed gnomAD
CA2873977 rs774626572	458	M>T		No	ClinGen ExAC
TCGA novel	458	M>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775331061 CA2873975	459	D>G		No	ClinGen ExAC gnomAD
rs775331061 CA2873974	459	D>V		No	ClinGen ExAC gnomAD
CA2873973 RCV001213605 rs140136425	460	V>I		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2873972 rs554820677	461	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA2873971 rs776558396	462	F>S		No	ClinGen ExAC gnomAD
RCV001243529 CA2873969 CA2873970 rs146147575	463	V>L		No	ClinGen ESP ExAC TOPMed gnomAD ClinVar dbSNP
CA93527134 rs76958962	464	A>E		No	ClinGen Ensembl
CA356481756 rs1391604757	469	K>T		No	ClinGen TOPMed
rs1473472971 CA356481747	470	F>C		No	ClinGen gnomAD
CA356481751 rs1159438867	470	F>L		No	ClinGen gnomAD
rs1156423477 CA356481739	471	G>V		No	ClinGen gnomAD
rs1435340118 CA356481718	474	T>I		No	ClinGen TOPMed
RCV001240572 rs1716349880	476	E>Q		No	ClinVar dbSNP
CA356481694 rs1369276600	477	E>D		No	ClinGen TOPMed
TCGA novel	480	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1239060075	481	E>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA356481667 rs1483553634	481	E>G		No	ClinGen gnomAD
rs757813561 CA2873943	485	V>M		No	ClinGen ExAC gnomAD
rs1450787202 CA356481622	486	M>T		No	ClinGen TOPMed
rs1322694737 CA356481606	488	D>V		No	ClinGen gnomAD
CA2873942 rs752027303	489	I>F		No	ClinGen ExAC TOPMed gnomAD
rs569186866 CA2873941	489	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1715842817 RCV001225361	490	A>T		No	ClinVar dbSNP
rs752909223 CA2873939	492	N>I		No	ClinGen ExAC gnomAD
CA356481569 rs1484819280	494	M>V		No	ClinGen TOPMed
CA2873938 rs765436150	495	L>V		No	ClinGen ExAC gnomAD
rs759821657 CA2873937	497	D>E		No	ClinGen ExAC gnomAD
rs1324783599 CA356481549	497	D>N		No	ClinGen gnomAD
CA2873936 rs551038567	499	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs551038567 CA93520512	499	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1168004015 CA356481532	499	R>H		No	ClinGen TOPMed gnomAD
CA2873935 rs368631510	500	V>F		No	ClinGen ESP ExAC gnomAD
rs766992855 CA2873932	504	A>G		No	ClinGen ExAC TOPMed gnomAD
rs760613528 CA2873934	504	A>T		No	ClinGen ExAC gnomAD
rs766992855 CA2873933	504	A>V		No	ClinGen ExAC TOPMed gnomAD
CA356481479 rs1406341778	508	A>T		No	ClinGen TOPMed
rs1046334786 CA93520465	509	K>E		No	ClinGen Ensembl
rs138525539 CA2873929 RCV000888535	509	K>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA356481465 rs1267628742	510	A>G		No	ClinGen TOPMed gnomAD
CA2873928 rs748993423	510	A>T		No	ClinGen ExAC gnomAD
CA356481448 rs927971816	512	S>R		No	ClinGen TOPMed gnomAD
rs771450752 CA2873926	513	R>K		No	ClinGen ExAC gnomAD
rs1387020032 CA356481430	515	V>A		No	ClinGen gnomAD
rs778158742 CA2873924	515	V>M		No	ClinGen ExAC gnomAD
CA356481425 rs1365267631	516	Q>R		No	ClinGen TOPMed
rs201298150 CA93520366	517	C>Y		No	ClinGen gnomAD
CA356481408 rs1436878617	519	Q>*		No	ClinGen TOPMed
rs759006494 CA2873923	519	Q>R		No	ClinGen ExAC gnomAD
CA2873922 rs748176960	520	R>C		No	ClinGen ExAC gnomAD
CA356481398 rs372207735	520	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763848937 CA93520337	522	A>V		No	ClinGen gnomAD
CA356481384 rs1355146073	523	T>A		No	ClinGen TOPMed
rs1355146073 CA356481385	523	T>P		No	ClinGen TOPMed
rs1577339736 CA356481376	524	Y>S		No	ClinGen Ensembl
rs200043303 CA2873918	525	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2873916 rs754246566	525	R>Q		No	ClinGen ExAC gnomAD
rs200043303 CA2873917	525	R>W		No	ClinGen ExAC TOPMed gnomAD
rs61745011 CA2873912	528	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763718218 CA2873911	530	A>T		No	ClinGen ExAC gnomAD
CA2873909 rs564893051	532	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2873908 rs368578310	535	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1318837353 CA356481123	536	Y>C		No	ClinGen gnomAD
rs147996007 RCV001210667 CA2873891	536	Y>H		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs747895989 CA93517724	538	P>T		No	ClinGen Ensembl
CA93517718 rs893860967	539	N>S		No	ClinGen TOPMed
CA2873889 RCV001305588 rs759273052	541	A>S		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs773431146 CA2873888	541	A>V		No	ClinGen ExAC
rs1479232242 CA356481075	544	A>S		No	ClinGen TOPMed gnomAD
rs1479232242 CA356481077	544	A>T		No	ClinGen TOPMed gnomAD
CA356481070 rs1371696798	545	Y>H		No	ClinGen gnomAD
rs1474425391 CA356481053	547	I>T		No	ClinGen gnomAD
CA356481056 rs1194329663	547	I>V		No	ClinGen TOPMed
CA356481045 rs1368465165	548	K>M		No	ClinGen gnomAD
rs762271006 CA2873886	550	T>A		No	ClinGen ExAC TOPMed gnomAD
rs762271006 CA356481035	550	T>S		No	ClinGen ExAC TOPMed gnomAD
rs774845797 CA2873885	551	G>S		No	ClinGen ExAC TOPMed gnomAD
CA2873884 rs769206447	551	G>V		No	ClinGen ExAC gnomAD
CA356481019 rs1269561753	553	T>A		No	ClinGen gnomAD
COSM1429165 rs186077400 CA2873882	553	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA356481007 rs199947143	555	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2873878 rs199947143	555	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1246867013 CA356481000	556	T>P		No	ClinGen gnomAD
RCV001341521 rs1246867013 CA356480998	556	T>S		No	ClinGen ClinVar dbSNP gnomAD
CA2873877 rs751487183	557	C>R		No	ClinGen ExAC gnomAD
CA356480987 rs777841628	558	T>A		No	ClinGen ExAC TOPMed gnomAD
CA2873875 rs758478204	558	T>N		No	ClinGen ExAC TOPMed gnomAD
CA2873876 rs777841628	558	T>P		No	ClinGen ExAC TOPMed gnomAD
rs530568926 CA2873874	559	V>M		No	ClinGen ExAC gnomAD
rs143510925 CA2873873 RCV001327034	560	F>L		No	ClinGen ESP ExAC gnomAD ClinVar dbSNP
CA2873872 rs759064703	562	K>E		No	ClinGen ExAC gnomAD
CA356480952 rs1371776203	563	V>A		No	ClinGen gnomAD
CA356480949 rs753561919	564	A>P		No	ClinGen ExAC TOPMed gnomAD
CA2873871 rs753561919	564	A>S		No	ClinGen ExAC TOPMed gnomAD
CA2873870 rs767710429	564	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1191322487 CA356480943	565	A>G		No	ClinGen gnomAD
rs910805841 CA93517624	565	A>T		No	ClinGen gnomAD
CA93517615 rs753149268	566	S>F		No	ClinGen TOPMed gnomAD
rs1577337425 CA356480940	566	S>P		No	ClinGen Ensembl
rs762150194 CA2873869	567	D>V		No	ClinGen ExAC gnomAD
rs375354992 CA2873867	568	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2873865 rs148867805 RCV000968574	568	R>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs148867805 CA356480928	568	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV001050839 CA2873866 rs148867805	568	R>P		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2873868 rs375354992	568	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2873863 rs200835396	569	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200835396 CA2873864	569	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771338422 CA2873861	570	G>R		No	ClinGen ExAC gnomAD
rs1300158966 CA356480911	572	S>A		No	ClinGen TOPMed gnomAD
RCV001213203 rs112799193 CA2873860	572	S>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1300158966 CA356480910	572	S>P		No	ClinGen TOPMed gnomAD
rs1577337375 CA356480903	573	D>G		No	ClinGen Ensembl
CA356480906 rs1324620061	573	D>H		No	ClinGen TOPMed gnomAD
rs758388407 CA2873858	576	R>K		No	ClinGen ExAC TOPMed gnomAD
CA2873856 rs778250454	577	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs147833167 CA2873857 RCV001305057	577	R>W		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA356480872 rs1429873917	578	D>G		No	ClinGen gnomAD
rs1429873917 CA356480871	578	D>V		No	ClinGen gnomAD
rs754525035 CA2873855	585	K>N		No	ClinGen ExAC gnomAD
rs908940796 CA93517495	585	K>T		No	ClinGen TOPMed
rs766047907 CA2873853	592	N>S		No	ClinGen ExAC TOPMed gnomAD
CA356480766 rs1246872554	593	V>D		No	ClinGen gnomAD
CA2873850 rs754733366 RCV001240099	598	S>L		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2873851 rs754733366	598	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1205759122 CA356480722	600	L>V		No	ClinGen gnomAD
CA356480718 rs1560307732	601	A>T		No	ClinGen Ensembl
CA93517450 rs554426046	601	A>V		No	ClinGen TOPMed gnomAD
rs1217479488 CA356480713	602	L>V		No	ClinGen gnomAD
TCGA novel	605	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1294568084 CA356480379	605	T>I		No	ClinGen gnomAD
CA2873804 rs760853167	605	T>S		No	ClinGen ExAC gnomAD
CA356480375 rs1489072907	606	I>T		No	ClinGen TOPMed
CA356480376 rs1225630558	606	I>V		No	ClinGen gnomAD
CA2873803 rs750591769	607	V>M		No	ClinGen ExAC gnomAD
CA356480356 rs1208258136	609	A>S		No	ClinGen TOPMed
rs763960292 CA2873801	610	S>VI*		No	ClinGen ExAC
rs1364998880 CA356480337	612	Q>*		No	ClinGen gnomAD
rs111319670 CA93511426	612	Q>R		No	ClinGen Ensembl
rs1485856723 CA356480326	614	P>S		No	ClinGen TOPMed
rs1189602021 CA356480316	615	P>L		No	ClinGen TOPMed
CA93511412 rs955891778 RCV001237804	617	L>F		No	ClinGen ClinVar Ensembl dbSNP
CA2873799 rs761987546	618	F>V		No	ClinGen ExAC gnomAD
rs1560304095 CA356480291	619	S>L		No	ClinGen Ensembl
CA2873798 rs774143861	621	K>*		No	ClinGen ExAC gnomAD
rs1427964548 CA356480274	622	Q>P		No	ClinGen gnomAD
rs1427964548 RCV001313121 CA356480273	622	Q>R		No	ClinGen ClinVar dbSNP gnomAD
rs374035964 CA2873797	623	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA93511376 rs1000071093	624	R>G		No	ClinGen Ensembl
rs202220872 CA93511372	625	E>K		No	ClinGen Ensembl
CA356480246 rs1469532300	626	L>P		No	ClinGen TOPMed
CA356480241 rs1159227390	627	R>K		No	ClinGen TOPMed
CA356480234 rs1430526781	628	P>S		No	ClinGen gnomAD
CA2873795 RCV001059562 rs201067452	629	T>A		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2873794 RCV001053319 rs769779231	629	T>I		No	ClinGen ClinVar ExAC dbSNP gnomAD
CA93511359 rs533683078	630	D>E		No	ClinGen TOPMed gnomAD
CA2873793 rs745377198	630	D>N		No	ClinGen ExAC gnomAD
CA356480216 rs1173247225	631	D>G		No	ClinGen TOPMed
rs780722256 CA2873792	632	S>C		No	ClinGen ExAC TOPMed gnomAD
CA356480207 rs1342011699	633	L>I		No	ClinGen gnomAD
rs1342011699 CA356480206	633	L>V		No	ClinGen gnomAD
rs755306068 CA2873788	637	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA356480170 rs1483299979	638	L>F		No	ClinGen gnomAD
CA2873786 rs754342871	639	I>T		No	ClinGen ExAC gnomAD
rs146115905 CA2873784 RCV001235074	642	R>C		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs750505698 COSM1054546 CA2873783	642	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs750505698 CA356480144	642	R>L		No	ClinGen ExAC TOPMed gnomAD
CA2873785 rs146115905	642	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs767514267 CA2873782	643	N>D		No	ClinGen ExAC gnomAD
CA93511321 rs767514267	643	N>H		No	ClinGen ExAC gnomAD
rs1409169570 CA356480141	643	N>S		No	ClinGen gnomAD
TCGA novel	644	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356480128 rs1371018612	645	K>E		No	ClinGen gnomAD
rs1577332662 CA356480115	645	K>N		No	ClinGen Ensembl
CA2873781 rs367787883	645	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	645	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1560303935 CA356480099	647	F>I		No	ClinGen Ensembl
CA2873778 rs765515331	648	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	648	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763890087 CA2873779	648	P>S		No	ClinGen ExAC gnomAD
rs752614746 CA93511286	651	G>E		No	ClinGen Ensembl
rs1290085452 CA356480022	652	N>S		No	ClinGen TOPMed gnomAD
CA2873775 rs759521071	654	T>A		No	ClinGen ExAC gnomAD
CA2873774 rs563105823	654	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA2873773 rs544787330	655	N>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA356479979 rs1255105519	656	L>F		No	ClinGen gnomAD
rs746608601 CA2873772	656	L>S		No	ClinGen ExAC gnomAD
rs777307868 CA356479978	657	A>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs777307868 CA2873771	657	A>T		No	ClinGen ExAC gnomAD
rs867880712 CA93511250	657	A>V		No	ClinGen TOPMed
rs1715309231 RCV001220971	658	D>A		No	ClinVar dbSNP
rs771817943 CA2873770	660	G>R		No	ClinGen ExAC gnomAD
CA356479951 rs1227494906	661	K>Q		No	ClinGen gnomAD
rs1351094542 CA356479943	662	R>Q		No	ClinGen gnomAD
CA93511205 rs940891886	663	R>C		No	ClinGen gnomAD
rs767574676 CA93511200	663	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs532985930 CA93511197	664	T>A		No	ClinGen 1000Genomes TOPMed gnomAD
CA356479935 rs532985930	664	T>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs754703389 CA93511173	665	V>A		No	ClinGen gnomAD
RCV001244259 rs752436150	666	V>missing		No	ClinVar dbSNP
TCGA novel	670	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356479881 rs1413427790	673	K>E		No	ClinGen TOPMed gnomAD
rs1184576559 CA356479880	673	K>T		No	ClinGen gnomAD
CA2873765 rs781262046	674	I>M		No	ClinGen ExAC gnomAD
rs368424948 CA93511154	674	I>V		No	ClinGen Ensembl
CA356479847 COSM1054545 rs1368342362	676	G>D	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA356479845 rs1368342362	676	G>V		No	ClinGen gnomAD
rs771596646 CA2873752	677	V>M		No	ClinGen ExAC gnomAD
CA356479825 rs1445920836	680	D>Y		No	ClinGen gnomAD
rs747821711 CA2873751	681	T>I		No	ClinGen ExAC gnomAD
CA356479793 rs1560303667	684	I>N		No	ClinGen Ensembl
TCGA novel	685	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1332604226 CA356479758	689	T>I		No	ClinGen TOPMed
CA2873746 rs775106705 RCV001308783	690	L>P		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs149970910 CA2873745	691	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs149970910 CA356479752	691	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2873744 rs201944807	691	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1167154806 CA356479748	692	R>*		No	ClinGen TOPMed gnomAD
CA356479746 rs758572665	692	R>L		No	ClinGen ExAC TOPMed gnomAD
CA2873743 rs758572665 COSM176520	692	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA2873741 rs764946459	693	I>T		No	ClinGen ExAC gnomAD
rs754785204 CA2873740	694	A>T		No	ClinGen ExAC gnomAD
CA356479732 rs1385446433	695	H>Y		No	ClinGen gnomAD
CA356479721 rs1390734306	696	G>V		No	ClinGen gnomAD
rs1053193878 CA93510861	697	A>V		No	ClinGen TOPMed
CA2873737 rs760709986	698	D>G		No	ClinGen ExAC gnomAD
rs1715291846 RCV001207512	698	D>H		No	ClinVar dbSNP
CA356479708 rs1472886257	699	A>T		No	ClinGen gnomAD
COSM3409231 rs1387803603 CA356479702	700	V>I	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA2873736 rs772544398	701	A>T		No	ClinGen ExAC TOPMed gnomAD
CA2873735 rs572591405	702	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs774156010 CA2873733	703	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2873734 rs745775771 RCV001056091	703	R>W		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
TCGA novel	704	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873732 rs768480545	705	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2873730 rs142367791	707	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2873728 rs747575122 RCV001344596	710	N>K		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2873727 CA356479633 RCV001344152 rs777675128	711	G>R		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1715289393 RCV001202581	714	G>missing		No	ClinVar dbSNP
CA93510775 rs948715025	714	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs772146024 CA2873726	715	W>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	719	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1314672624 CA356479526	720	C>*		No	ClinGen gnomAD
CA356479510 rs1330865653	721	H>Q		No	ClinGen gnomAD
CA2873724 rs561661155	721	H>R		No	ClinGen ExAC gnomAD
rs779952033 CA2873721	722	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1255931700 CA356479488	723	L>H		No	ClinGen TOPMed
rs372587041 CA93510737	724	Y>C		No	ClinGen ESP TOPMed gnomAD
rs755960877 CA2873720	728	N>S		No	ClinGen ExAC gnomAD
TCGA novel	731	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356479414 rs1421290700	731	T>M		No	ClinGen TOPMed gnomAD
rs1170411373 CA356479410	732	I>V		No	ClinGen gnomAD
CA356479403 rs1477601827	733	Q>E		No	ClinGen gnomAD
rs372920953 CA2873717	735	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA2873716 rs751180630	736	S>F		No	ClinGen ExAC gnomAD
CA356479378 rs751180630	736	S>Y		No	ClinGen ExAC gnomAD
CA2873715 rs763806214	737	L>H		No	ClinGen ExAC gnomAD
rs762715861 CA2873714	738	S>T		No	ClinGen ExAC gnomAD
rs1204613361 CA356479352	740	Y>C		No	ClinGen gnomAD
CA2873713 RCV001306924 rs776810635	741	A>G		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA356479332 rs1160048893	743	L>F		No	ClinGen TOPMed
rs1233471138 CA356478071	746	L>S		No	ClinGen TOPMed
RCV001063349 rs767983432 CA2873692	747	T>M		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA356478059 rs1338263672	748	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs774369733 CA2873690	749	S>F		No	ClinGen ExAC gnomAD
CA93495811 rs985889186	753	T>A		No	ClinGen Ensembl
rs763701661 CA93495807	753	T>I		No	ClinGen TOPMed
rs763701661 CA93495809	753	T>S		No	ClinGen TOPMed
CA2873686 rs61736468	755	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781179280 CA2873684	757	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1444080461 CA356478003	757	S>T		No	ClinGen TOPMed gnomAD
rs757212411 CA2873682	759	L>R		No	ClinGen ExAC TOPMed gnomAD
CA93495773 rs962028246	761	P>A		No	ClinGen Ensembl
CA356477956 rs1405326679	765	T>A		No	ClinGen TOPMed
CA356477946 rs1313212730	766	T>I		No	ClinGen gnomAD
CA2873679 rs757939413	767	A>T		No	ClinGen ExAC TOPMed gnomAD
rs200151762 CA93495759	768	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2873678 RCV000982965 rs200151762	768	I>V		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA93495736 rs888461384	770	L>V		No	ClinGen Ensembl
CA93495724 rs202009640	771	L>P		No	ClinGen gnomAD
rs1026919746 CA93495714	772	L>I		No	ClinGen Ensembl
rs1309299292 CA356477899	773	C>R		No	ClinGen TOPMed
CA2873677 rs764939986	774	L>I		No	ClinGen ExAC gnomAD
CA2873676 rs754628680	776	A>D		No	ClinGen ExAC gnomAD
rs200590610 CA2873674	777	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA356477826 rs1437420221	778	I>V		No	ClinGen gnomAD
rs759285934 CA356477795	780	S>N		No	ClinGen ExAC TOPMed gnomAD
rs759285934 CA2873673	780	S>T		No	ClinGen ExAC TOPMed gnomAD
CA2873671 rs764564057	782	I>M		No	ClinGen ExAC gnomAD
CA2873672 rs774847867	782	I>V		No	ClinGen ExAC gnomAD
CA356477746 rs1165502271	784	H>R		No	ClinGen gnomAD
rs752771993 CA2873652	787	L>M		No	ClinGen ExAC gnomAD
CA93494323 rs1027252943 RCV001235998	787	L>S		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs765263100 CA2873651	788	I>V		No	ClinGen ExAC gnomAD
rs144842539 CA2873650	789	R>I		No	ClinGen ESP ExAC
rs1251579254 CA356477015	790	I>V		No	ClinGen gnomAD
rs777181294 CA93494286	791	S>N		No	ClinGen TOPMed gnomAD
rs771337983 CA2873648	793	K>Q		No	ClinGen ExAC
CA356476985 rs1282400692	794	S>N		No	ClinGen gnomAD
CA2873647 rs760544324	794	S>R		No	ClinGen ExAC gnomAD
rs1347393129 CA356476971	796	H>Y		No	ClinGen gnomAD
CA356476960 CA2873645 rs772026749	797	M>I		No	ClinGen ExAC gnomAD
rs772921916 CA2873646	797	M>L		No	ClinGen ExAC TOPMed gnomAD
CA2873642 rs375478986	799	V>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778449412 CA2873643	799	V>M		No	ClinGen ExAC TOPMed gnomAD
RCV001206099 rs1714646783	803	F>C		No	ClinVar dbSNP
rs532745434 CA2873641	804	H>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2873640 rs779674920	805	I>T		No	ClinGen ExAC gnomAD
CA356476900 rs1432129952	806	F>C		No	ClinGen gnomAD
rs76919858 CA93494237	807	L>P		No	ClinGen Ensembl
CA93494230 rs773893970	809	C>S		No	ClinGen Ensembl
rs755799959 CA2873639	811	V>F		No	ClinGen ExAC gnomAD
CA2873638 rs751897365	813	V>L		No	ClinGen ExAC TOPMed
CA356476856 rs1418955047	814	G>*		No	ClinGen gnomAD
TCGA novel	814	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873637 rs778019443	815	G>R		No	ClinGen ExAC gnomAD
rs1178362132 CA356476839	816	I>M		No	ClinGen gnomAD
rs758897543 CA2873636	817	T>A		No	ClinGen ExAC TOPMed gnomAD
CA93494161 rs1053057775	818	Q>H		No	ClinGen Ensembl
rs759676986 RCV001303222 CA2873633	819	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar ExAC NCI-TCGA dbSNP gnomAD
rs1577324720 CA356476801	822	A>V		No	ClinGen Ensembl
CA2873604 rs763995383	828	V>I		No	ClinGen ExAC gnomAD
CA2873603 rs762898122	829	G>W		No	ClinGen ExAC
rs1210975307 CA356476291	834	Y>C		No	ClinGen TOPMed
rs1208009143 CA356476269	836	T>A		No	ClinGen gnomAD
rs745467266 CA2873600 RCV001245556	836	T>I		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs776135006 CA2873599	838	A>T		No	ClinGen ExAC TOPMed gnomAD
CA356476233 rs1188388600	838	A>V		No	ClinGen TOPMed
rs1246728107 CA356476219	840	V>I		No	ClinGen TOPMed gnomAD
rs1246728107 CA356476218	840	V>L		No	ClinGen TOPMed gnomAD
rs1366226630 CA356476184	843	V>I		No	ClinGen TOPMed
rs1227219051 RCV001319026 CA356476138	847	A>T		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA93486082 rs966886838	848	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA356476096 rs1396674772	850	I>T		No	ClinGen TOPMed
rs150741187 CA2873596	852	K>E		No	ClinGen ESP ExAC gnomAD
rs117922332 RCV000968031 CA2873595	852	K>N		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs576433232 CA2873594	854	V>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1304493575 CA356476021	856	K>T		No	ClinGen gnomAD
rs138826721 CA93486049	857	K>T		No	ClinGen ESP
rs145912220 CA356475991	858	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	858	A>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1033366450 CA93486023	859	K>E		No	ClinGen TOPMed gnomAD
CA356475980 rs1310595425	860	R>I		No	ClinGen TOPMed
RCV001351315 rs1714178209	862	Q>H		No	ClinVar dbSNP
CA356475963 rs1166931783	862	Q>P		No	ClinGen gnomAD
CA93486011 rs577682714	865	D>E		No	ClinGen TOPMed gnomAD
CA2873592 rs374755307	867	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
RCV001204679 rs374755307 CA2873591	867	P>T		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1714177282 RCV001062585	868	P>L		No	ClinVar dbSNP
rs374191474 CA93485988	868	P>S		No	ClinGen ESP TOPMed gnomAD
CA2873590 rs767600094	869	P>S		No	ClinGen ExAC gnomAD
CA356475899 rs1269498639	871	P>T		No	ClinGen gnomAD
rs1270912911 CA356475861	874	M>I		No	ClinGen gnomAD
CA2873589 rs112141640	874	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356475848 rs1431270333 RCV001247430	875	L>P		No	ClinGen ClinVar dbSNP gnomAD
rs1195477299 CA356475837	876	R>K		No	ClinGen gnomAD
CA2873572 rs745910766	878	Y>C		No	ClinGen ExAC gnomAD
rs890100727 CA356475347	878	Y>D		No	ClinGen TOPMed
CA93481901 rs890100727	878	Y>H		No	ClinGen TOPMed
CA356475341 rs1175982894	879	L>V		No	ClinGen TOPMed gnomAD
rs781352594 CA2873571	881	G>D		No	ClinGen ExAC gnomAD
CA2873570 rs757380056	882	G>A		No	ClinGen ExAC TOPMed gnomAD
RCV001227893 CA93481860 rs757380056	882	G>D		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA356475322 rs757380056	882	G>V		No	ClinGen ExAC TOPMed gnomAD
CA2873569 rs751782928	884	I>T		No	ClinGen ExAC gnomAD
rs1456908890 CA356475307	885	P>S		No	ClinGen TOPMed
rs1560291579 CA356475303	886	I>L		No	ClinGen Ensembl
rs1560291579 CA356475302	886	I>V		No	ClinGen Ensembl
rs758176633 CA2873566	887	I>T		No	ClinGen ExAC gnomAD
CA2873562 rs753239712	890	G>S		No	ClinGen ExAC TOPMed gnomAD
rs765947339 CA2873561	891	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1407148896 CA356475257	893	A>S		No	ClinGen gnomAD
TCGA novel	893	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1168753717 CA356475242	895	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA2873558 rs763374789	897	I>F		No	ClinGen ExAC TOPMed gnomAD
CA2873557 rs763374789	897	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2873554 rs377710469	900	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs746416100 RCV001337418 CA2873552	901	G>S		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs781064615 CA2873551	901	G>V		No	ClinGen ExAC
CA2873550 RCV001318271 rs572491468	902	S>G		No	ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD
rs1315719740 CA356475145	902	S>N		No	ClinGen gnomAD
CA2873548 rs777967328	903	R>Q		No	ClinGen ExAC gnomAD
CA2873549 rs747149778	903	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1352247777 CA356475126 RCV001069792	904	P>A		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1352247777 CA356475127	904	P>T		No	ClinGen TOPMed gnomAD
CA2873546 rs553984951	905	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs143611399 CA356475104	905	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs553984951 CA2873547	905	N>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2873544 rs754833054	906	A>S		No	ClinGen ExAC TOPMed gnomAD
rs754833054 CA93481602	906	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA93481581 rs915849022	907	P>H		No	ClinGen TOPMed
rs190503014 CA2873543	907	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA356474985 rs1343631662	910	W>*		No	ClinGen gnomAD
TCGA novel	912	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356474955 rs779731665	914	E>D		No	ClinGen ExAC TOPMed
rs749100890 CA2873509	914	E>G		No	ClinGen ExAC gnomAD
rs1404464045 CA356474960	914	E>K		No	ClinGen gnomAD
CA356474925 rs1298179237	919	A>G		No	ClinGen TOPMed
CA356474928 rs1460672477	919	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA356474924 rs1298179237	919	A>V		No	ClinGen TOPMed
rs745834285 CA2873506	921	Y>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	924	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001309388 CA2873504 rs201366227	925	S>T		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2873503 rs201744100	928	T>I		No	ClinGen 1000Genomes ExAC
CA93481234 rs201744100	928	T>N		No	ClinGen 1000Genomes ExAC
CA2873502 rs200130550 RCV001350161	929	F>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs758044799 CA2873501	929	F>Y		No	ClinGen ExAC gnomAD
RCV001307769 rs369017846 CA2873500	932	C>Y		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1174910166 CA356474831	933	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA93481218 rs924491196	933	M>V		No	ClinGen Ensembl
rs137992274 CA2873499 RCV001338222	934	Y>C		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
TCGA novel	934	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873497 rs200205370	936	L>M		No	ClinGen ExAC gnomAD
CA356474806 rs1321122468	937	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1055148045 RCV001309061 CA93481206	937	S>R		No	ClinGen ClinVar TOPMed dbSNP
TCGA novel	938	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262223662 CA356474798	938	I>T		No	ClinGen gnomAD
CA356474794 rs1224053675	939	F>L		No	ClinGen gnomAD
CA356474785 rs1313825028	940	I>F		No	ClinGen TOPMed gnomAD
CA356474786 rs1313825028	940	I>V		No	ClinGen TOPMed gnomAD
rs1486056684 CA356474752	944	R>S		No	ClinGen TOPMed
rs768058984 CA2873495	946	P>A		No	ClinGen ExAC gnomAD
CA11640624 rs768058984	946	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1254285360 CA356474731	947	E>D		No	ClinGen TOPMed
CA2873494 rs761917636	948	R>C		No	ClinGen ExAC TOPMed gnomAD
rs761917636 CA356474729	948	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2873493 rs774357237	948	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA356474715 rs1298941024	950	Y>C		No	ClinGen gnomAD
CA93481170 rs562119691	953	K>E		No	ClinGen Ensembl
rs756147612 CA2873492	955	P>S		No	ClinGen ExAC TOPMed gnomAD
CA93481168 rs756147612	955	P>T		No	ClinGen ExAC TOPMed gnomAD
rs989956146 COSM1235071 CA93481167	956	T>M	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
rs775387546 RCV001318689	957	E>D		No	ClinVar dbSNP
rs748229758 CA93481154	958	E>K		No	ClinGen Ensembl
CA356474653 rs1235047219	959	Q>P		No	ClinGen Ensembl
rs1250855965 CA356474641	961	R>G		No	ClinGen gnomAD
rs1180147610 CA356474635	961	R>S		No	ClinGen TOPMed gnomAD
rs1242316288 CA356474632	962	L>S		No	ClinGen gnomAD
rs1204047056 CA356474627	963	A>P		No	ClinGen gnomAD
rs149797128 RCV001237039 CA2873487	965	N>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs141318113 CA356474595	967	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
COSM733704 rs746516223 CA2873484	969	E>K	lung Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs535821659 CA2873483	971	N>D		No	ClinGen ExAC gnomAD
TCGA novel	971	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA93481099 rs372378305	971	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
RCV001348496 CA2873482 rs758000828	972	H>N		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2873481 rs752322002	972	H>R		No	ClinGen ExAC TOPMed
CA356474566 rs758000828	972	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA356474556 rs1336547600	973	Q>R		No	ClinGen TOPMed gnomAD
CA2873480 rs780346073	974	D>N		No	ClinGen ExAC gnomAD
rs1290822324 CA356474545	975	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs201849173 CA2873478	976	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs200785534 RCV001229068 CA2873479	976	M>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA356474529 rs768003943	977	S>F		No	ClinGen ExAC TOPMed gnomAD
CA356474523 rs1355491882	978	L>F		No	ClinGen Ensembl
rs762281496 CA2873476	978	L>S		No	ClinGen ExAC TOPMed gnomAD
CA2873475 rs558086324	979	S>F		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	981	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356474472 rs1184017057	986	L>S		No	ClinGen TOPMed gnomAD
TCGA novel	987	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs879252809 CA93481022	988	N>S		No	ClinGen Ensembl
rs1178126424 CA356474435	989	E>A		No	ClinGen TOPMed
CA356474429 rs1259344870	989	E>D		No	ClinGen gnomAD
CA2873473 RCV001337568 rs763188344	989	E>Q		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs1713961106 RCV001231412	992	F>S		No	ClinVar dbSNP
TCGA novel	992	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	993	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775834962 CA2873472	995	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1421402767 CA356474346	996	L>I		No	ClinGen TOPMed
CA2873469 rs776625709	998	G>R		No	ClinGen ExAC gnomAD
TCGA novel	999	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA93481004 rs372520777	1000	S>N		No	ClinGen Ensembl
rs113103104 CA93480991	1002	T>A		No	ClinGen Ensembl
CA2873467 rs770843149	1003	L>S		No	ClinGen ExAC gnomAD
CA356474203 rs1342658773	1006	Y>C		No	ClinGen gnomAD
CA356474200 rs1342658773	1006	Y>F		No	ClinGen gnomAD
RCV001309441 rs376335542 CA2873465	1006	Y>H		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA356474191 rs1560291142	1007	V>I		No	ClinGen Ensembl
rs752813660 RCV001308442 CA2873463	1008	A>V		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1299573183 CA356474126	1010	W>C		No	ClinGen gnomAD
rs1013071529 CA93480955	1010	W>L		No	ClinGen Ensembl
rs200434814 CA2873460 RCV001202222	1011	M>I		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs754689153 CA2873461	1011	M>V		No	ClinGen ExAC TOPMed gnomAD
rs199772355 CA93480935	1012	F>L		No	ClinGen 1000Genomes
rs781545499 CA2873459	1014	A>T		No	ClinGen ExAC gnomAD
rs76872619 CA93480914	1015	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201588033 CA2873458	1015	L>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1804110 CA93480909	1016	A>D		No	ClinGen Ensembl
RCV001234940 rs765544362 CA2873453	1017	V>I		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001320352 CA2873454 rs765544362	1017	V>L		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2873452 rs759851528	1019	L>S		No	ClinGen ExAC gnomAD
rs1577316408 CA356473941	1021	Y>S		No	ClinGen Ensembl
CA356473918 rs1195981314	1022	P>L		No	ClinGen gnomAD
rs1713955224 RCV001230182	1022	P>S		No	ClinVar dbSNP
rs776502251 CA2873451	1023	L>V		No	ClinGen ExAC gnomAD
CA93480868 rs200971638	1024	D>G		No	ClinGen 1000Genomes
RCV001067414 rs535177320 CA2873450	1024	D>N		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
TCGA novel	1024	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760611198 CA2873449	1025	L>F		No	ClinGen ExAC gnomAD
rs772999406 CA2873448	1026	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1028	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772085550 CA2873447	1028	S>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1028	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873444 rs188925350	1030	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA356473789 rs1403583552	1031	F>L		No	ClinGen gnomAD
TCGA novel	1032	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356473772 rs1344353731	1033	A>T		No	ClinGen TOPMed gnomAD
CA356473755 rs1323564710	1034	T>A		No	ClinGen gnomAD
CA93480816 rs950238474 RCV001294370	1034	T>I		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1267317428 CA356473710 COSM1694201	1036	L>*	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
rs372047016 CA2873443	1036	L>F		No	ClinGen ESP ExAC gnomAD
CA356473678 rs1258417575	1038	F>L		No	ClinGen Ensembl
rs1167183051 CA356473652	1039	S>N		No	ClinGen gnomAD
rs1560291043 CA356473632	1040	A>V		No	ClinGen Ensembl
CA2873441 rs145468268 RCV001223078	1042	F>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1169394079 CA356473599	1043	V>A		No	ClinGen TOPMed
rs9002 VAR_033971 CA2873440	1043	V>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA93480758 rs202156282	1045	H>R		No	ClinGen 1000Genomes gnomAD
CA2873438 rs759002626	1049	N>S		No	ClinGen ExAC gnomAD
rs752767172 CA2873437	1052	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1054	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1054	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873436 rs765410811	1055	L>F		No	ClinGen ExAC gnomAD
CA356473512 rs200161840	1056	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs200161840 CA93480697	1056	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs909558515 CA93480704	1056	A>P		No	ClinGen TOPMed
CA2873435 rs200161840 RCV001244137 COSM1540131	1056	A>V	lung [Cosmic]	No	ClinGen cosmic curated ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1222222537 CA356473505	1057	W>*		No	ClinGen gnomAD
rs1274992241 CA356473482	1060	T>I		No	ClinGen TOPMed gnomAD
CA2873433 rs766671772	1060	T>S		No	ClinGen ExAC gnomAD
CA356473480 rs1333665906	1061	C>R		No	ClinGen gnomAD
rs761749221 CA2873430	1062	C>S		No	ClinGen ExAC TOPMed gnomAD
rs761749221 CA2873429	1062	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs773814543 CA2873428	1063	P>R		No	ClinGen ExAC gnomAD
CA356473462 CA2873427 rs768181664	1064	G>R		No	ClinGen ExAC TOPMed gnomAD
CA2873425 rs144467569 COSM1054535	1065	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2873426 rs748848943	1065	R>W		No	ClinGen ExAC gnomAD
TCGA novel	1066	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001302754 CA2873422 rs778214023	1067	S>L		No	ClinGen ClinVar ExAC dbSNP gnomAD
CA2873423 rs778214023	1067	S>W		No	ClinGen ExAC gnomAD
CA356473429 rs1458329968	1069	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA93480563 rs752989731	1070	V>L		No	ClinGen Ensembl
CA356473421 rs1433768320	1071	Q>*		No	ClinGen gnomAD
CA93480544 rs779087301	1073	N>S		No	ClinGen ExAC gnomAD
CA2873419 rs779087301	1073	N>T		No	ClinGen ExAC gnomAD
CA356473402 rs753989394	1074	V>I		No	ClinGen ExAC TOPMed gnomAD
rs753989394 CA2873417	1074	V>L		No	ClinGen ExAC TOPMed gnomAD
CA2873416 rs766503450	1075	Q>*		No	ClinGen ExAC gnomAD
RCV001071651 rs142747862 CA2873415	1076	P>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1413284630 CA356473383	1077	P>R		No	ClinGen TOPMed gnomAD
rs530216418 CA2873412	1077	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA2873409 rs764061080	1078	N>K		No	ClinGen ExAC gnomAD
CA356473368 rs1336114054	1080	N>D		No	ClinGen gnomAD
CA356473366 rs1364816123	1080	N>S		No	ClinGen TOPMed
rs117576731 RCV000927666 CA2873407	1082	T>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2873408 rs117576731	1082	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356473340 rs138696398	1084	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000917663 CA2873405 rs138696398	1084	G>E		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1382402404 CA356473332	1085	E>D		No	ClinGen gnomAD
RCV001234398 rs1035414702 CA93480438	1086	A>V		No	ClinGen ClinVar dbSNP gnomAD
CA356473320 rs1472663450	1087	P>R		No	ClinGen gnomAD
rs1002678197 CA93480437	1088	K>R		No	ClinGen TOPMed gnomAD
rs369248230 CA2873403	1091	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1355458789 CA356473277	1093	S>R		No	ClinGen gnomAD
CA93480426 rs376102632	1093	S>T		No	ClinGen ESP TOPMed
CA356473272 rs141619991	1094	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV001351462 rs141619991 CA2873401	1094	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001322373 rs1713940449	1096	S>C		No	ClinVar dbSNP
rs1379659692 CA356473251	1096	S>P		No	ClinGen gnomAD
CA356473187 rs1285667518	1099	T>I		No	ClinGen gnomAD
CA2873398 rs749313362	1102	S>G		No	ClinGen ExAC
CA2873397 rs111298499	1102	S>R		No	ClinGen ExAC gnomAD
rs756220717 CA2873396	1104	S>L		No	ClinGen ExAC gnomAD
TCGA novel	1105	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1225355665 CA356473080	1105	S>N		No	ClinGen TOPMed
CA93480384 rs557122010	1105	S>R		No	ClinGen Ensembl
CA2873395 rs750684538 RCV001063736	1108	N>D		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
TCGA novel	1108	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1362749762 CA356473000	1109	S>T		No	ClinGen gnomAD
CA2873393 rs757017927	1110	S>F		No	ClinGen ExAC
CA356472945 rs1183905881	1112	G>A		No	ClinGen TOPMed gnomAD
CA2873391 rs764007687	1112	G>C		No	ClinGen ExAC gnomAD
rs1183905881 CA356472944	1112	G>V		No	ClinGen TOPMed gnomAD
rs1474747175 CA356472903 RCV001345947	1115	L>S		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1263098863 CA356472863	1117	N>I		No	ClinGen gnomAD
TCGA novel	1118	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762963845 CA356472851	1118	L>V		No	ClinGen ExAC TOPMed gnomAD
CA2873389 rs764835658	1120	A>E		No	ClinGen ExAC TOPMed gnomAD
CA2873388 rs764835658 RCV001294953	1120	A>V		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA356472791 rs1220378614	1122	A>T		No	ClinGen gnomAD
rs371121360 CA2873386	1123	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2873385 RCV001314732 rs371121360	1123	A>V		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2873384 rs762262067	1124	Q>E		No	ClinGen ExAC gnomAD
CA356472746 rs1212578761	1125	C>Y		No	ClinGen gnomAD
CA2873383 RCV001248711 rs774910758	1126	H>R		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001201463 CA356472726 rs1401716242	1127	A>S		No	ClinGen ClinVar dbSNP gnomAD
CA2873381 rs545763677	1128	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2873380 rs545763677	1128	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769898786 CA93480248	1129	S>C		No	ClinGen ExAC gnomAD
rs769898786 CA2873379	1129	S>F		No	ClinGen ExAC gnomAD
CA2873377 rs769898786	1129	S>Y		No	ClinGen ExAC gnomAD
rs755147070 CA2873376	1130	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1440656843 CA356472656 RCV001205790	1131	P>L		No	ClinGen ClinVar dbSNP gnomAD
CA93480205 rs879876606	1131	P>T		No	ClinGen gnomAD
rs757536970 CA2873375	1134	S>A		No	ClinGen ExAC gnomAD
CA2873373 rs751299637	1134	S>C		No	ClinGen ExAC gnomAD
rs757536970 CA2873374	1134	S>P		No	ClinGen ExAC gnomAD
CA93480168 rs972347319	1135	T>I		No	ClinGen TOPMed gnomAD
CA93480177 rs972347319	1135	T>N		No	ClinGen TOPMed gnomAD
TCGA novel	1137	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356472527 rs1488639060	1139	D>E		No	ClinGen gnomAD
CA356472543 rs1190107172	1139	D>N		No	ClinGen gnomAD
rs1248057817 CA356472522	1140	N>D		No	ClinGen gnomAD
CA93480146 rs922253997	1141	S>C		No	ClinGen TOPMed
rs1560290672 CA356472481	1142	L>Q		No	ClinGen Ensembl
rs143592195 CA93480145	1143	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs200450492 CA2873370	1143	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2873371 RCV001064717 rs143592195	1143	T>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA2873369 rs765136152	1146	S>A		No	ClinGen ExAC TOPMed gnomAD
rs909429953 CA93480134	1147	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA356472438 rs1220401065	1147	M>V		No	ClinGen gnomAD
CA356472419 rs1321264210	1149	N>S		No	ClinGen gnomAD
rs753463580 CA356472412	1150	D>G		No	ClinGen ExAC gnomAD
CA2873368 rs138052583	1150	D>N		No	ClinGen ESP ExAC gnomAD
CA2873367 rs753463580	1150	D>V		No	ClinGen ExAC gnomAD
TCGA novel	1150	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3946277 CA2873364 rs774785929	1153	M>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1201359520 CA356472385	1154	H>L		No	ClinGen TOPMed
rs1310868759 CA356472386	1154	H>Y		No	ClinGen TOPMed
CA356472377 rs1272124406	1155	V>A		No	ClinGen gnomAD
rs763279377 CA2873362	1155	V>M		No	ClinGen ExAC gnomAD
CA356472371 rs776038380	1156	A>G		No	ClinGen ExAC TOPMed gnomAD
CA2873361 rs776038380 COSM1319345	1156	A>V	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1035873766 CA93480110	1157	P>T		No	ClinGen Ensembl
rs199616944 CA93480109	1160	V>I		No	ClinGen 1000Genomes
rs1426606242 CA356472341	1161	Q>R		No	ClinGen gnomAD
RCV001239361 rs771076973 CA2873357	1163	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1412596885 CA356472321	1164	T>I		No	ClinGen TOPMed
CA93480091 rs3814416	1166	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2873355 VAR_033972 rs3814416	1166	V>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1713927434 RCV001227654	1166	V>M		No	ClinVar dbSNP
CA93480079 rs201813100	1168	S>*		No	ClinGen Ensembl
CA356472294 rs1255310057	1169	S>G		No	ClinGen gnomAD
rs373531543 CA2873354	1169	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA2873353 RCV001234197 rs758188846	1170	R>C		No	ClinGen ClinVar ExAC dbSNP
COSM1208620 CA2873352 rs370767567 RCV001229867	1170	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
rs1303415611 CA356472278	1171	H>Q		No	ClinGen gnomAD
rs778903224 CA2873351	1172	H>R		No	ClinGen ExAC TOPMed gnomAD
CA356472231 rs754927845	1177	K>N		No	ClinGen ExAC gnomAD
rs765990340 CA2873348	1180	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2873349 rs753338561	1180	R>W		No	ClinGen ExAC TOPMed gnomAD
rs893051811 CA93480012	1181	A>S		No	ClinGen Ensembl
rs893051811 CA356472213	1181	A>T		No	ClinGen Ensembl
rs370861136 CA2873347 RCV001325582	1182	S>N		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA93479993 rs1039596576	1183	R>*		No	ClinGen gnomAD
CA356472198 rs1360396330	1183	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs766589305 CA93479987	1187	L>V		No	ClinGen Ensembl
TCGA novel	1188	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1380526639 CA356472152	1191	A>T		No	ClinGen gnomAD
CA93479974 rs201631240	1192	Y>D		No	ClinGen Ensembl
rs1442522622 CA356472139	1193	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	1194	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1200968685 CA356472123	1195	P>S		No	ClinGen gnomAD
RCV001069801 rs763375816	1196	T>A		No	ClinVar dbSNP
rs61729361 CA2873342	1196	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61729361 CA2873341 RCV001212278	1196	T>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs61729361 CA2873340	1196	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2873343 rs763375816	1196	T>S		No	ClinGen ExAC gnomAD
CA356472114 rs1353305478	1197	S>N		No	ClinGen TOPMed gnomAD
RCV001206712 CA2873337 rs747139796	1198	V>M		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
TCGA novel	1200	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873336 rs773391144	1200	G>E		No	ClinGen ExAC gnomAD
rs772250586 CA356472084	1201	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1381955291 CA356472080	1202	V>A		No	ClinGen TOPMed gnomAD
rs1381955291 CA356472079	1202	V>G		No	ClinGen TOPMed gnomAD
CA356472082 rs141222776 COSM1540133	1202	V>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2873334 rs141222776 RCV001337537	1202	V>M		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1713920613 RCV001296419	1203	Q>*		No	ClinVar dbSNP
rs146569496 CA356472063	1204	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA356472066 rs1418527266	1204	N>S		No	ClinGen gnomAD
TCGA novel	1207	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873332 rs754874591	1207	P>R		No	ClinGen ExAC gnomAD
rs111871117 CA93479871	1209	S>G		No	ClinGen gnomAD
rs367946371 RCV001349300 CA2873329	1210	R>Q		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2873330 rs779659276 RCV001322735	1210	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs756876606 CA2873326	1211	L>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1212	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1472494774 CA356472012 RCV001347997	1213	N>S		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA93479803 rs867956456	1214	N>K		No	ClinGen TOPMed gnomAD
CA93479820 rs144314535	1214	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2873325 rs144314535	1214	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM183098 rs1404660498 CA356472003	1215	E>K	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs765552184 CA2873324	1217	H>R		No	ClinGen ExAC gnomAD
CA2873323 rs759989405	1218	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1040664017 CA93479787	1221	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs140656046 RCV000948675 CA2873322	1221	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA356471930 rs1299434323	1226	A>S		No	ClinGen gnomAD
rs761942285 CA2873317	1227	Y>C		No	ClinGen ExAC gnomAD
rs1195892800 CA356471925	1227	Y>H		No	ClinGen TOPMed
rs768355147 CA2873315	1230	R>K		No	ClinGen ExAC gnomAD
RCV001294571 CA2873314 rs749141341	1231	Q>E		No	ClinGen ClinVar ExAC dbSNP
rs780138287 CA2873313	1232	Y>C		No	ClinGen ExAC gnomAD
CA2873312 rs140031824	1233	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA356471875 rs1478070733	1234	P>S		No	ClinGen gnomAD
rs1195923256 CA356471862	1236	Q>R		No	ClinGen gnomAD
rs745319168 CA2873311	1237	Q>K		No	ClinGen ExAC gnomAD
RCV001037524 rs151117015 CA2873310	1238	D>N		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	1240	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001058376 rs756895556 COSM281460 CA2873309	1241	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs755303518 CA2873307	1243	C>F		No	ClinGen ExAC TOPMed gnomAD
CA2873308 rs765533879	1243	C>R		No	ClinGen ExAC gnomAD
rs755303518 CA2873306	1243	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs754265789 CA2873305	1244	S>G		No	ClinGen ExAC gnomAD
CA356471803 rs1169737414	1244	S>R		No	ClinGen TOPMed
CA2873304 rs766858551	1247	P>L		No	ClinGen ExAC gnomAD
CA2873303 rs201312574	1248	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA356471718 rs1397857748	1256	P>L		No	ClinGen gnomAD
CA356471717 rs1577315686	1257	V>I		No	ClinGen Ensembl
CA356471710 rs967844609	1258	S>A		No	ClinGen TOPMed gnomAD
rs967844609 CA93479491	1258	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1307838636 CA356471698	1260	T>A		No	ClinGen TOPMed gnomAD
CA356471695 rs1577315674	1260	T>I		No	ClinGen Ensembl
CA2873300 rs762044074	1261	S>G		No	ClinGen ExAC TOPMed gnomAD
rs774412141 CA2873299	1262	K>E		No	ClinGen ExAC gnomAD
rs1713908676 RCV001245207	1263	K>Q		No	ClinVar dbSNP
CA2873298 rs769070654	1263	K>R		No	ClinGen ExAC gnomAD
CA93479461 rs144172018	1264	D>G		No	ClinGen ESP gnomAD
rs778863401	1264	D>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2873295 rs564104204	1265	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2873296 rs762830701	1265	A>T		No	ClinGen ExAC TOPMed gnomAD
CA93479449 rs564104204	1265	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1404905871 CA356471654	1267	R>K		No	ClinGen TOPMed gnomAD
rs958945150 CA93479404	1270	A>G		No	ClinGen TOPMed
CA2873292 rs147162304	1272	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs147162304 CA356471624	1272	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs146897125 RCV000917174 CA2873291	1276	N>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs746569747 CA2873290	1277	Q>*		No	ClinGen ExAC
CA356471570 rs1274857391	1279	K>N		No	ClinGen gnomAD
rs780401247 CA2873286	1280	S>F		No	ClinGen ExAC gnomAD
CA2873288 rs144568977 RCV001211623	1280	S>P		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs780401247 CA2873287	1280	S>Y		No	ClinGen ExAC gnomAD
CA356471559 rs768269484 CA93479341	1281	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA2873283 rs149299752	1282	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149299752 CA2873284	1282	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA93479319 rs897922444	1283	L>V		No	ClinGen TOPMed gnomAD
rs751722049 CA2873281	1284	N>K		No	ClinGen ExAC gnomAD
CA93479295 rs372373246	1285	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA356471531 rs1560290274	1286	A>V		No	ClinGen Ensembl
rs369701146 CA2873279	1287	I>V		No	ClinGen ESP ExAC gnomAD
CA2873277 RCV001296023 rs765147381	1289	N>S		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA356471506 rs1386213420	1290	G>E		No	ClinGen TOPMed
rs1440717794 CA356471501	1291	P>S		No	ClinGen gnomAD
rs776404075 CA2873275	1292	I>T		No	ClinGen ExAC gnomAD
CA2873276 rs759424403	1292	I>V		No	ClinGen ExAC gnomAD
TCGA novel	1294	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2873274 COSM3428431 rs770969743	1294	S>N	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA
RCV001067150 rs1713901682	1295	N>K		No	ClinVar dbSNP
rs772721601 CA2873272	1295	N>S		No	ClinGen ExAC gnomAD
rs772721601 CA2873273	1295	N>T		No	ClinGen ExAC gnomAD
CA356471471 rs1382420948	1296	G>R		No	ClinGen TOPMed
CA356471466 rs1278788508	1296	G>V		No	ClinGen gnomAD
CA356471463 rs1201674630	1297	Q>*		No	ClinGen gnomAD
CA356471454 rs1351110091	1298	E>A		No	ClinGen gnomAD
COSM4153458 CA93479216 rs936569551	1298	E>D	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
TCGA novel	1301	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1302	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs147716223 RCV001324021 CA2873270	1303	G>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs928853508 COSM183097 CA93479170	1305	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs568318170 CA93479161	1306	S>C		No	ClinGen TOPMed
rs568318170 CA356471408	1306	S>G		No	ClinGen TOPMed
CA93479159 rs879455722	1306	S>N		No	ClinGen Ensembl
CA356471401 rs1351207539	1307	T>A		No	ClinGen TOPMed
CA356471396 rs1207100182	1308	G>S		No	ClinGen TOPMed
rs144907660 CA2873266	1309	N>S		No	ClinGen ESP ExAC gnomAD
rs543888546 CA2873265 RCV001325131	1311	R>K		No	ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD
CA356471328 rs751531670	1317	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs576557418 COSM1429163 CA2873263	1318	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs758645151 CA2873262	1319	T>A		No	ClinGen ExAC gnomAD
TCGA novel	1322	V>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q8IWK6

12 regional properties for Q8IWK6

Type	Name	Position	InterPro Accession
domain	GPS motif	697 - 749	IPR000203
domain	Cysteine-rich flanking region, C-terminal	187 - 236	IPR000483
repeat	Leucine-rich repeat	85 - 141	IPR001611
domain	GPCR, family 2, extracellular hormone receptor domain	323 - 418	IPR001879
repeat	Leucine-rich repeat, typical subtype	79 - 103	IPR003591-1
repeat	Leucine-rich repeat, typical subtype	104 - 127	IPR003591-2
repeat	Leucine-rich repeat, typical subtype	128 - 151	IPR003591-3
repeat	Leucine-rich repeat, typical subtype	152 - 175	IPR003591-4
domain	Immunoglobulin subtype	249 - 342	IPR003599
domain	Immunoglobulin-like domain	242 - 340	IPR007110
domain	Immunoglobulin I-set	247 - 340	IPR013098
domain	GPCR, family 2-like, transmembrane domain	756 - 1050	IPR017981

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
G protein-coupled receptor activity	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

2 GO annotations of biological process

Name	Definition
cell surface receptor signaling pathway	The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.

39 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3MHH9	ECM2	Extracellular matrix protein 2	Bos taurus (Bovine)	PR
P58874	OPTC	Opticin	Bos taurus (Bovine)	PR
Q24K06	LRRC10	Leucine-rich repeat-containing protein 10	Bos taurus (Bovine)	PR
A6H789	LRRC3B	Leucine-rich repeat-containing protein 3B	Bos taurus (Bovine)	PR
Q9V780	Lap1	Protein lap1	Drosophila melanogaster (Fruit fly)	PR
Q96NW7	LRRC7	Leucine-rich repeat-containing protein 7	Homo sapiens (Human)	PR
Q8IWT6	LRRC8A	Volume-regulated anion channel subunit LRRC8A	Homo sapiens (Human)	PR
Q9HCJ2	LRRC4C	Leucine-rich repeat-containing protein 4C	Homo sapiens (Human)	PR
Q9UFC0	LRWD1	Leucine-rich repeat and WD repeat-containing protein 1	Homo sapiens (Human)	PR
Q96L50	LRR1	Leucine-rich repeat protein 1	Homo sapiens (Human)	PR
Q86UN2	RTN4RL1	Reticulon-4 receptor-like 1	Homo sapiens (Human)	PR
Q7L1W4	LRRC8D	Volume-regulated anion channel subunit LRRC8D	Homo sapiens (Human)	PR
Q96FE5	LINGO1	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	Homo sapiens (Human)	PR
Q8TDW0	LRRC8C	Volume-regulated anion channel subunit LRRC8C	Homo sapiens (Human)	PR
Q38SD2	LRRK1	Leucine-rich repeat serine/threonine-protein kinase 1	Homo sapiens (Human)	EV
Q96PB8	LRRC3B	Leucine-rich repeat-containing protein 3B	Homo sapiens (Human)	PR
A6H694	Lrrc63	Leucine-rich repeat-containing protein 63	Mus musculus (Mouse)	PR
Q9D9Q0	Lrrc69	Leucine-rich repeat-containing protein 69	Mus musculus (Mouse)	PR
Q8BGI7	Lrrc39	Leucine-rich repeat-containing protein 39	Mus musculus (Mouse)	PR
P59383	Lrrn4	Leucine-rich repeat neuronal protein 4	Mus musculus (Mouse)	PR
Q9D1T0	Lingo1	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1	Mus musculus (Mouse)	PR
Q8VCH9	Lrrc3b	Leucine-rich repeat-containing protein 3B	Mus musculus (Mouse)	PR
Q8R502	Lrrc8c	Volume-regulated anion channel subunit LRRC8C	Mus musculus (Mouse)	PR
Q80WG5	Lrrc8a	Volume-regulated anion channel subunit LRRC8A	Mus musculus (Mouse)	PR
Q8K0S5	Rtn4rl1	Reticulon-4 receptor-like 1	Mus musculus (Mouse)	PR
Q80TE7	Lrrc7	Leucine-rich repeat-containing protein 7	Mus musculus (Mouse)	PR
Q5DU41	Lrrc8b	Volume-regulated anion channel subunit LRRC8B	Mus musculus (Mouse)	PR
Q5RKR3	Islr2	Immunoglobulin superfamily containing leucine-rich repeat protein 2	Mus musculus (Mouse)	PR
Q8C031	Lrrc4c	Leucine-rich repeat-containing protein 4C	Mus musculus (Mouse)	PR
Q7TT36	Adgra3	Adhesion G protein-coupled receptor A3	Mus musculus (Mouse)	PR
P70587	Lrrc7	Leucine-rich repeat-containing protein 7	Rattus norvegicus (Rat)	PR
Q4V8G0	Lrrc63	Leucine-rich repeat-containing protein 63	Rattus norvegicus (Rat)	PR
Q80WD0	Rtn4rl1	Reticulon-4 receptor-like 1	Rattus norvegicus (Rat)	PR
Q9TZM3	lrk-1	Leucine-rich repeat serine/threonine-protein kinase 1	Caenorhabditis elegans	SS
Q9SHI4	RLP3	Receptor-like protein 3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q5G5E0	PIRL5	Plant intracellular Ras-group-related LRR protein 5	Arabidopsis thaliana (Mouse-ear cress)	PR
B0JZ65	lrwd1	Leucine-rich repeat and WD repeat-containing protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q68F79	lrrc8e	Volume-regulated anion channel subunit LRRC8E	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
B0R160	lrwd1	Leucine-rich repeat and WD repeat-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEPPGRRRGR	AQPPLLLPLS	LLALLALLGG	GGGGGAAALP	AGCKHDGRPR	GAGRAAGAAE
70	80	90	100	110	120
GKVVCSSLEL	AQVLPPDTLP	NRTVTLILSN	NKISELKNGS	FSGLSLLERL	DLRNNLISSI
130	140	150	160	170	180
DPGAFWGLSS	LKRLDLTNNR	IGCLNADIFR	GLTNLVRLNL	SGNLFSSLSQ	GTFDYLASLR
190	200	210	220	230	240
SLEFQTEYLL	CDCNILWMHR	WVKEKNITVR	DTRCVYPKSL	QAQPVTGVKQ	ELLTCDPPLE
250	260	270	280	290	300
LPSFYMTPSH	RQVVFEGDSL	PFQCMASYID	QDMQVLWYQD	GRIVETDESQ	GIFVEKNMIH
310	320	330	340	350	360
NCSLIASALT	ISNIQAGSTG	NWGCHVQTKR	GNNTRTVDIV	VLESSAQYCP	PERVVNNKGD
370	380	390	400	410	420
FRWPRTLAGI	TAYLQCTRNT	HGSGIYPGNP	QDERKAWRRC	DRGGFWADDD	YSRCQYANDV
430	440	450	460	470	480
TRVLYMFNQM	PLNLTNAVAT	ARQLLAYTVE	AANFSDKMDV	IFVAEMIEKF	GRFTKEEKSK
490	500	510	520	530	540
ELGDVMVDIA	SNIMLADERV	LWLAQREAKA	CSRIVQCLQR	IATYRLAGGA	HVYSTYSPNI
550	560	570	580	590	600
ALEAYVIKST	GFTGMTCTVF	QKVAASDRTG	LSDYGRRDPE	GNLDKQLSFK	CNVSNTFSSL
610	620	630	640	650	660
ALKNTIVEAS	IQLPPSLFSP	KQKRELRPTD	DSLYKLQLIA	FRNGKLFPAT	GNSTNLADDG
670	680	690	700	710	720
KRRTVVTPVI	LTKIDGVNVD	THHIPVNVTL	RRIAHGADAV	AARWDFDLLN	GQGGWKSDGC
730	740	750	760	770	780
HILYSDENIT	TIQCYSLSNY	AVLMDLTGSE	LYTQAASLLH	PVVYTTAIIL	LLCLLAVIVS
790	800	810	820	830	840
YIYHHSLIRI	SLKSWHMLVN	LCFHIFLTCV	VFVGGITQTR	NASICQAVGI	ILHYSTLATV
850	860	870	880	890	900
LWVGVTARNI	YKQVTKKAKR	CQDPDEPPPP	PRPMLRFYLI	GGGIPIIVCG	ITAAANIKNY
910	920	930	940	950	960
GSRPNAPYCW	MAWEPSLGAF	YGPASFITFV	NCMYFLSIFI	QLKRHPERKY	ELKEPTEEQQ
970	980	990	1000	1010	1020
RLAANENGEI	NHQDSMSLSL	ISTSALENEH	TFHSQLLGAS	LTLLLYVALW	MFGALAVSLY
1030	1040	1050	1060	1070	1080
YPLDLVFSFV	FGATSLSFSA	FFVVHHCVNR	EDVRLAWIMT	CCPGRSSYSV	QVNVQPPNSN
1090	1100	1110	1120	1130	1140
GTNGEAPKCP	NSSAESSCTN	KSASSFKNSS	QGCKLTNLQA	AAAQCHANSL	PLNSTPQLDN
1150	1160	1170	1180	1190	1200
SLTEHSMDND	IKMHVAPLEV	QFRTNVHSSR	HHKNRSKGHR	ASRLTVLREY	AYDVPTSVEG
1210	1220	1230	1240	1250	1260
SVQNGLPKSR	LGNNEGHSRS	RRAYLAYRER	QYNPPQQDSS	DACSTLPKSS	RNFEKPVSTT
1270	1280	1290	1300	1310	1320
SKKDALRKPA	VVELENQQKS	YGLNLAIQNG	PIKSNGQEGP	LLGTDSTGNV	RTGLWKHETT

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