Q8IVW1

SS
Gene name
ARL17A (ARL17P1;, ARL17B, ARF1P2, ARL17A, PRO2667)
Protein name
ADP-ribosylation factor-like protein 17
Names
ADP-ribosylation factor 7 variant
Species
Homo sapiens (Human)
KEGG Pathway
hsa:100506084, hsa:100996709, hsa:51326,
EC number
Protein Class

Descriptions

Small GTPases couple their GDP/GTP structural cycle to cytosol/membrane alternation to function as versatile molecular switches in the cell. Membrane localization of their active, GTP-bound form is pivotal to their ability to propagate information, and this requires their post-translational modification by lipids.<br>Arf GTPases are modified by a myristate attached to their N-terminus, which is shielded by intramolecular interactions in their inactive state. The myristoylated N-terminus of Arf is autoinhibitory in solution and is displaced by membranes, priming Arf GTPases for activation by their GEFs. Replacement of the N-terminal myristate by a 6xHis-tag preserves autoinhibition, representing that membranes unlock the N-terminal region to facilitate subsequent activation.

Autoinhibitory domains (AIDs)

3-16 (N-terminal helix) SS

Target domain

16-140 (Small GTP-binding protein domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8IVW1

Entry ID Method Resolution Chain Position Source
AF-Q8IVW1-F1 Predicted AlphaFoldDB

140 variants for Q8IVW1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs899731669 51 F>L No gnomAD
rs1433227841 51 F>V No Ensembl
rs1039625880 53 V>M No gnomAD
rs1272252058 55 T>R No Ensembl
rs2052802876 57 E>A No TOPMed
rs2052802697 58 Y>C No TOPMed
gnomAD
rs1466193723 60 N>S No Ensembl
rs770647542 62 T>P No ExAC
gnomAD
rs35595570 64 A>G No 1000Genomes
ExAC
gnomAD
rs139705193 64 A>G No Ensembl
rs1435399280 64 A>T No gnomAD
rs2052800944 65 V>F No gnomAD
rs2052800944 65 V>L No gnomAD
rs2052800652 66 W>* No Ensembl
rs1327021555 69 G>A No gnomAD
rs1184249634 70 S>N No gnomAD
rs1300289222 70 S>R No Ensembl
rs2052799843 73 K>R No Ensembl
rs1376129748 76 P>S No gnomAD
rs1263281645 78 W>* No gnomAD
rs1212435549 80 H>D No TOPMed
rs2052799171 80 H>R No Ensembl
rs1218292370 81 F>I No gnomAD
rs1424848305 87 G>D No Ensembl
rs2057355717 88 A>S No Ensembl
rs1191472596 89 R>G No gnomAD
rs2057355509 90 S>G No Ensembl
rs2057355400 91 P>L No Ensembl
rs1474004245 93 S>G No gnomAD
rs2057355306 93 S>R No Ensembl
rs2052454762 94 T>A No Ensembl
rs1255125559 94 T>I No gnomAD
rs1489339329 95 H>Y No gnomAD
rs1598200141 96 Q>E No Ensembl
rs2057355003 97 G>V No Ensembl
rs2052453642 99 L>V No Ensembl
rs1215787789 99 L>V No TOPMed
gnomAD
rs2057354568 100 A>V No Ensembl
rs1484078016 102 G>R No gnomAD
rs1024895539 102 G>R No gnomAD
rs1598200076 103 V>G No Ensembl
rs1367043950 103 V>L No Ensembl
rs2052453133 103 V>L No Ensembl
rs1231078042 105 P>R No gnomAD
rs1391137367 107 K>E No Ensembl
rs2057353980 107 K>T No Ensembl
rs1330613807 108 C>R No gnomAD
rs1397807464 108 C>Y No gnomAD
rs929144989 108 C>Y No 1000Genomes
gnomAD
rs1302227300 110 H>Y No gnomAD
rs1231570758 111 V>M No gnomAD
rs1338859679 113 F>C No gnomAD
rs1448626823 113 F>S No Ensembl
rs990771779 115 M>T No gnomAD
rs2052451500 116 W>* No Ensembl
rs1598592785 119 G>D No Ensembl
rs2057353157 119 G>S No TOPMed
rs1300590514 120 R>G No gnomAD
rs1346591457 120 R>I No Ensembl
rs2057352703 121 S>G No Ensembl
rs1598592747 122 H>P No Ensembl
rs2057352236 123 P>A No Ensembl
rs1233370645 123 P>L No Ensembl
rs2057352053 125 L>F No Ensembl
rs2052450320 126 P>L No Ensembl
rs1294096547 126 P>S No TOPMed
rs2057351576 127 H>R No Ensembl
rs1171339307 130 R>G No gnomAD
rs1464052695 130 R>S No gnomAD
rs1398013176 130 R>S No gnomAD
rs2057351119 131 C>F No Ensembl
rs1376644757 131 C>R No 1000Genomes
gnomAD
rs1176298642 132 A>T No gnomAD
rs2145968843 134 S>C No 1000Genomes
rs1331128643 134 S>P No gnomAD
rs2052449414 135 G>C No gnomAD
rs995372645 135 G>R No Ensembl
rs2052449235 135 G>V No Ensembl
rs1260624770 136 G>D No gnomAD
rs2057350681 136 G>R No Ensembl
rs2057350478 137 Q>* No Ensembl
rs1464398565 139 D>E No gnomAD
rs2052448876 139 D>E No Ensembl
rs2057350288 139 D>H No Ensembl
rs1192618836 140 S>C No gnomAD
rs1403139051 140 S>P No gnomAD
rs2057349974 141 I>V No Ensembl
rs1297130679 143 P>L No gnomAD
rs1172187484 143 P>L No gnomAD
rs896861093 144 H>D No gnomAD
rs896861093 144 H>N No gnomAD
rs896861093 144 H>Y No gnomAD
rs1332026528 145 Q>L No Ensembl
rs1339774552 146 S>* No gnomAD
rs2057349060 147 P>T No Ensembl
rs2057348917 149 W>* No Ensembl
rs2057348917 149 W>C No Ensembl
rs1015343463 151 P>A No Ensembl
rs1198719858 151 P>L No gnomAD
rs975942204 151 P>R No Ensembl
rs1198719858 151 P>R No gnomAD
rs1353176379 152 W>* No Ensembl
rs1264701128 152 W>R No gnomAD
rs1353176379 152 W>S No Ensembl
rs2144190756 153 G>C No Ensembl
rs1199086996 153 G>C No Ensembl
rs1190099233 153 G>D No gnomAD
rs2052447465 154 C>R No gnomAD
rs2057347799 155 K>R No Ensembl
rs2057347698 156 D>E No gnomAD
rs1256703698 158 S>N No gnomAD
rs58091269 160 G>C No 1000Genomes
gnomAD
rs58091269 160 G>R No 1000Genomes
gnomAD
rs1425217825 160 G>S No gnomAD
rs58091269 160 G>S No 1000Genomes
gnomAD
rs1239974448 160 G>V No gnomAD
rs2057346850 162 P>S No Ensembl
rs1461928944 163 S>N No Ensembl
rs944434938 164 F>S No gnomAD
rs1342787293 166 T>I No gnomAD
rs1466847385 166 T>I No Ensembl
rs890825606 166 T>P No gnomAD
rs1263510334 167 S>A No gnomAD
rs2057346076 167 S>Y No TOPMed
rs1236080783 169 I>L No gnomAD
rs2052446001 169 I>T No Ensembl
rs2057345878 170 L>F No gnomAD
VAR_017170 170 L>I No UniProt
rs1401172185 171 W>R No TOPMed
rs932927171 174 A>D No gnomAD
rs2052445525 174 A>P No Ensembl
rs1049953626 174 A>S No gnomAD
rs2057345169 175 V>L No gnomAD
rs2057345169 175 V>M No gnomAD
rs2145967051 176 V>A No Ensembl
rs2057344975 176 V>I No Ensembl
rs967714293 176 V>I No Ensembl
rs1374587218 177 K>Q No Ensembl
rs2057344533 178 K>Q No gnomAD
rs1302785793 178 K>Q No Ensembl

No associated diseases with Q8IVW1

1 regional properties for Q8IVW1

Type Name Position InterPro Accession
domain ADP-ribosylation factor-like protein 17, C-terminal 115 - 176 IPR031687

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction

2 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

49 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KJ96 ARL5A ADP-ribosylation factor-like protein 5A Bos taurus (Bovine) SS
P84081 ARF2 ADP-ribosylation factor 2 Bos taurus (Bovine) SS
P84080 ARF1 ADP-ribosylation factor 1 Bos taurus (Bovine) SS
Q3SZF2 ARF4 ADP-ribosylation factor 4 Bos taurus (Bovine) SS
Q0VC18 ARL4D ADP-ribosylation factor-like protein 4D Bos taurus (Bovine) PR
P49702 ARF5 ADP-ribosylation factor 5 Gallus gallus (Chicken) SS
P61209 Arf1 ADP-ribosylation factor 1 Drosophila melanogaster (Fruit fly) SS
P40945 Arf4 ADP ribosylation factor 4 Drosophila melanogaster (Fruit fly) SS
Q8IVW1 ARL17A ADP-ribosylation factor-like protein 17 Homo sapiens (Human) SS
Q8N4G2 ARL14 ADP-ribosylation factor-like protein 14 Homo sapiens (Human) SS
Q969Q4 ARL11 ADP-ribosylation factor-like protein 11 Homo sapiens (Human) PR
P49703 ARL4D ADP-ribosylation factor-like protein 4D Homo sapiens (Human) PR
P62330 ARF6 ADP-ribosylation factor 6 Homo sapiens (Human) EV
Q9H0F7 ARL6 ADP-ribosylation factor-like protein 6 Homo sapiens (Human) SS
P40616 ARL1 ADP-ribosylation factor-like protein 1 Homo sapiens (Human) SS
P18085 ARF4 ADP-ribosylation factor 4 Homo sapiens (Human) EV
P84085 ARF5 ADP-ribosylation factor 5 Homo sapiens (Human) EV
P61204 ARF3 ADP-ribosylation factor 3 Homo sapiens (Human) EV
P84077 ARF1 ADP-ribosylation factor 1 Homo sapiens (Human) EV
Q9Y689 ARL5A ADP-ribosylation factor-like protein 5A Homo sapiens (Human) SS
A6NH57 ARL5C Putative ADP-ribosylation factor-like protein 5C Homo sapiens (Human) SS
Q96KC2 ARL5B ADP-ribosylation factor-like protein 5B Homo sapiens (Human) SS
P49076 ARF1 ADP-ribosylation factor Zea mays (Maize) SS
P61750 Arf4 ADP-ribosylation factor 4 Mus musculus (Mouse) SS
Q99PE9 Arl4d ADP-ribosylation factor-like protein 4D Mus musculus (Mouse) PR
Q6P068 Arl5c ADP-ribosylation factor-like protein 5C Mus musculus (Mouse) SS
Q80ZU0 Arl5a ADP-ribosylation factor-like protein 5A Mus musculus (Mouse) SS
P61205 Arf3 ADP-ribosylation factor 3 Mus musculus (Mouse) SS
Q9D4P0 Arl5b ADP-ribosylation factor-like protein 5B Mus musculus (Mouse) SS
P84078 Arf1 ADP-ribosylation factor 1 Mus musculus (Mouse) SS
Q8BSL7 Arf2 ADP-ribosylation factor 2 Mus musculus (Mouse) SS
P84084 Arf5 ADP-ribosylation factor 5 Mus musculus (Mouse) SS
P51824 ADP-ribosylation factor 1 Solanum tuberosum (Potato) SS
P84082 Arf2 ADP-ribosylation factor 2 Rattus norvegicus (Rat) SS
P51646 Arl5a ADP-ribosylation factor-like protein 5A Rattus norvegicus (Rat) SS
P36407 Trim23 E3 ubiquitin-protein ligase TRIM23 Rattus norvegicus (Rat) SS
P61751 Arf4 ADP-ribosylation factor 4 Rattus norvegicus (Rat) SS
P61206 Arf3 ADP-ribosylation factor 3 Rattus norvegicus (Rat) SS
P84079 Arf1 ADP-ribosylation factor 1 Rattus norvegicus (Rat) SS
P84083 Arf5 ADP-ribosylation factor 5 Rattus norvegicus (Rat) SS
P51823 ARF ADP-ribosylation factor 2 Oryza sativa subsp. japonica (Rice) SS
Q06396 Os01g0813400 ADP-ribosylation factor 1 Oryza sativa subsp. japonica (Rice) SS
Q10943 arf-1.2 ADP-ribosylation factor 1-like 2 Caenorhabditis elegans SS
P34212 arl-5 ADP-ribosylation factor-like protein 5 Caenorhabditis elegans SS
P40940 ARF3 ADP-ribosylation factor 3 Arabidopsis thaliana (Mouse-ear cress) SS
P36397 ARF1 ADP-ribosylation factor 1 Arabidopsis thaliana (Mouse-ear cress) SS
P0DH91 ARF2-B ADP-ribosylation factor 2-B Arabidopsis thaliana (Mouse-ear cress) SS
Q9LQC8 ARF2-A ADP-ribosylation factor 2-A Arabidopsis thaliana (Mouse-ear cress) SS
Q5M9P8 arl6 ADP-ribosylation factor-like protein 6 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGNIFEKLFK SLLGKKKMRI LILSLDTAGK TTILYKLKLG ETVPAVPTVG FCVETVEYKN
70 80 90 100 110 120
NTFAVWDVGS HFKIRPLWQH FFQNTKGARS PGSTHQGSLA SGVLPIKCSH VEFGMWKGGR
130 140 150 160 170
SHPFLPHSSR CAGSGGQLDS ILPHQSPAWG PWGCKDLSSG FPSFLTSSIL WKSAVVK