Q8IUE0
PR
Gene name |
TGIF2LY (TGIFLY) |
Protein name |
Homeobox protein TGIF2LY |
Names |
TGF-beta-induced transcription factor 2-like protein, TGFB-induced factor 2-like protein, Y-linked, TGIF-like on the Y |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:90655 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8IUE0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8IUE0-F1 | Predicted | AlphaFoldDB |
62 variants for Q8IUE0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| TCGA novel | 4 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs764833415 CA10571464 |
5 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA414952678 rs1188148342 |
6 | D>E | No |
ClinGen gnomAD |
|
| TCGA novel | 7 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414952680 rs1237026679 |
7 | G>R | No |
ClinGen gnomAD |
|
|
CA10571465 rs752369378 |
8 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA10571466 rs752369378 |
8 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs1424540801 CA414952697 |
10 | E>* | No |
ClinGen gnomAD |
|
|
rs751502144 CA10571468 |
10 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA414952732 rs1569468735 |
15 | V>L | No |
ClinGen Ensembl |
|
|
rs757128360 CA10571469 |
19 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs1415598677 CA414952842 |
30 | T>S | No |
ClinGen gnomAD |
|
|
rs745691913 CA10571471 |
33 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1556380393 CA414952889 |
37 | N>S | No |
ClinGen Ensembl |
|
|
CA10571472 rs371942276 |
38 | A>V | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10571473 rs779064026 |
40 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA10571474 rs748379846 |
53 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs867407840 CA337463291 |
55 | G>R | No |
ClinGen Ensembl |
|
|
CA10571477 rs747545924 |
56 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA414953048 rs1201007545 |
61 | S>P | No |
ClinGen gnomAD |
|
|
CA414953053 rs1603326202 |
62 | V>I | No |
ClinGen Ensembl |
|
|
CA10571480 rs759864266 |
70 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
rs1264174140 CA414953126 |
71 | K>N | No |
ClinGen gnomAD |
|
|
rs765619540 CA10571481 |
72 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA10571483 rs376345032 |
74 | F>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs376345032 CA10571482 |
74 | F>Y | No |
ClinGen ESP ExAC gnomAD |
|
|
CA414953197 rs1478541472 |
82 | E>K | No |
ClinGen gnomAD |
|
|
CA10571485 rs763607137 |
85 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1400623496 CA414953228 |
86 | L>V | No |
ClinGen gnomAD |
|
| TCGA novel | 88 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414953259 rs1412268303 |
90 | T>N | No |
ClinGen gnomAD |
|
|
rs751021029 CA10571486 |
91 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA414953275 rs1360595447 |
93 | S>P | No |
ClinGen gnomAD |
|
|
rs1275879266 CA414953312 |
99 | N>H | No |
ClinGen gnomAD |
|
|
rs767404235 CA10571488 |
102 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA414953347 rs1233642961 |
103 | N>S | No |
ClinGen gnomAD |
|
|
rs750363094 CA10571489 |
105 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs367841917 CA10571490 |
107 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
rs1603326209 CA414953371 |
107 | R>H | No |
ClinGen Ensembl |
|
|
COSM3408053 CA10571491 rs779833813 |
116 | R>H | Variant assessed as Somatic; impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA |
|
CA414953476 rs748398356 |
122 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA10571492 rs748398356 |
122 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs758648891 CA10571493 |
123 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs778034889 CA10571494 |
125 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 129 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414953534 rs1269684641 |
131 | H>Y | No |
ClinGen gnomAD |
|
|
CA10571499 rs770057401 |
136 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs775772290 CA10571500 |
140 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA337463331 rs866342217 |
143 | P>S | No |
ClinGen Ensembl |
|
|
rs763776856 CA10571502 |
145 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs1286782287 CA414953668 |
152 | T>P | No |
ClinGen gnomAD |
|
|
CA414953679 rs1392362871 |
153 | M>R | No |
ClinGen gnomAD |
|
|
CA414953686 rs370000054 |
154 | Y>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs370000054 CA10571505 |
154 | Y>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10571507 rs201108862 |
157 | C>G | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10571508 rs766112873 |
163 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs753650371 CA10571509 |
163 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
rs1353113520 CA414953762 |
165 | A>G | No |
ClinGen gnomAD |
|
|
CA414953764 rs1237986111 |
166 | R>G | No |
ClinGen gnomAD |
|
| TCGA novel | 175 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10571510 rs377412222 |
175 | R>W | No |
ClinGen ESP ExAC gnomAD |
|
|
rs201753203 CA10571512 |
181 | R>G | No |
ClinGen ESP ExAC gnomAD |
No associated diseases with Q8IUE0
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8MIB7 | TGIF2LX | Homeobox protein TGIF2LX | Pan troglodytes (Chimpanzee) | PR |
| Q75LX9 | Os03g0673500 | Putative homeobox protein knotted-1-like 5 | Oryza sativa subsp japonica (Rice) | PR |
| Q75LX7 | OSH10 | Homeobox protein knotted-1-like 4 | Oryza sativa subsp japonica (Rice) | PR |
| Q1PFD1 | BLH11 | BEL1-like homeodomain protein 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIW1 | BLH7 | BEL1-like homeodomain protein 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAAADGPAE | TQSPVEKDSP | AKTQSPAQDT | SIMSRNNADT | GRVLALPEHK | KKRKGNLPAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SVKILRDWMY | KHRFKAYPSE | EEKQMLSEKT | NLSLLRISNW | FINARRRILP | DMLQQRRNDP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IIGHKTGKDA | HATHLQSTEA | SVPAKSGPVV | QTMYKACPCG | PCQRARCQER | SNQIRSRPLA |
| RSSPE |