Q8IMX7

PR
Gene name
Miro (CG5410)
Protein name
Mitochondrial Rho GTPase
Names
Miro, dMiro
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG5410
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-240 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q8IMX7

Entry ID Method Resolution Chain Position Source
4C0J X-ray 282 A A 201-617 PDB
4C0K X-ray 280 A A 201-617 PDB
4C0L X-ray 300 A A 201-617 PDB
AF-Q8IMX7-F1 Predicted AlphaFoldDB

No variants for Q8IMX7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8IMX7

No associated diseases with Q8IMX7

6 regional properties for Q8IMX7

Type Name Position InterPro Accession
domain EF-hand domain 330 - 365 IPR002048
domain Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 372 - 441 IPR013566
domain EF hand associated, type-2 245 - 331 IPR013567
binding_site EF-Hand 1, calcium-binding site 223 - 235 IPR018247
domain MIRO domain 9 - 194 IPR020860-1
domain MIRO domain 444 - 607 IPR020860-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass type IV membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
axon cytoplasm Any cytoplasm that is part of a axon.
integral component of mitochondrial outer membrane The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

4 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.

11 GO annotations of biological process

Name Definition
axonal transport of mitochondrion The directed movement of mitochondria along microtubules in nerve cell axons.
cellular homeostasis Any process involved in the maintenance of an internal steady state at the level of the cell.
establishment of mitochondrion localization, microtubule-mediated The directed movement of the mitochondrion to a specific location, by a process involving microtubules.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
mitochondrial outer membrane permeabilization The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
mitochondrion localization Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.
mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
mitochondrion transport along microtubule The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.
regulation of mitochondrion organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
synaptic vesicle transport The directed movement of synaptic vesicles.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39722 GEM1 Mitochondrial Rho GTPase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5ZM83 RHOT2 Mitochondrial Rho GTPase 2 Gallus gallus (Chicken) PR
P48148 Rho1 Ras-like GTP-binding protein Rho1 Drosophila melanogaster (Fruit fly) PR
Q9MA88 MIRO3 Mitochondrial Rho GTPase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGQYTASQRK NVRILLVGDA GVGKTSLILS LVSEEYPEEV PPRAEEITIP ANVTPEQVPT
70 80 90 100 110 120
SIVDFSAVEQ SEDALAAEIN KAHVVCIVYA VDDDDTLDRI TSHWLPLVRA KCNPSLDGEG
130 140 150 160 170 180
DAEAEAEGDT QREPIRKPIV LVGNKIDLIE YSTMDSVLAI MEDYPEIESC VECSAKSLHN
190 200 210 220 230 240
ISEMFYYAQK AVLHPTSPLY MMEEQELTSA CKKSLVRIFK ICDIDGDNLL NDYELNLFQR
250 260 270 280 290 300
RCFNTPLQPQ ILDEVKAVIQ KNVPDGIYND AVTLKGFLFL HCLFIQRGRN ETTWAVLRRF
310 320 330 340 350 360
GYNDQLEMCQ EYLRPPLKIP PGSSTELSHR GQQFLIAVFE RYDRDGDGAL SPEEHKMLFS
370 380 390 400 410 420
TCPAAPWSYS TDIRKSCPIN ETTGWVTLHG WLCRWTLMTL IDVVKTMEYL AYLGFNVHEN
430 440 450 460 470 480
DSQLAAIHVT RERRIDLAKR QSSRSVYKCH VIGPKGSGKT GMCRGFLVED MHKLIGKEFK
490 500 510 520 530 540
TNVVNCINSV QVYGQEKHLI LRDIDVRHAL DPLQPQEVNC DVACLVYDSS NPRSFEYVAR
550 560 570 580 590 600
IYIKYYAESK IPVMIVGTKC DMDERRQDYL MQPSEFCDKY KLLPPHLFSL KTNKKELYTK
610 620 630 640 650
LATMAAFPHL RQFGLMTEDP KLWLKAGLGV AAATMLGFIV LKTISAAGAH TR