Q8I7I5

PR
Gene name
rol-3 (C16D9.2)
Protein name
Protein roller-3
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C16D9.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2237-2318 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

2117-2124 (Activation loop from InterPro)

Target domain

1966-2235 (Protein kinase domain)

Relief mechanism

Assay

2136-2142 (Activation loop from InterPro)

Target domain

1966-2235 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8I7I5

Entry ID Method Resolution Chain Position Source
AF-Q8I7I5-F1 Predicted AlphaFoldDB

No variants for Q8I7I5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8I7I5

No associated diseases with Q8I7I5

4 regional properties for Q8I7I5

Type Name Position InterPro Accession
domain Protein kinase domain 96 - 384 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 130 - 232 IPR003527
active_site Serine/threonine-protein kinase, active site 216 - 228 IPR008271
binding_site Protein kinase, ATP binding site 102 - 126 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cell leading edge The area of a motile cell closest to the direction of movement.
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

6 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
locomotion Self-propelled movement of a cell or organism from one location to another.
protein phosphorylation The process of introducing a phosphate group on to a protein.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

32 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
Q0VBZ0 CSK Tyrosine-protein kinase CSK Bos taurus (Bovine) SS
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
P41239 CSK Tyrosine-protein kinase CSK Gallus gallus (Chicken) SS
P29376 LTK Leukocyte tyrosine kinase receptor Homo sapiens (Human) SS
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
Q9UM73 ALK ALK tyrosine kinase receptor Homo sapiens (Human) EV
P08922 ROS1 Proto-oncogene tyrosine-protein kinase ROS Homo sapiens (Human) SS
P41240 CSK Tyrosine-protein kinase CSK Homo sapiens (Human) SS
P42679 MATK Megakaryocyte-associated tyrosine-protein kinase Homo sapiens (Human) SS
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P97793 Alk ALK tyrosine kinase receptor Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
P41241 Csk Tyrosine-protein kinase CSK Mus musculus (Mouse) EV
P41242 Matk Megakaryocyte-associated tyrosine-protein kinase Mus musculus (Mouse) SS
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
Q64716 Insrr Insulin receptor-related protein Rattus norvegicus (Rat) SS
P32577 Csk Tyrosine-protein kinase CSK Rattus norvegicus (Rat) SS
P41243 Matk Megakaryocyte-associated tyrosine-protein kinase Rattus norvegicus (Rat) SS
H2KZU7 svh-2 Tyrosine-protein kinase receptor svh-2 Caenorhabditis elegans SS
O45539 src-2 Tyrosine protein-kinase src-2 Caenorhabditis elegans SS
O01798 spe-8 Spermatocyte protein spe-8 Caenorhabditis elegans PR
O16262 nipi-4 Protein nipi-4 Caenorhabditis elegans PR
P03949 abl-1 Tyrosine-protein kinase abl-1 Caenorhabditis elegans SS
G5ECJ6 csk-1 Tyrosine-protein kinase csk-1 Caenorhabditis elegans SS
G5EE56 src-1 Tyrosine protein-kinase src-1 Caenorhabditis elegans SS
Q95YD4 kin-32 Inactive tyrosine-protein kinase kin-32 Caenorhabditis elegans PR
F1QVU0 ltk Tyrosine-protein kinase receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
F8W3R9 alk ALK tyrosine kinase receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MLSLHLRSLA ILFLLFFLLH DVVKSATVFS SSLKTCQSQC EERNLAYPLD SGEVHWTGLA
70 80 90 100 110 120
EYNYSSRISS CRHGCEDVDE RESKCDVKCS EEGIVSNACK QGCRAVLVSF LAQAQALLIQ
130 140 150 160 170 180
VHVNMEVLET SMKLKWEFPE TLAEELKEIA NADIFWFSQT KPLNGILGWR WTSLPQNSFR
190 200 210 220 230 240
NSSLSSEVHV PFEHGEHVEV RLALSYRNQV LVSRTTTYHL PLSKSGTTLE VIGQLQLSDD
250 260 270 280 290 300
RVAVCYRTNQ PTPKFKLTIM TLNDNTINTE ESIARCHLFS NLPRDNCCKA SISAIDEHGA
310 320 330 340 350 360
TTAFVEIKLD FYVNQVEIEL VSVASSRLIF SNGTHLLESE IDQYALGDSA TVIPFPLPTD
370 380 390 400 410 420
DTITAIAGIS DTTIAIGSSK GSLWTYQMSA NQTDEDQPSS VIQLKTVGEM DTKINQIEID
430 440 450 460 470 480
HIQRTLYAVQ HDKGIIRCKL RTMEAEESPN CVLIVNNDAL NAPKEITLDS VNGHVYTLNA
490 500 510 520 530 540
DNKVYRTEMV AFNATGIETV ASLQYLQDMS PSNGIFFDVS KFLLYSALQN GSMMTLNPVT
550 560 570 580 590 600
DHVHIFKDVG YADIQHFRIK NDLIYWMKKK CGETDADENC IFAENLQRSE EDIPNKFTYS
610 620 630 640 650 660
SSLMSFGVLE EILLKPRITA VSTIAMLTSD KTARVSWDES NTLPFQAQGS SWRNFTYFLK
670 680 690 700 710 720
VTAPDITDFS PIEIYTSNTE MKIDVTPGNI YNAQVQVCSD DFCSIPTSTS NTALPDLGDV
730 740 750 760 770 780
VPFVFTKRQA DDIISVDILG NIIPADDSVK IVEKLQYPHV LDNTTKTVYL AGDHSMGIFK
790 800 810 820 830 840
KYLDDTAGLP KPFKDGLFVE MMSIMPARSI ILIASSYKIT SYRLPTTFDF EYFSCEEPLE
850 860 870 880 890 900
ACSEVMGISS DDTTGMVHFL TQARNGTITL WESDPENRTP RDIASVPSIV PFRRFLILHD
910 920 930 940 950 960
KMILVTKNNH IVQTDKKLKV VNVATELERV DHILPLRYAT ISHKIEFSDE IKFIDGSKTN
970 980 990 1000 1010 1020
LQWTLSPPLE AGTVLFKVSI FREKMGGQDP PIITIQSETN FTIPSEVLEA WSSAQRFDVS
1030 1040 1050 1060 1070 1080
VQAMTPWATA VLNRTGLTAP VKPPTSPTQL RIFATQQKTV DGPRALISFF WGPPSEWNGT
1090 1100 1110 1120 1130 1140
PYQYIVNCTK DDGSWIGGPV TTSQSHYSFA VKSGKVSCQA AAANEPTNIG SFSELITIDS
1150 1160 1170 1180 1190 1200
SELKPLVKLF AIDSTNSLIS INDLAHEEPR RETRQVAQPV KLEYQAMAFI GEDLYAVRKE
1210 1220 1230 1240 1250 1260
GESAQPVLVQ IDTNHIDNTV HKVSIGGDVT RIDAMTSDWV GNRLIFVAGT NVYQLSLEPF
1270 1280 1290 1300 1310 1320
LSTSLLNPHK LIQLTSATDA KQLAYDPFMN TAYLLTKNGS LFALDMNKNT EANLALTVSC
1330 1340 1350 1360 1370 1380
LASQTVTWMM TEFAWNRASS PKIYALTWNG LIYVDLTEDS QCNEVRIDWT KFGDKGLKDI
1390 1400 1410 1420 1430 1440
SSFAIADKLF AFVTSSEMLI YGKDTVTPIT IANPPLKQIL AVSQSSQPYP ERSCFELPSS
1450 1460 1470 1480 1490 1500
KGIVFSIVNE GKTGSFLEVT KSSSSSSCQE VSMPQTQYEI YFTRKNTDKV KHVRSFSDRI
1510 1520 1530 1540 1550 1560
HVENGILDKE TDYDVTVTWL NRYSPASGVS ASKSFRTGFG YPSAPRDPHA IPVTPDTVYL
1570 1580 1590 1600 1610 1620
YWNLPETLNA PISEIKYKIS QQAAGISVPT SIAVIALSET VSSNISSDTT SCLINPCRVK
1630 1640 1650 1660 1670 1680
IANLRPSNEY KFWVTATHIS HLDAATILKD DDAVSSEAVA RTLDVPGTLR PDNVTGSSLL
1690 1700 1710 1720 1730 1740
LRWNGLEPEH RPSSIAVQYR ESGGANNEWQ FPMNVSFEPD VTTELVPITN LLSATSYDYR
1750 1760 1770 1780 1790 1800
FVATYTGTYT IDGKVLAFKE DYLQLPQQAR TKAGVPTAPQ FVEAKQDEEG WIVTWKEPMS
1810 1820 1830 1840 1850 1860
DGGSPITSYA VETRINKTAE WEIAERGLDG WKTWWRPGKS DTTSSTSTSS TEVSEFRIRA
1870 1880 1890 1900 1910 1920
ANIEGFGAYA YTEDKKEEKE EEPSSVLPYL LLLSIIFLLA AMILVACFWL KSRRRQQQKK
1930 1940 1950 1960 1970 1980
REAEDERNCI RLDVVANMNF SSSHQSLPPE YESEMRNLPV VNYSTVTFND YIDTCAYGIV
1990 2000 2010 2020 2030 2040
HSGTAEEVPM SWEKDVRVAI KKLKPNHSFQ EKMMFMKEAI LLNNLDHPNI VKELGVCITP
2050 2060 2070 2080 2090 2100
GQELILLEYM EGGNLLKFLQ KSTPNEYQSS ELSPRDLLSI SVDIARGMNY LERLPHVHKN
2110 2120 2130 2140 2150 2160
LSARKCLLAG RPGVTKLEMG MSKELSNGQV NRSDLENMEI VRWMAPEVLK DFQFSSKSDV
2170 2180 2190 2200 2210 2220
WAYGVLLYEV FSFGEVPYGD KDNRRIMTDV RNGSVLPIPS YCPSKRIYKV IKQCLTSDST
2230 2240 2250 2260 2270 2280
KRANFATILK IFETFRDDQK CQDDKPIQFN DGTDNTNFSA SQDSTSSREP PSPSHRMRDF
2290 2300 2310 2320 2330 2340
IDTRDLEPPS PSHLNQSFGG FEHPYEGERP ATMWNGSGAR NSAKNSIGRS MKKEKLRNPI
2350 2360 2370 2380 2390 2400
HSMDDLVARN QRPLSIHSED TESTDYGASS SMYSPGSSNR ISSQVDPPIG RLSSAPGIGI
2410 2420 2430 2440 2450 2460
VNDAFESSNP SLNLSRSWAG LSREVNQNPA GAGSSGTLPQ HTNSAGHLRL PGVQVGAGGG
2470 2480
RVYRNASGGG GPSNRGRISQ V