Q8HY67

SS
Gene name
ANP32A
Protein name
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Names
Inhibitor-1 of protein phosphatase type 2A
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
EC number
Protein Class

Descriptions

ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.

Autoinhibitory domains (AIDs)

121-163 (Autoinhibitory domain) SS

Target domain

1-163 (Leucine-rich region)

Relief mechanism

PTM, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q8HY67

Entry ID Method Resolution Chain Position Source

No variants for Q8HY67

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8HY67

No associated diseases with Q8HY67

2 regional properties for Q8HY67

Type Name Position InterPro Accession
domain ABC1 atypical kinase-like domain 148 - 406 IPR004147
domain ADCK1-like domain 147 - 408 IPR045307

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Endoplasmic reticulum
  • Shuttles between nucleus and cytoplasm
  • Translocates to the cytoplasm during the process of neuritogenesis (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

1 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

2 GO annotations of biological process

Name Definition
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P51122 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Bos taurus (Bovine) SS
Q9V895 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Drosophila melanogaster (Fruit fly) SS
P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A Homo sapiens (Human) EV
O43423 ANP32CP Putative uncharacterized protein ANP32CP Homo sapiens (Human) SS
O35381 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Mus musculus (Mouse) SS
P49911 Anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Rattus norvegicus (Rat) SS
Q7Y180 Os03g0668900 Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 Oryza sativa subsp. japonica (Rice) SS
Q9SCQ7 At3g50690 Acidic leucine-rich nuclear phosphoprotein 32-related protein Arabidopsis thaliana (Mouse-ear cress) SS
Q7ZUP0 anp32a Acidic leucine-rich nuclear phosphoprotein 32 family member A Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MEMGRRIHLE LRNRTPSDVK ELVLDNCRSI EGKIEGLTDE FEELEFLSTI NVGLTSVANL
70 80 90 100 110 120
PKLNKLKKLE LSDNRISGGL EVLAEKCPNL THLNLSGNKI KDLSTIEPLK KLENLKSLDL
130 140 150 160 170 180
FNCEVTNLND YRENVFKLLP QLTYLDGYDR DDKEAPDSDA EGYVEGLDDD EEDEDEEEYD
190 200 210 220 230 240
EDAQVVEDEE DEEEEEEGEE EDVSGEEEED EEGYNDGEVD DEEDEEDVGE EERGQKRKRE
PXDXGEDDD