Q8HXQ5

PR
Gene name
ABCC1
Protein name
Multidrug resistance-associated protein 1
Names
ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, LTC4 transporter
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281588
EC number
7.6.2.2: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

238-333 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q8HXQ5

Entry ID Method Resolution Chain Position Source
5UJ9 EM 349 A A 205-1530 PDB
5UJA EM 334 A A 205-1530 PDB
6BHU EM 314 A A 1-1530 PDB
6UY0 EM 323 A A 1-1530 PDB
8F4B EM 327 A A 205-1530 PDB
AF-Q8HXQ5-F1 Predicted AlphaFoldDB

262 variants for Q8HXQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs381952166 45 Y>F No EVA
rs442185083 81 L>V No EVA
rs457604628 88 D>G No EVA
rs470963120 155 S>Y No EVA
rs441378435 158 M>R No EVA
rs1117689955 173 V>I No EVA
rs438020106 210 E>V No EVA
rs457421663 245 N>T No EVA
rs436486463 268 S>A No EVA
rs454967007 270 K>E No EVA
rs455394615 274 K>Q No EVA
rs457223649 288 S>R No EVA
rs457290870 311 P>L No EVA
rs439719150 331 F>C No EVA
rs451853897 332 K>E No EVA
rs473518034 335 H>D No EVA
rs440608223 336 D>V No EVA
rs480930720 338 M>I No EVA
rs441010567 351 N>T No EVA
rs459551715 352 F>C No EVA
rs474879655 358 A>P No EVA
rs1116180005 360 E>D No EVA
rs483126128 363 G>S No EVA
rs450072101 363 G>V No EVA
rs477321265 364 Y>S No EVA
rs465477679 367 T>P No EVA
rs447751969 373 S>G No EVA
rs466252148 375 C>W No EVA
rs436681998 377 Q>K No EVA
rs469779082 380 V>G No EVA
rs436750939 382 H>D No EVA
rs452142970 383 Q>P No EVA
rs470640799 384 Y>S No EVA
rs434470367 385 F>S No EVA
rs453123152 387 I>L No EVA
rs441889485 388 C>* No EVA
rs474849508 388 C>G No EVA
rs463645259 390 V>I No EVA
rs443550073 394 R>G No EVA
rs477309088 397 T>A No EVA
rs447739739 398 A>D No EVA
rs481701412 404 Y>C No EVA
rs481701412 404 Y>S No EVA
rs456699658 412 N>T No EVA
rs471927140 413 A>P No EVA
rs438325559 414 A>S No EVA
rs453645824 417 S>F No EVA
rs472280314 418 S>P No EVA
rs443469122 454 A>D No EVA
rs458798922 456 Y>S No EVA
rs439909293 470 V>G No EVA
rs458418541 490 Y>D No EVA
rs465582916 508 I>N No EVA
rs447195191 520 W>* No EVA
rs465813388 521 E>D No EVA
rs436054834 522 L>Q No EVA
rs436054834 522 L>R No EVA
rs454596155 525 K>I No EVA
rs519622295 528 V>M No EVA
rs469892005 531 I>N No EVA
rs452288919 544 Y>S No EVA
rs470870782 556 T>A No EVA
rs470870782 556 T>P No EVA
rs450669315 609 A>V No EVA
rs462871925 610 S>G No EVA
rs482234812 614 K>T No EVA
rs434912816 624 D>G No EVA
rs464653868 624 D>Y No EVA
rs447047148 629 S>R No EVA
rs468782354 634 P>A No EVA
rs439354880 643 S>T No EVA
rs457817328 645 T>P No EVA
rs479494437 658 P>T No EVA
rs466287533 671 G>A No EVA
rs447648859 671 G>C No EVA
rs436579178 688 L>I No EVA
rs476885657 689 S>* No EVA
rs455169768 689 S>A No EVA
rs437521748 702 V>E No EVA
rs452851294 703 T>I No EVA
rs440789241 704 V>G No EVA
rs465249731 708 V>E No EVA
rs137665907 735 R>W No EVA
rs442490177 749 D>E No EVA
rs461034140 755 S>R No EVA
rs480028155 770 G>W No EVA
rs450518824 776 V>L No EVA
rs469101240 779 A>S No EVA
rs432963337 779 A>V No EVA
rs466849829 781 A>S No EVA
rs516891570 785 D>G No EVA
rs455635901 789 Y>S No EVA
rs474952183 793 D>E No EVA
rs438454870 821 T>A No EVA
rs460215876 822 R>W No EVA
rs449020755 837 V>G No EVA
rs461109743 842 S>G No EVA
rs482878484 855 L>Q No EVA
rs465318542 858 R>P No EVA
rs433166856 859 D>G No EVA
rs466883203 862 F>L No EVA
rs455692486 864 E>A No EVA
rs434025278 864 E>Q No EVA
rs468177669 865 F>L No EVA
rs468177669 865 F>V No EVA
rs438230070 866 L>Q No EVA
rs438393440 869 Y>H No EVA
rs460104400 870 A>G No EVA
rs472201361 873 E>G No EVA
rs442504250 874 Q>P No EVA
rs461053724 876 Q>E No EVA
rs42064343 902 V>E No EVA
rs438644385 912 R>S No EVA
rs460319645 917 S>P No EVA
rs42064369 922 R>G No EVA
rs480463455 926 Q>H No EVA
rs42064371 926 Q>R No EVA
rs450897355 928 H>L No EVA
rs450897355 928 H>P No EVA
rs469337474 930 S>R No EVA
rs433332084 931 T>A No EVA
rs433332084 931 T>S No EVA
rs467160543 932 A>D No EVA
rs455972856 937 P>S No EVA
rs473779866 938 G>W No EVA
rs437640920 939 P>L No EVA
rs437640920 939 P>R No EVA
rs457654518 940 T>M No EVA
rs471460028 949 A>E No EVA
rs438507103 954 T>K No EVA
rs460308678 955 G>E No EVA
rs42064389 986 V>M No EVA
rs457525107 1023 I>N No EVA
rs460370001 1032 Y>F No EVA
rs472276875 1034 M>I No EVA
rs442684147 1037 S>P No EVA
rs461941113 1038 I>S No EVA
rs480463681 1042 F>L No EVA
rs444524881 1045 R>L No EVA
rs463038016 1059 P>H No EVA
rs478434418 1070 N>Y No EVA
rs483059186 1071 L>P No EVA
rs211441841 1072 V>L No EVA
rs445353423 1082 V>G No EVA
rs467209227 1083 D>V No EVA
rs479258775 1084 S>L No EVA
rs449612123 1085 M>T No EVA
rs456198906 1103 A>S No EVA
rs432080054 1104 C>F No EVA
rs464991980 1104 C>S No EVA
rs453796818 1105 I>T No EVA
rs472216146 1106 I>S No EVA
rs442671893 1107 I>M No EVA
rs473979437 1110 A>S No EVA
rs444423872 1114 A>P No EVA
rs438890012 1118 I>L No EVA
rs460696780 1122 G>C No EVA
rs479246203 1125 Y>F No EVA
rs479246203 1125 Y>S No EVA
rs449599652 1128 V>L No EVA
rs448271736 1131 F>L No EVA
rs470065373 1133 V>A No EVA
rs437101822 1135 S>P No EVA
rs465375157 1137 R>P No EVA
rs432437639 1138 Q>P No EVA
rs432437639 1138 Q>R No EVA
rs472772317 1139 L>P No EVA
rs454248860 1139 L>V No EVA
rs442977999 1140 K>* No EVA
rs443900625 1141 R>L No EVA
rs476890532 1141 R>S No EVA
rs440849601 1143 E>D No EVA
rs476851154 1143 E>G No EVA
rs481195017 1144 S>* No EVA
rs459320116 1144 S>A No EVA
rs469972364 1145 V>G No EVA
rs482129869 1146 S>R No EVA
rs446003387 1147 R>G No EVA
rs465361103 1148 S>A No EVA
rs454138583 1150 V>F No EVA
rs466236801 1150 V>G No EVA
rs436486755 1152 S>P No EVA
rs455076507 1153 H>L No EVA
rs476876738 1153 H>Q No EVA
rs443911558 1154 F>L No EVA
rs452716223 1154 F>Y No EVA
rs440733546 1155 N>K No EVA
rs470396815 1155 N>T No EVA
rs459208303 1156 E>A No EVA
rs474677645 1156 E>D No EVA
rs441704014 1157 T>S No EVA
rs482124180 1158 L>F No EVA
rs463557545 1158 L>S No EVA
rs447634946 1163 V>F No EVA
rs466132891 1164 I>L No EVA
rs436481172 1164 I>M No EVA
rs470373774 1166 A>G No EVA
rs448527650 1166 A>S No EVA
rs435058511 1167 F>L No EVA
rs452607871 1167 F>L No EVA
rs471082969 1167 F>S No EVA
rs474651459 1168 E>D No EVA
rs452752850 1168 E>G No EVA
rs463448699 1169 E>D No EVA
rs441703705 1169 E>Q No EVA
rs475560567 1170 Q>H No EVA
rs439399009 1171 E>K No EVA
rs479665579 1172 R>L No EVA
rs457934402 1172 R>S No EVA
rs459741625 1173 F>S No EVA
rs481502842 1174 I>T No EVA
rs448549344 1175 R>G No EVA
rs470239683 1175 R>P No EVA
rs437282741 1176 Q>K No EVA
rs446159338 1177 S>G No EVA
rs464605972 1184 N>S No EVA
rs435046233 1188 Y>* No EVA
rs453588403 1189 Y>S No EVA
rs474600026 1191 S>C No EVA
rs456942302 1195 N>T No EVA
rs433933598 1197 W>G No EVA
rs455672492 1203 E>G No EVA
rs474276260 1204 C>G No EVA
rs455179131 1247 V>L No EVA
rs476722419 1258 V>L No EVA
rs137702565 1260 V>G No EVA
rs443152099 1261 E>G No EVA
rs433880385 1301 Y>F No EVA
rs473860335 1318 G>C No EVA
rs456718650 1333 S>A No EVA
rs472024853 1355 I>M No EVA
rs454378695 1369 I>M No EVA
rs432642467 1369 I>N No EVA
rs455108353 1377 V>F No EVA
rs470324514 1387 L>V No EVA
rs452082423 1390 F>V No EVA
rs470631596 1391 S>R No EVA
rs440932209 1417 K>N No EVA
rs442805563 1434 R>S No EVA
rs461393976 1437 V>G No EVA
rs483189586 1451 V>A No EVA
rs450194132 1453 D>H No EVA
rs459068644 1457 A>G No EVA
rs477376621 1458 A>D No EVA
rs466260549 1459 V>G No EVA
rs436697306 1460 D>G No EVA
rs447982464 1463 T>K No EVA
rs436863478 1471 I>L No EVA
rs452144107 1471 I>T No EVA
rs434519819 1477 D>A No EVA
rs453139154 1478 C>R No EVA
rs474892918 1479 T>S No EVA
rs441989545 1480 V>F No EVA
rs476679878 1485 H>R No EVA
rs458999342 1487 L>P No EVA
rs477315339 1493 Y>D No EVA
rs447784659 1494 T>P No EVA
rs876084645 1496 V>L No EVA
rs876538681 1512 D>G No EVA
rs457082785 1517 R>I No EVA
rs469292421 1525 K>N No EVA
rs876336554 1530 V>G No EVA

No associated diseases with Q8HXQ5

12 regional properties for Q8HXQ5

Type Name Position InterPro Accession
repeat WD40 repeat 516 - 562 IPR001680-1
repeat WD40 repeat 565 - 610 IPR001680-2
repeat WD40 repeat 660 - 697 IPR001680-3
repeat WD40 repeat 703 - 742 IPR001680-4
repeat WD40 repeat 792 - 831 IPR001680-5
repeat WD40 repeat 832 - 869 IPR001680-6
repeat WD40 repeat 872 - 911 IPR001680-7
repeat WD40 repeat 918 - 956 IPR001680-8
repeat WD40 repeat 1032 - 1072 IPR001680-9
domain Doublecortin domain 166 - 253 IPR003533-1
domain Doublecortin domain 295 - 380 IPR003533-2
domain HELP 449 - 515 IPR005108

Functions

Description
EC Number 7.6.2.2 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

11 GO annotations of molecular function

Name Definition
ABC-type glutathione S-conjugate transporter activity Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out).
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled lipid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out).
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
carboxylic acid transmembrane transporter activity Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
efflux transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
glutathione transmembrane transporter activity Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

11 GO annotations of biological process

Name Definition
export across plasma membrane The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.
glutathione transmembrane transport A process in which glutathione is transported across a membrane.
leukotriene transport The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups.
phospholipid translocation The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sphingolipid translocation The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
transepithelial transport The directed movement of a substance from one side of an epithelium to the other.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
xenobiotic transport The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
xenobiotic transport across blood-brain barrier The directed movement of a xenobiotic through the blood-brain barrier.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14772 BPT1 Bile pigment transporter 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2QLE5 CFTR Cystic fibrosis transmembrane conductance regulator Pan troglodytes (Chimpanzee) PR
Q6UR05 ABCC1 Multidrug resistance-associated protein 1 Canis lupus familiaris (Dog) (Canis familiaris) PR
P91660 Rh5 Probable multidrug resistance-associated protein lethal(2)03659 Drosophila melanogaster (Fruit fly) PR
P13569 CFTR Cystic fibrosis transmembrane conductance regulator Homo sapiens (Human) PR
O15439 ABCC4 ATP-binding cassette sub-family C member 4 Homo sapiens (Human) PR
Q96J66 ABCC11 ATP-binding cassette sub-family C member 11 Homo sapiens (Human) PR
O15438 ABCC3 ATP-binding cassette sub-family C member 3 Homo sapiens (Human) PR
O95255 ABCC6 ATP-binding cassette sub-family C member 6 Homo sapiens (Human) PR
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 Homo sapiens (Human) SS
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens (Human) PR
B2RX12 Abcc3 ATP-binding cassette sub-family C member 3 Mus musculus (Mouse) PR
P26361 Cftr Cystic fibrosis transmembrane conductance regulator Mus musculus (Mouse) PR
Q80WJ6 Abcc12 ATP-binding cassette sub-family C member 12 Mus musculus (Mouse) PR
O35379 Abcc1 Multidrug resistance-associated protein 1 Mus musculus (Mouse) PR
Q8VI47 Abcc2 ATP-binding cassette sub-family C member 2 Mus musculus (Mouse) SS
Q6PQZ2 CFTR Cystic fibrosis transmembrane conductance regulator Sus scrofa (Pig) PR
Q6Y306 Abcc12 ATP-binding cassette sub-family C member 12 Rattus norvegicus (Rat) PR
Q63120 Abcc2 ATP-binding cassette sub-family C member 2 Rattus norvegicus (Rat) EV
Q8CG09 Abcc1 Multidrug resistance-associated protein 1 Rattus norvegicus (Rat) PR
Q00553 CFTR Cystic fibrosis transmembrane conductance regulator Macaca mulatta (Rhesus macaque) PR
Q9SKX0 ABCC13 ABC transporter C family member 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZZ4 ABCC6 ABC transporter C family member 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1C7 ABCC9 ABC transporter C family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8G9 ABCC1 ABC transporter C family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8H0 ABCC12 ABC transporter C family member 12 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALRDFCSVD GSDLFWEWNV TWNTSNPDFT KCFQNTVLVW VPCSYLWVCF PFYFLYLSHH
70 80 90 100 110 120
DRGYIQMTHL NKAKTALGFL LWIVCWADLF YSFWERSMGK LLAPVFLVSP TLLGITMLLA
130 140 150 160 170 180
TFLIQIERRR GVQSSGIMLT FWLIALLCAL AILRSKIMTA LKEDARVDVF RDVTFYIYFS
190 200 210 220 230 240
LVLIQLVLSC FSDRSPLFSE TINDPNPCPE SSASFLSRIT FWWITGMMVQ GYRQPLESTD
250 260 270 280 290 300
LWSLNKEDTS EQVVPVLVKN WKKECAKSRK QPVKIVYSSK DPAKPKGSSK VDVNEEAEAL
310 320 330 340 350 360
IVKCPQKERD PSLFKVLYKT FGPYFLMSFL FKAVHDLMMF AGPEILKLLI NFVNDKKAPE
370 380 390 400 410 420
WQGYFYTALL FISACLQTLV LHQYFHICFV SGMRIKTAVI GAVYRKALVI TNAARKSSTV
430 440 450 460 470 480
GEIVNLMSVD AQRFMDLATY INMIWSAPLQ VILALYLLWL NLGPSVLAGV AVMVLMVPLN
490 500 510 520 530 540
AVMAMKTKTY QVAHMKSKDN RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK
550 560 570 580 590 600
KSAYLAAVGT FTWVCTPFLV ALSTFAVYVT VDENNILDAQ KAFVSLALFN ILRFPLNILP
610 620 630 640 650 660
MVISSIVQAS VSLKRLRVFL SHEDLDPDSI QRRPIKDAGA TNSITVKNAT FTWARNDPPT
670 680 690 700 710 720
LHGITFSVPE GSLVAVVGQV GCGKSSLLSA LLAEMDKVEG HVTVKGSVAY VPQQAWIQNI
730 740 750 760 770 780
SLRENILFGR QLQERYYKAV VEACALLPDL EILPSGDRTE IGEKGVNLSG GQKQRVSLAR
790 800 810 820 830 840
AVYCDSDVYL LDDPLSAVDA HVGKHIFENV IGPKGLLKNK TRLLVTHAIS YLPQMDVIIV
850 860 870 880 890 900
MSGGKISEMG SYQELLARDG AFAEFLRTYA SAEQEQGQPE DGLAGVGGPG KEVKQMENGM
910 920 930 940 950 960
LVTDTAGKQM QRQLSSSSSY SRDVSQHHTS TAELRKPGPT EETWKLVEAD KAQTGQVKLS
970 980 990 1000 1010 1020
VYWDYMKAIG LFISFLSIFL FLCNHVASLV SNYWLSLWTD DPIVNGTQEH TQVRLSVYGA
1030 1040 1050 1060 1070 1080
LGISQGITVF GYSMAVSIGG IFASRRLHLD LLHNVLRSPI SFFERTPSGN LVNRFSKELD
1090 1100 1110 1120 1130 1140
TVDSMIPQVI KMFMGSLFNV IGACIIILLA TPMAAVIIPP LGLIYFFVQR FYVASSRQLK
1150 1160 1170 1180 1190 1200
RLESVSRSPV YSHFNETLLG VSVIRAFEEQ ERFIRQSDLK VDENQKAYYP SIVANRWLAV
1210 1220 1230 1240 1250 1260
RLECVGNCIV LFASLFAVIS RHSLSAGLVG LSVSYSLQVT TYLNWLVRMS SEMETNIVAV
1270 1280 1290 1300 1310 1320
ERLKEYSETE KEAPWQIQDM APPKDWPQVG RVEFRDYGLR YREDLDLVLK HINVTIDGGE
1330 1340 1350 1360 1370 1380
KVGIVGRTGA GKSSLTLGLF RIKESAEGEI IIDDINIAKI GLHDLRFKIT IIPQDPVLFS
1390 1400 1410 1420 1430 1440
GSLRMNLDPF SQYSDEEVWT SLELAHLKGF VSALPDKLNH ECAEGGENLS VGQRQLVCLA
1450 1460 1470 1480 1490 1500
RALLRKTKIL VLDEATAAVD LETDDLIQST IRTQFDDCTV LTIAHRLNTI MDYTRVIVLD
1510 1520
KGEIQEWGSP SDLLQQRGLF YSMAKDSGLV