Q8H136

PR
Gene name
RH14 (DRH1, At3g01540, F4P13.9)
Protein name
DEAD-box ATP-dependent RNA helicase 14
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G01540
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-124 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8H136

Entry ID Method Resolution Chain Position Source
AF-Q8H136-F1 Predicted AlphaFoldDB

26 variants for Q8H136

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_216139_C_T 2 A>T No 1000Genomes
ENSVATH02102396 53 L>Q No 1000Genomes
tmp_3_215965_C_G 60 A>P No 1000Genomes
tmp_3_215937_A_G 69 V>A No 1000Genomes
tmp_3_215916_G_C 76 A>G No 1000Genomes
ENSVATH05753209 80 D>N No 1000Genomes
tmp_3_215883_C_T 87 G>D No 1000Genomes
tmp_3_215749_A_G 105 S>P No 1000Genomes
tmp_3_215715_G_C 116 A>G No 1000Genomes
ENSVATH13856179 147 T>A No 1000Genomes
ENSVATH13856177 151 G>D No 1000Genomes
ENSVATH13856162 196 R>K No 1000Genomes
tmp_3_214647_A_C 220 L>R No 1000Genomes
ENSVATH13856161 224 R>* No 1000Genomes
ENSVATH00300771 252 K>E No 1000Genomes
tmp_3_214527_G_A 260 S>L No 1000Genomes
ENSVATH10450744 358 V>I No 1000Genomes
ENSVATH05753191 473 A>V No 1000Genomes
ENSVATH05753189 530 P>L No 1000Genomes
tmp_3_213353_T_C 561 D>G No 1000Genomes
ENSVATH05753188 564 Y>N No 1000Genomes
ENSVATH02102369 568 G>A No 1000Genomes
ENSVATH05753183 582 G>E No 1000Genomes
ENSVATH05753182 583 R>K No 1000Genomes
tmp_3_213138_G_A 600 P>L No 1000Genomes
tmp_3_213114_C_T 608 R>H No 1000Genomes

No associated diseases with Q8H136

6 regional properties for Q8H136

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 309 - 317 IPR000629
domain WW domain 17 - 51 IPR001202
domain Helicase, C-terminal 389 - 536 IPR001650
domain DEAD/DEAH box helicase domain 182 - 351 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 177 - 380 IPR014001
domain RNA helicase, DEAD-box type, Q motif 158 - 186 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

24 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL08 DDX55 ATP-dependent RNA helicase DDX55 Bos taurus (Bovine) PR
Q8NHQ9 DDX55 ATP-dependent RNA helicase DDX55 Homo sapiens (Human) PR
P17844 DDX5 Probable ATP-dependent RNA helicase DDX5 Homo sapiens (Human) PR
Q99MJ9 Ddx50 ATP-dependent RNA helicase DDX50 Mus musculus (Mouse) PR
Q6ZPL9 Ddx55 ATP-dependent RNA helicase DDX55 Mus musculus (Mouse) PR
Q501J6 Ddx17 Probable ATP-dependent RNA helicase DDX17 Mus musculus (Mouse) PR
Q61656 Ddx5 Probable ATP-dependent RNA helicase DDX5 Mus musculus (Mouse) PR
Q5QMN3 Os01g0197200 DEAD-box ATP-dependent RNA helicase 20 Oryza sativa subsp japonica (Rice) PR
Q5N7W4 Os01g0911100 DEAD-box ATP-dependent RNA helicase 30 Oryza sativa subsp japonica (Rice) PR
Q0E2Z7 Os02g0201900 DEAD-box ATP-dependent RNA helicase 41 Oryza sativa subsp japonica (Rice) PR
Q56X76 RH39 DEAD-box ATP-dependent RNA helicase 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4R3 RH30 DEAD-box ATP-dependent RNA helicase 30 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C718 RH20 DEAD-box ATP-dependent RNA helicase 20 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FZ92 RH44 Putative DEAD-box ATP-dependent RNA helicase 44 Arabidopsis thaliana (Mouse-ear cress) PR
Q84W89 RH37 DEAD-box ATP-dependent RNA helicase 37 Arabidopsis thaliana (Mouse-ear cress) SS
Q94A52 EIF4A3 Eukaryotic initiation factor 4A-III homolog Arabidopsis thaliana (Mouse-ear cress) PR
Q8LA13 RH11 DEAD-box ATP-dependent RNA helicase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M2F9 RH52 DEAD-box ATP-dependent RNA helicase 52 Arabidopsis thaliana (Mouse-ear cress) SS
Q56XG6 RH15 DEAD-box ATP-dependent RNA helicase 15 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E9C3 RH58 DEAD-box ATP-dependent RNA helicase 58, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZG7 RH38 DEAD-box ATP-dependent RNA helicase 38 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFN6 RH56 DEAD-box ATP-dependent RNA helicase 56 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SZB4 RH43 Putative DEAD-box ATP-dependent RNA helicase 43 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LU46 RH35 DEAD-box ATP-dependent RNA helicase 35 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAATAAASVV RYAPEDHTLP KPWKGLIDDR TGYLYFWNPE TNVTQYEKPT PSLPPKFSPA
70 80 90 100 110 120
VSVSSSVQVQ QTDAYAPPKD DDKYSRGSER VSRFSEGGRS GPPYSNGAAN GVGDSAYGAA
130 140 150 160 170 180
STRVPLPSSA PASELSPEAY SRRHEITVSG GQVPPPLMSF EATGFPPELL REVLSAGFSA
190 200 210 220 230 240
PTPIQAQSWP IAMQGRDIVA IAKTGSGKTL GYLIPGFLHL QRIRNDSRMG PTILVLSPTR
250 260 270 280 290 300
ELATQIQEEA VKFGRSSRIS CTCLYGGAPK GPQLRDLERG ADIVVATPGR LNDILEMRRI
310 320 330 340 350 360
SLRQISYLVL DEADRMLDMG FEPQIRKIVK EIPTKRQTLM YTATWPKGVR KIAADLLVNP
370 380 390 400 410 420
AQVNIGNVDE LVANKSITQH IEVVAPMEKQ RRLEQILRSQ EPGSKVIIFC STKRMCDQLT
430 440 450 460 470 480
RNLTRQFGAA AIHGDKSQPE RDNVLNQFRS GRTPVLVATD VAARGLDVKD IRAVVNYDFP
490 500 510 520 530 540
NGVEDYVHRI GRTGRAGATG QAFTFFGDQD SKHASDLIKI LEGANQRVPP QIREMATRGG
550 560 570 580 590 600
GGMNKFSRWG PPSGGRGRGG DSGYGGRGSF ASRDSRSSNG WGRERERSRS PERFNRAPPP
610
SSTGSPPRSF HETMMMKHR