Q8GYX0
SS
Gene name |
MOB1B (At4g19045, F13C5.220, T18B16.1) |
Protein name |
MOB kinase activator-like 1B |
Names |
Mob1 homolog 1B , Mps one binder kinase activator-like 1B |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G19045 |
EC number |
|
Protein Class |
|
Descriptions
MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. Full-length MOB1B is in the autoinhibited form, showing that the N-terminal extension blocks the LATS1 binding surface of MOB2B. Phosphorylation of Thr12 and Thr35 residues accelerates dissociation of the Switch helix from the LATS1-binding surface by the pull-the-string mechanism, thereby enabling LATS1 binding.
Autoinhibitory domains (AIDs)
Target domain |
41-204 (MH domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GYX0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GYX0-F1 | Predicted | AlphaFoldDB |
13 variants for Q8GYX0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_10439405_T_A | 16 | K>M | No | 1000Genomes | |
| ENSVATH06721717 | 42 | R>G | No | 1000Genomes | |
| ENSVATH00521787 | 46 | K>Q | No | 1000Genomes | |
| ENSVATH06721715 | 76 | T>S | No | 1000Genomes | |
| tmp_4_10439013_T_C | 92 | K>R | No | 1000Genomes | |
| tmp_4_10438669_T_G | 127 | D>A | No | 1000Genomes | |
| ENSVATH12003046 | 139 | A>V | No | 1000Genomes | |
| tmp_4_10438544_G_A | 142 | P>S | No | 1000Genomes | |
| tmp_4_10438502_A_G | 156 | F>L | No | 1000Genomes | |
| ENSVATH12003045 | 168 | Q>H | No | 1000Genomes | |
| ENSVATH12002984 | 173 | L>I | No | 1000Genomes | |
| ENSVATH06721693 | 196 | I>V | No | 1000Genomes | |
| ENSVATH02879073 | 215 | Y>F | No | 1000Genomes |
No associated diseases with Q8GYX0
No regional properties for Q8GYX0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8GYX0 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| hippo signaling | The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| regulation of jasmonic acid biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43563 | MOB2 | CBK1 kinase activator protein MOB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P40484 | MOB1 | DBF2 kinase activator protein MOB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q95RA8 | mats | MOB kinase activator-like 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q86TA1 | MOB3B | MOB kinase activator 3B | Homo sapiens (Human) | SS |
| Q70IA8 | MOB3C | MOB kinase activator 3C | Homo sapiens (Human) | SS |
| Q96BX8 | MOB3A | MOB kinase activator 3A | Homo sapiens (Human) | SS |
| Q9H8S9 | MOB1A | MOB kinase activator 1A | Homo sapiens (Human) | EV |
| Q7L9L4 | MOB1B | MOB kinase activator 1B | Homo sapiens (Human) | SS |
| Q8BPB0 | Mob1b | MOB kinase activator 1B | Mus musculus (Mouse) | EV |
| Q8BSU7 | Mob3a | MOB kinase activator 3A | Mus musculus (Mouse) | SS |
| Q8BJG4 | Mob3c | MOB kinase activator 3C | Mus musculus (Mouse) | SS |
| Q8VE04 | Mob3b | MOB kinase activator 3B | Mus musculus (Mouse) | SS |
| Q8VI63 | Mob2 | MOB kinase activator 2 | Mus musculus (Mouse) | EV |
| Q921Y0 | Mob1a | MOB kinase activator 1A | Mus musculus (Mouse) | SS |
| Q3T1J9 | Mob1a | MOB kinase activator 1A | Rattus norvegicus (Rat) | SS |
| Q9FHI1 | MOB1A | MOB kinase activator-like 1A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLFGLGRNQ | KTFRPKKSAP | SGTKGAELRK | HIDATLGSGN | LREAVKLPPG | EDLNEWLAVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVDFFNQVNL | LFGTLTEFCT | PENCSTMTAG | PKYEYRWADG | VQIKKPIEVS | APKYVEYLMD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WIETQLDDET | IFPQKLGAAF | PPNFKEVVKT | IFKRLFRVYA | HIYHSHFQKI | VSLKEEAHLN |
| 190 | 200 | 210 | |||
| TCFKHFILFT | HEFVLIDKKE | LAPLQELIES | IIAPY |