Q8GYT9
Gene name |
SIS3 (At3g47990, T17F15.140) |
Protein name |
E3 ubiquitin-protein ligase SIS3 |
Names |
Protein SUGAR INSENSITIVE 3, RING-type E3 ubiquitin transferase SIS3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G47990 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GYT9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GYT9-F1 | Predicted | AlphaFoldDB |
14 variants for Q8GYT9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_17715393_G_A | 49 | T>I | No | 1000Genomes | |
| ENSVATH02466187 | 82 | C>F | No | 1000Genomes | |
| ENSVATH02466186 | 92 | S>A | No | 1000Genomes | |
| tmp_3_17714546_C_A | 159 | A>S | No | 1000Genomes | |
| tmp_3_17714297_C_T | 191 | G>S | No | 1000Genomes | |
| ENSVATH14397672 | 196 | A>V | No | 1000Genomes | |
| ENSVATH12626259 | 233 | G>S | No | 1000Genomes | |
| ENSVATH02466169 | 245 | G>S | No | 1000Genomes | |
| tmp_3_17713575_T_C | 290 | N>S | No | 1000Genomes | |
| ENSVATH06265434 | 307 | S>L | No | 1000Genomes | |
| ENSVATH00406886 | 307 | S>T | No | 1000Genomes | |
| ENSVATH06265433 | 310 | R>L | No | 1000Genomes | |
| tmp_3_17713440_T_C | 335 | D>G | No | 1000Genomes | |
| tmp_3_17713411_C_T | 345 | G>R | No | 1000Genomes |
No associated diseases with Q8GYT9
1 regional properties for Q8GYT9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, RING-type | 234 - 276 | IPR001841 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| sugar mediated signaling pathway | The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VE61 | CG7694 | E3 ubiquitin-protein ligase RNF181 homolog | Drosophila melanogaster (Fruit fly) | PR |
| O00237 | RNF103 | E3 ubiquitin-protein ligase RNF103 | Homo sapiens (Human) | PR |
| Q86Y13 | DZIP3 | E3 ubiquitin-protein ligase DZIP3 | Homo sapiens (Human) | PR |
| Q9Y3E7 | CHMP3 | Charged multivesicular body protein 3 | Homo sapiens (Human) | EV |
| Q9R1W3 | Rnf103 | E3 ubiquitin-protein ligase RNF103 | Mus musculus (Mouse) | PR |
| Q9EPZ8 | Rnf103 | E3 ubiquitin-protein ligase RNF103 | Rattus norvegicus (Rat) | PR |
| Q9ZV51 | ATL56 | RING-H2 finger protein ATL56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKK8 | ATL22 | RING-H2 finger protein ATL22 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P0CH02 | ATL21B | Putative RING-H2 finger protein ATL21B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P0CH01 | ATL21A | Putative RING-H2 finger protein ATL21A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GXF8 | SGR9 | E3 ubiquitin-protein ligase SGR9, amyloplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUZ9 | ATL63 | RING-H2 finger protein ATL63 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SI09 | XERICO | Probable E3 ubiquitin-protein ligase XERICO | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22255 | ATL64 | RING-H2 finger protein ATL64 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LGA5 | ATL31 | E3 ubiquitin-protein ligase ATL31 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RXX9 | ATL6 | E3 ubiquitin-protein ligase ATL6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZJ6 | ATL5 | RING-H2 finger protein ATL5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAMRGVDFKW | YDGFFLSMLA | TSVIIVAVNW | NRYRACEYPL | HIWIVVDYTT | VFIFRVFMFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DNGLASGLGL | DFGSQQRNAM | FCGRVVVLSV | LSLLLYPFLW | AWTVIGTQWF | TKSKTCLPEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GQKWGFLIWL | MFSYCGLLCI | AFICVGKWLT | RRQVHLLRAQ | QGIPISEFGI | LVDMIRVPDW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AFEAAGQEMR | GISQDAATYH | PGLYLTPAQT | EAVEALIQEL | PKFRLKAVPD | DCGECLICLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EFHIGHEVRG | LPCAHNFHVE | CIDQWLRLNV | KCPRCRCSVF | PDLDLSALSN | LQSSGTEQHS |
| 310 | 320 | 330 | 340 | 350 | |
| QVNTETSEAR | YIRSQPQSES | YFLRVQSLIH | PVHTDTALET | AENGGVPPVL | TDLSPSRR |