Q8GYM6
PR
Gene name |
CYCT1-4 (At4g19600, F24J7.161) |
Protein name |
Cyclin-T1-4 |
Names |
CycT14, Protein AtCycT-like2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G19600 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GYM6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GYM6-F1 | Predicted | AlphaFoldDB |
77 variants for Q8GYM6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_10673647_C_T | 10 | S>L | No | 1000Genomes | |
| ENSVATH02885216 | 14 | S>I | No | 1000Genomes | |
| tmp_4_10673697_C_A | 27 | Q>K | No | 1000Genomes | |
| tmp_4_10673793_C_A | 59 | L>I | No | 1000Genomes | |
| ENSVATH12030754 | 94 | R>C | No | 1000Genomes | |
| tmp_4_10674859_A_G | 133 | I>V | No | 1000Genomes | |
| ENSVATH12030888 | 165 | V>L | No | 1000Genomes | |
| tmp_4_10675547_G_T | 254 | R>L | No | 1000Genomes | |
| tmp_4_10675774_C_A | 290 | H>N | No | 1000Genomes | |
| tmp_4_10675786_T_C | 294 | S>P | No | 1000Genomes | |
| ENSVATH00523902 | 300 | L>P | No | 1000Genomes | |
| tmp_4_10675822_A_T | 306 | N>Y | No | 1000Genomes | |
| ENSVATH06726963 | 310 | L>F | No | 1000Genomes | |
| ENSVATH06726964 | 310 | L>H | No | 1000Genomes | |
| ENSVATH00523903 | 312 | G>A | No | 1000Genomes | |
| ENSVATH00523904 | 313 | S>L | No | 1000Genomes | |
| ENSVATH12030890 | 314 | T>I | No | 1000Genomes | |
| ENSVATH00523906 | 314 | T>S | No | 1000Genomes | |
| ENSVATH00523907 | 320 | R>W | No | 1000Genomes | |
| ENSVATH06726965 | 324 | N>D | No | 1000Genomes | |
| tmp_4_10675935_A_T | 343 | E>D | No | 1000Genomes | |
| ENSVATH12030892 | 344 | T>K | No | 1000Genomes | |
| ENSVATH12030892 | 344 | T>M | No | 1000Genomes | |
| tmp_4_10675943_A_T | 346 | D>V | No | 1000Genomes | |
| tmp_4_10675945_A_G | 347 | S>G | No | 1000Genomes | |
| ENSVATH06726968 | 348 | M>L | No | 1000Genomes | |
| tmp_4_10675952_A_G | 349 | H>R | No | 1000Genomes | |
| tmp_4_10675959_A_C | 351 | E>D | No | 1000Genomes | |
| ENSVATH06726969 | 352 | S>N | No | 1000Genomes | |
| ENSVATH06726970 | 354 | P>S | No | 1000Genomes | |
| ENSVATH06726971 | 355 | A>S | No | 1000Genomes | |
| ENSVATH06726972 | 356 | H>N | No | 1000Genomes | |
| tmp_4_10675979_C_A | 358 | S>Y | No | 1000Genomes | |
| ENSVATH06726973 | 360 | S>P | No | 1000Genomes | |
| ENSVATH02885228 | 364 | A>V | No | 1000Genomes | |
| ENSVATH06726975 | 365 | P>S | No | 1000Genomes | |
| ENSVATH06726976 | 368 | D>E | No | 1000Genomes | |
| tmp_4_10676015_T_C | 370 | I>T | No | 1000Genomes | |
| ENSVATH06726977 | 372 | K>T | No | 1000Genomes | |
| ENSVATH06726978 | 373 | A>V | No | 1000Genomes | |
| tmp_4_10676034_T_A | 376 | H>Q | No | 1000Genomes | |
| tmp_4_10676054_C_T,G | 383 | S>C | No | 1000Genomes | |
| tmp_4_10676054_C_T,G | 383 | S>F | No | 1000Genomes | |
| ENSVATH02885229 | 386 | V>A | No | 1000Genomes | |
| ENSVATH06726980 | 387 | G>A | No | 1000Genomes | |
| ENSVATH06726979 | 387 | G>S | No | 1000Genomes | |
| ENSVATH06726981 | 388 | T>I | No | 1000Genomes | |
| ENSVATH06726982 | 389 | A>G | No | 1000Genomes | |
| ENSVATH06726983 | 391 | V>A | No | 1000Genomes | |
| ENSVATH06726985 | 392 | T>M | No | 1000Genomes | |
| ENSVATH06726984 | 392 | T>P | No | 1000Genomes | |
| ENSVATH02885230 | 400 | I>L | No | 1000Genomes | |
| ENSVATH06726986 | 403 | F>L | No | 1000Genomes | |
| ENSVATH06726987 | 407 | V>L | No | 1000Genomes | |
| ENSVATH14256473 | 417 | Q>L | No | 1000Genomes | |
| tmp_4_10676166_G_T | 420 | K>N | No | 1000Genomes | |
| ENSVATH14256474 | 429 | E>A | No | 1000Genomes | |
| tmp_4_10676221_G_A | 439 | D>N | No | 1000Genomes | |
| ENSVATH06726997 | 441 | E>K | No | 1000Genomes | |
| ENSVATH06726998 | 441 | E>V | No | 1000Genomes | |
| ENSVATH00523911 | 446 | D>V | No | 1000Genomes | |
| ENSVATH12030893 | 452 | N>I | No | 1000Genomes | |
| ENSVATH06726999 | 456 | M>I | No | 1000Genomes | |
| tmp_4_10676290_G_A | 462 | E>K | No | 1000Genomes | |
| ENSVATH06727001 | 469 | L>F | No | 1000Genomes | |
| ENSVATH02885231 | 501 | L>F | No | 1000Genomes | |
| ENSVATH12030947 | 508 | H>R | No | 1000Genomes | |
| ENSVATH00523915 | 509 | D>N | No | 1000Genomes | |
| ENSVATH06727004 | 518 | Q>H | No | 1000Genomes | |
| ENSVATH00523916 | 521 | N>D | No | 1000Genomes | |
| tmp_4_10676482_A_T | 526 | S>C | No | 1000Genomes | |
| ENSVATH12030949 | 527 | H>L | No | 1000Genomes | |
| ENSVATH00523917 | 529 | Y>H | No | 1000Genomes | |
| ENSVATH06727006 | 535 | R>G | No | 1000Genomes | |
| tmp_4_10676510_G_A | 535 | R>K | No | 1000Genomes | |
| tmp_4_10676517_C_A | 537 | H>Q | No | 1000Genomes | |
| tmp_4_10676522_A_T | 539 | Q>L | No | 1000Genomes |
No associated diseases with Q8GYM6
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cyclin/CDK positive transcription elongation factor complex | A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase activator activity | Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. |
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| positive regulation of DNA-templated transcription, elongation | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to virus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. |
| trichome morphogenesis | The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6T8E9 | CCNT1 | Cyclin-T1 | Bos taurus (Bovine) | SS |
| Q8HXN7 | CCNT1 | Cyclin-T1 | Pan troglodytes (Chimpanzee) | SS |
| Q9XT26 | CCNT1 | Cyclin-T1 | Equus caballus (Horse) | SS |
| Q8N1B3 | CCNQ | Cyclin-Q | Homo sapiens (Human) | PR |
| O60563 | CCNT1 | Cyclin-T1 | Homo sapiens (Human) | EV |
| O75909 | CCNK | Cyclin-K | Homo sapiens (Human) | PR |
| Q9QWV9 | Ccnt1 | Cyclin-T1 | Mus musculus (Mouse) | SS |
| O88874 | Ccnk | Cyclin-K | Mus musculus (Mouse) | PR |
| Q6Z7H3 | CYCT1_2 | Cyclin-T1-2 | Oryza sativa subsp japonica (Rice) | PR |
| Q2QQS5 | CYCT1-1 | Cyclin-T1-4 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAC5 | CYCT1-3 | Cyclin-T1-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q503D6 | ccnq | Cyclin-Q | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGVLAGDCS | FGESGVSSYS | RNSNEKQDEV | ARWYFGRKEI | EENSPSRLDS | IDLKKETYLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSYCTFLQDL | GMRLKVPQVT | IATAIIFCHR | FFIRQSHARN | DRRTIATVCM | FLAGKVEETP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RPLKDVIVVS | YEIIHKKDPT | TAQKIKQKEV | YEQQKELILN | GEKIVLSTLG | FDFNVYHPYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLVEAIKKFK | VAQNALAQVA | WNFVNDGLRT | SLCLQFKPHH | IAAGAIFLAA | KFLKVKLPSD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GEKVWWQEFD | VTPRQLEDVS | NQMLELYEQN | RVPASQVSEV | ESSVGGGSAH | HVGSRPSARL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| THEHSNSDNL | GGSTKATQNR | SNDNGSGEAG | SVITEQKGER | DTETKDSMHT | ESHPAHKSRS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GVEAPGEDKI | EKAGAHFPED | DKSRIVGTAD | VTVSQSPKDI | KMFRDKVKAK | LEAKKVQGEK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TRKKDLVDED | DLIERELEDV | ELAVEDDKDI | QNKSSMGTEH | GEILDGNNLV | VNTEEGEMID |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DVSSTMPSRK | RKMESPCEKQ | LGEGKRRHDN | SENVEEGQKT | NPGGSSHSYG | DREPRRHSQE |
| R |