Q8GXA1

SS
Gene name
PME23 (ARATH23, At3g06830, F3E22.3)
Protein name
Probable pectinesterase/pectinesterase inhibitor 23
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G06830
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

49-198 (PMEI region) SS

Target domain

251-548 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8GXA1

Entry ID Method Resolution Chain Position Source
AF-Q8GXA1-F1 Predicted AlphaFoldDB

53 variants for Q8GXA1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13880706 22 V>L No 1000Genomes
ENSVATH05787312 30 V>I No 1000Genomes
tmp_3_2154315_A_T 41 E>D No 1000Genomes
ENSVATH10534144 61 K>E No 1000Genomes
ENSVATH02120126 65 V>A No 1000Genomes
ENSVATH05787313 66 N>I No 1000Genomes
ENSVATH10534155 74 D>N No 1000Genomes
tmp_3_2154436_A_G 82 I>V No 1000Genomes
tmp_3_2154497_G_A 102 G>E No 1000Genomes
tmp_3_2154496_G_A 102 G>R No 1000Genomes
ENSVATH05787314 113 E>D No 1000Genomes
ENSVATH05787315 117 A>T No 1000Genomes
tmp_3_2154542_C_T 117 A>V No 1000Genomes
tmp_3_2154553_T_A 121 C>S No 1000Genomes
ENSVATH00310213 145 I>V No 1000Genomes
ENSVATH05787317 151 D>E No 1000Genomes
ENSVATH05787319 167 M>I No 1000Genomes
ENSVATH05787320 179 Q>K No 1000Genomes
tmp_3_2154736_C_A 182 L>I No 1000Genomes
tmp_3_2154751_A_C 187 T>P No 1000Genomes
tmp_3_2154791_C_T 200 T>I No 1000Genomes
ENSVATH00310216 238 P>Q No 1000Genomes
ENSVATH00310217 254 V>M No 1000Genomes
ENSVATH00310218 265 T>S No 1000Genomes
ENSVATH05787323 271 I>V No 1000Genomes
ENSVATH05787324 273 D>H No 1000Genomes
tmp_3_2155132_G_A 284 V>M No 1000Genomes
tmp_3_2155197_G_T,A 305 M>I No 1000Genomes
tmp_3_2155197_G_T,A 305 M>I No 1000Genomes
tmp_3_2155223_G_C 314 G>A No 1000Genomes
tmp_3_2155300_A_G 340 T>A No 1000Genomes
ENSVATH10534159 359 P>S No 1000Genomes
tmp_3_2155455_T_C 367 L>S No 1000Genomes
ENSVATH00310220 368 R>T No 1000Genomes
ENSVATH00310221 382 D>N No 1000Genomes
ENSVATH05787327 401 T>R No 1000Genomes
ENSVATH05787328 403 S>T No 1000Genomes
ENSVATH00310223 432 T>S No 1000Genomes
tmp_3_2155661_A_G 436 T>A No 1000Genomes
tmp_3_2155702_G_C 449 L>F No 1000Genomes
tmp_3_2155721_A_G 456 I>V No 1000Genomes
tmp_3_2155742_A_G 463 I>V No 1000Genomes
ENSVATH02120129 469 N>K No 1000Genomes
ENSVATH05787331 483 T>A No 1000Genomes
tmp_3_2155811_A_G 486 M>V No 1000Genomes
tmp_3_2155875_C_G 507 A>G No 1000Genomes
ENSVATH13880707 527 Q>* No 1000Genomes
tmp_3_2155938_G_T 528 R>I No 1000Genomes
tmp_3_2155940_G_A 529 V>I No 1000Genomes
ENSVATH13880708 534 I>V No 1000Genomes
ENSVATH05787333 544 L>S No 1000Genomes
ENSVATH13880709 554 D>H No 1000Genomes
ENSVATH10534161 567 K>E No 1000Genomes

No associated diseases with Q8GXA1

3 regional properties for Q8GXA1

Type Name Position InterPro Accession
domain Pectinesterase inhibitor domain 21 - 200 IPR006501
active_site Pectinesterase, Tyr active site 282 - 301 IPR018040
active_site Pectinesterase, Asp active site 402 - 411 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
pollen tube A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MGSDGDKKKK FIVAGSVSGF LVIMVVSVAV VTSKHSPKDD ENHIRKTTKA VQAVCAPTDF
70 80 90 100 110 120
KDTCVNSLMG ASPDSDDPVD LIKLGFKVTI KSINESLEKA SGDIKAKADK NPEAKGAFEL
130 140 150 160 170 180
CEKLMIDAID DLKKCMDHGF SVDQIEVFVE DLRVWLSGSI AFQQTCMDSF GEIKSNLMQD
190 200 210 220 230 240
MLKIFKTSRE LSSNSLAMVT RISTLIPNSN LTGLTGALAK YARKLLSTED SIPTWVGPEA
250 260 270 280 290 300
RRLMAAQGGG PGPVKANAVV AQDGTGQFKT ITDALNAVPK GNKVPFIIHI KEGIYKEKVT
310 320 330 340 350 360
VTKKMPHVTF IGDGPNKTLI TGSLNFGIGK VKTFLTATIT IEGDHFTAKN IGIENTAGPE
370 380 390 400 410 420
GGQAVALRVS ADYAVFHSCQ IDGHQDTLYV HSHRQFYRDC TVSGTVDFIF GDAKCILQNC
430 440 450 460 470 480
KIVVRKPNKG QTCMVTAQGR SNVRESTGLV LHGCHITGDP AYIPMKSVNK AYLGRPWKEF
490 500 510 520 530 540
SRTIIMKTTI DDVIDPAGWL PWSGDFALKT LYYAEHMNTG PGSNQAQRVK WPGIKKLTPQ
550 560
DALLYTGDRF LRGDTWIPQT QVPYTAKV