Q8GX86

SS
Gene name
PME21 (ARATH21, At3g05610, F18C1.12)
Protein name
Probable pectinesterase/pectinesterase inhibitor 21
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G05610
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

56-205 (PMEI region) SS

Target domain

255-551 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8GX86

Entry ID Method Resolution Chain Position Source
AF-Q8GX86-F1 Predicted AlphaFoldDB

43 variants for Q8GX86

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05777015 16 I>V No 1000Genomes
tmp_3_1627802_T_C 59 K>E No 1000Genomes
ENSVATH00307680 78 N>D No 1000Genomes
ENSVATH00307679 87 E>Q No 1000Genomes
ENSVATH00307678 94 N>S No 1000Genomes
ENSVATH05777012 103 A>T No 1000Genomes
ENSVATH00307677 117 S>P No 1000Genomes
tmp_3_1627610_G_A 123 L>F No 1000Genomes
tmp_3_1627597_T_C 127 K>R No 1000Genomes
ENSVATH05777011 133 A>V No 1000Genomes
ENSVATH10508715 138 S>N No 1000Genomes
ENSVATH13874122 145 G>* No 1000Genomes
ENSVATH10508674 145 G>E No 1000Genomes
ENSVATH05777010 146 K>N No 1000Genomes
ENSVATH00307675 168 S>N No 1000Genomes
ENSVATH05777009 199 T>I No 1000Genomes
tmp_3_1627301_G_T 226 L>I No 1000Genomes
tmp_3_1627183_T_A 265 Q>L No 1000Genomes
tmp_3_1627140_C_A 279 K>N No 1000Genomes
tmp_3_1627109_C_T 290 A>T No 1000Genomes
tmp_3_1627087_A_G 297 V>A No 1000Genomes
tmp_3_1627058_C_A 307 V>L No 1000Genomes
tmp_3_1627040_G_A 313 P>S No 1000Genomes
tmp_3_1626995_T_C 328 I>V No 1000Genomes
ENSVATH10508673 356 A>P No 1000Genomes
ENSVATH13874121 357 I>R No 1000Genomes
ENSVATH05777002 357 I>V No 1000Genomes
tmp_3_1626790_C_T 366 V>I No 1000Genomes
ENSVATH05777001 379 D>N No 1000Genomes
ENSVATH05776999 455 G>C No 1000Genomes
ENSVATH00307671 457 P>Q No 1000Genomes
tmp_3_1626172_C_T 572 A>T No 1000Genomes
ENSVATH13874120 577 P>Q No 1000Genomes
tmp_3_1626153_C_G 578 S>T No 1000Genomes
ENSVATH05776997 595 A>T No 1000Genomes
ENSVATH13874119 600 P>L No 1000Genomes
tmp_3_1626088_G_A 600 P>S No 1000Genomes
ENSVATH05776996 609 E>G No 1000Genomes
tmp_3_1625985_G_A 634 T>M No 1000Genomes
ENSVATH02115824 653 I>F No 1000Genomes
ENSVATH02115823 654 M>T No 1000Genomes
ENSVATH02115822 655 V>E No 1000Genomes
tmp_3_1625887_T_C 667 M>V No 1000Genomes

No associated diseases with Q8GX86

2 regional properties for Q8GX86

Type Name Position InterPro Accession
domain MerR-type HTH domain 1 - 72 IPR000551
domain TipAS antibiotic-recognition domain 131 - 247 IPR012925

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MSYGYDDESK RKRRYIVITI SSVLLISMVV AVTVGVSLNK HDGDSKGKAE VNASVKAVKD
70 80 90 100 110 120
VCAPTDYRKT CEDTLIKNGK NTTDPMELVK TAFNVTMKQI TDAAKKSQTI MELQKDSRTR
130 140 150 160 170 180
MALDQCKELM DYALDELSNS FEELGKFEFH LLDEALINLR IWLSAAISHE ETCLEGFQGT
190 200 210 220 230 240
QGNAGETMKK ALKTAIELTH NGLAIISEMS NFVGQMQIPG LNSRRLLAEG FPSWVDQRGR
250 260 270 280 290 300
KLLQAAAAYS DVKPDIVVAQ DGSGQYKTIN EALQFVPKKR NTTFVVHIKA GLYKEYVQVN
310 320 330 340 350 360
KTMSHLVFIG DGPDKTIISG NKNYKDGITT YRTATVAIVG NYFIAKNIGF ENTAGAIKHQ
370 380 390 400 410 420
AVAVRVQSDE SIFFNCRFDG YQDTLYTHSH RQFFRDCTIS GTIDFLFGDA AAVFQNCTLL
430 440 450 460 470 480
VRKPLPNQAC PITAHGRKDP RESTGFVFQG CTIAGEPDYL AVKETSKAYL GRPWKEYSRT
490 500 510 520 530 540
IIMNTFIPDF VQPQGWQPWL GDFGLKTLFY SEVQNTGPGS ALANRVTWAG IKTLSEEDIL
550 560 570 580 590 600
KFTPAQYIQG DDWIPGKGVP YTTGLLAGNP AAATTTPSVS AAAPGFSTFT DTSGADSIAP
610 620 630 640 650 660
TASPAASPES SISMAYTGTA SPESSIKVSS STETASPESS FTEASTASPE SSIMVASTES
SGSFFSMFT