Q8CJH3

SS
Gene name
Plxnb1 (Kiaa0407)
Protein name
Plexin-B1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:235611
EC number
Protein Class

Descriptions

Plexin cell surface receptors bind to semaphorin ligands and transduce signals for regulating neuronal axon guidance. In mouse Plexin-A3 (P70208), the autoinhibitory regions including an Rho GTPase-binding domain (RBD) and a segment preceding C1 domain make extensive interactions with the GAP domain (C1 and C2 domains), which may enable it to regulate the GAP conformation in response to semaphorin binding. According to human Plexin-A1 (Q9UIW2) study, the Sema domain in Plexin-A3 may be also involved in autoinhibition.

Autoinhibitory domains (AIDs)

37-460 (Sema domain) SS

Target domain

1546-2086 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

1496-1580 (Segment preceding C1 domain) SS

Target domain

1546-2086 (Plexin, RasGAP domain)

Relief mechanism

Assay

1704-1897 (RBD domain) SS

Target domain

1546-2086 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q8CJH3

Entry ID Method Resolution Chain Position Source
8BB7 X-ray 295 A A/B 20-535 PDB
8BF4 X-ray 215 A C/F 20-535 PDB
AF-Q8CJH3-F1 Predicted AlphaFoldDB

15 variants for Q8CJH3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs242325003 67 V>M No Ensembl
rs29588950 114 V>I No Ensembl
rs243493700 292 V>I No Ensembl
rs249963125 346 R>L No Ensembl
rs249489732 412 M>T No Ensembl
rs212992244 548 E>D No Ensembl
rs219185022 910 S>A No Ensembl
rs261163824 969 P>L No Ensembl
rs47633942 977 I>V No Ensembl
rs258321637 1016 V>L No Ensembl
rs51391340 1190 L>R No Ensembl
rs248245681 1218 G>D No Ensembl
rs231277059 1218 G>S No Ensembl
rs237893398 1297 A>T No Ensembl
rs231311263 1410 V>M No Ensembl

No associated diseases with Q8CJH3

12 regional properties for Q8CJH3

Type Name Position InterPro Accession
domain Sema domain 8 - 479 IPR001627
repeat Plexin repeat 482 - 529 IPR002165
domain IPT domain 1067 - 1158 IPR002909-1
domain IPT domain 1159 - 1247 IPR002909-2
domain IPT domain 1249 - 1359 IPR002909-3
domain Plexin, cytoplasmic RasGAP domain 1546 - 2086 IPR013548
domain PSI domain 481 - 534 IPR016201-1
domain PSI domain 628 - 678 IPR016201-2
domain PSI domain 1019 - 1066 IPR016201-3
domain Plexin, TIG domain 1 541 - 627 IPR041019
domain Plexin, TIG domain 2 920 - 1018 IPR041362
domain Plexin, cytoplasmic RhoGTPase-binding domain 1718 - 1833 IPR046800

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

2 GO annotations of molecular function

Name Definition
GTPase activating protein binding Binding to a GTPase activating protein.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

15 GO annotations of biological process

Name Definition
inhibitory synapse assembly The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
negative regulation of osteoblast proliferation Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
ossification involved in bone maturation The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
positive regulation of phosphatidylinositol 3-kinase signaling Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.
semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MSVLGPVLLQ VFWAGCVVTL RSPLPAAFTA NGTHLQHLAR DPTTGTLYVG ATNFLFQLSP
70 80 90 100 110 120
GLQLEAVVST GPVNDSRDCL PPVIPDECPQ AQPTNNPNQL LLVSPEALVV CGSVHQGICE
130 140 150 160 170 180
LRSLGQIRQL LLRPERPGDT QYVAANDPAV STVGLVAQGL VGEPLLFVGR GYTSRGVGGG
190 200 210 220 230 240
IPPITTRALR PPDPQAAFSY EETAKLAVGR LSEYSHHFVS AFVRGASAYF LFLRRDLKAP
250 260 270 280 290 300
SRAFRAYVSR VCLQDQHYYS YVELPLACQG GRYGLIQAAA VATSKEVARG DVLFAAFSSV
310 320 330 340 350 360
APPTVDWPLS ASTGASGTSV LCAFPLDEVD QLANYTRDAC YTREGRAENG TKVADIAYDV
370 380 390 400 410 420
LSDCAQLPVD TPDAFPCGSD HTPSPMVSCV PLEATPILEL PGVQLTAVAV TMEDGHTIAF
430 440 450 460 470 480
LGDSQGQLHR VYLGPGRSAA PYSKQSIQPG SPVNRDLTFD GTFEHLYVAT QTTLVKVPVA
490 500 510 520 530 540
PCAQHLDCDS CLAHRDPYCG WCVLLGRCSR RSECSRDQGP EQWLWSFQPE LGCLRVVAVS
550 560 570 580 590 600
PANISREERR EVFLSVPGLP SLWPGESYFC YFGDQQSPAL LTSSGVMCPS PDPSEAPVLQ
610 620 630 640 650 660
RGADHISVNV ELRFGAVVIA STSLSFYDCV AVTASSPSAP CRACVSSRWG CNWCVWQQLC
670 680 690 700 710 720
THKASCDAGP MVASQQSPLL PLIPPARDEL TPFPPTVPQT TVTPTPNSFP IEPRAPSTAS
730 740 750 760 770 780
DVLPGAKPSR LSLWGPWAGP GPILSPTSTE SPLHEKPLPP DPPTIPGTTV PAPTGLGPST
790 800 810 820 830 840
TPEDLLASYP FPSDAAAVSP AEPGPEALPS MVALDQPPGT VPDTTFPGAP GSMKPVLDWL
850 860 870 880 890 900
TKGGGELPEA DEWMGGDTPA FSTSTLLSGD GDSAEHEGPP APLILLSSLD YQYDTPGLWE
910 920 930 940 950 960
LGEVNQRVSS CPCVETVQGS LLIPVHVERE VQLRGRNLWL FQDGPRSSEC VLELGSREVA
970 980 990 1000 1010 1020
VEAQVECAPP PDVWCHIKCQ QHQFSYEALK PELQVGLFLR WAGGLRVDSA DGLHVVLYDC
1030 1040 1050 1060 1070 1080
SVGHGDCSRC QTAMPQYDCV WCEGERPRCV AREACNEAET VATQCPAPLI HSVDPLTGPI
1090 1100 1110 1120 1130 1140
DGGTRVTIRG SNLGQHVQDV LDMVRVAGVP CAVDAGEYDV SSSLVCITGA SGEEVTGTVA
1150 1160 1170 1180 1190 1200
VEVPGRGHGV SEFSFAYQDP KVHSIFPARG PRAGGTRLTL HGSKLLTGRL EDIRVVVGDQ
1210 1220 1230 1240 1250 1260
PCHLLLEQQS EQLHCETGPY PVPAELPVTV LFGATERRLQ HGQFKYTSDP NVTSVGPSKS
1270 1280 1290 1300 1310 1320
FFSGGREIWV RGQDLDVVQR PRIRVTVVPR QHGQGLAQKQ HVVPEKFEEP CLVNSSHLLM
1330 1340 1350 1360 1370 1380
CRTPALPGPP WDSGVQVEFI LDNMVFDFAA LSPTPFSYEA DPTLRSLNPE DPSTPFRHKP
1390 1400 1410 1420 1430 1440
GSVFSVEGEN LDLAMSKEEV VAMIGDGPCV VKTLTRNHLY CEPPVEQPLP HPHALREAPD
1450 1460 1470 1480 1490 1500
ALPEFTVQMG NLRFSLGHVQ YDGESPVAFP VAAQVGLGVG TSLLALGVII IVLIYRRKSK
1510 1520 1530 1540 1550 1560
QALRDYKKVQ IQLENLESSV RDRCKKEFTD LMTEMTDLTS DLLGSGIPFL DYKVYAERVF
1570 1580 1590 1600 1610 1620
FPGYRESPLH RDLGVPDSRR PTVEQGLGQL SNLLNSKLFL TKFIHTLESQ RTFSARDRAY
1630 1640 1650 1660 1670 1680
VASLLTVALH GKLEYFTDIL RTLLSDLVAQ YVAKNPKLML RRTETVVEKL LTNWMSICLY
1690 1700 1710 1720 1730 1740
TFVRDSVGEP LYMLFRGIKH QVDKGPVDSV TGKAKYTLND NRLLREDVEY RPLTLNALLA
1750 1760 1770 1780 1790 1800
VGPGAGEAQC VPVKVLDCDT ISQAKEKMLD QLYKGVPLAQ RPDSCTLDVE WRSGVAGHLI
1810 1820 1830 1840 1850 1860
LSDEDVTSEL QGLWRRLNTL QHYKVPDGAT VALVPCLTKH ILRENQDYVP GERTPMLEDV
1870 1880 1890 1900 1910 1920
DEGGIRPWHL VKPSDEPEPP RPRRGSLRGG ERERAKAIPE IYLTRLLSMK GTLQKFVDDL
1930 1940 1950 1960 1970 1980
FQVILSTSRP VPLAVKYFFD LLDEQAQQHG ISDQDTIHIW KTNSLPLRFW INIIKNPQFV
1990 2000 2010 2020 2030 2040
FDVQTSDNMD AVLLVIAQTF MDACTLADHK LGRDSPINKL LYARDIPRYK QMVERYYADI
2050 2060 2070 2080 2090 2100
RQTVPASDQE MNSVLAELSR NCSADLGARV ALHELYKYIN KYYDQIITAL EEDGTAQKMQ
2110
LGYRLQQIAA AVENKVTDL