Q8CIS0

SS
Gene name
Card11 (Carma1)
Protein name
Caspase recruitment domain-containing protein 11
Names
CARD-containing MAGUK protein 1 , Carma 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:108723
EC number
Protein Class

Descriptions

CARD11 is a multidomain adapter that is required for TCR signaling to the IκB kinase (IKK) complex. CARD11 has an inhibitory domain (ID) that controls the association of CARD11 with multiple signaling cofactors through an interaction that requires both the caspase recruitment domain (CARD) and the coiled-coil domain. The ID that functions to keep CARD11 inactive in the absence of TCR signaling targets both the CARD and the coiled-coil domains of CARD11. Upon signaling, the ID would disengage the other portions of CARD11 and allow the signal-induced recruitment of other signaling cofactors.

Autoinhibitory domains (AIDs)

441-676 (Inhibitory domain) SS

Target domain

2-115 (CARD domain);152-447 (Coiled-coil domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q8CIS0

Entry ID Method Resolution Chain Position Source
4I16 X-ray 175 A A 18-110 PDB
AF-Q8CIS0-F1 Predicted AlphaFoldDB

No variants for Q8CIS0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8CIS0

No associated diseases with Q8CIS0

106 regional properties for Q8CIS0

Type Name Position InterPro Accession
domain Protein kinase domain 15934 - 16189 IPR000719
domain Immunoglobulin subtype 2 102 - 167 IPR003598-1
domain Immunoglobulin subtype 2 833 - 904 IPR003598-2
domain Immunoglobulin subtype 2 957 - 1025 IPR003598-3
domain Immunoglobulin subtype 2 1147 - 1214 IPR003598-4
domain Immunoglobulin subtype 2 1691 - 1758 IPR003598-5
domain Immunoglobulin subtype 2 3192 - 3261 IPR003598-6
domain Immunoglobulin subtype 2 3910 - 3976 IPR003598-7
domain Immunoglobulin subtype 2 4245 - 4311 IPR003598-8
domain Immunoglobulin subtype 2 12296 - 12367 IPR003598-9
domain Immunoglobulin subtype 2 12452 - 12523 IPR003598-10
domain Immunoglobulin subtype 2 13977 - 14044 IPR003598-11
domain Immunoglobulin subtype 2 14463 - 14531 IPR003598-12
domain Immunoglobulin subtype 2 14559 - 14625 IPR003598-13
domain Immunoglobulin subtype 2 14651 - 14718 IPR003598-14
domain Immunoglobulin subtype 2 15208 - 15266 IPR003598-15
domain Immunoglobulin subtype 2 15295 - 15362 IPR003598-16
domain Immunoglobulin subtype 2 15611 - 15678 IPR003598-17
domain Immunoglobulin subtype 2 15707 - 15775 IPR003598-18
domain Immunoglobulin subtype 2 16280 - 16349 IPR003598-19
domain Immunoglobulin subtype 2 16410 - 16478 IPR003598-20
domain Immunoglobulin subtype 2 16509 - 16578 IPR003598-21
domain Immunoglobulin subtype 2 16618 - 16684 IPR003598-22
domain Immunoglobulin subtype 2 16717 - 16785 IPR003598-23
domain Immunoglobulin subtype 2 16842 - 16909 IPR003598-24
domain Immunoglobulin subtype 2 16945 - 17014 IPR003598-25
domain Immunoglobulin subtype 2 17050 - 17117 IPR003598-26
domain Immunoglobulin subtype 2 17262 - 17327 IPR003598-27
domain Immunoglobulin subtype 2 17370 - 17438 IPR003598-28
domain Immunoglobulin subtype 2 17469 - 17537 IPR003598-29
domain Immunoglobulin subtype 2 17583 - 17652 IPR003598-30
domain Immunoglobulin subtype 2 17688 - 17761 IPR003598-31
domain Immunoglobulin subtype 2 17794 - 17862 IPR003598-32
domain Immunoglobulin subtype 2 18021 - 18088 IPR003598-33
domain Immunoglobulin subtype 2 18134 - 18202 IPR003598-34
domain Immunoglobulin subtype 2 18239 - 18307 IPR003598-35
domain Immunoglobulin subtype 2 18341 - 18408 IPR003598-36
domain Immunoglobulin subtype 2 18441 - 18509 IPR003598-37
domain Immunoglobulin subtype 96 - 178 IPR003599-1
domain Immunoglobulin subtype 211 - 294 IPR003599-2
domain Immunoglobulin subtype 413 - 495 IPR003599-3
domain Immunoglobulin subtype 713 - 802 IPR003599-4
domain Immunoglobulin subtype 827 - 915 IPR003599-5
domain Immunoglobulin subtype 955 - 1038 IPR003599-6
domain Immunoglobulin subtype 1141 - 1225 IPR003599-7
domain Immunoglobulin subtype 1685 - 1769 IPR003599-8
domain Immunoglobulin subtype 2911 - 2995 IPR003599-9
domain Immunoglobulin subtype 3009 - 3089 IPR003599-10
domain Immunoglobulin subtype 3111 - 3269 IPR003599-11
domain Immunoglobulin subtype 3795 - 3880 IPR003599-12
domain Immunoglobulin subtype 3904 - 3987 IPR003599-13
domain Immunoglobulin subtype 4239 - 4318 IPR003599-14
domain Immunoglobulin subtype 8772 - 8945 IPR003599-15
domain Immunoglobulin subtype 10279 - 10364 IPR003599-16
domain Immunoglobulin subtype 10373 - 10468 IPR003599-17
domain Immunoglobulin subtype 12180 - 12268 IPR003599-18
domain Immunoglobulin subtype 12290 - 12378 IPR003599-19
domain Immunoglobulin subtype 12446 - 12534 IPR003599-20
domain Immunoglobulin subtype 13880 - 13960 IPR003599-21
domain Immunoglobulin subtype 13971 - 14052 IPR003599-22
domain Immunoglobulin subtype 14064 - 14148 IPR003599-23
domain Immunoglobulin subtype 14457 - 14542 IPR003599-24
domain Immunoglobulin subtype 14553 - 14634 IPR003599-25
domain Immunoglobulin subtype 14644 - 14727 IPR003599-26
domain Immunoglobulin subtype 14739 - 14821 IPR003599-27
domain Immunoglobulin subtype 15196 - 15278 IPR003599-28
domain Immunoglobulin subtype 15289 - 15373 IPR003599-29
domain Immunoglobulin subtype 15605 - 15689 IPR003599-30
domain Immunoglobulin subtype 15701 - 15788 IPR003599-31
domain Immunoglobulin subtype 16274 - 16360 IPR003599-32
domain Immunoglobulin subtype 16404 - 16489 IPR003599-33
domain Immunoglobulin subtype 16503 - 16589 IPR003599-34
domain Immunoglobulin subtype 16612 - 16695 IPR003599-35
domain Immunoglobulin subtype 16711 - 16796 IPR003599-36
domain Immunoglobulin subtype 16836 - 16920 IPR003599-37
domain Immunoglobulin subtype 16939 - 17025 IPR003599-38
domain Immunoglobulin subtype 17044 - 17128 IPR003599-39
domain Immunoglobulin subtype 17256 - 17338 IPR003599-40
domain Immunoglobulin subtype 17364 - 17449 IPR003599-41
domain Immunoglobulin subtype 17463 - 17548 IPR003599-42
domain Immunoglobulin subtype 17577 - 17663 IPR003599-43
domain Immunoglobulin subtype 17682 - 17772 IPR003599-44
domain Immunoglobulin subtype 17788 - 17873 IPR003599-45
domain Immunoglobulin subtype 18015 - 18099 IPR003599-46
domain Immunoglobulin subtype 18128 - 18213 IPR003599-47
domain Immunoglobulin subtype 18233 - 18318 IPR003599-48
domain Immunoglobulin subtype 18335 - 18419 IPR003599-49
domain Immunoglobulin subtype 18435 - 18520 IPR003599-50
domain Fibronectin type III 8948 - 9041 IPR003961-1
domain Fibronectin type III 10459 - 10553 IPR003961-2
domain Fibronectin type III 14151 - 14247 IPR003961-3
domain Fibronectin type III 14251 - 14348 IPR003961-4
domain Fibronectin type III 14350 - 14448 IPR003961-5
domain Fibronectin type III 14824 - 14920 IPR003961-6
domain Fibronectin type III 14937 - 15027 IPR003961-7
domain Fibronectin type III 15380 - 15475 IPR003961-8
domain Fibronectin type III 15501 - 15596 IPR003961-9
domain Fibronectin type III 15602 - 15680 IPR003961-10
domain Fibronectin type III 15789 - 15883 IPR003961-11
domain Fibronectin type III 17152 - 17245 IPR003961-12
active_site Serine/threonine-protein kinase, active site 16051 - 16063 IPR008271
domain Immunoglobulin V-set domain 14563 - 14620 IPR013106-1
domain Immunoglobulin V-set domain 16721 - 16780 IPR013106-2
domain Immunoglobulin V-set domain 17374 - 17433 IPR013106-3
domain Immunoglobulin V-set domain 17473 - 17532 IPR013106-4
binding_site Protein kinase, ATP binding site 15940 - 15963 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane raft
  • Colocalized with DPP4 in membrane rafts
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
CBM complex A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
immunological synapse An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
CARD domain binding Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.
protein self-association Binding to a domain within the same polypeptide.

23 GO annotations of biological process

Name Definition
B cell differentiation The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
B cell proliferation The expansion of a B cell population by cell division. Follows B cell activation.
canonical NF-kappaB signal transduction The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
CD4-positive, alpha-beta T cell proliferation The expansion of a CD4-positive, alpha-beta T cell population by cell division.
homeostasis of number of cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
lymphocyte activation A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation.
positive regulation of canonical NF-kappaB signal transduction Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of CD4-positive, alpha-beta T cell proliferation Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.
positive regulation of interleukin-2 production Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of T cell activation Any process that activates or increases the frequency, rate or extent of T cell activation.
positive regulation of T cell receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of B cell differentiation Any process that modulates the frequency, rate or extent of B cell differentiation.
regulation of immune response Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
regulation of T cell differentiation Any process that modulates the frequency, rate or extent of T cell differentiation.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
T cell activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
T cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
thymic T cell selection The process of T cell selection that occurs in the thymus.
TORC1 signaling A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12959 DLG1 Disks large homolog 1 Homo sapiens (Human) SS
Q92796 DLG3 Disks large homolog 3 Homo sapiens (Human) SS
Q15700 DLG2 Disks large homolog 2 Homo sapiens (Human) SS
P78352 DLG4 Disks large homolog 4 Homo sapiens (Human) SS
Q9BXL7 CARD11 Caspase recruitment domain-containing protein 11 Homo sapiens (Human) EV
Q9H257 CARD9 Caspase recruitment domain-containing protein 9 Homo sapiens (Human) EV
Q62108 Dlg4 Disks large homolog 4 Mus musculus (Mouse) SS
Q811D0 Dlg1 Disks large homolog 1 Mus musculus (Mouse) SS
P70175 Dlg3 Disks large homolog 3 Mus musculus (Mouse) SS
Q91XM9 Dlg2 Disks large homolog 2 Mus musculus (Mouse) SS
Q99KF0 Card14 Caspase recruitment domain-containing protein 14 Mus musculus (Mouse) PR
A2AIV8 Card9 Caspase recruitment domain-containing protein 9 Mus musculus (Mouse) EV
Q62936 Dlg3 Disks large homolog 3 Rattus norvegicus (Rat) SS
Q63622 Dlg2 Disks large homolog 2 Rattus norvegicus (Rat) EV
Q62696 Dlg1 Disks large homolog 1 Rattus norvegicus (Rat) SS
P31016 Dlg4 Disks large homolog 4 Rattus norvegicus (Rat) SS
G5ECY0 dlg-1 Disks large homolog 1 Caenorhabditis elegans SS
Q28C55 dlg1 Disks large homolog 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6R005 dlg4 Disks large homolog 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH5 dlg1l Discs large homolog 1-like protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH7 dlg2 Disks large homolog 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MPGGGPAMDD YMETLKDEEE ALWDNVECNR HMLSRYINPA KLTPYLRQCK VIDEQDEDEV
70 80 90 100 110 120
LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP ELYKLVTGKE PTRRFSTIVV
130 140 150 160 170 180
EEGHEGLTHF LMNEVIKLQQ QVKAKDLQRC ELLAKSRQLE DEKKQLSLIR VELLTFQERY
190 200 210 220 230 240
YKMKEERDSY NDELVKVKDD NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME
250 260 270 280 290 300
EECKLERNQS LKLKNDIENR PRKEQVLELE RENEMLKTKI QELQSIIQAG KRSLPDSDKA
310 320 330 340 350 360
ILDILEHDRK EALEDRQELV NKIYNLQEEV RQAEELRDKY LEEKEDLELK CSTLGKDCEM
370 380 390 400 410 420
YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK DKYRKQIREL EEKNDEMRIE
430 440 450 460 470 480
MVRREACIVN LESKLRRLSK DNGSLDQSLP RHLPATIISQ NLGDTSPRTN GQEADDSSTS
490 500 510 520 530 540
EESPEDSKYF LPYHPPRRRM NLKGIQLQRA KSPISMKQAS EFQALMRTVK GHEEDFTDGS
550 560 570 580 590 600
PSSSRSLPVT SSFSKMQPHR SRSSIMSITA EPPGNDSIVR RCKEDAPHRS TVEEDNDSCG
610 620 630 640 650 660
FDALDLDDEN HERYSFGPPS IHSSSSSHQS EGLDAYDLEQ VNLMLRKFSL ERPFRPSVTS
670 680 690 700 710 720
GGHVRGTGPL VQHTTLNGDG LITQLTLLGG NARGSFIHSV KPGSLAERAG LREGHQLLLL
730 740 750 760 770 780
EGCIRGERQS VPLDACTKEE ARWTIQRCSG LITLHYKVNH EGYRKLLKEM EDGLITSGDS
790 800 810 820 830 840
FYIRLNLNIS SQLDACSMSL KCDDVVHVLD TMYQDRHEWL CARVDPFTDQ DLDTGTIPSY
850 860 870 880 890 900
SRAQQLLLVK LQRLVHRGNR EEADSAHHTL RSLRNTLQPE EMLSTSDPRV SPRLSRASFF
910 920 930 940 950 960
FGQLLQFVSR SENKYKRMNS NERVRIISGS PLGSLSRSSL DATKLLTEKH EELDPENELS
970 980 990 1000 1010 1020
RNLTLIPYSL VRAFHCERRR PVLFTPTMLA KTLVQKLLNS GGAMEFTICK SDIVTRDEFL
1030 1040 1050 1060 1070 1080
RKQKTETIIY SREKNPNTFE CIVPANIEAV AAKNKHCLLE AGIGCVRDLI KCKVYPIVLL
1090 1100 1110 1120 1130 1140
IRVSEKNIKR FRKLLPRPET EEEFLRVCRL KEKELEALPC LYATVEAEMW SSVEELLRVL
1150
KDKIVEEQRK TIWVDEDQL