Q8CFI0
PR
Gene name |
Nedd4l (Kiaa0439, Nedd4b) |
Protein name |
E3 ubiquitin-protein ligase NEDD4-like |
Names |
HECT-type E3 ubiquitin transferase NED4L, NEDD4.2, Nedd4-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
2.3.2.26: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q8CFI0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1WR3 | NMR | - | A | 221-254 | PDB |
| 1WR4 | NMR | - | A | 414-447 | PDB |
| 1WR7 | NMR | - | A | 525-560 | PDB |
| AF-Q8CFI0-F1 | Predicted | AlphaFoldDB |
No variants for Q8CFI0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8CFI0 | |||||
No associated diseases with Q8CFI0
6 regional properties for Q8CFI0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 30 - 154 | IPR000008 |
| domain | HECT domain | 647 - 1003 | IPR000569 |
| domain | WW domain | 221 - 254 | IPR001202-1 |
| domain | WW domain | 414 - 447 | IPR001202-2 |
| domain | WW domain | 526 - 559 | IPR001202-3 |
| domain | WW domain | 577 - 610 | IPR001202-4 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.26 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| multivesicular body | A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| potassium channel inhibitor activity | Binds to and stops, prevents, or reduces the activity of a potassium channel. |
| potassium channel regulator activity | Binds to and modulates the activity of a potassium channel. |
| sodium channel inhibitor activity | Binds to and stops, prevents, or reduces the activity of a sodium channel. |
| sodium channel regulator activity | Binds to and modulates the activity of a sodium channel. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
32 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| negative regulation of potassium ion transmembrane transport | Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. |
| negative regulation of potassium ion transmembrane transporter activity | Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. |
| negative regulation of protein localization to cell surface | Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface. |
| negative regulation of sodium ion transmembrane transport | Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport. |
| negative regulation of sodium ion transmembrane transporter activity | Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. |
| negative regulation of sodium ion transport | Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| negative regulation of systemic arterial blood pressure | The process that reduces the force with which blood travels through the systemic arterial circulatory system. |
| positive regulation of cation channel activity | Any process that activates or increases the frequency, rate or extent of cation channel activity. |
| positive regulation of caveolin-mediated endocytosis | Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis. |
| positive regulation of dendrite extension | Any process that activates or increases the frequency, rate or extent of dendrite extension. |
| positive regulation of protein catabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| positive regulation of sodium ion transport | Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein K48-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. |
| protein monoubiquitination | Addition of a single ubiquitin group to a protein. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of bicellular tight junction assembly | Any process that modulates the frequency, rate or extent of tight junction assembly. |
| regulation of dendrite morphogenesis | Any process that modulates the frequency, rate or extent of dendrite morphogenesis. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| regulation of membrane depolarization | Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| regulation of membrane repolarization | Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. |
| regulation of potassium ion transmembrane transporter activity | Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. |
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
| regulation of sodium ion transmembrane transport | Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
| ventricular cardiac muscle cell action potential | An action potential that occurs in a ventricular cardiac muscle cell. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39940 | RSP5 | E3 ubiquitin-protein ligase RSP5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9Y0H4 | Su(dx) | E3 ubiquitin-protein ligase Su | Drosophila melanogaster (Fruit fly) | SS |
| Q9V853 | Smurf | E3 ubiquitin-protein ligase Smurf1 | Drosophila melanogaster (Fruit fly) | SS |
| Q9HAU4 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | Homo sapiens (Human) | EV |
| O00308 | WWP2 | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Homo sapiens (Human) | EV |
| Q9HCE7 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | Homo sapiens (Human) | PR |
| O95817 | BAG3 | BAG family molecular chaperone regulator 3 | Homo sapiens (Human) | PR |
| O60861 | GAS7 | Growth arrest-specific protein 7 | Homo sapiens (Human) | PR |
| P46934 | NEDD4 | E3 ubiquitin-protein ligase NEDD4 | Homo sapiens (Human) | EV |
| Q9H0M0 | WWP1 | NEDD4-like E3 ubiquitin-protein ligase WWP1 | Homo sapiens (Human) | EV |
| Q96J02 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | Homo sapiens (Human) | EV |
| Q96PU5 | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like | Homo sapiens (Human) | PR |
| Q60780 | Gas7 | Growth arrest-specific protein 7 | Mus musculus (Mouse) | PR |
| A2A5Z6 | Smurf2 | E3 ubiquitin-protein ligase SMURF2 | Mus musculus (Mouse) | SS |
| P46935 | Nedd4 | E3 ubiquitin-protein ligase NEDD4 | Mus musculus (Mouse) | PR |
| Q8BZZ3 | Wwp1 | NEDD4-like E3 ubiquitin-protein ligase WWP1 | Mus musculus (Mouse) | SS |
| Q8C863 | Itch | E3 ubiquitin-protein ligase Itchy | Mus musculus (Mouse) | EV |
| Q9CUN6 | Smurf1 | E3 ubiquitin-protein ligase SMURF1 | Mus musculus (Mouse) | PR |
| Q9DBH0 | Wwp2 | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Mus musculus (Mouse) | SS |
| Q3U0D9 | Hace1 | E3 ubiquitin-protein ligase HACE1 | Mus musculus (Mouse) | SS |
| Q62940 | Nedd4 | E3 ubiquitin-protein ligase NEDD4 | Rattus norvegicus (Rat) | PR |
| Q9N2Z7 | wwp-1 | E3 ubiquitin-protein ligase wwp-1 | Caenorhabditis elegans | SS |
| A9JRZ0 | smurf2 | E3 ubiquitin-protein ligase SMURF2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLCEAPVHV | GDKELKYFQI | PQMLSQLSLL | ASHHSRGLEF | SGGQGESRIL | RVKVVSGIDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AKKDIFGASD | PYVKLSLYVA | DENRELALVQ | TKTIKKTLNP | KWNEEFYFRV | NPSNHRLLFE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFDENRLTRD | DFLGQVDVPL | SHLPTEDPTM | ERPYTFKDFL | LRPRSHKSRV | KGFLRLKMAY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MPKNGGQDEE | NSEQRDDMEH | GWEVVDSNDS | ASQHQEELPP | PPLPPGWEEK | VDNLGRTYYV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NHNNRSTQWH | RPSLMDVSSE | SDNNIRQINQ | EAAHRRFRSR | RHISEDLEPE | ASEGGGEGPE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PWETISEEMN | MAGDSLSLAL | PPPPASPVSR | TSPQELSEEV | SRRLQITPDS | NGEQFSSLIQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| REPSSRLRSC | SVTDTVAEQA | HLPPPSTPTR | RARSSTVTGG | EEPTPSVAYV | HTTPGLPSGW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EERKDAKGRT | YYVNHNNRTT | TWTRPIMQLA | EDGASGSATN | SNNHLVEPQI | RRPRSLSSPT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VTLSAPLEGA | KDSPIRRAVK | DTLSNPQSPQ | PSPYNSPKPQ | HKVTQSFLPP | GWEMRIAPNG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RPFFIDHNTK | TTTWEDPRLK | FPVHMRSKAS | LNPNDLGPLP | PGWEERIHLD | GRTFYIDHNS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KITQWEDPRL | QNPAITGPAV | PYSREFKQKY | DYFRKKLKKP | ADIPNRFEMK | LHRNNIFEES |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YRRIMSVKRP | DVLKARLWIE | FESEKGLDYG | GVAREWFFLL | SKEMFNPYYG | LFEYSATDNY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TLQINPNSGL | CNEDHLSYFT | FIGRVAGLAV | FHGKLLDGFF | IRPFYKMMLG | KQITLNDMES |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VDSEYYNSLK | WILENDPTEL | DLMFCIDEEN | FGQTYQVDLK | PNGSEIMVTN | ENKREYIDLV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IQWRFVNRVQ | KQMNAFLEGF | TELLPIDLIK | IFDENELELL | MCGLGDVDVN | DWRQHSIYKN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GYCPNHPVIQ | WFWKAVLLMD | AEKRIRLLQF | VTGTSRVPMN | GFAELYGSNG | PQLFTIEQWG |
| 970 | 980 | 990 | 1000 | ||
| SPEKLPRAHT | CFNRLDLPPY | ETFEDLREKL | LMAVENAQGF | EGVD |