Q8CFA1
PR
Gene name |
Irak2 |
Protein name |
Interleukin-1 receptor-associated kinase-like 2 |
Names |
IRAK-2, mu-IRAK-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:108960 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CFA1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CFA1-F1 | Predicted | AlphaFoldDB |
53 variants for Q8CFA1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs211747614 | 2 | A>T | No | EVA | |
| rs37036021 | 81 | L>V | No | EVA | |
| rs225976400 | 99 | S>R | No | EVA | |
| rs3388854559 | 108 | E>D | No | EVA | |
| rs245199911 | 121 | N>Y | No | EVA | |
| rs226476369 | 130 | R>W | No | EVA | |
| rs38512186 | 135 | R>H | No | EVA | |
| rs260597448 | 144 | M>V | No | EVA | |
| rs3388846521 | 146 | G>W | No | EVA | |
| rs226170286 | 155 | M>T | No | EVA | |
| rs3388853470 | 163 | T>A | No | EVA | |
| rs3388837144 | 166 | P>S | No | EVA | |
| rs225166808 | 175 | S>N | No | EVA | |
| rs3388837095 | 186 | L>P | No | EVA | |
| rs37375040 | 188 | G>S | No | EVA | |
| rs264503594 | 189 | L>V | No | EVA | |
| rs38338723 | 190 | P>H | No | EVA | |
| rs3388833079 | 230 | V>M | No | EVA | |
| rs3388837063 | 249 | D>H | No | EVA | |
| rs3388853488 | 255 | E>D | No | EVA | |
| rs3397299604 | 256 | M>L | No | EVA | |
| rs3397168617 | 257 | Q>H | No | EVA | |
| rs38518964 | 267 | V>I | No | EVA | |
| rs37618764 | 273 | F>V | No | EVA | |
| rs36894093 | 293 | H>Q | No | EVA | |
| rs3388845255 | 347 | P>T | No | EVA | |
| rs3388814882 | 349 | L>Q | No | EVA | |
| rs215977254 | 369 | R>K | No | EVA | |
| rs3397224878 | 374 | Q>R | No | EVA | |
| rs3388846798 | 377 | A>T | No | EVA | |
| rs38906064 | 438 | C>G | No | EVA | |
| rs585441981 | 444 | M>V | No | EVA | |
| rs3388854478 | 451 | E>D | No | EVA | |
| rs36832442 | 455 | R>S | No | EVA | |
| rs3388845201 | 456 | H>D | No | EVA | |
| rs228053882 | 459 | K>* | No | EVA | |
| rs243962624 | 459 | K>R | No | EVA | |
| rs3396994260 | 496 | G>V | No | EVA | |
| rs3388845213 | 497 | V>A | No | EVA | |
| rs237044820 | 500 | Q>R | No | EVA | |
| rs3397168567 | 506 | S>C | No | EVA | |
| rs3388849627 | 515 | A>V | No | EVA | |
| rs3388851825 | 541 | M>K | No | EVA | |
| rs3388856924 | 547 | G>W | No | EVA | |
| rs3388852316 | 551 | S>Y | No | EVA | |
| rs3412732045 | 554 | F>I | No | EVA | |
| rs36892605 | 554 | F>S | No | EVA | |
| rs3388829178 | 555 | T>M | No | EVA | |
| rs3388833085 | 560 | A>V | No | EVA | |
| rs585877031 | 579 | G>V | No | EVA | |
| rs3388856911 | 584 | Q>H | No | EVA | |
| rs223020513 | 585 | N>D | No | EVA | |
| rs583132249 | 607 | V>L | No | EVA |
No associated diseases with Q8CFA1
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| I-kappaB kinase/NF-kappaB signaling | The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| interleukin-1-mediated signaling pathway | The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| lipopolysaccharide-mediated signaling pathway | The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
| MyD88-dependent toll-like receptor signaling pathway | A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. |
| negative regulation of DNA-binding transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| negative regulation of NF-kappaB transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of cytokine-mediated signaling pathway | Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway. |
| response to interleukin-1 | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y616 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | Homo sapiens (Human) | PR |
| P53667 | LIMK1 | LIM domain kinase 1 | Homo sapiens (Human) | PR |
| P53671 | LIMK2 | LIM domain kinase 2 | Homo sapiens (Human) | PR |
| O54785 | Limk2 | LIM domain kinase 2 | Mus musculus (Mouse) | PR |
| Q8K4B2 | Irak3 | Interleukin-1 receptor-associated kinase 3 | Mus musculus (Mouse) | PR |
| Q4QQS0 | Irak2 | Interleukin-1 receptor-associated kinase-like 2 | Rattus norvegicus (Rat) | PR |
| Q9ASQ5 | CRCK3 | Calmodulin-binding receptor-like cytoplasmic kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWW0 | ALE2 | Receptor-like serine/threonine-protein kinase ALE2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93050 | BSH | Probable LRR receptor-like serine/threonine-protein kinase RKF3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STF0 | LECRKS3 | Receptor like protein kinase S.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LYN6 | At3g56050 | Probable inactive receptor-like protein kinase At3g56050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43293 | PBL11 | Probable serine/threonine-protein kinase PBL11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTC0 | PBL19 | Probable serine/threonine-protein kinase PBL19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIL7 | CRCK1 | Calmodulin-binding receptor-like cytoplasmic kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MACYIYQLPS | WVLDDLCRNI | DTLSEWDWMQ | FASYVITDLT | QLRKIKSMER | VQGVSITREL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LWWWSMRQAT | VQQLVDLLCH | LELYRAAQIV | LSWKPVPEST | SPLPAFPEAV | KPGAVATSRR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLKDEQEKVR | PVKPRSLLDT | GPIMAGAQRQ | RPCEMDAPCS | LKTDAPDSPQ | SKYCSTSTSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PKQERLLGLP | GDRLFWSEAD | VVQATEDFDQ | SHRISEGTFA | DIYQGQRNGV | AFAFKKLREV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AGSSPGSMDR | FLQAEMQLCL | RCCHANVLPL | LGFCTGRQFH | SLIYPYMANG | SLHDRLWAQG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSDMLPWPQR | ASICSGLLLA | VEHLHSLDII | HSNVKSANVL | LDQHLNPKLA | HPVAHPHPDN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKTKYTVMRT | HLFQASAAYL | PEHFIRVGQL | TKQVDIFSCG | IVLAEVLTGI | PAMDKDRSPV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLKDLLLSEI | PNSTSSVCSR | KTSMGKAVVK | EICQRHVEKR | AGLLPEACEE | AWATAVSVCL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RRRNASVEEA | RVSLAGVEEQ | LRGQLSLPWS | RVSEATGSSS | NTPEETDDVD | NSSLSVPSLV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MMASCPGAAS | SPLFTGHGAA | QPSTSGRQEA | DSSSEACTGP | QTPQNATETS | WKIEINEAKR |
| 610 | 620 | ||||
| RLMENIVLYK | EERLDSSELF | GP |