Q8CEE6

SS
Gene name
Pask (Kiaa0135)
Protein name
PAS domain-containing serine/threonine-protein kinase
Names
PAS-kinase , PASKIN , EC 2.7.11.1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:269224
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

PASK is PAS (Per-Arnt-Sim) domain-containing serine/threonine-protein kinase and is involved in energy homeostasis and regulation of protein synthesis. The N-terminal domain (PAS-A) directly inhibits its kinase domain, specifically the FG loop at residues 185-194. The FG loop directly binds the kinase domain, thus inhibiting its kinase activity. The binding of organic compounds to the hydrophobic core of PAS-A induces conformational changes and relieves the inhibition.

Autoinhibitory domains (AIDs)

183-192 (The FG loop of the PAS-A domain) SS

Target domain

1011-1383 (Kinase domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

1205-1227 (Activation loop from InterPro)

Target domain

1059-1317 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8CEE6

Entry ID Method Resolution Chain Position Source
AF-Q8CEE6-F1 Predicted AlphaFoldDB

87 variants for Q8CEE6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388489917 69 Y>H No EVA
rs3388488692 70 C>Y No EVA
rs3388488623 104 S>A No EVA
rs3388488623 104 S>T No EVA
rs3388488871 121 L>R No EVA
rs3388491671 129 N>K No EVA
rs3388489418 204 R>L No EVA
rs30379561 205 I>S No EVA
rs3388490370 224 L>M No EVA
rs3388490421 236 V>M No EVA
rs225416114 244 S>N No EVA
rs3388488618 268 V>I No EVA
rs3388489963 317 P>S No EVA
rs236001836 320 R>G No EVA
rs3388492777 345 G>C No EVA
rs3388488833 352 D>E No EVA
rs3388487599 367 F>I No EVA
rs216531202 418 M>I No EVA
rs231594274 434 G>D No EVA
rs255500795 443 R>P No EVA
rs3388489596 445 H>R No EVA
rs229929069 478 S>T No EVA
rs3388487593 492 D>Y No EVA
rs3390341340 496 S>* No EVA
rs3390284435 496 S>* No EVA
rs3388491269 511 A>P No EVA
rs3388491271 513 G>D No EVA
rs3388492872 514 G>D No EVA
rs3388489395 519 D>N No EVA
rs3390338689 576 Q>H No EVA
rs247168183 586 P>S No EVA
rs242389548 595 S>R No EVA
rs3388492945 605 V>M No EVA
rs3388488889 610 F>L No EVA
rs3388487620 617 E>G No EVA
rs219647277 627 S>R No EVA
rs242638732 631 T>M No EVA
rs3390284457 636 Q>H No EVA
rs3388487618 675 Q>* No EVA
rs30383434 675 Q>H No EVA
rs3388491050 679 E>G No EVA
rs3388489453 681 A>P No EVA
rs3539481325 689 S>L No EVA
rs3388492859 692 S>G No EVA
rs265649685 748 E>A No EVA
rs3388491376 757 V>M No EVA
rs3390322751 760 C>* No EVA
rs3390334754 760 C>* No EVA
rs3390340455 760 C>* No EVA
rs3388489353 764 G>C No EVA
rs3388489353 764 G>R No EVA
rs1132096169 771 R>H No EVA
rs3388489662 786 P>H No EVA
rs3388489322 796 E>D No EVA
rs3388488658 808 E>G No EVA
rs30383435 832 A>V No EVA
rs3388492794 851 T>I No EVA
rs3539480569 858 R>P No EVA
rs234797486 869 D>N No EVA
rs3388489875 871 S>C No EVA
rs30383436 871 S>N No EVA
rs3388491221 909 C>F No EVA
rs237991920 918 P>S No EVA
rs219543825 930 P>L No EVA
rs258349415 941 R>H No EVA
rs224315167 966 Q>R No EVA
rs3388489802 986 C>S No EVA
rs3388491289 987 C>S No EVA
rs3388491701 991 K>N No EVA
rs3388488876 1012 P>S No EVA
rs3388489447 1014 S>F No EVA
rs225674065 1054 E>K No EVA
rs258291211 1056 D>A No EVA
rs245240371 1057 Y>H No EVA
rs3388488817 1063 S>G No EVA
rs3388492923 1088 K>S No EVA
rs3388491298 1143 K>R No EVA
rs3388491051 1170 R>L No EVA
rs3388489807 1192 E>D No EVA
rs3388491072 1200 F>I No EVA
rs3388487543 1208 G>D No EVA
rs3388487547 1239 Y>C No EVA
rs3388489779 1247 W>* No EVA
rs3388492825 1248 S>Y No EVA
rs3388491272 1281 S>F No EVA
rs30387388 1344 G>R No EVA
rs238051677 1354 R>T No EVA

No associated diseases with Q8CEE6

2 regional properties for Q8CEE6

Type Name Position InterPro Accession
domain Calponin homology domain 14 - 117 IPR001715
domain EB1, C-terminal 175 - 245 IPR004953

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

8 GO annotations of biological process

Name Definition
energy homeostasis Any process involved in the balance between food intake (energy input) and energy expenditure.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of glycogen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of glucagon secretion Any process that modulates the frequency, rate or extent of the regulated release of glucagon.
regulation of respiratory gaseous exchange Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08217 PSK2 Serine/threonine-protein kinase PSK2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q96RG2 PASK PAS domain-containing serine/threonine-protein kinase Homo sapiens (Human) EV
Q8VBY2 Camkk1 Calcium/calmodulin-dependent protein kinase kinase 1 Mus musculus (Mouse) PR
Q8CIP4 Mark4 MAP/microtubule affinity-regulating kinase 4 Mus musculus (Mouse) SS
Q8VHJ5 Mark1 Serine/threonine-protein kinase MARK1 Mus musculus (Mouse) SS
Q05512 Mark2 Serine/threonine-protein kinase MARK2 Mus musculus (Mouse) SS
Q03141 Mark3 MAP/microtubule affinity-regulating kinase 3 Mus musculus (Mouse) SS
10 20 30 40 50 60
MEDRGPPVFA EDWKCLSESP PVQEGPAAQA TFEPSKPLSI AHKHLSRKNG LSRLCQSRMA
70 80 90 100 110 120
LSEDRWSSYC LSSLAAQNIC TSKLHCAAAP EYADPTAGPL GSTSCCSLLR GLASGCSGSL
130 140 150 160 170 180
LSTPVCNPNK AVFTVDAKTT EILVANDKAC SLLGYSSHDL IGQKLAQFFL KSDSEVVEAL
190 200 210 220 230 240
SEEHVEADGH AAVVFGTVVD IVSRIGEKIP VSVWIKRLQQ DRGLCCVVVL EPVERVSAWV
250 260 270 280 290 300
AFQSDGTITS CDSLFAHLHG FTSPKDVVGQ CVIDLIPSMQ LPPPGQHIPK SLKIQRSVGR
310 320 330 340 350 360
ARDGTTFPLS LKLKSKPSGR AVADSEAASE PGYQASVWVF CTISGLITLL PDGTIYGVNH
370 380 390 400 410 420
SFALMLFGYG KTELLGKNIT FLIPGFYHYM DLTYDSSVQL PDLVNCLDIG RKSGPGEMNS
430 440 450 460 470 480
DAQHNWELAS GAQGPRIDVV LARDHMPSQD ETLKLVGGQV SSRTQTRLET GYKILPSSAC
490 500 510 520 530 540
QPSLGVDSNP EDGEQSLLTD QQSIPKRNLP AHGGQNQLDT SEISLPVLKE HLLSEIQKNI
550 560 570 580 590 600
SEESPLTHRK WLSKVQQNPT KGSLPIHEEQ LLFAGQHIHV LGKEDPSAAE SYRESLLEES
610 620 630 640 650 660
KSKPVDAKLF ASCEDSEPLV SVKDRGSSVD TCNLHQEAQL ELMGVSSPNP WADATMPEPH
670 680 690 700 710 720
TTGQIAGGSL TYCPQYRSEW ASQQRGQDSA PSPSGMACVL LGTPTLDEPW PGVRNDREEL
730 740 750 760 770 780
QTCLIKEQLS KSSCEGNLGI SRVELVPEEH PPFTAPVSFC DLGGRDLHAS RSGSSSACYA
790 800 810 820 830 840
LATDLPGVLE AVEAQEADVN SYSWNLKELF LKDQTDRTPS HCSCTTSELS EAPSLSVVGS
850 860 870 880 890 900
DLDVGILHRQ TSDILVDREM LLLTGTYFDL SEGQRFQEMG AGHDRAELSN ISLVSSEHYE
910 920 930 940 950 960
TSDIESPGCD PPLPDPGPND MCLSAEKPRP SAQITSTPVA RGATSLQQEI QEGIYSGSCY
970 980 990 1000 1010 1020
HRDGLQLSIQ FEVKRVELQG SATLFCCWLV KDLFHSHRDS ATRTRLFLAS LPSSTHSMPE
1030 1040 1050 1060 1070 1080
LSGSSFGEVL RAKPWFEESP TPAELEGLAA CEGEYDYKYN TISPLGSGAF GFVWTAVEKE
1090 1100 1110 1120 1130 1140
CNKEVVVKFI KKEKVLEDCW IEDPKLGRVT LEIAILSKVD HANIIKVLDI FENQEFFQLV
1150 1160 1170 1180 1190 1200
MEKHGSGMDL FAFIDHHPCL DEPLASFIFR QLVSAVGYLH SQGIIHRDIK DENIVIAEDF
1210 1220 1230 1240 1250 1260
TIKLIDFGSA AYLERGKLFY TFCGTIEYCA PEVLIGNPYR GPELEMWSLG VTLYTLIFEE
1270 1280 1290 1300 1310 1320
NPFCEVEETM EAVIHPPFLV SQELMSLLSG LLQPCPEQRT TLEKLIRDPW VTQPVNLASY
1330 1340 1350 1360 1370 1380
TWEEVCRTNQ PESGLLSAAS LEIGSRSPSE MAQREGLCGP PAPRETRGDQ HCLHLKDPSL
PVS