Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CB87
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CB87-F1 | Predicted | AlphaFoldDB |
31 variants for Q8CB87
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3407543263 | 50 | G>D | No | EVA | |
| rs3405760817 | 139 | E>* | No | EVA | |
| rs3407212845 | 153 | I>R | No | EVA | |
| rs3407212868 | 153 | I>V | No | EVA | |
| rs3405760839 | 164 | E>G | No | EVA | |
| rs3407899912 | 220 | Y>H | No | EVA | |
| rs3407608853 | 253 | A>PWPPGPPACEH* | No | EVA | |
| rs3389416578 | 366 | G>R | No | EVA | |
| rs3389448825 | 368 | N>I | No | EVA | |
| rs3407481139 | 380 | A>D | No | EVA | |
| rs3389443771 | 394 | P>A | No | EVA | |
| rs3389448828 | 405 | P>S | No | EVA | |
| rs3389362192 | 489 | T>S | No | EVA | |
| rs3389447305 | 510 | P>L | No | EVA | |
| rs3389408053 | 544 | P>Q | No | EVA | |
| rs3389441181 | 613 | P>H | No | EVA | |
| rs3389441250 | 621 | S>R | No | EVA | |
| rs3389408078 | 627 | P>L | No | EVA | |
| rs3389447339 | 628 | Q>H | No | EVA | |
| rs3389439171 | 629 | S>T | No | EVA | |
| rs3389460050 | 648 | D>E | No | EVA | |
| rs3389439165 | 803 | H>Y | No | EVA | |
| rs3389441206 | 850 | L>P | No | EVA | |
| rs3389416569 | 854 | L>Q | No | EVA | |
| rs3389398948 | 862 | V>M | No | EVA | |
| rs3406563309 | 876 | V>L | No | EVA | |
| rs3407608821 | 891 | V>PATVPRSEERRVR* | No | EVA | |
| rs3389446381 | 934 | N>Y | No | EVA | |
| rs3412788242 | 938 | P>Q | No | EVA | |
| rs3389398900 | 945 | S>L | No | EVA | |
| rs3411870016 | 949 | Q>H | No | EVA |
No associated diseases with Q8CB87
1 regional properties for Q8CB87
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 785 - 937 | IPR005225 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| histamine secretion by mast cell | The regulated release of histamine by a mast cell or group of mast cells. |
| histamine secretion mediated by IgE immunoglobulin | Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen. |
| mast cell degranulation | The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2HJI8 | RAB8B | Ras-related protein Rab-8B | Bos taurus (Bovine) | PR |
| A4FV54 | RAB8A | Ras-related protein Rab-8A | Bos taurus (Bovine) | PR |
| Q1RMR4 | RAB15 | Ras-related protein Rab-15 | Bos taurus (Bovine) | PR |
| Q5F470 | RAB8A | Ras-related protein Rab-8A | Gallus gallus (Chicken) | PR |
| P0C0E4 | RAB40AL | Ras-related protein Rab-40A-like | Homo sapiens (Human) | PR |
| P61006 | RAB8A | Ras-related protein Rab-8A | Homo sapiens (Human) | PR |
| Q92930 | RAB8B | Ras-related protein Rab-8B | Homo sapiens (Human) | PR |
| Q6IQ22 | RAB12 | Ras-related protein Rab-12 | Homo sapiens (Human) | PR |
| Q8WXH6 | RAB40A | Ras-related protein Rab-40A | Homo sapiens (Human) | PR |
| Q96S21 | RAB40C | Ras-related protein Rab-40C | Homo sapiens (Human) | PR |
| Q12829 | RAB40B | Ras-related protein Rab-40B | Homo sapiens (Human) | PR |
| P55258 | Rab8a | Ras-related protein Rab-8A | Mus musculus (Mouse) | PR |
| Q8K386 | Rab15 | Ras-related protein Rab-15 | Mus musculus (Mouse) | PR |
| P61028 | Rab8b | Ras-related protein Rab-8B | Mus musculus (Mouse) | PR |
| P35283 | Rab12 | Ras-related protein Rab-12 | Mus musculus (Mouse) | PR |
| Q9DD03 | Rab13 | Ras-related protein Rab-13 | Mus musculus (Mouse) | PR |
| Q8VHP8 | Rab40b | Ras-related protein Rab-40B | Mus musculus (Mouse) | PR |
| Q8VHQ4 | Rab40c | Ras-related protein Rab-40C | Mus musculus (Mouse) | PR |
| Q99P58 | Rab27b | Ras-related protein Rab-27B | Mus musculus (Mouse) | PR |
| Q9ERI2 | Rab27a | Ras-related protein Rab-27A | Mus musculus (Mouse) | PR |
| Q8CAM5 | Rab36 | Ras-related protein Rab-36 | Mus musculus (Mouse) | PR |
| P35289 | Rab15 | Ras-related protein Rab-15 | Rattus norvegicus (Rat) | PR |
| P35280 | Rab8a | Ras-related protein Rab-8A | Rattus norvegicus (Rat) | PR |
| P70550 | Rab8b | Ras-related protein Rab-8B | Rattus norvegicus (Rat) | PR |
| P35284 | Rab12 | Ras-related protein Rab-12 | Rattus norvegicus (Rat) | PR |
| P35281 | Rab10 | Ras-related protein Rab-10 | Rattus norvegicus (Rat) | PR |
| Q9SF91 | RABE1E | Ras-related protein RABE1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O24466 | RABE1A | Ras-related protein RABE1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZD4 | RABE1D | Ras-related protein RABE1d | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEKGKGVSRK | GRKLASSRRR | QAREPADGQD | APVAAEAESW | PSDADAELQG | FFQDCGAKER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GFVTREDLAE | ARFSFLGGEE | PQMIFDWVDV | ESRGHLSLEE | FSSGLKNVFG | SSPGTHRLRT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KRSLPSQRES | VTSTLPVPEE | ADAEEKEAFL | ALIGQMETGH | SLSEQAEIWK | LWRELRQEEP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLAGNLEGFL | AKMSSRLQEA | QADREALAWT | LRKRDSDHLY | KVRQLYEETE | EQIRREKQQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QAQSDSRGMA | LSAHMQEALE | AKEQEVQRLA | EGQRELEAQL | LHLSSTQQEA | NRENLQLREA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ERDLAGQLEE | VRGQLQVTRG | HLDTARTRGK | VSWQIEEEPS | VPRANKEAPD | PQAVPTEEAP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPELFGNNDN | WDQFLSSIEA | HSHRTLRLCW | SPPPSPSSTS | APQTPRIVRQ | ISISKISALQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSQEPASDPD | PGPRGSPEVP | PGGAKDGKGV | EDPKGQDEQD | VSSKQPVDSP | DSDARPKGSF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LWSLPGALTA | ESGTVEAAFR | DQLAFEAEPP | PQGLSSSPQS | PAGSRKQTQT | PDLGDKSLWS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GPDPAKQSLE | REVMAEDLKL | GLGSQGATAL | PEGATEPSLS | LESVDQVGPE | RPVQDATHLA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RQESHAKGFQ | EAPGQVLSLD | SLPTHLPQSL | EEQLRPEEGN | LGERGQQDPG | SEASESHGLE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ARSMESPQQD | DPLPNTSQPP | AETEVPAPGQ | MSPPRGSPIL | GAGAGLAVGT | PETTHTLLTL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AESEAQPGPV | SMPVQVESKS | GAPQPTEPEA | ESRPEDPRTD | LQEAERSSSP | GDLTAGKPQA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DPDYLYHVVF | LGDSNVGKTS | FLHLLHHDAF | ATGLTATVGV | DFRVKNLLVD | NKTFALQLWD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TAGQERYHSL | TRQLLRKAEG | VVLMYDVTSQ | ESFTHVRYWL | DCLQDAGVEG | VAMVLLGNKM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DCEEERQVPT | EAGRRLAQEL | GVSFGECSAA | LGHNILEPMM | NLARSLKMQE | DRLKASLAEV |
| 970 | |||||
| THPQSTKRAG | CCH |