Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8CAM5

Entry ID Method Resolution Chain Position Source
AF-Q8CAM5-F1 Predicted AlphaFoldDB

16 variants for Q8CAM5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389116337 36 H>Y No EVA
rs3389083238 68 V>L No EVA
rs3389083265 78 C>* No EVA
rs46885979 84 H>R No EVA
rs3389049304 90 I>V No EVA
rs3389117628 92 V>M No EVA
rs3389093915 122 I>N No EVA
rs3389110869 131 Q>* No EVA
rs3389102846 164 C>Y No EVA
rs3389079693 171 T>S No EVA
rs3401591270 177 S>* No EVA
rs3389106404 184 A>P No EVA
rs3389093907 218 A>V No EVA
rs220873246 224 Q>K No EVA
rs3389107929 258 N>Y No EVA
rs235884791 263 G>S No EVA

No associated diseases with Q8CAM5

3 regional properties for Q8CAM5

Type Name Position InterPro Accession
domain EF-hand domain 53 - 118 IPR002048-1
domain EF-hand domain 149 - 177 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 66 - 78 IPR018247

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

2 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QR46 RAB6B Ras-related protein Rab-6B Bos taurus (Bovine) PR
Q1KME6 RAB6A Ras-related protein Rab-6A Gallus gallus (Chicken) PR
O18334 Rab6 Ras-related protein Rab6 Drosophila melanogaster (Fruit fly) PR
Q5JT25 RAB41 Ras-related protein Rab-41 Homo sapiens (Human) PR
Q9NRW1 RAB6B Ras-related protein Rab-6B Homo sapiens (Human) PR
P20340 RAB6A Ras-related protein Rab-6A Homo sapiens (Human) PR
Q9BZG1 RAB34 Ras-related protein Rab-34 Homo sapiens (Human) PR
O95755 RAB36 Ras-related protein Rab-36 Homo sapiens (Human) PR
P35279 Rab6a Ras-related protein Rab-6A Mus musculus (Mouse) PR
P61294 Rab6b Ras-related protein Rab-6B Mus musculus (Mouse) PR
Q8CB87 Rab44 Ras-related protein Rab-44 Mus musculus (Mouse) PR
Q99P58 Rab27b Ras-related protein Rab-27B Mus musculus (Mouse) PR
Q9ERI2 Rab27a Ras-related protein Rab-27A Mus musculus (Mouse) PR
Q9WVB1 Rab6a Ras-related protein Rab-6A Rattus norvegicus (Rat) PR
P34213 rab-6.1 Ras-related protein rab-6.1 Caenorhabditis elegans PR
Q22782 rab-6.2 Ras-related protein rab-6.2 Caenorhabditis elegans PR
O80501 RABH1B Ras-related protein RABH1b Arabidopsis thaliana (Mouse-ear cress) PR
Q9SMR4 RABH1C Ras-related protein RABH1c Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFT9 RABH1E Ras-related protein RABH1e Arabidopsis thaliana (Mouse-ear cress) PR
Q9LV79 RABH1A Ras-related protein RABH1a Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRSSWTPLGP PVSQDRIITS FPKWYTPDAC LQLKEHFHSR VSTACQHRNT GTAGLRLSKV
70 80 90 100 110 120
VVVGDLYVGK TSLIHRLCKN VFDHDYKATI GVDFEIERFE IAGIPYSLQI WDTAGQEKFK
130 140 150 160 170 180
CIASAYYRGA QVIITAFDLT DVQTLEHTRQ WLEDVLRENE AGSCFIFLVG TKKDLLSGAA
190 200 210 220 230 240
CEQAEAEAVH LANEMQAEYW SVSAKTGENV KAFFSRVAAL AFEQSVLQDL EKRPSTQSQV
250 260
GDGDGDLIRI EVPKTQENKR PPGLGCC