Q8C8R3
SS
Gene name |
Ank2 (AnkB) |
Protein name |
Ankyrin-2 |
Names |
ANK-2 , Ankyrin-B , Brain ankyrin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:109676 |
EC number |
|
Protein Class |
|
Descriptions
Ankyrins are a widely expressed scaffold protein family, which mainly function to link great varieties of functionally related but structurally diverse integral membrane proteins. Autoinhibition in Ankyrin-2 and Ankyrin-3 is facilitated by the combinatorial and quasi-independent bindings of multiple disordered segments located in the linker and tail regions. These segments interact with the membrane binding domain's ANK repeats, adopting a head-to-tail conformation that inhibits the binding to membrane proteins.
Autoinhibitory domains (AIDs)
Target domain |
28-828 (Membrane binding domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
28-828 (Membrane binding domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for Q8C8R3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for Q8C8R3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8C8R3 | |||||
No associated diseases with Q8C8R3
Functions
19 GO annotations of cellular component
| Name | Definition |
|---|---|
| A band | The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. |
| costamere | Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| M band | The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| paranodal junction | A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
| T-tubule | Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| potassium channel regulator activity | Binds to and modulates the activity of a potassium channel. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
35 GO annotations of biological process
| Name | Definition |
|---|---|
| atrial cardiac muscle cell action potential | An action potential that occurs in an atrial cardiac muscle cell. |
| atrial cardiac muscle cell to AV node cell communication | The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. |
| cardiac muscle contraction | Muscle contraction of cardiac muscle tissue. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. |
| intracellular calcium ion homeostasis | A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. |
| positive regulation of calcium ion transmembrane transporter activity | Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. |
| positive regulation of calcium ion transport | Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of cation channel activity | Any process that activates or increases the frequency, rate or extent of cation channel activity. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of potassium ion transmembrane transporter activity | Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. |
| positive regulation of potassium ion transport | Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| protein localization to cell surface | A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. |
| protein localization to endoplasmic reticulum | A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. |
| protein localization to M-band | Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein localization to T-tubule | A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of atrial cardiac muscle cell action potential | Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| regulation of AV node cell action potential | Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| regulation of calcium ion transmembrane transporter activity | Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. |
| regulation of calcium ion transport | Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of cardiac muscle cell contraction | Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. |
| regulation of cardiac muscle cell membrane potential | Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| regulation of cardiac muscle contraction | Any process that modulates the frequency, rate or extent of cardiac muscle contraction. |
| regulation of cardiac muscle contraction by calcium ion signaling | Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. |
| regulation of heart rate | Any process that modulates the frequency or rate of heart contraction. |
| regulation of heart rate by cardiac conduction | A cardiac conduction process that modulates the frequency or rate of heart contraction. |
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
| regulation of SA node cell action potential | Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| SA node cell action potential | An action potential that occurs in a sinoatrial node cardiac muscle cell. |
| SA node cell to atrial cardiac muscle cell communication | The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. |
| T-tubule organization | A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F1N6G5 | HACE1 | E3 ubiquitin-protein ligase HACE1 | Bos taurus (Bovine) | SS |
| E1C656 | HACE1 | E3 ubiquitin-protein ligase HACE1 | Gallus gallus (Chicken) | SS |
| Q8IYU2 | HACE1 | E3 ubiquitin-protein ligase HACE1 | Homo sapiens (Human) | EV |
| P16157 | ANK1 | Ankyrin-1 | Homo sapiens (Human) | EV |
| Q01484 | ANK2 | Ankyrin-2 | Homo sapiens (Human) | EV |
| Q12955 | ANK3 | Ankyrin-3 | Homo sapiens (Human) | SS |
| Q3U0D9 | Hace1 | E3 ubiquitin-protein ligase HACE1 | Mus musculus (Mouse) | SS |
| Q02357 | Ank1 | Ankyrin-1 | Mus musculus (Mouse) | SS |
| D3ZBM7 | Hace1 | E3 ubiquitin-protein ligase HACE1 | Rattus norvegicus (Rat) | SS |
| O70511 | Ank3 | Ankyrin-3 | Rattus norvegicus (Rat) | EV |
| Q28BK1 | hace1 | E3 ubiquitin-protein ligase HACE1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| F8W2M1 | hace1 | E3 ubiquitin-protein ligase HACE1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMNEDAAQKS | DSGEKFNGSS | QRRKRPKKSD | SNASFLRAAR | AGNLDKVVEY | LKGGIDINTC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NQNGLNALHL | AAKEGHVGLV | QELLGRGSSV | DSATKKGNTA | LHIASLAGQA | EVVKVLVKEG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ANINAQSQNG | FTPLYMAAQE | NHIDVVKYLL | ENGANQSTAT | EDGFTPLAVA | LQQGHNQAVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILLENDTKGK | VRLPALHIAA | RKDDTKSAAL | LLQNDHNADV | QSKMMVNRTT | ESGFTPLHIA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AHYGNVNVAT | LLLNRGAAVD | FTARNGITPL | HVASKRGNTN | MVKLLLDRGG | QIDAKTRDGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TPLHCAARSG | HDQVVELLLE | RKAPLLARTK | NGLSPLHMAA | QGDHVECVKH | LLQYKAPVDD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VTLDYLTALH | VAAHCGHYRV | TKLLLDKRAN | PNARALNGFT | PLHIACKKNR | IKVMELLVKY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GASIQAITES | GLTPIHVAAF | MGHLNIVLLL | LQNGASPDVT | NIRGETALHM | AARAGQVEVV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RCLLRNGALV | DARAREEQTP | LHIASRLGKT | EIVQLLLQHM | AHPDAATTNG | YTPLHISARE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GQVDVASVLL | EAGAAHSLAT | KKGFTPLHVA | AKYGSLDVAK | LLLQRRAAAD | SAGKNGLTPL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HVAAHYDNQK | VALLLLEKGA | SPHATAKNGY | TPLHIAAKKN | QMQIASTLLN | YGAETNTVTK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QGVTPLHLAS | QEGHTDMVTL | LLDKGANIHM | STKSGLTSLH | LAAQEDKVNV | ADILTKHGAD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RDAYTKLGYT | PLIVACHYGN | VKMVNFLLKQ | GANVNAKTKN | GYTPLHQAAQ | QGHTHIINVL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LQHGAKPNAT | TANGNTALAI | AKRLGYISVV | DTLKVVTEEV | TTTTTTITEK | HKLNVPETMT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EVLDVSDEEG | DDTVTGDGGE | YLRPEDLKEL | GDDSLPSSQF | LDGMNYLRYS | LEGGRSDSLR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SFSSDRSHTL | SHASYLRDSA | MIDDTVVIPS | HQVSALAKEA | ERNSYRLSWG | TENLDNVALS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SSPIHSGFLV | SFMVDARGGA | MRGCRHNGLR | IIIPPRKCTA | PTRVTCRLVK | RHRLATMPPM |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VEGEGLASRL | IEVGPSGAQF | LGPVIVEIPH | FAALRGKERE | LVVLRSENGD | SWKEHFCDYT |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EDELNEILNG | MDEVLDSPED | LEKKRICRII | TRDFPQYFAV | VSRIKQDSNL | IGPEGGVLSS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| TVVSQVQAVF | PEGALTKRIR | VGLQAQPMHS | ELVKKILGNK | ATFSPIVTLE | PRRRKFHKPI |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| TMTIPVPKAS | SDVMLNGFGG | DAPTLRLLCS | ITGGTTPAQW | EDITGTTPLT | FVNECVSFTT |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| NVSARFWLID | CRQIQESVAF | ASQVYREIIC | VPYMAKFVVF | AKSHDPIEAR | LRCFCMTDDK |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| VDKTLEQQEN | FSEVARSRDV | EVLEGKPIYV | DCFGNLVPLT | KSGQHHIFSF | FAFKENRLPL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| FVKVRDTTQE | PCGRLSFMKE | PKSTRGLVHQ | AICNLNITLP | IYAKESESDQ | EPEEEIGMTS |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| EKNDETESTE | TSVLKSHLVN | EVPVLASPDL | LSEVSEMKQD | LIKMTAILTT | DVSDKAGSLK |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| VKELAKAGEE | EPGEPFEIVE | RVKEDLEKVN | AILRSGTCMR | DEGRARSSQS | ERELEEEWVI |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| VSDEEIQEAK | QHAPVEIDEH | PCIEVRVDRE | TKAKVEKDST | GLVNYLTDDL | NSYTSPHEKK |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| PHTAPEKSGE | TSQASAVGKS | SESNKGKATS | AEEKQSAQKQ | LKPGLAIKKP | VRRKLKEKQK |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| QKEESSQSSE | EKTELKKGSS | EESVDEDRGL | VPEPLPTAKA | TSPLIEETPI | GSIKDKVKAL |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| QKRVEDEQKG | RSKLPVRVKG | KEDVPKRTTP | RTHPAVSPSS | KSSTSSKAER | HSSLSSSAKP |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| ERHTPVSPSS | KNEKLSPVSP | SAKTERHSPV | FSGKPEKHSP | GSPSTKNERH | SPVSSLKTER |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| HTPGSPSGKT | DKRPPVPSSG | RTEKHPPVSP | GKTEKHLPGS | PSIRTPEKPA | PGSATGKHEK |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| HLPVSPGKTE | KQPPISPTSK | TERIEETMSV | RELMKAFQSG | QDPSKHKTGL | FEHKSAKQKQ |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| PQDKSKSRVE | KEKGHTVTQR | EVTQRETQRI | ESQTAKRGQR | FQVSAATESR | RFRSTTITVG |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| LRMEDPVRER | FERTPIIKTP | EVVPSVAAEE | SHRGSEKIVD | EQGDMDFQIS | PDRKTSTDFS |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| EVIKQELEDN | DKYQQFRLTE | DTEKAQVHLD | QVITSPFNTA | FPLDYMKDEF | LPALSLQSGA |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| LGGSSESLKQ | EVIAGSPCSS | LMEGTPQISS | EESYKHEGLA | ETPETSPESL | SFSPKKSEEQ |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| IGEAKETTKV | GTPTDIHSEK | ELPITNDITD | SSQKQGAGVT | RGSEPSTEHS | QKEVTQDPHK |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| DVCSKQDGCP | ESQSVSLASE | VFTEKGSCGE | SQLPLVSSAF | KTQSESETQE | SLTPSEVTKP |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| FPPSDASVKT | AEGTEPKPQG | AIRSPQGLEL | PLPNRDSEVL | SPMADESLAV | SHKDSLEASP |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| VLEDNSSHKT | PDSLEPSPLK | ESPCRDSLES | SPVEPKMKAG | ILPSHFPLPA | AIAKTDLVAE |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| VASMRSRLLR | DPDGSAEDDS | LEQTSLMESS | GKSPLSPDTP | SSEEVSYEVT | PKPSDSSTPK |
| 2530 | 2540 | 2550 | 2560 | 2570 | 2580 |
| PAVIHECAEE | DDSENGEKKR | FTPEEEMFKM | VTKIKTFDEL | EQEAKQKRDY | KKEPRQDGSS |
| 2590 | 2600 | 2610 | 2620 | 2630 | 2640 |
| SASDPDADYS | AEVNDEKQMA | GTEGEGEVPV | LVTSENRKVS | SSSSESEPEL | TQLSKGADSG |
| 2650 | 2660 | 2670 | 2680 | 2690 | 2700 |
| LLTEPVIRVQ | PPSPLPSSID | SNSSPEEATQ | FQPIVPKQYT | FKMNEEIQEE | PATSEDKDCK |
| 2710 | 2720 | 2730 | 2740 | 2750 | 2760 |
| SHLAEDSQTH | SADAADGSDG | DLNRETTQPE | TCDGHGCETV | SPSNSATPVS | LGVQSPEHKD |
| 2770 | 2780 | 2790 | 2800 | 2810 | 2820 |
| VDKPLAIDKD | SLAHQDTCEN | DREEREFDPS | GVESTQADLP | NESSSLSSRC | AIPEGNESAK |
| 2830 | 2840 | 2850 | 2860 | 2870 | 2880 |
| EIASPSSPVK | VEVTITDQAL | ESMPEDCPIQ | DSSTTMQTER | FAMDVPVSEL | AETDENSDPQ |
| 2890 | 2900 | 2910 | 2920 | 2930 | 2940 |
| IISPYENVPS | SSFFSAEPSK | IQTDTCHSTV | VHSPEVYSVI | IRSSPEDVVV | TNSSNRTVSG |
| 2950 | 2960 | 2970 | 2980 | 2990 | 3000 |
| EESHCESHDL | ETESEQKSAL | WAAQSDAPPL | AVAPTASDAA | SVTGEQASKV | IITKTDADAD |
| 3010 | 3020 | 3030 | 3040 | 3050 | 3060 |
| SWSEIREDDA | AFEARVKEEE | QKIFGLMVDR | QSQGTTPDTT | PARTPTEEGT | PTSEQNPFLF |
| 3070 | 3080 | 3090 | 3100 | 3110 | 3120 |
| QEGKLFEMTR | SGAIDMTKRP | YADESLHFFQ | IGQESNEEAI | SEDLKEGATG | AEPPQTETTS |
| 3130 | 3140 | 3150 | 3160 | 3170 | 3180 |
| ESLELSEPKE | AMDDEGELLP | DDVSEEIEDL | PASDANIDSQ | VIISASTETP | TKEAVSTAVE |
| 3190 | 3200 | 3210 | 3220 | 3230 | 3240 |
| EPPTTQRSDS | LSTVKQTPRP | AVPGPVGQLD | FSPVTRSVYS | GQDDESPESS | PEEQKSVIEI |
| 3250 | 3260 | 3270 | 3280 | 3290 | 3300 |
| PTAPVDNVPS | AESKPQIPIR | TLPTLVPAPP | SAEDESAFSD | DFPSSLDEDS | KEGGAKPKSK |
| 3310 | 3320 | 3330 | 3340 | 3350 | 3360 |
| IPVKAPTQRT | EWQPSPTDIP | LQKTAVPQGQ | ETLSRAPDGR | SKSESDASSL | DAKTKCPVKA |
| 3370 | 3380 | 3390 | 3400 | 3410 | 3420 |
| RSYIETETES | RERAEGFESE | SEDGATKPKL | FASRLPVKSR | STSSSGRPGT | SPTRESREHF |
| 3430 | 3440 | 3450 | 3460 | 3470 | 3480 |
| FDLYRNSIEF | FEEISDEASK | LVDRLTQSER | EQEPPSDDES | SSALEVSVIE | SLPPVDIEHS |
| 3490 | 3500 | 3510 | 3520 | 3530 | 3540 |
| APEDIFDTRP | IWDESIETMI | ERIPDENGHD | RAEDPQDEQE | RMEERLAYIA | DHLGFSWTEL |
| 3550 | 3560 | 3570 | 3580 | 3590 | 3600 |
| ARELDFTEEQ | IHQIRIENPN | SLQDQSHALL | KYWLERDGKH | ATDTILIECL | TKINRMDIVH |
| 3610 | 3620 | 3630 | 3640 | 3650 | 3660 |
| LLETNTEPLQ | ERMGRSYAEI | EQTITLDHSE | GFSVLPDELC | AAKEKKEQEA | SKESESSDHP |
| 3670 | 3680 | 3690 | 3700 | 3710 | 3720 |
| PMVSEEDISV | GYSTFQDCLP | KTEGDSPAAA | LSPQMHQEPV | QQDFSGKTQD | QQEYYVTTPG |
| 3730 | 3740 | 3750 | 3760 | 3770 | 3780 |
| AEVEDPQKAT | AVPDSLCKTP | EDISTPPEGT | KPCLQTPVTS | ERGSPIVQEP | EEASEPKEES |
| 3790 | 3800 | 3810 | 3820 | 3830 | 3840 |
| SPRKTSLVIV | ESTDDQSQVF | ERLDGDAAFQ | KGDDMPDIPP | ETVTEEEYVD | ENGHTVVKKV |
| 3850 | 3860 | 3870 | 3880 | 3890 | |
| TRKIIRRYVS | SDGTEKEEVT | MQGMPQEPVN | IEDGDNYSKV | IKRVVLKSDT | QQSEDNNE |