Q8C5W4
PR
Gene name |
Morc2b |
Protein name |
ATPase MORC2B |
Names |
MORC family CW-type zinc finger protein 2B, TCE6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:240069 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C5W4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C5W4-F1 | Predicted | AlphaFoldDB |
65 variants for Q8C5W4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389432612 | 19 | L>Q | No | EVA | |
| rs3389464049 | 37 | I>M | No | EVA | |
| rs3389452399 | 39 | N>K | No | EVA | |
| rs3389412260 | 71 | V>I | No | EVA | |
| rs3389446488 | 97 | I>N | No | EVA | |
| rs3389458700 | 101 | G>V | No | EVA | |
| rs3389457114 | 124 | T>I | No | EVA | |
| rs3389452343 | 137 | E>G | No | EVA | |
| rs3389450768 | 189 | T>A | No | EVA | |
| rs3389447533 | 230 | Q>* | No | EVA | |
| rs3389402863 | 231 | E>* | No | EVA | |
| rs3412660074 | 268 | C>* | No | EVA | |
| rs3389366608 | 274 | P>L | No | EVA | |
| rs3389447504 | 280 | T>K | No | EVA | |
| rs257698185 | 282 | H>R | No | EVA | |
| rs3389446412 | 300 | Q>* | No | EVA | |
| rs3389470245 | 311 | S>G | No | EVA | |
| rs3389464107 | 321 | G>C | No | EVA | |
| rs3407647653 | 322 | G>E | No | EVA | |
| rs3407506412 | 323 | D>N | No | EVA | |
| rs3389421376 | 329 | R>G | No | EVA | |
| rs3389447509 | 330 | V>M | No | EVA | |
| rs3407582200 | 332 | L>S | No | EVA | |
| rs3389366654 | 334 | Q>R | No | EVA | |
| rs3389402835 | 347 | D>N | No | EVA | |
| rs224888523 | 358 | Q>R | No | EVA | |
| rs3406677471 | 391 | I>F | No | EVA | |
| rs3389447528 | 425 | H>R | No | EVA | |
| rs3389446459 | 437 | R>L | No | EVA | |
| rs3389464082 | 468 | F>L | No | EVA | |
| rs3389443499 | 483 | L>* | No | EVA | |
| rs3389447558 | 496 | T>I | No | EVA | |
| rs13482953 | 521 | I>V | No | EVA | |
| rs3413096497 | 528 | N>S | No | EVA | |
| rs3389402873 | 573 | R>SE* | No | EVA | |
| rs3389366561 | 574 | K>R | No | EVA | |
| rs3389401356 | 579 | K>N | No | EVA | |
| rs3389446448 | 584 | I>T | No | EVA | |
| rs3389446440 | 593 | L>I | No | EVA | |
| rs246223033 | 601 | P>S | No | EVA | |
| rs3389458712 | 603 | S>Y | No | EVA | |
| rs229039197 | 618 | H>R | No | EVA | |
| rs260339177 | 619 | V>A | No | EVA | |
| rs243979134 | 622 | T>M | No | EVA | |
| rs3389431871 | 628 | P>T | No | EVA | |
| rs227349207 | 647 | N>D | No | EVA | |
| rs265274713 | 652 | F>S | No | EVA | |
| rs33493422 | 674 | L>P | No | EVA | |
| rs257100768 | 683 | P>T | No | EVA | |
| rs241687408 | 700 | P>L | No | EVA | |
| rs222099496 | 721 | V>L | No | EVA | |
| rs3389464091 | 732 | R>L | No | EVA | |
| rs3389446478 | 735 | E>G | No | EVA | |
| rs249108141 | 749 | M>I | No | EVA | |
| rs262200061 | 758 | K>N | No | EVA | |
| rs239083917 | 771 | S>A | No | EVA | |
| rs239083917 | 771 | S>T | No | EVA | |
| rs52767231 | 820 | E>D | No | EVA | |
| rs3389421355 | 830 | D>V | No | EVA | |
| rs3389364377 | 837 | S>R | No | EVA | |
| rs3389364381 | 869 | Q>E | No | EVA | |
| rs3389458758 | 887 | D>N | No | EVA | |
| rs3389458748 | 906 | W>C | No | EVA | |
| rs3389453087 | 942 | K>T | No | EVA | |
| rs3389450727 | 991 | I>N | No | EVA |
No associated diseases with Q8C5W4
5 regional properties for Q8C5W4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 407 - 567 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 205 - 384 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 200 - 411 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 181 - 209 | IPR014014 |
| domain | DDX41, DEAD-box helicase domain | 192 - 397 | IPR044113 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| heterochromatin | A compact and highly condensed form of chromatin that is refractory to transcription. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| identical protein binding | Binding to an identical protein or proteins. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| zinc ion binding | Binding to a zinc ion (Zn). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| double-strand break repair involved in meiotic recombination | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. |
| gamete generation | The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. |
| homologous chromosome pairing at meiosis | The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. |
| negative regulation of gene expression, epigenetic | An epigenetic process that silences gene expression at specific genomic regions through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. |
| negative regulation of single stranded viral RNA replication via double stranded DNA intermediate | Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. |
| positive regulation of DNA methylation-dependent heterochromatin assembly | Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q14149 | MORC3 | MORC family CW-type zinc finger protein 3 | Homo sapiens (Human) | EV |
| Q8TE76 | MORC4 | MORC family CW-type zinc finger protein 4 | Homo sapiens (Human) | SS |
| Q9Y6X9 | MORC2 | ATPase MORC2 | Homo sapiens (Human) | PR |
| F7BJB9 | Morc3 | MORC family CW-type zinc finger protein 3 | Mus musculus (Mouse) | SS |
| Q8BMD7 | Morc4 | MORC family CW-type zinc finger protein 4 | Mus musculus (Mouse) | SS |
| Q69ZX6 | Morc2a | ATPase MORC2A | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFTNYSTLN | RAQLTFDYLH | TNSTTHAFLF | GALAELIDNA | RDADATRIDI | YAEKREDLQG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GFMLCFLDNG | VGMDPNDVIN | VIQFGKSAKR | TPESTQIGRY | GNGLKSGSMR | IGKDFILFTK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KENTMSCLFL | SRTFHEEEGI | DEVIVPLPTW | NSQTREPVTD | NMEKFAIETE | LIYKYSPFHT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEEVMTQFTK | ISGTSGTLVV | IFNLKLTDNG | EPELDVTSNP | KDIRMAEISQ | EGVKPERHSF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CAYAAVLYID | PRMRIFIHGH | KVQTKKLCCC | LYKPRKYTFT | SHRFKTRAEQ | EVKKADQVAQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAEEKAREAE | SKARTLEIHM | GGDITRDSRV | MLRQVQNTAI | TLRREADVKK | RIRDAKQQAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KEPKELTFVF | GVNIEHRDHD | GMFIYNCSRL | IKMYEKVGPQ | LEKGMVCGGV | VGVIDVPYLV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEPTHNKQDF | ADAKEYRHLL | RAMGEHLAQY | WKDIEIAQHG | IIKFWDEFGY | LSANWNRPPS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DELHFKRKRA | MQVPTTIQCD | LCLKWRTLPF | QLSAVEEGYP | INWVCSMNPD | PEQDQCEAFE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LKQKIPLGIL | KKAPKTQEER | QKQLTEKIQQ | EQRKLKALKK | IKPIHSQSDL | KKLPLEVTSR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PFSKYPAHIF | QGPQSSFHVV | KTNARRRPQS | RHAPFRQLQR | SSIICTNPKP | PFLVDKTEAV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLQPPETPQK | SVSLLVKTIP | QPPPLVQSLS | PSVVPKSNNP | WKVETPQIMN | TPVAEMPYVP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VNPSLVICDH | KRSPEVSDEI | EDEDRRKRMC | KRGRFTVKKE | KIQASELSDS | SGEENPVDLK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TAQKDKGLYV | EVRMMGECYK | GHVTAVEVGD | NVVWWKVKFE | DMPKDSTPRD | CWVEKGSENV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| WLVKPSPEYQ | STDEQQEDRK | GEEDTVVQQA | LALQQTSTSE | CFCTEPDTTA | STANHKTIDL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LVQILWNCLH | YFMPLSFPIS | KKELGAMNSE | ELLSLPLKEC | FKQYEVGLQN | LCRSYQRCAD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SQAKVSEESL | RISQKKLQET | EEKLQKLRTN | IQTLLQMAQQ | GINIRADDEL | DAYIEDLVSS |
| DD |