AiPD: Autoinhibited Protein Database

Gene name	Dennd2a
Protein name	DENN domain-containing protein 2A
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:209773
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

477-547 (Predicted disordered autoinhibitory region) PR

477-547 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8C4S8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388821336	13	M>K	No	EVA
rs3388821281	25	K>N	No	EVA
rs36704218	31	W>R	No	EVA
rs224762605	41	S>P	No	EVA
rs262694958	43	P>S	No	EVA
rs239997120	48	R>K	No	EVA
rs37453329	71	A>T	No	EVA
rs3396720373	82	E>V	No	EVA
rs248875896	100	T>A	No	EVA
rs36783071	113	N>S	No	EVA
rs3388830725	142	H>R	No	EVA
rs214271868	150	S>I	No	EVA
rs3388824654	156	S>N	No	EVA
rs3388817412	163	R>K	No	EVA
rs3388819346	177	A>D	No	EVA
rs215949203	201	L>Q	No	EVA
rs260252493	202	P>H	No	EVA
rs3388827220	204	L>R	No	EVA
rs3388814160	215	A>T	No	EVA
rs3388824577	220	H>Y	No	EVA
rs233162360	227	P>L	No	EVA
rs3388821345	236	K>E	No	EVA
rs212986258	240	S>C	No	EVA
rs3388802335	284	K>N	No	EVA
rs259354401	382	H>P	No	EVA
rs3388817959	529	L>R	No	EVA
rs3388817401	540	P>L	No	EVA
rs3388810560	545	L>I	No	EVA
rs3388825446	589	K>R	No	EVA
rs3388825446	589	K>T	No	EVA
rs3388830733	593	F>Y	No	EVA
rs3388827188	604	I>T	No	EVA
rs3396593068	618	V>I	No	EVA
rs3388819384	623	S>G	No	EVA
rs229791782	630	L>F	No	EVA
rs3388824149	648	G>E	No	EVA
rs3388822058	718	T>I	No	EVA
rs3388825449	760	R>I	No	EVA
rs3388810536	785	F>L	No	EVA
rs3388817407	798	A>D	No	EVA
rs3388817409	841	R>S	No	EVA
rs3388819420	872	Q>*	No	EVA
rs3388827241	888	L>S	No	EVA
rs3388814155	901	V>M	No	EVA
rs3388824454	904	V>E	No	EVA
rs3388817933	943	T>I	No	EVA
rs3388819358	949	F>L	No	EVA
rs3388824606	952	E>*	No	EVA
rs3388827221	980	H>Y	No	EVA
rs3388819331	994	M>L	No	EVA
rs3388819338	998	H>Y	No	EVA

Type	Name	Position	InterPro Accession
domain	cDENN domain	653 - 837	IPR001194
domain	dDENN domain	888 - 965	IPR005112
domain	uDENN domain	554 - 646	IPR005113
domain	Tripartite DENN domain	559 - 960	IPR037516

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton	Associated with actin filaments
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

Name	Definition
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde transport, endosome to Golgi	The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8TEH3	DENND1A	DENN domain-containing protein 1A	Homo sapiens (Human)	SS
Q6P3S1	DENND1B	DENN domain-containing protein 1B	Homo sapiens (Human)	SS
Q3U1T9	Dennd1b	DENN domain-containing protein 1B	Mus musculus (Mouse)	PR
Q8K382	Dennd1a	DENN domain-containing protein 1A	Mus musculus (Mouse)	EV