Q8C3J5
PR
Gene name |
Dock2 |
Protein name |
Dedicator of cytokinesis protein 2 |
Names |
Protein Hch |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:94176 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C3J5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C3J5-F1 | Predicted | AlphaFoldDB |
83 variants for Q8C3J5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1132928266 | 49 | L>H | No | EVA | |
| rs1132577917 | 52 | H>Y | No | EVA | |
| rs1133651358 | 53 | K>E | No | EVA | |
| rs3389137363 | 66 | L>I | No | EVA | |
| rs3389160959 | 93 | T>I | No | EVA | |
| rs3389088537 | 103 | K>R | No | EVA | |
| rs3412920802 | 120 | M>I | No | EVA | |
| rs3389137398 | 133 | S>L | No | EVA | |
| rs3401440151 | 141 | L>QFLQLILG* | No | EVA | |
| rs3401440151 | 142 | K>Q | No | EVA | |
| rs3389142412 | 156 | N>I | No | EVA | |
| rs3389149578 | 157 | K>Q | No | EVA | |
| rs3389125374 | 176 | D>N | No | EVA | |
| rs3389149968 | 236 | E>K | No | EVA | |
| rs50663009 | 251 | T>M | No | EVA | |
| rs3389146959 | 260 | R>* | No | EVA | |
| rs3389149562 | 284 | G>* | No | EVA | |
| rs3389137393 | 305 | M>I | No | EVA | |
| rs3389149577 | 315 | C>Y | No | EVA | |
| rs3389113120 | 341 | D>N | No | EVA | |
| rs3389145505 | 398 | P>Q | No | EVA | |
| rs3389125359 | 422 | V>F | No | EVA | |
| rs3389149619 | 427 | Y>N | No | EVA | |
| rs3389088533 | 444 | R>Q | No | EVA | |
| rs3402058138 | 446 | V>M | No | EVA | |
| rs3389113073 | 467 | G>S | No | EVA | |
| rs3389113099 | 468 | A>V | No | EVA | |
| rs3402204083 | 522 | K>T | No | EVA | |
| rs3389149606 | 655 | A>T | No | EVA | |
| rs3389125385 | 676 | A>V | No | EVA | |
| rs3389088502 | 681 | I>K | No | EVA | |
| rs3389160967 | 729 | Q>* | No | EVA | |
| rs3389160921 | 750 | S>* | No | EVA | |
| rs26854812 | 804 | H>Q | No | EVA | |
| rs3389145519 | 811 | D>G | No | EVA | |
| rs3389154518 | 823 | Y>C | No | EVA | |
| rs3389149997 | 860 | V>D | No | EVA | |
| rs387029568 | 879 | A>T | No | EVA | |
| rs236117994 | 883 | H>Y | No | EVA | |
| rs214624146 | 897 | C>Y | No | EVA | |
| rs3389158458 | 929 | H>Y | No | EVA | |
| rs3389146984 | 941 | A>V | No | EVA | |
| rs3389122054 | 971 | T>I | No | EVA | |
| rs3389137424 | 1005 | K>N | No | EVA | |
| rs3389088480 | 1010 | M>T | No | EVA | |
| rs3389149655 | 1019 | S>R | No | EVA | |
| rs3389124707 | 1043 | L>M | No | EVA | |
| rs3389088467 | 1075 | K>M | No | EVA | |
| rs3389113102 | 1101 | E>K | No | EVA | |
| rs3389137452 | 1104 | K>T | No | EVA | |
| rs29417660 | 1161 | A>V | No | EVA | |
| rs3389160907 | 1188 | R>Q | No | EVA | |
| rs3389149960 | 1210 | Y>* | No | EVA | |
| rs3389088506 | 1214 | N>D | No | EVA | |
| rs3389088453 | 1220 | I>K | No | EVA | |
| rs3389148222 | 1225 | K>E | No | EVA | |
| rs3389149649 | 1225 | K>I | No | EVA | |
| rs3389146958 | 1228 | D>G | No | EVA | |
| rs240997656 | 1258 | A>T | No | EVA | |
| rs26836061 | 1322 | T>I | No | EVA | |
| rs256499734 | 1337 | T>P | No | EVA | |
| rs3389113118 | 1376 | Q>* | No | EVA | |
| rs253426435 | 1398 | R>K | No | EVA | |
| rs3389160963 | 1420 | F>S | No | EVA | |
| rs3389146980 | 1431 | N>K | No | EVA | |
| rs3389151993 | 1466 | T>S | No | EVA | |
| rs3389122081 | 1469 | L>P | No | EVA | |
| rs3389113069 | 1482 | E>D | No | EVA | |
| rs3389148245 | 1484 | V>L | No | EVA | |
| rs3389144142 | 1493 | P>S | No | EVA | |
| rs3389147034 | 1518 | D>E | No | EVA | |
| rs3389146993 | 1526 | L>V | No | EVA | |
| rs248629049 | 1544 | K>Q | No | EVA | |
| rs3389113088 | 1558 | H>Y | No | EVA | |
| rs3410685157 | 1572 | I>F | No | EVA | |
| rs3389160969 | 1590 | V>M | No | EVA | |
| rs3389149571 | 1646 | S>Y | No | EVA | |
| rs3389154600 | 1655 | S>I | No | EVA | |
| rs3389144197 | 1663 | E>D | No | EVA | |
| rs3389135654 | 1743 | V>M | No | EVA | |
| rs3389149989 | 1752 | A>S | No | EVA | |
| rs3402050859 | 1776 | N>T | No | EVA | |
| rs3389158515 | 1828 | M>V | No | EVA |
No associated diseases with Q8C3J5
4 regional properties for Q8C3J5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 142 - 522 | IPR002073 |
| domain | HD/PDEase domain | 216 - 389 | IPR003607 |
| domain | 3'5'-cyclic nucleotide phosphodiesterase N-terminal | 73 - 133 | IPR013706 |
| conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 259 - 270 | IPR023174 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| small GTPase binding | Binding to a small monomeric GTPase. |
| T cell receptor binding | Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. |
19 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| alpha-beta T cell activation | The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| alpha-beta T cell proliferation | The expansion of an alpha-beta T cell population by cell division. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| establishment of T cell polarity | The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. |
| immunological synapse formation | The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. |
| macropinocytosis | An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. |
| membrane raft polarization | The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. |
| myeloid dendritic cell activation involved in immune response | The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. |
| myoblast fusion | A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
| negative thymic T cell selection | The process of elimination of immature T cells in the thymus which react strongly with self-antigens. |
| positive regulation of phagocytosis | Any process that activates or increases the frequency, rate or extent of phagocytosis. |
| positive regulation of Rac protein signal transduction | Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction. |
| positive thymic T cell selection | The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
| T cell activation | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| T cell proliferation | The expansion of a T cell population by cell division. Follows T cell activation. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H7D0 | DOCK5 | Dedicator of cytokinesis protein 5 | Homo sapiens (Human) | PR |
| Q14185 | DOCK1 | Dedicator of cytokinesis protein 1 | Homo sapiens (Human) | PR |
| Q92608 | DOCK2 | Dedicator of cytokinesis protein 2 | Homo sapiens (Human) | PR |
| Q8BUR4 | Dock1 | Dedicator of cytokinesis protein 1 | Mus musculus (Mouse) | PR |
| Q8CIQ7 | Dock3 | Dedicator of cytokinesis protein 3 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPWRKTDKE | RHGVAIYNFQ | GSEAQHLTLQ | IGDVVRIQET | CGDWYRGYLI | KHKLSQGIFP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TSFIHLKEVT | VEKRRNIENI | IPAEIPLAQE | VTTTLWEWGS | IWKQLYVASK | KERFLQVQSM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MYDLMEWRSQ | LLSGTLPKDE | LKELKQKVTS | KIDYGNKILE | LDLIVRDEDG | NILDPDKTSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ISLFHAHEEA | TYKITERIKE | EMSKDQPDYG | VYSRISSSPT | HSLYVFVRNF | VCRIGEDAEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FMSLYDPHKQ | TVISENYLVR | WGSKGFPKEI | EMLNNLKVVF | TDLGNKDLNR | DKIFLICQIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RIGKMDLKDI | NAKKCTQGLR | RPFGVAVMDI | TDIIKGKAES | DEEKQHFIPF | HPVSAENDFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HSLLGKVIAS | KGDSGGQGLW | VTMKMLVGDI | IQIRKDYPHL | VDRTTVVARK | LGFPEIIMPG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DVRNDIYITL | LQGDFDKYTK | TTQRNVEVIM | CVCTEDGKVL | PNAICVGAGD | KAMNEYHSVV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YYQVKQPRWM | ETVKVAVPIE | DMQRIHLRFM | FRHRSSLESK | DKGEKNFAMS | YVKLMKEDGT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLHDGYHELV | VLKGDSKKME | DASAYLTLPS | YRHPVENKGA | TLSRSSSSVG | GLSVSSRDVF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SISTLVCSTK | LTQNVGLLGL | LKWRMKPQLL | QENLEKLKIV | DGEEVVKFLQ | DTLDALFNIM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MEHSQSNEYD | ILVFDALIYI | IGLIADRKFQ | HFNTVLEAYI | QQHFSATLAY | KKLMTVLKTY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LDTSSRGEQC | EPILRTLKAL | EYVFKFIVRS | RTLFSQLYEG | KEQMEFEESM | RRLFESINNL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MKSQYKTTIL | LQVAALKYIP | SVLHDVETVF | DAKLLSQLLY | EFYTCIPPVK | LQKQKVQSMN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EIVQSNLFKK | QECRDILLPV | ITKELKELLE | QRDDGQHQAE | KKHCVELLNS | ILEVLSCQDA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AFTYDHIQEI | MVQLLRTVNR | TVITMGRDHA | LISHFVACMT | AILDQMGDQH | YSFYIETFQT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SSDLVDFLME | TFIMFKDLIG | KNVYPGDWMA | MSMVQNRVFL | RAINKFAETM | NQKFLEHTSF |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EFQLWNNYFH | LAVAFITQDS | LQLEQFTHAK | YNKILNKYGD | MRRLIGFSIR | DMWYKLGQNK |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| ICFIPGMVGP | ILEMTLIPEA | ELRKATIPIF | FDMMLCEYQR | TGAFKKFENE | IILKLDHEVE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GGRGDEQYMQ | LLESILMECT | AEHPTIAKSV | ENFVSLVKGL | LEKLLDYRGV | MTDESKDNRM |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SCTVNLLNFY | KDNNREEMYI | RYLYKLRDLH | LDCENYTEAA | YTLLLHTWLL | KWSDEQCASQ |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VMQTGQQHPQ | THRQLKETLY | ETIIGYFDKG | KMWEEAISLC | KELAEQYEME | IFDYELLSQN |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LTQQAKFYEN | IMKILRTKPD | YFAVGYYGQG | FPSFLRNKVF | IYRGKEYERR | EDFQMQLLSQ |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| FPNAEKMNTT | SAPGDDVRNA | PGQYIQCFTV | QPVLDEHPRF | KNKPVPDQII | NFYKSNYVQK |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| FHYSRPVRRG | KVDPENEFAS | MWIERTSFLT | AYKLPGILRW | FEVVHMSQTT | ISPLENAIET |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| MSTVNEKILM | MINQYQSDES | LPINPLSMLL | NGIVDPAVMG | GFAKYEKAFF | TEEYSREHPE |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| DQDKLSHLKD | LIAWQIPFLG | AGIKIHEKRV | SDNLRPFHDR | MEECFKNLKM | KVEKEYGVRE |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| MPDFEDRRVG | RPRSMLRSYR | QMSVISLASM | HSDCSTPSKV | PAESFDLESA | PPKTPKVEEE |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| PISPGSTLPE | VKLRRSKKRT | KRSSVVFADE | KAATESDLKR | LSRKQEFMSD | TNLSEHAAIP |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| ARVSILSQMS | FASQSMPTIP | ALTLSVAGVP | GLDEANTSPR | LSQTFFQVSD | GDKKTLKKKK |
| 1810 | 1820 | ||||
| VNQFFKTMLA | SKSSEESKQI | PDFLSTNM |