Q8C0X8

PR
Gene name
Protein name
Sperm motility kinase X
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:381393
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

329-528 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

159-181 (Activation loop from InterPro)

Target domain

24-271 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8C0X8

Entry ID Method Resolution Chain Position Source
AF-Q8C0X8-F1 Predicted AlphaFoldDB

43 variants for Q8C0X8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388599766 7 C>S No EVA
rs108083617 17 D>E No EVA
rs27353683 37 E>D No EVA
rs3388595861 52 I>M No EVA
rs108110686 62 S>P No EVA
rs3388597743 68 I>L No EVA
rs582374828 89 T>S No EVA
rs3388600945 270 W>* No EVA
rs3388585958 281 S>Y No EVA
rs27353686 318 D>N No EVA
rs3388597638 321 M>K No EVA
rs3388599799 333 W>R No EVA
rs3388597614 346 C>Y No EVA
rs108794793 377 L>F No EVA
rs3388590852 381 S>* No EVA
rs3388600983 394 H>P No EVA
rs3388594911 397 P>L No EVA
rs587152872 399 T>M No EVA
rs3388603206 402 C>S No EVA
rs3388601749 404 N>K No EVA
rs3388595940 412 S>T No EVA
rs27353687 421 A>V No EVA
rs3388594909 426 S>N No EVA
rs3388595944 432 E>A No EVA
rs3388597584 454 H>Q No EVA
rs584248689 457 Q>H No EVA
rs580716518 524 G>R No EVA
rs587359440 533 V>F No EVA
rs3388597728 542 E>* No EVA
rs3388603261 543 A>V No EVA
rs3388590766 549 A>T No EVA
rs583777365 550 L>I No EVA
rs580564129 554 E>V No EVA
rs587159549 574 V>A No EVA
rs3388592368 581 R>* No EVA
rs3388601384 586 T>A No EVA
rs3388600930 588 R>K No EVA
rs585861760 599 C>F No EVA
rs3388600421 604 I>V No EVA
rs1132499911 617 A>V No EVA
rs3388597563 626 S>I No EVA
rs3388601717 631 A>V No EVA
rs3388597568 639 E>D No EVA

No associated diseases with Q8C0X8

9 regional properties for Q8C0X8

Type Name Position InterPro Accession
domain Protein kinase domain 68 - 326 IPR000719
domain EF-hand domain 369 - 440 IPR002048-1
domain EF-hand domain 441 - 511 IPR002048-2
active_site Serine/threonine-protein kinase, active site 188 - 200 IPR008271
binding_site Protein kinase, ATP binding site 74 - 101 IPR017441
binding_site EF-Hand 1, calcium-binding site 382 - 394 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 418 - 430 IPR018247-2
binding_site EF-Hand 1, calcium-binding site 454 - 466 IPR018247-3
binding_site EF-Hand 1, calcium-binding site 489 - 501 IPR018247-4

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P06782 SNF1 Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q96L34 MARK4 MAP/microtubule affinity-regulating kinase 4 Homo sapiens (Human) SS
P57059 SIK1 Serine/threonine-protein kinase SIK1 Homo sapiens (Human) PR
Q7KZI7 MARK2 Serine/threonine-protein kinase MARK2 Homo sapiens (Human) SS
P27448 MARK3 MAP/microtubule affinity-regulating kinase 3 Homo sapiens (Human) SS
Q9P0L2 MARK1 Serine/threonine-protein kinase MARK1 Homo sapiens (Human) EV
O60285 NUAK1 NUAK family SNF1-like kinase 1 Homo sapiens (Human) PR
Q8VHJ5 Mark1 Serine/threonine-protein kinase MARK1 Mus musculus (Mouse) SS
Q03141 Mark3 MAP/microtubule affinity-regulating kinase 3 Mus musculus (Mouse) SS
Q8CIP4 Mark4 MAP/microtubule affinity-regulating kinase 4 Mus musculus (Mouse) SS
Q05512 Mark2 Serine/threonine-protein kinase MARK2 Mus musculus (Mouse) SS
Q8C0N0 Gm4922 Sperm motility kinase Z Mus musculus (Mouse) PR
O35280 Chek1 Serine/threonine-protein kinase Chk1 Mus musculus (Mouse) PR
Q69Z98 Brsk2 Serine/threonine-protein kinase BRSK2 Mus musculus (Mouse) EV
Q5RJI5 Brsk1 Serine/threonine-protein kinase BRSK1 Mus musculus (Mouse) EV
Q61846 Melk Maternal embryonic leucine zipper kinase Mus musculus (Mouse) PR
O54863 Tssk2 Testis-specific serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q61241 Tssk1b Testis-specific serine/threonine-protein kinase 1 Mus musculus (Mouse) PR
A0AUV4 Gm7168 Sperm motility kinase Y Mus musculus (Mouse) PR
Q641K5 Nuak1 NUAK family SNF1-like kinase 1 Mus musculus (Mouse) PR
Q5EG47 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus (Mouse) SS
Q8BRK8 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Mus musculus (Mouse) SS
A2KF29 Smoktcr Sperm motility kinase Tcr mutant form Mus musculus (Mouse) PR
O08678 Mark1 Serine/threonine-protein kinase MARK1 Rattus norvegicus (Rat) SS
Q8VHF0 Mark3 MAP/microtubule affinity-regulating kinase 3 Rattus norvegicus (Rat) SS
O08679 Mark2 Serine/threonine-protein kinase MARK2 Rattus norvegicus (Rat) SS
Q8LIG4 CIPK3 CBL-interacting protein kinase 3 Oryza sativa subsp japonica (Rice) PR
Q852Q1 OSK4 Serine/threonine protein kinase OSK4 Oryza sativa subsp. japonica (Rice) SS
Q852Q2 OSK1 Serine/threonine protein kinase OSK1 Oryza sativa subsp. japonica (Rice) SS
Q6ZLP5 CIPK23 CBL-interacting protein kinase 23 Oryza sativa subsp japonica (Rice) PR
Q2RAX3 CIPK33 CBL-interacting protein kinase 33 Oryza sativa subsp japonica (Rice) PR
Q2QY53 CIPK32 CBL-interacting protein kinase 32 Oryza sativa subsp japonica (Rice) PR
Q9TW45 par-1 Serine/threonine-protein kinase par-1 Caenorhabditis elegans SS
Q94CG0 CIPK21 CBL-interacting serine/threonine-protein kinase 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q93VD3 CIPK23 CBL-interacting serine/threonine-protein kinase 23 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDI3 CIPK24 CBL-interacting serine/threonine-protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLZ3 KIN12 SNF1-related protein kinase catalytic subunit alpha KIN12 Arabidopsis thaliana (Mouse-ear cress) SS
P92958 KIN11 SNF1-related protein kinase catalytic subunit alpha KIN11 Arabidopsis thaliana (Mouse-ear cress) PR
Q38997 KIN10 SNF1-related protein kinase catalytic subunit alpha KIN10 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MKRWQACQDL RSNTFEDAAL TEHYEILTTL GQGTFGEVKL ASHLVTQTKV AIKILPKSRK
70 80 90 100 110 120
NSLVQPEIEI MKSLDHPHII KLLHIIDTTR NIFIVLEHAV GGELMSRIEE FGYLAEVECH
130 140 150 160 170 180
RLFKQLVYAL QYCHEKGIVH RDLKPENILL DHRGNVKLTD FGLGTKIIMG QKLVTFCGTL
190 200 210 220 230 240
PYCAPELFED RGYDGRATDV WSLGVVLYFM ATGCLPFNGY SYEAIKQKII AGKYPRSFSL
250 260 270 280 290 300
SPELWEVIAK LLTVNPGERP TVHDIARFKW LKPDNEASPA SLGENIESHP DPSIMVLMGV
310 320 330 340 350 360
MGYNPGEIRE SLREKKFDQV MATYLMLKQQ SAWENKTTKK PDPRLCDRML RSTEPTIKNQ
370 380 390 400 410 420
TSVRRASSVP THSTFSLPNE SESLEKGKRT TMSHSMPPTR NCFNEETTPL HSICPQLVQK
430 440 450 460 470 480
AHYRRSIWGE TEISDTSEES STGESLEHPS LKIHTLQTSM GVSKAGSTYS KSKGSSQCVS
490 500 510 520 530 540
SHHTSVEEDQ CEGTNISREI NPPLSPVSPQ ENLMGQLHIV TTAGSMDIMN TQVTSPPFSR
550 560 570 580 590 600
KEAKGEGPAL QQRESRPSSP NTLQGHLHGR RQTVPQAPFQ RRVWRTLRNG LIRGLRTLCC
610 620 630
CLPIERRVHP TNNRDLAVSQ KSHGGSHGIR AFRGTVLPEK