Q8C0N2

PR
Gene name
Gpat3
Protein name
Glycerol-3-phosphate acyltransferase 3
Names
GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, AGPAT 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, 1-AGP acyltransferase 9, 1-AGPAT 9, Acyl-CoA:glycerol-3-phosphate acyltransferase 3, mGPAT3, Lysophosphatidic acid acyltransferase theta, LPAAT-theta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:231510
EC number
2.3.1.15: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C0N2

Entry ID Method Resolution Chain Position Source
AF-Q8C0N2-F1 Predicted AlphaFoldDB

17 variants for Q8C0N2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388768856 24 L>* No EVA
rs3388754287 24 L>F No EVA
rs3413157062 29 G>R No EVA
rs3388773570 105 E>G No EVA
rs3388766691 106 A>P No EVA
rs3388759181 124 W>R No EVA
rs3388773723 141 L>R No EVA
rs3388774112 146 V>E No EVA
rs3388754316 153 Y>C No EVA
rs3395898452 170 L>* No EVA
rs3395257593 170 L>M No EVA
rs223133221 185 S>R No EVA
rs3388773294 221 K>N No EVA
rs3388771279 240 T>I No EVA
rs3412028325 375 E>D No EVA
rs3388766313 426 M>K No EVA
rs244804103 430 N>K No EVA

No associated diseases with Q8C0N2

No regional properties for Q8C0N2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8C0N2

Functions

Description
EC Number 2.3.1.15 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
1-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
glycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate.

5 GO annotations of biological process

Name Definition
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol.
phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.
regulation of TOR signaling Any process that modulates the frequency, rate or extent of TOR signaling.
triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A3FPG8 GPAT4 Glycerol-3-phosphate acyltransferase 4 Bos taurus (Bovine) PR
Q5ZLL8 GPAT3 Glycerol-3-phosphate acyltransferase 3 Gallus gallus (Chicken) PR
Q8NF37 LPCAT1 Lysophosphatidylcholine acyltransferase 1 Homo sapiens (Human) PR
Q86UL3 GPAT4 Glycerol-3-phosphate acyltransferase 4 Homo sapiens (Human) PR
Q8K2C8 Gpat4 Glycerol-3-phosphate acyltransferase 4 Mus musculus (Mouse) PR
Q6NVG1 Lpcat4 Lysophospholipid acyltransferase LPCAT4 Mus musculus (Mouse) PR
Q3TFD2 Lpcat1 Lysophosphatidylcholine acyltransferase 1 Mus musculus (Mouse) PR
Q8S8S2 LPEAT2 Lysophospholipid acyltransferase LPEAT2 Arabidopsis thaliana (Mouse-ear cress) PR
Q6PBN5 aup1 Lipid droplet-regulating VLDL assembly factor AUP1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
A3KGT9 agpat9l Glycerol-3-phosphate acyltransferase 3-like Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEGADLAVKL LSTWLTLVGG LILLPSAFGL SLGISEIYMK ILVKTLEWAT LRIQKGAPKE
70 80 90 100 110 120
SALKNSASVG IIQRDESPME KGLSGLRGRD FELSDVFYFS KKGLEAIVED EVTQRFSSEE
130 140 150 160 170 180
LVSWNLLTRT NVNFQYISPR LTMVWVLGVL VRYCFLLPLR VTLAFIGISL LIIGTTLVGQ
190 200 210 220 230 240
LPDSSLKNWL SELVHLTCCR ICVRSLSGTI HYHNKQYRPQ KGGICVANHT SPIDVLILAT
250 260 270 280 290 300
DGCYAMVGQV HGGLMGIIQR AMVKACPHVW FERSEIKDRH LVTKRLKEHI ADKKKLPILI
310 320 330 340 350 360
FPEGTCINNT SVMMFKKGSF EIGGTIYPVA IKYNPQFGDA FWNSSKYNLV SYLLRIMTSW
370 380 390 400 410 420
AIVCDVWYMP PMTREEGEDA VQFANRVKSA IAVQGGLTEL PWDGGLKRAK VKDTFKEEQQ
430
KNYSKMIVGN GSPNLARD