Q8C0N0

PR
Gene name
Gm4922
Protein name
Sperm motility kinase Z
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:237300
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

315-439 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

163-185 (Activation loop from InterPro)

Target domain

28-275 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8C0N0

Entry ID Method Resolution Chain Position Source
AF-Q8C0N0-F1 Predicted AlphaFoldDB

44 variants for Q8C0N0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs232250949 18 M>V No EVA
rs243766765 48 H>R No EVA
rs3389092688 49 L>I No EVA
rs3389092900 51 G>D No EVA
rs264170513 53 T>P No EVA
rs50928512 60 K>N No EVA
rs231812230 65 W>C No EVA
rs3389064421 84 V>I No EVA
rs51925484 93 E>G No EVA
rs3389078087 109 H>L No EVA
rs49611107 113 Q>R No EVA
rs3389087027 114 E>A No EVA
rs3389083752 181 C>Y No EVA
rs3389078097 202 V>I No EVA
rs3389064368 213 Y>N No EVA
rs3389092881 216 T>A No EVA
rs3389101458 218 I>F No EVA
rs3389092850 220 P>Q No EVA
rs231309130 232 E>G No EVA
rs262266858 232 E>K No EVA
rs3389068802 250 S>N No EVA
rs3389090560 251 M>V No EVA
rs3389033868 258 T>A No EVA
rs3389092698 267 Q>H No EVA
rs3389099416 275 L>F No EVA
rs3389083735 280 K>N No EVA
rs213234533 282 I>V No EVA
rs249970666 285 H>Y No EVA
rs3389099410 286 S>P No EVA
rs1131747140 287 N>H No EVA
rs1135089369 287 N>I No EVA
rs1132817836 288 G>V No EVA
rs50935046 289 D>G No EVA
rs1132499478 291 S>C No EVA
rs3389064380 310 D>V No EVA
rs3389089705 312 R>I No EVA
rs3389033882 317 H>N No EVA
rs47403792 339 G>C No EVA
rs51926525 352 P>S No EVA
rs45710395 357 V>A No EVA
rs215008568 406 M>T No EVA
rs47069570 408 R>K No EVA
rs3389092636 452 S>G No EVA
rs3389058300 459 P>H No EVA

No associated diseases with Q8C0N0

2 regional properties for Q8C0N0

Type Name Position InterPro Accession
domain Protein kinase domain 28 - 275 IPR000719
active_site Serine/threonine-protein kinase, active site 142 - 154 IPR008271

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P06782 SNF1 Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q96L34 MARK4 MAP/microtubule affinity-regulating kinase 4 Homo sapiens (Human) SS
P57059 SIK1 Serine/threonine-protein kinase SIK1 Homo sapiens (Human) PR
Q7KZI7 MARK2 Serine/threonine-protein kinase MARK2 Homo sapiens (Human) SS
P27448 MARK3 MAP/microtubule affinity-regulating kinase 3 Homo sapiens (Human) SS
Q9P0L2 MARK1 Serine/threonine-protein kinase MARK1 Homo sapiens (Human) EV
O60285 NUAK1 NUAK family SNF1-like kinase 1 Homo sapiens (Human) PR
Q8VHJ5 Mark1 Serine/threonine-protein kinase MARK1 Mus musculus (Mouse) SS
Q03141 Mark3 MAP/microtubule affinity-regulating kinase 3 Mus musculus (Mouse) SS
Q8CIP4 Mark4 MAP/microtubule affinity-regulating kinase 4 Mus musculus (Mouse) SS
Q05512 Mark2 Serine/threonine-protein kinase MARK2 Mus musculus (Mouse) SS
Q8C0X8 Sperm motility kinase X Mus musculus (Mouse) PR
O35280 Chek1 Serine/threonine-protein kinase Chk1 Mus musculus (Mouse) PR
Q69Z98 Brsk2 Serine/threonine-protein kinase BRSK2 Mus musculus (Mouse) EV
Q5RJI5 Brsk1 Serine/threonine-protein kinase BRSK1 Mus musculus (Mouse) EV
Q61846 Melk Maternal embryonic leucine zipper kinase Mus musculus (Mouse) PR
O54863 Tssk2 Testis-specific serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q61241 Tssk1b Testis-specific serine/threonine-protein kinase 1 Mus musculus (Mouse) PR
A0AUV4 Gm7168 Sperm motility kinase Y Mus musculus (Mouse) PR
Q641K5 Nuak1 NUAK family SNF1-like kinase 1 Mus musculus (Mouse) PR
Q5EG47 Prkaa1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus (Mouse) SS
Q8BRK8 Prkaa2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Mus musculus (Mouse) SS
A2KF29 Smoktcr Sperm motility kinase Tcr mutant form Mus musculus (Mouse) PR
O08678 Mark1 Serine/threonine-protein kinase MARK1 Rattus norvegicus (Rat) SS
Q8VHF0 Mark3 MAP/microtubule affinity-regulating kinase 3 Rattus norvegicus (Rat) SS
O08679 Mark2 Serine/threonine-protein kinase MARK2 Rattus norvegicus (Rat) SS
Q8LIG4 CIPK3 CBL-interacting protein kinase 3 Oryza sativa subsp japonica (Rice) PR
Q852Q1 OSK4 Serine/threonine protein kinase OSK4 Oryza sativa subsp. japonica (Rice) SS
Q852Q2 OSK1 Serine/threonine protein kinase OSK1 Oryza sativa subsp. japonica (Rice) SS
Q6ZLP5 CIPK23 CBL-interacting protein kinase 23 Oryza sativa subsp japonica (Rice) PR
Q2RAX3 CIPK33 CBL-interacting protein kinase 33 Oryza sativa subsp japonica (Rice) PR
Q2QY53 CIPK32 CBL-interacting protein kinase 32 Oryza sativa subsp japonica (Rice) PR
Q9TW45 par-1 Serine/threonine-protein kinase par-1 Caenorhabditis elegans SS
Q94CG0 CIPK21 CBL-interacting serine/threonine-protein kinase 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q93VD3 CIPK23 CBL-interacting serine/threonine-protein kinase 23 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDI3 CIPK24 CBL-interacting serine/threonine-protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FLZ3 KIN12 SNF1-related protein kinase catalytic subunit alpha KIN12 Arabidopsis thaliana (Mouse-ear cress) SS
P92958 KIN11 SNF1-related protein kinase catalytic subunit alpha KIN11 Arabidopsis thaliana (Mouse-ear cress) PR
Q38997 KIN10 SNF1-related protein kinase catalytic subunit alpha KIN10 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MYSDSEDESS ELSTVLSMFE EKEFTRQYTV LKTLSQHGTT EVRLCSHHLT GVTVAVKALK
70 80 90 100 110 120
YQRWWEPKVS EVEIMKMLSH PNIVSLLQVI ETEQNIYLIM EVAQGTQLHN RVQEARCLKE
130 140 150 160 170 180
DEARSIFVQL LSAIGYCHGE GVVHRDLKPD NVIVDEHGNV KIVDFGLGAR FMPGQKLERL
190 200 210 220 230 240
CGAFQFIPPE IFLGLPYDGP KVDIWALGVL LYYMVTGIFP FVGSTLSEIS KEVLQGRYEI
250 260 270 280 290 300
PYNLSKDLRS MIGLLLATNA RQRPTAQDLL SHPWLQEGEK TITFHSNGDT SFPDPDIMAA
310 320 330 340 350 360
MKNIGFHVQD IRESLKHRKF DETMATYNLL RAEACQDDGN YVQTKLMNPG MPPFPSVTDS
370 380 390 400 410 420
GAFSLPPRRR ASEPSFKVLV SSTEEHQLRQ TGGTNAPFPP KKTPTMGRSQ KQKRAMTAPC
430 440 450 460 470 480
ICLLRNTYID TEDSSFCTSS QAEKTSSDPE KSETSTSCPL TPRGWRKWKK RIVACIQTLC
490
CCTLPQKKCP RSVHPQK