Q8C078
PR
Gene name |
Camkk2 (Kiaa0787) |
Protein name |
Calcium/calmodulin-dependent protein kinase kinase 2 |
Names |
CaM-KK 2, CaM-kinase kinase 2, CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:207565 |
EC number |
2.7.11.17: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C078
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C078-F1 | Predicted | AlphaFoldDB |
29 variants for Q8C078
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388785589 | 8 | Q>H | No | EVA | |
| rs3388782395 | 15 | A>T | No | EVA | |
| rs3388775056 | 61 | R>Q | No | EVA | |
| rs3388796842 | 118 | N>T | No | EVA | |
| rs3388790953 | 181 | L>Q | No | EVA | |
| rs3388791542 | 205 | A>T | No | EVA | |
| rs3388787541 | 208 | P>T | No | EVA | |
| rs3388782330 | 213 | P>S | No | EVA | |
| rs3388796837 | 222 | G>D | No | EVA | |
| rs3388779132 | 223 | C>Y | No | EVA | |
| rs37682198 | 244 | D>H | No | EVA | |
| rs3396050400 | 271 | N>H | No | EVA | |
| rs3412964911 | 311 | R>L | No | EVA | |
| rs3388771888 | 331 | F>C | No | EVA | |
| rs3388796810 | 335 | N>I | No | EVA | |
| rs51665226 | 348 | V>G | No | EVA | |
| rs3388796849 | 358 | S>P | No | EVA | |
| rs3388793483 | 369 | K>E | No | EVA | |
| rs3388791463 | 375 | A>V | No | EVA | |
| rs3388779216 | 421 | D>Y | No | EVA | |
| rs3388785598 | 427 | L>V | No | EVA | |
| rs3388790574 | 432 | E>K | No | EVA | |
| rs3388796851 | 434 | R>M | No | EVA | |
| rs3388785935 | 450 | G>E | No | EVA | |
| rs3388783994 | 476 | K>I | No | EVA | |
| rs3388790365 | 496 | F>L | No | EVA | |
| rs3388790581 | 508 | R>S | No | EVA | |
| rs3388782378 | 553 | S>C | No | EVA | |
| rs3388771880 | 572 | S>P | No | EVA |
No associated diseases with Q8C078
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.17 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of protein kinase activity | Any process that initiates the activity of an inactive protein kinase. |
| CAMKK-AMPK signaling cascade | The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N5S9 | CAMKK1 | Calcium/calmodulin-dependent protein kinase kinase 1 | Homo sapiens (Human) | SS |
| Q96RR4 | CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2 | Homo sapiens (Human) | PR |
| Q8VBY2 | Camkk1 | Calcium/calmodulin-dependent protein kinase kinase 1 | Mus musculus (Mouse) | PR |
| Q5JLQ9 | CIPK30 | CBL-interacting protein kinase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q5QNM6 | CIPK13 | Putative CBL-interacting protein kinase 13 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ERS4 | CIPK16 | CBL-interacting protein kinase 16 | Oryza sativa subsp japonica (Rice) | PR |
| Q852Q0 | OSK3 | Serine/threonine protein kinase OSK3 | Oryza sativa subsp. japonica (Rice) | SS |
| O65554 | CIPK6 | CBL-interacting serine/threonine-protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJ54 | CIPK20 | CBL-interacting serine/threonine-protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22971 | CIPK13 | CBL-interacting serine/threonine-protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q2V452 | CIPK3 | CBL-interacting serine/threonine-protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSCVSSQPT | SDRVAPQDEL | GSGGGSREGQ | KPCEALRGLS | SLSIHLGMES | FIVVTECEPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGVDLNLARD | QPPEADGQEL | PLEASDPESR | SPLSGRKMSL | QEPSQGGPAS | SSNSLDMNGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CICPSLSYSP | ASSPQSSPRM | PRRPTVESHH | VSITGLQDCV | QLNQYTLKDE | IGKGSYGVVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAYNENDNTY | YAMKVLSKKK | LIRQAGFPRR | PPPRGARPAP | GGCIQPRGPI | EQVYQEIAIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKLDHPNVVK | LVEVLDDPNE | DHLYMVFELV | NQGPVMEVPT | LKPLSEDQAR | FYFQDLIKGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EYLHYQKIIH | RDIKPSNLLV | GEDGHIKIAD | FGVSNEFKGS | DALLSNTVGT | PAFMAPESLS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ETRKIFSGKA | LDVWAMGVTL | YCFVFGQCPF | MDERIMCLHS | KIKSQALEFP | DQPDIAEDLK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLITRMLDKN | PESRIVVPEI | KLHPWVTRHG | AEPLPSEDEN | CTLVEVTEEE | VENSVKHIPS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LATVILVKTM | IRKRSFGNPF | EGSRREERSL | SAPGNLLTKK | PTREWEPLSE | PKEARQRRQP |
| 550 | 560 | 570 | 580 | ||
| PGPRAGPCGG | GGSALVKGGP | CVESWGAPAP | GSPPRMPPLQ | PEEVMEPE |