Q8C050
Gene name |
Rps6ka5 (Msk1) |
Protein name |
Ribosomal protein S6 kinase alpha-5 |
Names |
S6K-alpha-5, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, RSK-like protein kinase, RLSK |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:73086 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
628-651 (Activation loop from InterPro)
Target domain |
425-751 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8C050
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C050-F1 | Predicted | AlphaFoldDB |
48 variants for Q8C050
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389213894 | 41 | E>V | No | EVA | |
| rs3389255421 | 42 | K>S | No | EVA | |
| rs3389248123 | 52 | K>SDG* | No | EVA | |
| rs3389251918 | 63 | F>S | No | EVA | |
| rs3389264728 | 87 | I>K | No | EVA | |
| rs3389258481 | 112 | F>C | No | EVA | |
| rs3389251933 | 116 | L>W | No | EVA | |
| rs3389255469 | 117 | H>L | No | EVA | |
| rs3389264703 | 135 | G>V | No | EVA | |
| rs3389269456 | 137 | E>G | No | EVA | |
| rs3389187215 | 138 | L>P | No | EVA | |
| rs3389256696 | 138 | L>V | No | EVA | |
| rs3389269453 | 150 | E>* | No | EVA | |
| rs3389256686 | 172 | I>F | No | EVA | |
| rs3389256680 | 172 | I>S | No | EVA | |
| rs3389263400 | 181 | N>D | No | EVA | |
| rs3389187218 | 201 | F>Y | No | EVA | |
| rs3402974452 | 207 | E>* | No | EVA | |
| rs3389251666 | 215 | T>A | No | EVA | |
| rs3389187298 | 220 | A>T | No | EVA | |
| rs3389251919 | 234 | A>T | No | EVA | |
| rs3389255460 | 250 | G>R | No | EVA | |
| rs1135340979 | 260 | K>N | No | EVA | |
| rs256425866 | 335 | K>R | No | EVA | |
| rs3389248115 | 380 | S>Y | No | EVA | |
| rs3389269387 | 393 | L>F | No | EVA | |
| rs3389213971 | 403 | G>E | No | EVA | |
| rs3389256694 | 444 | H>L | No | EVA | |
| rs3389250507 | 464 | T>N | No | EVA | |
| rs3389256713 | 468 | I>K | No | EVA | |
| rs3389222789 | 470 | A>D | No | EVA | |
| rs3402270924 | 496 | Q>E | No | EVA | |
| rs229627675 | 519 | R>L | No | EVA | |
| rs3389222822 | 531 | T>S | No | EVA | |
| rs47223050 | 550 | L>F | No | EVA | |
| rs3412881350 | 593 | V>L | No | EVA | |
| rs3389252851 | 626 | K>N | No | EVA | |
| rs3403702896 | 700 | E>V | No | EVA | |
| rs3403951747 | 705 | I>V | No | EVA | |
| rs3389258490 | 785 | A>T | No | EVA | |
| rs3389251645 | 792 | E>G | No | EVA | |
| rs3389222771 | 805 | A>D | No | EVA | |
| rs3389256661 | 816 | S>I | No | EVA | |
| rs3389255388 | 818 | E>A | No | EVA | |
| rs3389240365 | 822 | S>N | No | EVA | |
| rs3389256656 | 826 | S>T | No | EVA | |
| rs3389187266 | 851 | E>A | No | EVA | |
| rs256164134 | 853 | S>G | No | EVA |
No associated diseases with Q8C050
5 regional properties for Q8C050
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 13 - 268 | IPR000719 |
| domain | NAF domain | 309 - 370 | IPR004041 |
| active_site | Serine/threonine-protein kinase, active site | 132 - 144 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 19 - 42 | IPR017441 |
| domain | NAF/FISL domain | 307 - 331 | IPR018451 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| histone kinase activity (H2A-S1 specific) | Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A. |
| histone kinase activity (H3-S10 specific) | Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3. |
| histone kinase activity (H3-S28 specific) | Catalysis of the transfer of a phosphate group to the serine-28 residue of histone H3. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| interleukin-1-mediated signaling pathway | The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of histone acetylation | Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| post-translational protein modification | The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P18652 | RPS6KA | Ribosomal protein S6 kinase 2 alpha | Gallus gallus (Chicken) | SS |
| Q5F3L1 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | Gallus gallus (Chicken) | SS |
| Q9UK32 | RPS6KA6 | Ribosomal protein S6 kinase alpha-6 | Homo sapiens (Human) | SS |
| O75676 | RPS6KA4 | Ribosomal protein S6 kinase alpha-4 | Homo sapiens (Human) | SS |
| Q96S38 | RPS6KC1 | Ribosomal protein S6 kinase delta-1 | Homo sapiens (Human) | PR |
| P51812 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | Homo sapiens (Human) | EV |
| Q15349 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | Homo sapiens (Human) | SS |
| Q15418 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | Homo sapiens (Human) | EV |
| O75582 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | Homo sapiens (Human) | SS |
| Q8BLK9 | Rps6kc1 | Ribosomal protein S6 kinase delta-1 | Mus musculus (Mouse) | PR |
| Q9WUT3 | Rps6ka2 | Ribosomal protein S6 kinase alpha-2 | Mus musculus (Mouse) | SS |
| P18653 | Rps6ka1 | Ribosomal protein S6 kinase alpha-1 | Mus musculus (Mouse) | SS |
| P18654 | Rps6ka3 | Ribosomal protein S6 kinase alpha-3 | Mus musculus (Mouse) | SS |
| Q9Z2B9 | Rps6ka4 | Ribosomal protein S6 kinase alpha-4 | Mus musculus (Mouse) | SS |
| Q9Z1M4 | Rps6kb2 | Ribosomal protein S6 kinase beta-2 | Mus musculus (Mouse) | SS |
| Q8BSK8 | Rps6kb1 | Ribosomal protein S6 kinase beta-1 | Mus musculus (Mouse) | SS |
| Q63531 | Rps6ka1 | Ribosomal protein S6 kinase alpha-1 | Rattus norvegicus (Rat) | SS |
| Q21734 | rskn-1 | Putative ribosomal protein S6 kinase alpha-1 | Caenorhabditis elegans | SS |
| Q18846 | rskn-2 | Putative ribosomal protein S6 kinase alpha-2 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGEGGGSGG | AGTSGDSGDG | GEQLLTVKHE | LRTANLTGHA | EKVGIENFEL | LKVLGTGAYG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KVFLVRKISG | HDAGKLYAMK | VLKKATIVQK | AKTTEHTRTE | RQVLEHIRQS | PFLVTLHYAF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QTETKLHLIL | DYINGGELFT | HLSQRERFTE | HEVQIYVGEI | VLALEHLHKL | GIIYRDIKLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NILLDSNGHV | VLTDFGLSKE | FVADETERAY | SFCGTIEYMA | PDIVRGGDSG | HDKAVDWWSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GVLMYELLTG | ASPFTVDGEK | NSQAEISRRI | LKSEPPYPQE | MSTVAKDLLQ | RLLMKDPKKR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGCGPRDAEE | IKEHLFFEKI | KWDDLAAKKV | PAPFKPVIRD | ELDVSNFAEE | FTEMDPTYSP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AALPQSSERL | FQGYSFVAPS | ILFKRNAAVI | DPLQFHMGVD | RPGVTNVARS | AMMKDSPFYQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HYDLDLKDKP | LGEGSFSICR | KCVHKKTNQA | FAVKIISKRM | EANTQKEITA | LKLCEGHPNI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VKLHEVFHDQ | VAASAQPPGQ | VVLCSLLLLA | LLFNRSLTRK | PVTWTWLVHS | TSQLPPLPPP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MPEIVLFILL | SDNGQLHTFL | VMELLNGGEL | FERIKRKKHF | SETEASYIMR | KLVSAVSHMH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DVGVVHRDLK | PENLLFTDEN | DNLEIKVIDF | GFARLKPPDN | QPLKTPCFTL | HYAAPELLTH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NGYDESCDLW | SLGVILYTML | SGQVPFQSHD | RSLTCTSAVE | IMKKIKKGDF | SFEGEAWKNV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SQEAKDLIQG | LLTVDPNKRL | KMSGLRYNEW | LQDGSQLSSN | PLMTPDILGS | SGAAVHTCVK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ATFHAFNKYK | REGFCLQNVD | KAPLAKRRKM | KRTSTSTETR | SSSSESSRSS | SSQSHGKTTP |
| 850 | 860 | ||||
| TKTLQPSNPT | EGSNPDTLFQ | FSD |