Q8BZZ3

SS
Gene name
Wwp1
Protein name
NEDD4-like E3 ubiquitin-protein ligase WWP1
Names
EC 2.3.2.26 , HECT-type E3 ubiquitin transferase WWP1 , WW domain-containing protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:107568
EC number
2.3.2.26: Aminoacyltransferases
Protein Class

Descriptions

The C2-WW-HECT-domain E3 proteins downregulates transforming growth factor-β (TGF-β) signaling by targeting itself, the adaptor protein Smad7, and TGF-β receptor kinases for degradation. Like Smurf2, which exhibits the inhibitory C2 and HECT domain interaction, the full-length WWP2 enzyme shows low ubiquitination levels by the C2 domain. The level is significantly enhanced by deleting C2 domain.

Autoinhibitory domains (AIDs)

1-115 (C2 domain) SS

Target domain

564-916 (HECT domain)

Relief mechanism

Partner binding

Assay

411-451 (WW2-WW3 linker region) SS

Target domain

563-918 (HECT domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BZZ3

Entry ID Method Resolution Chain Position Source
AF-Q8BZZ3-F1 Predicted AlphaFoldDB

31 variants for Q8BZZ3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388675221 56 S>A No EVA
rs3388667246 111 K>T No EVA
rs3388661329 142 L>F No EVA
rs239903435 152 R>C No EVA
rs223396609 152 R>L No EVA
rs27666867 172 D>N No EVA
rs3388672565 186 T>N No EVA
rs3388672158 209 N>D No EVA
rs264374284 216 S>P No EVA
rs247913285 226 N>T No EVA
rs3388667193 236 A>E No EVA
rs1131840325 305 E>D No EVA
rs1134985249 306 A>T No EVA
rs1131947117 309 L>I No EVA
rs1132857073 315 D>E No EVA
rs3507728617 325 V>A No EVA
rs3388670268 364 V>G No EVA
rs3388675776 411 E>Q No EVA
rs3388674703 490 N>K No EVA
rs3388668733 646 N>I No EVA
rs864267232 659 F>V No EVA
rs3394003738 683 L>V No EVA
rs3388661319 714 C>Y No EVA
rs3388678526 772 F>L No EVA
rs3388678545 782 L>R No EVA
rs3388663175 796 M>I No EVA
rs3388672124 812 T>A No EVA
rs3388667192 813 V>I No EVA
rs3388673399 826 W>R No EVA
rs3388675240 839 R>* No EVA
rs3542102385 902 K>T No EVA

No associated diseases with Q8BZZ3

6 regional properties for Q8BZZ3

Type Name Position InterPro Accession
domain C2 domain 1 - 116 IPR000008
domain HECT domain 564 - 918 IPR000569
domain WW domain 345 - 378 IPR001202-1
domain WW domain 377 - 410 IPR001202-2
domain WW domain 452 - 485 IPR001202-3
domain WW domain 492 - 525 IPR001202-4

Functions

Description
EC Number 2.3.2.26 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

6 GO annotations of biological process

Name Definition
lung development The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

23 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39940 RSP5 E3 ubiquitin-protein ligase RSP5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9V853 Smurf E3 ubiquitin-protein ligase Smurf1 Drosophila melanogaster (Fruit fly) SS
Q9Y0H4 Su(dx) E3 ubiquitin-protein ligase Su Drosophila melanogaster (Fruit fly) SS
Q9HAU4 SMURF2 E3 ubiquitin-protein ligase SMURF2 Homo sapiens (Human) EV
O00308 WWP2 NEDD4-like E3 ubiquitin-protein ligase WWP2 Homo sapiens (Human) EV
Q9HCE7 SMURF1 E3 ubiquitin-protein ligase SMURF1 Homo sapiens (Human) PR
O95817 BAG3 BAG family molecular chaperone regulator 3 Homo sapiens (Human) PR
Q96PU5 NEDD4L E3 ubiquitin-protein ligase NEDD4-like Homo sapiens (Human) PR
O60861 GAS7 Growth arrest-specific protein 7 Homo sapiens (Human) PR
P46934 NEDD4 E3 ubiquitin-protein ligase NEDD4 Homo sapiens (Human) EV
Q96J02 ITCH E3 ubiquitin-protein ligase Itchy homolog Homo sapiens (Human) EV
Q9H0M0 WWP1 NEDD4-like E3 ubiquitin-protein ligase WWP1 Homo sapiens (Human) EV
Q60780 Gas7 Growth arrest-specific protein 7 Mus musculus (Mouse) PR
P46935 Nedd4 E3 ubiquitin-protein ligase NEDD4 Mus musculus (Mouse) PR
Q9CUN6 Smurf1 E3 ubiquitin-protein ligase SMURF1 Mus musculus (Mouse) PR
Q9DBH0 Wwp2 NEDD4-like E3 ubiquitin-protein ligase WWP2 Mus musculus (Mouse) SS
A2A5Z6 Smurf2 E3 ubiquitin-protein ligase SMURF2 Mus musculus (Mouse) SS
Q8C863 Itch E3 ubiquitin-protein ligase Itchy Mus musculus (Mouse) EV
Q3U0D9 Hace1 E3 ubiquitin-protein ligase HACE1 Mus musculus (Mouse) SS
Q8CFI0 Nedd4l E3 ubiquitin-protein ligase NEDD4-like Mus musculus (Mouse) PR
Q62940 Nedd4 E3 ubiquitin-protein ligase NEDD4 Rattus norvegicus (Rat) PR
Q9N2Z7 wwp-1 E3 ubiquitin-protein ligase wwp-1 Caenorhabditis elegans SS
A9JRZ0 smurf2 E3 ubiquitin-protein ligase SMURF2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MATASPRSDT SDIHSGRLQL KVTVSSAKLK RKKNWFGTAI YTEVIVDGEV KKTAKSSSSS
70 80 90 100 110 120
NPKWDEQLIV NVTPQTTLEF RVWSHHTLKA DALLGKATVD LKQVLLTHNR KLEKVKEQLK
130 140 150 160 170 180
LSLENKNGIV QTGELTVVLD GLVIEQEPVT NRSSSPPIEI QQNGDALHEN GDPATRTTPR
190 200 210 220 230 240
LPVEGTIGID NHVSTNTVVP NSCCSHVVNG ENTPSSPSQV AARPKNAPAP KPVTSAPTSD
250 260 270 280 290 300
TVNGESSSVL ADNTSTMGTL LPSEDTTSTS NCTSTTTQEP PVQEPPASSE HSECIPSASA
310 320 330 340 350 360
EVGPEARSLI DPDSDSRNNS VFDKVRQPEG CVEPLRPQSG NTNTEALPSG WEQRKDPHGR
370 380 390 400 410 420
TYYVDHNTRT TTWERPQPLP PGWERRVDDR GRVYYVDHNT RTTTWQRPTM ESVRNFEQWQ
430 440 450 460 470 480
SQRNQLQGAM QQFNQRYLYS ASMLAAENDP YGPLPPGWEK RVDSTDRVYF VNHNTKTTQW
490 500 510 520 530 540
EDPRTQGLPN EEPLPEGWEI RYTREGVRYF VDHNTRTTTF KDPRNGKSSV TKGGPQIAYE
550 560 570 580 590 600
RSFRWKLAHF RYLCQSNALP SHVKINVSRQ TLFEDSFQQI MALKPYDLRR RLYVIFRGEE
610 620 630 640 650 660
GLDYGGLARE WFFLLSHEVL NPMYCLFEYA GKNNYCLQIN PASTINPDHL SYFCFIGRFI
670 680 690 700 710 720
AMALFHGKFI DTGFSLPFYK RMLSKKLTIK DLESIDTEFY NSLIWIRDNN IEECGLEMYF
730 740 750 760 770 780
SVDMEILGKV TSHDLKLGGS NILVTEENKD EYIGLMTEWR FSRGVQEQTK AFLDGFNEVV
790 800 810 820 830 840
PLQWLQYFDE KELEVMLCGM QEVDLADWQR NTVYRHYTRN SKQIIWFWQF VKETDNEVRM
850 860 870 880 890 900
RLLQFVTGTC RLPLGGFAEL MGSNGPQKFC IEKVGKDTWL PRSHTCFNRL DLPPYKSYEQ
910
LKEKLLFAIE ETEGFGQE