Q8BZT2
PR
Gene name |
Sh3rf2 (Posh3, Ppp1r39, Rnf158) |
Protein name |
E3 ubiquitin-protein ligase SH3RF2 |
Names |
Protein phosphatase 1 regulatory subunit 39, RING finger protein 158, RING-type E3 ubiquitin transferase SH3RF2, SH3 domain-containing RING finger protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:269016 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q8BZT2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2CUC | NMR | - | A | 385-441 | PDB |
| 2DJQ | NMR | - | A | 128-182 | PDB |
| AF-Q8BZT2-F1 | Predicted | AlphaFoldDB |
49 variants for Q8BZT2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389494563 | 2 | D>E | No | EVA | |
| rs3408101517 | 15 | C>G | No | EVA | |
| rs3407417914 | 16 | F>L | No | EVA | |
| rs3407417869 | 18 | K>N | No | EVA | |
| rs3389499259 | 18 | K>R | No | EVA | |
| rs247903170 | 21 | V>A | No | EVA | |
| rs3389447898 | 49 | C>S | No | EVA | |
| rs3389492520 | 51 | E>D | No | EVA | |
| rs3389447862 | 57 | F>Y | No | EVA | |
| rs3389466332 | 62 | A>T | No | EVA | |
| rs3389492506 | 86 | G>A | No | EVA | |
| rs224494940 | 120 | V>I | No | EVA | |
| rs3389514538 | 124 | M>L | No | EVA | |
| rs3408645502 | 125 | D>E | No | EVA | |
| rs3389500336 | 256 | L>I | No | EVA | |
| rs3389410564 | 257 | L>P | No | EVA | |
| rs3389503756 | 265 | S>L | No | EVA | |
| rs3389496388 | 267 | T>I | No | EVA | |
| rs3389494620 | 299 | G>R | No | EVA | |
| rs3408374916 | 351 | S>C | No | EVA | |
| rs3408557670 | 352 | S>C | No | EVA | |
| rs241026896 | 353 | T>A | No | EVA | |
| rs3408645468 | 353 | T>R | No | EVA | |
| rs3407418397 | 355 | Q>L | No | EVA | |
| rs3389514583 | 359 | S>Y | No | EVA | |
| rs3389457511 | 368 | H>Q | No | EVA | |
| rs259249556 | 372 | M>L | No | EVA | |
| rs3389514611 | 459 | T>S | No | EVA | |
| rs3389503806 | 461 | C>S | No | EVA | |
| rs3389494571 | 477 | F>L | No | EVA | |
| rs3389466329 | 479 | E>D | No | EVA | |
| rs244629030 | 483 | R>Q | No | EVA | |
| rs3389500310 | 496 | A>T | No | EVA | |
| rs3389496383 | 504 | T>I | No | EVA | |
| rs3389512224 | 518 | V>M | No | EVA | |
| rs3389492479 | 519 | R>W | No | EVA | |
| rs262772941 | 532 | V>I | No | EVA | |
| rs3408646869 | 539 | F>S | No | EVA | |
| rs3389466313 | 560 | Y>N | No | EVA | |
| rs3389512259 | 575 | E>V | No | EVA | |
| rs239931621 | 589 | T>P | No | EVA | |
| rs3389496385 | 604 | N>D | No | EVA | |
| rs3389496430 | 630 | S>F | No | EVA | |
| rs3389508532 | 632 | L>F | No | EVA | |
| rs3389499244 | 637 | N>H | No | EVA | |
| rs3389503750 | 641 | G>D | No | EVA | |
| rs3389514610 | 649 | V>A | No | EVA | |
| rs3389479139 | 666 | P>A | No | EVA | |
| rs3389501537 | 681 | Q>H | No | EVA |
No associated diseases with Q8BZT2
10 regional properties for Q8BZT2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Armadillo | 116 - 157 | IPR000225-1 |
| repeat | Armadillo | 159 - 203 | IPR000225-2 |
| repeat | Armadillo | 201 - 242 | IPR000225-3 |
| repeat | Armadillo | 245 - 284 | IPR000225-4 |
| repeat | Armadillo | 286 - 326 | IPR000225-5 |
| repeat | Armadillo | 328 - 368 | IPR000225-6 |
| repeat | Armadillo | 370 - 410 | IPR000225-7 |
| repeat | Armadillo | 413 - 453 | IPR000225-8 |
| domain | Importin-alpha, importin-beta-binding domain | 1 - 105 | IPR002652 |
| repeat | Atypical Arm repeat | 467 - 513 | IPR032413 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| phosphatase binding | Binding to a phosphatase. |
| protein phosphatase 1 binding | Binding to a protein phosphatase 1. |
| protein phosphatase inhibitor activity | Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of JNK cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
| negative regulation of protein ubiquitination | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of JNK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein autoubiquitination | The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9G4 | TRIM10 | Tripartite motif-containing protein 10 | Bos taurus (Bovine) | PR |
| Q2T9Z0 | TRIM17 | E3 ubiquitin-protein ligase TRIM17 | Bos taurus (Bovine) | PR |
| E1BJS7 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Bos taurus (Bovine) | PR |
| Q7YRV4 | TRIM21 | E3 ubiquitin-protein ligase TRIM21 | Bos taurus (Bovine) | PR |
| Q1PRL4 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Gallus gallus (Chicken) | PR |
| Q7YR32 | TRIM10 | Tripartite motif-containing protein 10 | Pan troglodytes (Chimpanzee) | PR |
| O15553 | MEFV | Pyrin | Homo sapiens (Human) | SS |
| Q9BTV5 | FSD1 | Fibronectin type III and SPRY domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q9H2S5 | RNF39 | RING finger protein 39 | Homo sapiens (Human) | PR |
| P19474 | TRIM21 | E3 ubiquitin-protein ligase TRIM21 | Homo sapiens (Human) | PR |
| Q9UJV3 | MID2 | Probable E3 ubiquitin-protein ligase MID2 | Homo sapiens (Human) | PR |
| P29590 | PML | Protein PML | Homo sapiens (Human) | PR |
| Q9C029 | TRIM7 | E3 ubiquitin-protein ligase TRIM7 | Homo sapiens (Human) | PR |
| Q9NQ86 | TRIM36 | E3 ubiquitin-protein ligase TRIM36 | Homo sapiens (Human) | PR |
| Q86UV6 | TRIM74 | Tripartite motif-containing protein 74 | Homo sapiens (Human) | PR |
| Q9UPQ4 | TRIM35 | E3 ubiquitin-protein ligase TRIM35 | Homo sapiens (Human) | PR |
| Q6ZMU5 | TRIM72 | Tripartite motif-containing protein 72 | Homo sapiens (Human) | PR |
| Q86UV7 | TRIM73 | Tripartite motif-containing protein 73 | Homo sapiens (Human) | PR |
| Q8N9V2 | TRIML1 | Probable E3 ubiquitin-protein ligase TRIML1 | Homo sapiens (Human) | PR |
| Q86XT4 | TRIM50 | E3 ubiquitin-protein ligase TRIM50 | Homo sapiens (Human) | PR |
| Q5EBN2 | TRIM61 | Putative tripartite motif-containing protein 61 | Homo sapiens (Human) | PR |
| Q9BZY9 | TRIM31 | E3 ubiquitin-protein ligase TRIM31 | Homo sapiens (Human) | PR |
| Q2Q1W2 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Homo sapiens (Human) | PR |
| Q9BXM9 | FSD1L | FSD1-like protein | Homo sapiens (Human) | PR |
| Q9WUH5 | Trim10 | Tripartite motif-containing protein 10 | Mus musculus (Mouse) | PR |
| Q7TPM3 | Trim17 | E3 ubiquitin-protein ligase TRIM17 | Mus musculus (Mouse) | PR |
| Q1XH17 | Trim72 | Tripartite motif-containing protein 72 | Mus musculus (Mouse) | PR |
| Q60953 | Pml | Protein PML | Mus musculus (Mouse) | PR |
| Q9JJ26 | Mefv | Pyrin | Mus musculus (Mouse) | SS |
| Q99PQ1 | Trim12a | Tripartite motif-containing protein 12A | Mus musculus (Mouse) | PR |
| Q61510 | Trim25 | E3 ubiquitin/ISG15 ligase TRIM25 | Mus musculus (Mouse) | PR |
| Q810I2 | Trim50 | E3 ubiquitin-protein ligase TRIM50 | Mus musculus (Mouse) | PR |
| Q1PSW8 | Trim71 | E3 ubiquitin-protein ligase TRIM71 | Mus musculus (Mouse) | PR |
| Q3TL54 | Trim43a | Tripartite motif-containing protein 43A | Mus musculus (Mouse) | PR |
| P86449 | Trim43c | Tripartite motif-containing protein 43C | Mus musculus (Mouse) | PR |
| Q9JK48 | Sh3glb1 | Endophilin-B1 | Mus musculus (Mouse) | PR |
| Q62420 | Sh3gl2 | Endophilin-A1 | Mus musculus (Mouse) | PR |
| Q62419 | Sh3gl1 | Endophilin-A2 | Mus musculus (Mouse) | PR |
| Q62421 | Sh3gl3 | Endophilin-A3 | Mus musculus (Mouse) | PR |
| Q9JLQ0 | Cd2ap | CD2-associated protein | Mus musculus (Mouse) | SS |
| Q8R550 | Sh3kbp1 | SH3 domain-containing kinase-binding protein 1 | Mus musculus (Mouse) | SS |
| O77666 | TRIM26 | Tripartite motif-containing protein 26 | Sus scrofa (Pig) | PR |
| O19085 | TRIM10 | Tripartite motif-containing protein 10 | Sus scrofa (Pig) | PR |
| Q865W2 | TRIM50 | E3 ubiquitin-protein ligase TRIM50 | Sus scrofa (Pig) | PR |
| Q920M2 | Rnf39 | RING finger protein 39 | Rattus norvegicus (Rat) | PR |
| Q9JJ25 | Mefv | Pyrin | Rattus norvegicus (Rat) | SS |
| A0JPQ4 | Trim72 | Tripartite motif-containing protein 72 | Rattus norvegicus (Rat) | PR |
| Q810I1 | Trim50 | E3 ubiquitin-protein ligase TRIM50 | Rattus norvegicus (Rat) | PR |
| D3ZVM4 | Trim71 | E3 ubiquitin-protein ligase TRIM71 | Rattus norvegicus (Rat) | PR |
| F6QEU4 | trim71 | E3 ubiquitin-protein ligase TRIM71 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q640S6 | trim72 | Tripartite motif-containing protein 72 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| E7FAM5 | trim71 | E3 ubiquitin-protein ligase TRIM71 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDDLTLLDLL | ECPVCFEKLD | VTAKVLPCQH | TFCKPCLQRI | FKAHKELRCP | ECRTLVFCSI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EALPANLLLV | RLLDGVRSGQ | SSWKGGSFRR | PRILTLQDNR | KAKSSPRSLQ | ASPFRLVPSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIHMDGVPRA | KALCNYRGKN | PGDLKFNKGD | VILLRRQLDE | NWYQGEINGV | SGIFPASSVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIKQLPQPPP | LCRALYNFDL | RDKDKSENQD | CLTFLKDDVI | TVISRVDENW | AEGKLGDKVG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IFPILFVEPN | VSARHLLENK | GHQLSRTRHL | SLMSSPSRGK | ATNTSSLRKS | PGSRRKGSGQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSMTTALNTL | NRTVHSPEGH | QMVEISTPML | ISSNSPSVLT | QHGDKADFPT | SSTGQVSSSQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PAPASPGHST | AMVSVPSSQQ | HLSNNMFVAL | HTYSAHRPEE | LDLQKGEGIR | VLGKYQDGWL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KGLSLLTGRT | GIFPSDYVIP | VFSSTARKTS | SFPDSRSPTV | CTTWALSTSS | VSSQGSFAEG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DPRQSGPFKS | VFVPTAVVNP | SRSTPGPGSS | GQGSLRKVRS | SMRKNGSLQR | PVQSGIPTFM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VGSLRCSPTM | VIRPQRFQFY | PPQGMTPSPT | PIMVEMGSKS | IYTGEPALTC | INRGSKTRIH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SAGNSIIMEG | KETPIKSEPP | PKPPASAPPS | ILVKPENSKN | GTEKQVKTVR | FQNYSPPPTK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HSASSPTSGK | HDHPATLKGS | QHEAVSSGGE | MTILFAHRSG | CHSGQQTDLR | RKSAFGKTMP |
| 730 | |||||
| LLSTASATQT | LFPSK |