Q8BZ03

SS
Gene name
Prkd2
Protein name
Serine/threonine-protein kinase D2
Names
EC 2.7.11.13 , nPKC-D2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:101540
EC number
2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

Protein kinase D (PKD) is a member of Ser/Thr kinases and plays a major role in Golgi function and organization. The PH domain within the PKD inhibits the function of the PKD. When PH domain is phosphorylated or deleted, the function of PKD is recovered.

Autoinhibitory domains (AIDs)

398-512 (PH domain) SS

Target domain

552-808 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

695-717 (Activation loop from InterPro)

Target domain

552-808 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8BZ03

Entry ID Method Resolution Chain Position Source
AF-Q8BZ03-F1 Predicted AlphaFoldDB

34 variants for Q8BZ03

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388855902 25 G>S No EVA
rs3397486358 27 D>E No EVA
rs3413084287 30 S>* No EVA
rs3388879730 47 F>Y No EVA
rs3388882873 82 P>S No EVA
rs3388862350 94 L>M No EVA
rs3397402297 109 V>M No EVA
rs3397708021 111 S>P No EVA
rs3388882341 203 S>N No EVA
rs240713316 310 R>H No EVA
rs244959058 326 P>Q No EVA
rs3388885394 332 D>V No EVA
rs3388882424 335 E>A No EVA
rs3388874002 353 G>D No EVA
rs214211872 358 S>N No EVA
rs3388879531 458 L>R No EVA
rs3388885917 462 G>D No EVA
rs3388862387 481 E>G No EVA
rs3388870238 485 G>R No EVA
rs3388870209 487 P>R No EVA
rs3388866096 492 G>R No EVA
rs3545452148 521 P>L No EVA
rs3388885023 525 P>T No EVA
rs3388879578 557 V>M No EVA
rs3388870217 562 Q>* No EVA
rs3397249224 571 H>Y No EVA
rs3388855865 585 K>T No EVA
rs3388882394 622 E>* No EVA
rs3388885930 649 E>K No EVA
rs3413068927 688 P>S No EVA
rs3388870297 691 Q>* No EVA
rs3388870239 701 R>H No EVA
rs3397709521 843 A>T No EVA
rs3388882843 865 M>K No EVA

No associated diseases with Q8BZ03

10 regional properties for Q8BZ03

Type Name Position InterPro Accession
domain Protein kinase domain 402 - 655 IPR000719
domain SH2 domain 279 - 377 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 402 - 650 IPR001245
domain SH3 domain 214 - 274 IPR001452
conserved_site Zinc finger, Btk motif 124 - 171 IPR001562
domain Pleckstrin homology domain 3 - 135 IPR001849
active_site Tyrosine-protein kinase, active site 517 - 529 IPR008266
binding_site Protein kinase, ATP binding site 408 - 430 IPR017441
domain Tyrosine-protein kinase, catalytic domain 402 - 651 IPR020635
domain Tyrosine-protein kinase BTK, SH3 domain 217 - 271 IPR035574

Functions

Description
EC Number 2.7.11.13 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Golgi apparatus, trans-Golgi network
  • Translocation to the cell membrane is required for kinase activation
  • Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors
  • Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diacylglycerol-dependent serine/threonine kinase activity Catalysis of the reaction
metal ion binding Binding to a metal ion.
protein kinase C binding Binding to protein kinase C.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

24 GO annotations of biological process

Name Definition
adaptive immune response An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
phospholipase C-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of blood vessel endothelial cell migration Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
positive regulation of cell adhesion Any process that activates or increases the frequency, rate or extent of cell adhesion.
positive regulation of DNA biosynthetic process Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
positive regulation of DNA-binding transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
positive regulation of endothelial cell migration Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of fibroblast growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
positive regulation of interleukin-2 production Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
positive regulation of interleukin-8 production Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of T cell receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of vascular endothelial growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
regulation of T cell apoptotic process Any process that modulates the occurrence or rate of T cell death by apoptotic process.
T cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O94806 PRKD3 Serine/threonine-protein kinase D3 Homo sapiens (Human) SS
Q15139 PRKD1 Serine/threonine-protein kinase D1 Homo sapiens (Human) EV
Q9BZL6 PRKD2 Serine/threonine-protein kinase D2 Homo sapiens (Human) SS
Q62101 Prkd1 Serine/threonine-protein kinase D1 Mus musculus (Mouse) SS
Q8K1Y2 Prkd3 Serine/threonine-protein kinase D3 Mus musculus (Mouse) SS
Q9WTQ1 Prkd1 Serine/threonine-protein kinase D1 Rattus norvegicus (Rat) SS
Q5XIS9 Prkd2 Serine/threonine-protein kinase D2 Rattus norvegicus (Rat) SS
O45818 dkf-2 Serine/threonine-protein kinase dkf-2 Caenorhabditis elegans SS
10 20 30 40 50 60
MAAAPSHPAG LPGSPGPGSP PPPGGLDLQS PPPLLPQIPA PGSGVSFHIQ IGLTREFVLL
70 80 90 100 110 120
PAASELAHVK QLACSIVDQK FPECGFYGLY DKILLFKHDP TSANLLQLVR SAADIQEGDL
130 140 150 160 170 180
VEVVLSASAT FEDFQIRPHA LTVHSYRAPA FCDHCGEMLF GLVRQGLKCD GCGLNYHKRC
190 200 210 220 230 240
AFSIPNNCSG ARKRRLSSTS LASGHSVRLG SSESLPCTAE ELSRSTTDLL PRRPPSSSSS
250 260 270 280 290 300
SSSSSFYTGR PIELDKMLMS KVKVPHTFLI HSYTRPTVCQ ACKKLLKGLF RQGLQCKDCK
310 320 330 340 350 360
FNCHKRCATR VPNDCLGEAL INGDVPMEEA ADYSEADKSS ISDELEDSGV IPGSHSESAL
370 380 390 400 410 420
HASEEEEGEG HKAQSSLGYI PLMRVVQSVR HTTRKSSTTL REGWVVHYSN KDTLRKRHYW
430 440 450 460 470 480
RLDCKCITLF QNNTTNRYYK EIPLSEILAV EPAQNFSLVP PGTNPHCFEI ITANVTYFVG
490 500 510 520 530 540
ETPGGAPGGP SGQGTEAVRG WETAIRQALM PVILQDAPSA PGHTPHRQAS LSISVSNSQI
550 560 570 580 590 600
QENVDIATVY QIFPDEVLGS GQFGVVYGGK HRKTGRDVAV KVIDKLRFPT KQESQLRNEV
610 620 630 640 650 660
AILQSLRHPG IVNLECMFET PEKVFVVMEK LHGDMLEMIL SSEKGRLPER LTKFLITQIL
670 680 690 700 710 720
VALRHLHFKN IVHCDLKPEN VLLASADPFP QVKLCDFGFA RIIGEKSFRR SVVGTPAYLA
730 740 750 760 770 780
PEVLLNQGYN RSLDMWSVGV IMYVSLSGTF PFNEDEDIND QIQNAAFMYP ASPWSHISSG
790 800 810 820 830 840
AIDLINNLLQ VKMRKRYSVD KSLSHPWLQE YQTWLDLREL EGKMGERYIT HESDDARWDQ
850 860 870
FVAERHGTPA EGDLGGACLP QDHEMQGLAE RISIL