Q8BYZ7
Gene name |
Elmo3 |
Protein name |
Engulfment and cell motility protein 3 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:234683 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
1-113 (Ras-binding domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
1-113 (Ras-binding domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Patel M et al. (2011) "The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family", The Journal of biological chemistry, 286, 38969-79
- Patel M et al. (2010) "An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling", Current biology : CB, 20, 2021-7
- Patel M et al. (2011) "Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complex", Small GTPases, 2, 268-275
Autoinhibited structure
Activated structure
1 structures for Q8BYZ7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BYZ7-F1 | Predicted | AlphaFoldDB |
39 variants for Q8BYZ7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389007503 | 2 | A>E | No | EVA | |
| rs3389008117 | 12 | V>D | No | EVA | |
| rs3398635865 | 26 | Q>L | No | EVA | |
| rs3389003048 | 40 | A>V | No | EVA | |
| rs3389000250 | 71 | N>K | No | EVA | |
| rs3389000173 | 80 | A>V | No | EVA | |
| rs3399470240 | 82 | D>E | No | EVA | |
| rs3399377600 | 153 | L>P | No | EVA | |
| rs3398635883 | 157 | G>R | No | EVA | |
| rs3389000210 | 173 | I>L | No | EVA | |
| rs3389003050 | 220 | L>V | No | EVA | |
| rs3389003068 | 241 | G>R | No | EVA | |
| rs3389006551 | 267 | I>F | No | EVA | |
| rs3389006486 | 284 | V>L | No | EVA | |
| rs3389006309 | 304 | Y>H | No | EVA | |
| rs3389011967 | 313 | Q>E | No | EVA | |
| rs3388998555 | 325 | E>K | No | EVA | |
| rs3389011885 | 333 | A>G | No | EVA | |
| rs248550917 | 360 | R>H | No | EVA | |
| rs3399470242 | 361 | V>G | No | EVA | |
| rs3399557973 | 363 | P>A | No | EVA | |
| rs3399796026 | 365 | L>P | No | EVA | |
| rs3399082147 | 367 | A>V | No | EVA | |
| rs3389003402 | 380 | S>N | No | EVA | |
| rs3388976129 | 441 | E>K | No | EVA | |
| rs3388981911 | 457 | M>K | No | EVA | |
| rs3389000195 | 477 | R>H | No | EVA | |
| rs3413053031 | 501 | V>M | No | EVA | |
| rs234561437 | 514 | G>C | No | EVA | |
| rs3389006339 | 539 | R>L | No | EVA | |
| rs3389011944 | 576 | G>W | No | EVA | |
| rs263554355 | 583 | K>N | No | EVA | |
| rs3547045793 | 635 | G>R | No | EVA | |
| rs3388986629 | 638 | E>K | No | EVA | |
| rs3389008169 | 659 | S>R | No | EVA | |
| rs3388976128 | 668 | S>N | No | EVA | |
| rs3389000258 | 683 | T>I | No | EVA | |
| rs3388981980 | 712 | C>* | No | EVA | |
| rs233566897 | 718 | T>I | No | EVA |
No associated diseases with Q8BYZ7
7 regional properties for Q8BYZ7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, TRAF-type | 151 - 192 | IPR001293-1 |
| domain | Zinc finger, TRAF-type | 204 - 261 | IPR001293-2 |
| domain | MATH/TRAF domain | 350 - 499 | IPR002083 |
| conserved_site | Zinc finger, RING-type, conserved site | 85 - 94 | IPR017907 |
| domain | TNF receptor-associated factor 6, C3HC3D-type RING zinc finger | 67 - 124 | IPR027139 |
| domain | TNF receptor-associated factor 6, MATH domain | 351 - 500 | IPR037309 |
| domain | TNF receptor-associated factor 6, zinc finger 2 | 157 - 183 | IPR041310 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cell motility | Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4FUD6 | ELMO2 | Engulfment and cell motility protein 2 | Bos taurus (Bovine) | SS |
| Q92556 | ELMO1 | Engulfment and cell motility protein 1 | Homo sapiens (Human) | EV |
| Q96JJ3 | ELMO2 | Engulfment and cell motility protein 2 | Homo sapiens (Human) | SS |
| Q96BJ8 | ELMO3 | Engulfment and cell motility protein 3 | Homo sapiens (Human) | SS |
| Q8BPU7 | Elmo1 | Engulfment and cell motility protein 1 | Mus musculus (Mouse) | SS |
| Q8BHL5 | Elmo2 | Engulfment and cell motility protein 2 | Mus musculus (Mouse) | SS |
| Q499U2 | Elmo3 | Engulfment and cell motility protein 3 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPPRNVVKI | AVQMSDAIPQ | LIQLDQAKPL | ATVLKEVCDA | WSLTHPEHYA | LQFADGHRKY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ITENNRLEIK | NGSILCLSTA | PDLKAQQLLG | RLQNTSREGC | CEVLRNLVLL | ASDMTFAQEV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISRDGLQKLS | TIIENGDDLG | EMLALGLRAF | LELMEHGVVS | WETLSISFVR | KVISYVNMNL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MDASVQPLAL | RLLESVTLSS | PALGQLVKSE | VPLDRLLVHL | QVMNHQLQTK | AMALLTALLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GASPTERKEM | LDHLWKKNLR | QFIYKNIIHS | ATPMGDEMAH | HLYVLQALTL | GLLEPRMRTP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LDPYSQEQRD | QLQALRQAAF | EPEGESLGTG | LSADRRRSLC | VREFRKLGFS | NSNPAQDLER |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VPPGLLALDN | MLYFSRHAPS | AYSRFVLENS | SREDKHECPF | ARSSIQLTAL | LCELLRVGEP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CSETAQDFSP | MFFSQDHSFH | ELFCVAIQLL | NKTWKEMRAT | QEDFDKVMQV | VREQLARTLA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LKPTSLELFR | TKVNALTYGE | VLRLRQTERL | HQEGTLAPPI | LELREKLKPE | LMGLIRQQRL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LRLCEGMLFR | KISSRRRQDK | LWFCCLSPNH | KVLQYGDVEE | GAKPPTLESL | PEQLPVADIR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ALLMGKDCPH | VREKGSGKQN | KDLYELAFSI | SYDHGEEEAY | LNFIAPSKRD | FYLWTDGLSA |
| 670 | 680 | 690 | 700 | 710 | |
| LLGSTMGSEL | TRLDLEQLLT | METKLRLLEL | ENVPIPEQPP | PVPPPPTNFN | FCYDYSITEP |