Q8BWD8
Gene name |
Cdk19 (Cdc2l6, Kiaa1028) |
Protein name |
Cyclin-dependent kinase 19 |
Names |
CDC2-related protein kinase 6, Cell division cycle 2-like protein kinase 6, Cell division protein kinase 19 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:78334 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
172-198 (Activation loop from InterPro)
Target domain |
21-335 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8BWD8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BWD8-F1 | Predicted | AlphaFoldDB |
12 variants for Q8BWD8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389089564 | 133 | Y>H | No | EVA | |
| rs3389039468 | 146 | W>C | No | EVA | |
| rs3389105321 | 178 | R>S | No | EVA | |
| rs3389095890 | 179 | L>* | No | EVA | |
| rs3389092138 | 197 | F>L | No | EVA | |
| rs3389096123 | 238 | Q>H | No | EVA | |
| rs3389095943 | 300 | H>L | No | EVA | |
| rs3389089618 | 302 | V>I | No | EVA | |
| rs3389039445 | 329 | A>D | No | EVA | |
| rs3389083352 | 331 | Q>K | No | EVA | |
| rs3389105368 | 355 | K>Q | No | EVA | |
| rs3389092053 | 365 | E>D | No | EVA |
No associated diseases with Q8BWD8
6 regional properties for Q8BWD8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Helix-turn-helix motif | 165 - 190 | IPR000047 |
| domain | Homeobox domain | 134 - 198 | IPR001356 |
| conserved_site | Homeobox, conserved site | 169 - 192 | IPR017970 |
| domain | Homeobox domain, metazoa | 158 - 169 | IPR020479-1 |
| domain | Homeobox domain, metazoa | 173 - 192 | IPR020479-2 |
| domain | Distal-less-like homeobox protein, N-terminal domain | 32 - 116 | IPR022135 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| RNA polymerase II CTD heptapeptide repeat kinase activity | Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to lipopolysaccharide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of inflammatory response | Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39073 | SSN3 | Meiotic mRNA stability protein kinase SSN3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9VT57 | Cdk8 | Cyclin-dependent kinase 8 | Drosophila melanogaster (Fruit fly) | PR |
| P49336 | CDK8 | Cyclin-dependent kinase 8 | Homo sapiens (Human) | PR |
| Q9BWU1 | CDK19 | Cyclin-dependent kinase 19 | Homo sapiens (Human) | PR |
| Q3UMM4 | Cdk10 | Cyclin-dependent kinase 10 | Mus musculus (Mouse) | PR |
| O35495 | Cdk14 | Cyclin-dependent kinase 14 | Mus musculus (Mouse) | PR |
| Q8K0D0 | Cdk17 | Cyclin-dependent kinase 17 | Mus musculus (Mouse) | PR |
| Q8R3L8 | Cdk8 | Cyclin-dependent kinase 8 | Mus musculus (Mouse) | PR |
| Q99J95 | Cdk9 | Cyclin-dependent kinase 9 | Mus musculus (Mouse) | PR |
| Q3TZA2 | Cdkl4 | Cyclin-dependent kinase-like 4 | Mus musculus (Mouse) | PR |
| Q8CEQ0 | Cdkl1 | Cyclin-dependent kinase-like 1 | Mus musculus (Mouse) | PR |
| Q8BLF2 | Cdkl3 | Cyclin-dependent kinase-like 3 | Mus musculus (Mouse) | PR |
| Q9QUK0 | Cdkl2 | Cyclin-dependent kinase-like 2 | Mus musculus (Mouse) | PR |
| Q9JHU3 | Cdk20 | Cyclin-dependent kinase 20 | Mus musculus (Mouse) | PR |
| Q6P3N6 | cdk8 | Cyclin-dependent kinase 8 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q8JH47 | cdk8 | Cyclin-dependent kinase 8 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDYDFKAKLA | AERERVEDLF | EYEGCKVGRG | TYGHVYKARR | KDGKDEKEYA | LKQIEGTGIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MSACREIALL | RELKHPNVIA | LQKVFLSHSD | RKVWLLFDYA | EHDLWHIIKF | HRASKANKKP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MQLPRSMVKS | LLYQILDGIH | YLHANWVLHR | DLKPANILVM | GEGPERGRVK | IADMGFARLF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSPLKPLADL | DPVVVTFWYR | APELLLGARH | YTKAIDIWAI | GCIFAELLTS | EPIFHCRQED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IKTSNPFHHD | QLDRIFSVMG | FPADKDWEDI | RKMPEYPTLQ | KDFRRTTYAN | SSLIKYMEKH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KVKPDSKVFL | LLQKLLTMDP | TKRITSEQAL | QDPYFQEDPL | PTLDVFAGCQ | IPYPKREFLN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EDEPEEKGDK | NQPQQQNPHQ | QPAAPAQQTA | APPQAPPPQQ | SSAQTNGTAG | GATAGGGGAG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AGLQHSQDPG | LNQVPPNKKP | RIGPSGANSG | GPVMPSDYQH | SSSRLNYQSS | VQGSSQSQST |
| 490 | 500 | ||||
| LGYSSSQQST | QYHSSHQTHR | Y |