Q8BWD8

PR
Gene name
Cdk19 (Cdc2l6, Kiaa1028)
Protein name
Cyclin-dependent kinase 19
Names
CDC2-related protein kinase 6, Cell division cycle 2-like protein kinase 6, Cell division protein kinase 19
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:78334
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

324-501 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

172-198 (Activation loop from InterPro)

Target domain

21-335 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8BWD8

Entry ID Method Resolution Chain Position Source
AF-Q8BWD8-F1 Predicted AlphaFoldDB

12 variants for Q8BWD8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389089564 133 Y>H No EVA
rs3389039468 146 W>C No EVA
rs3389105321 178 R>S No EVA
rs3389095890 179 L>* No EVA
rs3389092138 197 F>L No EVA
rs3389096123 238 Q>H No EVA
rs3389095943 300 H>L No EVA
rs3389089618 302 V>I No EVA
rs3389039445 329 A>D No EVA
rs3389083352 331 Q>K No EVA
rs3389105368 355 K>Q No EVA
rs3389092053 365 E>D No EVA

No associated diseases with Q8BWD8

3 regional properties for Q8BWD8

Type Name Position InterPro Accession
domain Protein kinase domain 21 - 335 IPR000719
active_site Serine/threonine-protein kinase, active site 147 - 159 IPR008271
binding_site Protein kinase, ATP binding site 27 - 52 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, perinuclear region
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

4 GO annotations of biological process

Name Definition
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
protein phosphorylation The process of introducing a phosphate group on to a protein.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39073 SSN3 Meiotic mRNA stability protein kinase SSN3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9VT57 Cdk8 Cyclin-dependent kinase 8 Drosophila melanogaster (Fruit fly) PR
P49336 CDK8 Cyclin-dependent kinase 8 Homo sapiens (Human) PR
Q9BWU1 CDK19 Cyclin-dependent kinase 19 Homo sapiens (Human) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
Q8K0D0 Cdk17 Cyclin-dependent kinase 17 Mus musculus (Mouse) PR
Q8R3L8 Cdk8 Cyclin-dependent kinase 8 Mus musculus (Mouse) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q3TZA2 Cdkl4 Cyclin-dependent kinase-like 4 Mus musculus (Mouse) PR
Q8CEQ0 Cdkl1 Cyclin-dependent kinase-like 1 Mus musculus (Mouse) PR
Q8BLF2 Cdkl3 Cyclin-dependent kinase-like 3 Mus musculus (Mouse) PR
Q9QUK0 Cdkl2 Cyclin-dependent kinase-like 2 Mus musculus (Mouse) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q6P3N6 cdk8 Cyclin-dependent kinase 8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q8JH47 cdk8 Cyclin-dependent kinase 8 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA LKQIEGTGIS
70 80 90 100 110 120
MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA EHDLWHIIKF HRASKANKKP
130 140 150 160 170 180
MQLPRSMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF
190 200 210 220 230 240
NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED
250 260 270 280 290 300
IKTSNPFHHD QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH
310 320 330 340 350 360
KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ IPYPKREFLN
370 380 390 400 410 420
EDEPEEKGDK NQPQQQNPHQ QPAAPAQQTA APPQAPPPQQ SSAQTNGTAG GATAGGGGAG
430 440 450 460 470 480
AGLQHSQDPG LNQVPPNKKP RIGPSGANSG GPVMPSDYQH SSSRLNYQSS VQGSSQSQST
490 500
LGYSSSQQST QYHSSHQTHR Y