Q8BWA8
Gene name |
Arhgef19 (Wgef) |
Protein name |
Rho guanine nucleotide exchange factor 19 |
Names |
Ephexin-2, Weakly similar to Rho GEF 5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:213649 |
EC number |
|
Protein Class |
|
Descriptions
(Annotation based on sequence homology with Q12774)
Dbl-related oncoproteins are guanine nucleotide exchange factors specific for Rho-family GTPases and typically possess tandem Dbl homology (DH) and pleckstrin homology (PH) domains that act in concert to catalyze exchange. The ability of many Dbl-family proteins to catalyze exchange is constitutively activated by truncations N-terminal to their DH domains. The Dbl-family protein Tim, called ARHGEF5, is autoinhibited by a short, helical motif immediately N-terminal to its DH domain, which directly occludes the catalytic surface of the DH domain to prevent GTPase activation.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BWA8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BWA8-F1 | Predicted | AlphaFoldDB |
21 variants for Q8BWA8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388715986 | 34 | F>L | No | EVA | |
| rs3388726250 | 67 | A>T | No | EVA | |
| rs233312612 | 85 | I>M | No | EVA | |
| rs3395067765 | 89 | S>G | No | EVA | |
| rs260015533 | 95 | G>S | No | EVA | |
| rs581595929 | 244 | A>T | No | EVA | |
| rs220660827 | 254 | D>A | No | EVA | |
| rs234290447 | 320 | G>R | No | EVA | |
| rs263992577 | 441 | R>H | No | EVA | |
| rs49325330 | 492 | G>S | No | EVA | |
| rs3394723853 | 511 | F>L | No | EVA | |
| rs3388728855 | 568 | E>* | No | EVA | |
| rs3388726178 | 571 | I>N | No | EVA | |
| rs3395059648 | 573 | L>I | No | EVA | |
| rs3388727422 | 607 | A>S | No | EVA | |
| rs3388724022 | 608 | A>T | No | EVA | |
| rs3388725195 | 623 | H>Q | No | EVA | |
| rs3388719699 | 681 | Q>* | No | EVA | |
| rs3388719734 | 686 | A>T | No | EVA | |
| rs3388726191 | 750 | D>N | No | EVA | |
| rs3388726226 | 773 | E>A | No | EVA |
No associated diseases with Q8BWA8
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| wound healing | The series of events that restore integrity to a damaged tissue, following an injury. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12774 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | Homo sapiens (Human) | EV |
| A5YM69 | ARHGEF35 | Rho guanine nucleotide exchange factor 35 | Homo sapiens (Human) | PR |
| O94989 | ARHGEF15 | Rho guanine nucleotide exchange factor 15 | Homo sapiens (Human) | SS |
| Q5VV41 | ARHGEF16 | Rho guanine nucleotide exchange factor 16 | Homo sapiens (Human) | PR |
| Q8N5V2 | NGEF | Ephexin-1 | Homo sapiens (Human) | EV |
| Q96DR7 | ARHGEF26 | Rho guanine nucleotide exchange factor 26 | Homo sapiens (Human) | SS |
| Q8IW93 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | Homo sapiens (Human) | SS |
| E9Q7D5 | Arhgef5 | Rho guanine nucleotide exchange factor 5 | Mus musculus (Mouse) | SS |
| Q3U5C8 | Arhgef16 | Rho guanine nucleotide exchange factor 16 | Mus musculus (Mouse) | PR |
| Q5FWH6 | Arhgef15 | Rho guanine nucleotide exchange factor 15 | Mus musculus (Mouse) | SS |
| Q8CHT1 | Ngef | Ephexin-1 | Mus musculus (Mouse) | SS |
| Q5BKC9 | Ngef | Ephexin-1 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDCGPPATLQ | PHLAGPPGTA | RRPVAVCQQE | SLSFVELPPS | RLCVDLFPIA | PEELQAPGSR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WSLATPAPLQ | GLLWPTSPGG | PDTHIASTSG | GMRPGRAGSW | PHCPGAQPPT | LVEPWSSQHM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QPQRRASHSG | SEKSAWRKMQ | VYHNEEATGT | ETPTGLLETG | QAAQEQALCA | LEPGPQELSG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NARGGLEAPE | RRRFSASELM | TRLHSSLRLG | RSTATRVLTS | GSGAGAIREG | KLPVRESRRA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ETRADSVSLP | GPVDLNEVHG | GLVEPRLDTQ | DKPTQDPSSA | TERRQSRFLL | NSVLYQEYSD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VASARELRRQ | QREEEGPGDG | AEGAEEGPGP | PRANLSPSSS | FRAQRSTRGS | TFSLWQDIPD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VRGSGVLATL | SLRDCKLQEA | KFELITSEAS | YIHSLSVAVG | HFLGSVELSE | CLGTQDKQWL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSKLPEVKST | SERFLHDLEQ | RLEADVLRFS | VCDVVLHHCP | AFRRVYLPYV | TNQAYQERTY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QRLLLENPKF | PGILARLEES | PVCQRLPLTS | FLILPFQRVT | RLKMLVENIL | KRTAPGSQDE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DMATKAFSAL | KELVQECNAS | VQSMKRTEEL | IHLSKKIHFE | GKIFPLISQA | RWLVRHGELV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELAPLPAAPP | AKLKLSSKAV | YLHLFNDCLL | LSRRKELGKF | AVFVHANMAE | LQVRDLSLKL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QGIPGHVFLL | RLLHGQRARH | QLLLRARTES | EKQRWISALR | PSSPQEDKEI | TCDGEDRPQV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QCVRTYKALQ | PDELTLEKTD | ILAVKTRTSD | GWLEGVRLAD | GEKGWVPQAH | VVEISSLSAR |
| 790 | 800 | ||||
| LRNLREYKRV | SNASSKLGDP | PA |