Q8BVD5
PR
Gene name |
Mpp7 |
Protein name |
MAGUK p55 subfamily member 7 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:75739 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BVD5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BVD5-F1 | Predicted | AlphaFoldDB |
No variants for Q8BVD5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8BVD5 | |||||
No associated diseases with Q8BVD5
No regional properties for Q8BVD5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BVD5 | |||
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| bicellular tight junction | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| MPP7-DLG1-LIN7 complex | A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| molecular adaptor activity | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
| protein domain specific binding | Binding to a specific domain of a protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| bicellular tight junction assembly | The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. |
| positive regulation of protein-containing complex assembly | Any process that activates or increases the frequency, rate or extent of protein complex assembly. |
| protein localization to adherens junction | Any process in which a protein is transported to, and/or maintained at the adherens junction. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q24210 | CASK | Peripheral plasma membrane protein CASK | Drosophila melanogaster (Fruit fly) | SS |
| Q9NZW5 | PALS2 | Protein PALS2 | Homo sapiens (Human) | PR |
| Q00013 | MPP1 | 55 kDa erythrocyte membrane protein | Homo sapiens (Human) | PR |
| O14936 | CASK | Peripheral plasma membrane protein CASK | Homo sapiens (Human) | EV |
| Q96JB8 | MPP4 | MAGUK p55 subfamily member 4 | Homo sapiens (Human) | PR |
| Q14168 | MPP2 | MAGUK p55 subfamily member 2 | Homo sapiens (Human) | PR |
| P70290 | Mpp1 | 55 kDa erythrocyte membrane protein | Mus musculus (Mouse) | PR |
| O70589 | Cask | Peripheral plasma membrane protein CASK | Mus musculus (Mouse) | SS |
| Q9JLB0 | Pals2 | Protein PALS2 | Mus musculus (Mouse) | PR |
| Q9WV34 | Mpp2 | MAGUK p55 subfamily member 2 | Mus musculus (Mouse) | PR |
| Q6P7F1 | Mpp4 | MAGUK p55 subfamily member 4 | Mus musculus (Mouse) | PR |
| O88910 | Mpp3 | MAGUK p55 subfamily member 3 | Mus musculus (Mouse) | PR |
| Q9QYH1 | Mpp4 | MAGUK p55 subfamily member 4 | Rattus norvegicus (Rat) | PR |
| P54936 | lin-2 | Protein lin-2 | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPALATGSAC | DMGLYELLAA | LPAQLQPHVD | SQEDLTFLWD | VFGEKSLHSL | VKIHEKLHCY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKQNPLPILH | GAAALADDLT | EELQNKLPNS | EIRELLKLLS | KPNVKALLSV | HDTVAQKSYD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVLPPVPDDI | DDEEDSVKII | RLVKNSEPLG | ATIKKDEQTG | AITVARIMRG | GAADRSGLIH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VGDELREVNG | IPVEDKRPEE | IIKILSQSKG | AITFKIIPST | KEETPSKEGK | IFIKALFDYD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKEDKAIPCK | EAGLSFRKGD | ILQIMSQDDV | TWWQAKHEGD | ANPRAGLIPS | KHFQERRLAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RRPEIVVQPL | KLSNTKSSGF | RRSFRLSRKN | KKINKSMYEC | KKSEQYDTAD | VPTYEEVTPY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RRQIHDKYRL | IVLVGPVGVG | LNELKRKLLM | SDAQHYGVIV | PHTTRARRSQ | ESDGVEYIFI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SKHLFETDVQ | INKFIEYGEY | KNNYYGTSID | SVRSVLAKNK | VCLLDVQPHT | VKHLRTLEFK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PYVIFIKPPS | IERLRETRKN | AKIISSRDDQ | GTAKPFTEED | FQEMIKSAQI | MESQYGHLFD |
| 550 | 560 | 570 | |||
| KIIINDDLTV | AFNELKTTFD | KLETDTHWVP | VSWLHS |