Q8BPM2

PR
Gene name
Map4k5
Protein name
Mitogen-activated protein kinase kinase kinase kinase 5
Names
MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:399510
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

266-506 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

157-180 (Activation loop from InterPro)

Target domain

20-277 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8BPM2

Entry ID Method Resolution Chain Position Source
AF-Q8BPM2-F1 Predicted AlphaFoldDB

33 variants for Q8BPM2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389252156 49 K>N No EVA
rs3389236967 111 P>S No EVA
rs3389252195 117 I>K No EVA
rs3389239846 173 K>M No EVA
rs3389215930 263 K>E No EVA
rs3389209453 320 T>A No EVA
rs3389202481 357 E>D No EVA
rs3389209518 388 I>K No EVA
rs3389215944 422 E>G No EVA
rs264475894 437 C>F No EVA
rs37037959 441 A>V No EVA
rs3389243692 447 I>T No EVA
rs3389244864 460 N>* No EVA
rs3389244800 460 N>I No EVA
rs3389244800 460 N>S No EVA
rs3389238675 461 T>P No EVA
rs3389238675 461 T>S No EVA
rs3389255511 462 E>G No EVA
rs3389227660 542 L>P No EVA
rs3389243715 549 Q>R No EVA
rs864286498 586 E>* No EVA
rs3389239855 606 I>N No EVA
rs3389209532 629 V>D No EVA
rs3389243728 632 P>L No EVA
rs3389236989 726 Q>H No EVA
rs3389244844 735 L>S No EVA
rs3389239784 739 T>I No EVA
rs3389240906 745 D>Y No EVA
rs13460549 758 K>N No EVA
rs3389238692 795 S>G No EVA
rs3389244836 804 E>D No EVA
rs3389244877 810 R>K No EVA
rs3389252127 815 L>M No EVA

No associated diseases with Q8BPM2

1 regional properties for Q8BPM2

Type Name Position InterPro Accession
conserved_site TATA-box binding protein, conserved site 143 - 192 IPR030491

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12851 MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens (Human) EV
Q8IVH8 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens (Human) SS
Q92918 MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens (Human) EV
Q9Y4K4 MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens (Human) PR
Q61161 Map4k2 Mitogen-activated protein kinase kinase kinase kinase 2 Mus musculus (Mouse) SS
P70218 Map4k1 Mitogen-activated protein kinase kinase kinase kinase 1 Mus musculus (Mouse) PR
Q99JP0 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Mus musculus (Mouse) SS
O54988 Slk STE20-like serine/threonine-protein kinase Mus musculus (Mouse) PR
O55098 Stk10 Serine/threonine-protein kinase 10 Mus musculus (Mouse) PR
Q6P9R2 Oxsr1 Serine/threonine-protein kinase OSR1 Mus musculus (Mouse) PR
Q9Z1W9 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus (Mouse) PR
Q99JT2 Stk26 Serine/threonine-protein kinase 26 Mus musculus (Mouse) PR
Q99KH8 Stk24 Serine/threonine-protein kinase 24 Mus musculus (Mouse) PR
Q9Z2W1 Stk25 Serine/threonine-protein kinase 25 Mus musculus (Mouse) PR
Q924I2 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEAPLRPAAD ILRRNPQHDY ELVQRVGSGT YGDVYKARNV HTGELAAVKI IKLEPGDDFS
70 80 90 100 110 120
LIQQEIFMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSEMQIAYV
130 140 150 160 170 180
CRETLQGLAY LHTKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY
190 200 210 220 230 240
WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LGELQPPMFD LHPMRALFLM SKSNFQPPKL
250 260 270 280 290 300
KDKTKWSSTF HNFVKIALTK NPKKRPTAER LLTHTFVGQP GLSRALAVEL LDKVSNPDNH
310 320 330 340 350 360
APYSEGDEDD LEPHAIIRHT IRSTNRNSRA ERTASEINFD KLQFEPPLRK ETEARDEMGL
370 380 390 400 410 420
SSEPNFILHW NPFVDGANTG RSTSKRAIPP PLPPKPRVNT YPEDSLPDEE KSSTIKRCPD
430 440 450 460 470 480
LEARAPQVLR RQSSPSCVPV AETSSSIGNG DGISKLISEN TEGSAQAPQL PRKKDKRDFP
490 500 510 520 530 540
KPTINGLPPT PKVLMGACFS KVFDGCPLKI NCATSWIHPD TKDQYIIFGT EDGIYTLNLN
550 560 570 580 590 600
ELHEATMEQL FPRKCTWLYV INNTLMSLSE GKTFQLYSHN LIALFEQAKK PGLAAHIQTH
610 620 630 640 650 660
RFPDRILPRK FALTTKIPDT KGCHKCCIVR NPYTGHKYLC GALQSGIVLL QWYEPMQKFM
670 680 690 700 710 720
LIKHFDFPLP SPLNVFEMLV IPEQEYPMVC VAISKGSDSS QVVQFETINL NSASSWFTEI
730 740 750 760 770 780
GAGSQQLDSI HVTQLERDTV LVCLDKFVKI VNLQGKLKSS KKLASELSFD FRIESVVCLQ
790 800 810 820 830 840
DSVLAFWKHG MQGKSFKSDE VTQEISDETR VFRLLGSDRV VVLESRPTEN PAAHSNLYIL
AGHENSY