Q8BPM0
PR
Gene name |
Daam1 |
Protein name |
Disheveled-associated activator of morphogenesis 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:208846 |
EC number |
|
Protein Class |
|
Descriptions
(Annotation based on sequence homology with Q9Y4D1)
Diaphanous-related formins (DRFs), such as DAAM1 and mDia1, play central roles in actin dynamics through assembling linear actin filaments. The amino-terminal diaphanous inhibitory domain (DID) and the carboxyl-terminal diaphanous autoinhibitory domain (DAD) segment form an intramolecular interaction to restrain the actin assembly activity of FH1-FH2 domains. This autoinhibition is disrupted by Rho GTPase that is able to bind to the GTPase-binding domain (GBD) near DID domain.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BPM0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BPM0-F1 | Predicted | AlphaFoldDB |
55 variants for Q8BPM0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389256936 | 25 | E>Q | No | EVA | |
| rs3389235914 | 31 | R>K | No | EVA | |
| rs3389175881 | 38 | L>F | No | EVA | |
| rs260374501 | 44 | A>S | No | EVA | |
| rs3389241040 | 60 | L>F | No | EVA | |
| rs3389242376 | 61 | V>G | No | EVA | |
| rs3389217110 | 91 | K>E | No | EVA | |
| rs3389238955 | 111 | N>S | No | EVA | |
| rs3389245053 | 118 | S>T | No | EVA | |
| rs3389246263 | 128 | E>G | No | EVA | |
| rs3389250778 | 150 | T>I | No | EVA | |
| rs3389228613 | 151 | R>I | No | EVA | |
| rs3389246270 | 157 | G>D | No | EVA | |
| rs3389250807 | 183 | G>S | No | EVA | |
| rs3403337313 | 211 | S>T | No | EVA | |
| rs3389211957 | 220 | K>E | No | EVA | |
| rs3389246259 | 252 | S>R | No | EVA | |
| rs3389245085 | 258 | Q>L | No | EVA | |
| rs3389235965 | 267 | S>G | No | EVA | |
| rs3389211958 | 295 | V>M | No | EVA | |
| rs3402715007 | 306 | Y>F | No | EVA | |
| rs3389216994 | 329 | D>E | No | EVA | |
| rs3389228639 | 352 | L>P | No | EVA | |
| rs3389256953 | 366 | L>P | No | EVA | |
| rs3389241084 | 367 | T>I | No | EVA | |
| rs3389256970 | 407 | R>I | No | EVA | |
| rs3389228629 | 425 | T>R | No | EVA | |
| rs3389256943 | 426 | P>S | No | EVA | |
| rs3403544003 | 439 | L>* | No | EVA | |
| rs3403739745 | 443 | N>K | No | EVA | |
| rs3389246287 | 475 | A>D | No | EVA | |
| rs3413020086 | 499 | T>S | No | EVA | |
| rs243128087 | 499 | T>S | No | EVA | |
| rs233739441 | 519 | N>T | No | EVA | |
| rs3389253101 | 525 | A>V | No | EVA | |
| rs1132285838 | 531 | P>H | No | EVA | |
| rs243116423 | 586 | V>I | No | EVA | |
| rs3389238982 | 718 | E>V | No | EVA | |
| rs3389202403 | 724 | K>E | No | EVA | |
| rs3389250788 | 727 | L>F | No | EVA | |
| rs3389241077 | 729 | Q>* | No | EVA | |
| rs3389245029 | 738 | S>G | No | EVA | |
| rs3389175885 | 806 | S>T | No | EVA | |
| rs216336487 | 807 | R>C | No | EVA | |
| rs216336487 | 807 | R>S | No | EVA | |
| rs3389212038 | 844 | D>G | No | EVA | |
| rs3389235863 | 851 | K>M | No | EVA | |
| rs238528567 | 864 | E>D | No | EVA | |
| rs3389253113 | 876 | E>D | No | EVA | |
| rs3389246257 | 909 | L>R | No | EVA | |
| rs3389175856 | 934 | A>D | No | EVA | |
| rs219571919 | 958 | H>R | No | EVA | |
| rs46112424 | 1019 | V>M | No | EVA | |
| rs3389228604 | 1037 | S>P | No | EVA | |
| rs3389228616 | 1050 | S>* | No | EVA |
No associated diseases with Q8BPM0
5 regional properties for Q8BPM0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 184 - 192 | IPR000629 |
| domain | Helicase, C-terminal | 249 - 410 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 62 - 223 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 56 - 253 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 37 - 65 | IPR014014 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| ciliary basal body | A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| stress fiber | A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| identical protein binding | Binding to an identical protein or proteins. |
| small GTPase binding | Binding to a small monomeric GTPase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0A1D5P556 | DAAM2 | Disheveled-associated activator of morphogenesis 2 | Gallus gallus (Chicken) | SS |
| O95466 | FMNL1 | Formin-like protein 1 | Homo sapiens (Human) | SS |
| Q27J81 | INF2 | Inverted formin-2 | Homo sapiens (Human) | EV |
| Q86T65 | DAAM2 | Disheveled-associated activator of morphogenesis 2 | Homo sapiens (Human) | SS |
| Q9Y4D1 | DAAM1 | Disheveled-associated activator of morphogenesis 1 | Homo sapiens (Human) | EV |
| Q0GNC1 | Inf2 | Inverted formin-2 | Mus musculus (Mouse) | SS |
| Q0QWG9 | Grid2ip | Delphilin | Mus musculus (Mouse) | PR |
| Q80U19 | Daam2 | Disheveled-associated activator of morphogenesis 2 | Mus musculus (Mouse) | SS |
| Q9C7S1 | FH12 | Formin-like protein 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LH02 | FH17 | Formin-like protein 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P0C5K4 | FH21A | Putative formin-like protein 21a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FF14 | FH19 | Formin-like protein 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPRKRGGRG | ISFIFCCFRN | NDHPEITYRL | RNDSNFALQT | MEPALPMPPV | EELDVMFSEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VDELDLTDKH | REAMFALPAE | KKWQIYCSKK | KDQEENKGAT | SWPEFYIDQL | NSMAARKSLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALEKEEEEER | SKTIESLKTA | LRTKPMRFVT | RFIDLDGLSC | ILNFLKTMDY | ETSESRIHTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LIGCIKALMN | NSQGRAHVLA | HSESINVIAQ | SLSTENIKTK | VAVLEILGAV | CLVPGGHKKV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LQAMLHYQKY | ASERTRFQTL | INDLDKSTGR | YRDEVSLKTA | IMSFINAVLS | QGAGVESLDF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLHLRYEFLM | LGIQPVIDKL | REHENSTLDR | HLDFFEMLRN | EDELEFAKRF | ELVHIDTKSA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TQMFELTRRR | LTHSEAYPHF | MSILHHCLQM | PYKRSGNTVQ | YWLLLDRIIQ | QIVIQNDKGQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DPDSTPLENF | NIKNVVRMLV | NENEVKQWKE | QAEKMRKEHN | ELQQKLEKKE | RECDAKTQEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EEMMQTLNKM | KEKLEKETTE | HKQVKQQVAD | LTAQLHELNR | RAVCAAVPGG | PSPGAPGGPF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PSSGLGSLLP | PPPPPLLSGG | ALPPPPPPLP | PGGPPPPPGP | PPLGGVLPPP | GAPVSLTLKK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KNIPQPTNAL | KSFNWSKLPE | NKLDGTVWTE | IDDTKVFKIL | DLEDLERTFS | AYQRQQEFFV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NNSKQKEADA | IDDTLSSKLK | VKELSVIDGR | RAQNCNILLS | RLKLSNDEIK | RAILTMDEQE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DLPKDMLEQL | LKFVPEKSDI | DLLEEHKHEL | DRMAKADRFL | FEMSRINHYQ | QRLQSLYFKK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KFAERVAEVK | PKVEAIRSGS | EEVFRSRALK | QLLEVVLAFG | NYMNKGQRGN | AYGFKISSLN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KIADTKSSID | KNITLLHYLI | TIVENKYPKV | LNLSEELRDI | PQAAKVNMTE | LDKEISTLRS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GLKAVETELE | YQKSQPPQPG | DKFVSVVSQF | ITLASFSFSD | VEDLLAEAKE | LFTKAVKHFG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EEAGKIQPDE | FFGIFDQFLQ | AVAEAKQENE | NMRKRKEEEE | RRARLEAQLK | EQRERERKVR |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| KAKESSEESG | EFDDLVSALR | SGEVFDKDLS | KLKRNRKRIS | NQVTDSSRER | PITKLNF |