Q8BPB0
Gene name |
Mob1b (Mobkl1a) |
Protein name |
MOB kinase activator 1B |
Names |
Mob1 homolog 1A , Mps one binder kinase activator-like 1A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68473 |
EC number |
|
Protein Class |
MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB (PTHR22599) |
Descriptions
MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. Full-length MOB1B is in the autoinhibited form, showing that the N-terminal extension blocks the LATS1 binding surface of MOB2B. Phosphorylation of Thr12 and Thr35 residues accelerates dissociation of the Switch helix from the LATS1-binding surface by the pull-the-string mechanism, thereby enabling LATS1 binding.
Autoinhibitory domains (AIDs)
Target domain |
41-204 (MH domain) |
Relief mechanism |
PTM |
Assay |
Mutagenesis experiment, Deletion assay, Structural analysis |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q8BPB0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5B5V | X-ray | 219 A | A/B/C/D/E/F | 1-216 | PDB |
| 5B5W | X-ray | 296 A | A | 33-216 | PDB |
| 5B6B | X-ray | 354 A | A/B/D/F/H/K/M/O | 1-216 | PDB |
| AF-Q8BPB0-F1 | Predicted | AlphaFoldDB |
10 variants for Q8BPB0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388739756 | 19 | I>K | No | EVA | |
| rs3388769164 | 72 | Y>C | No | EVA | |
| rs3388773158 | 79 | C>Y | No | EVA | |
| rs3388761926 | 103 | I>K | No | EVA | |
| rs3388751422 | 105 | K>R | No | EVA | |
| rs3388769144 | 114 | Y>* | No | EVA | |
| rs3388768217 | 135 | K>Q | No | EVA | |
| rs3395868091 | 157 | R>* | No | EVA | |
| rs3395750203 | 159 | Y>F | No | EVA | |
| rs3388765789 | 183 | F>S | No | EVA |
No associated diseases with Q8BPB0
No regional properties for Q8BPB0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BPB0 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR22599 | MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB |
| PANTHER Subfamily | PTHR22599:SF63 | MOB KINASE ACTIVATOR 1B |
| PANTHER Protein Class |
kinase modulator
kinase activator |
|
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| kinase activator activity | Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| metal ion binding | Binding to a metal ion. |
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| hippo signaling | The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| regulation of protein autophosphorylation | Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43563 | MOB2 | CBK1 kinase activator protein MOB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P40484 | MOB1 | DBF2 kinase activator protein MOB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q95RA8 | mats | MOB kinase activator-like 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q9H8S9 | MOB1A | MOB kinase activator 1A | Homo sapiens (Human) | EV |
| Q7L9L4 | MOB1B | MOB kinase activator 1B | Homo sapiens (Human) | SS |
| Q8BSU7 | Mob3a | MOB kinase activator 3A | Mus musculus (Mouse) | SS |
| Q8BJG4 | Mob3c | MOB kinase activator 3C | Mus musculus (Mouse) | SS |
| Q8VE04 | Mob3b | MOB kinase activator 3B | Mus musculus (Mouse) | SS |
| Q8VI63 | Mob2 | MOB kinase activator 2 | Mus musculus (Mouse) | EV |
| Q921Y0 | Mob1a | MOB kinase activator 1A | Mus musculus (Mouse) | SS |
| Q3T1J9 | Mob1a | MOB kinase activator 1A | Rattus norvegicus (Rat) | SS |
| Q8GYX0 | MOB1B | MOB kinase activator-like 1B | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHI1 | MOB1A | MOB kinase activator-like 1A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFLFGSRSS | KTFKPKKNIP | EGSHQYELLK | HAEATLGSGN | LRMAVMLPEG | EDLNEWVAVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVDFFNQINM | LYGTITDFCT | EESCPVMSAG | PKYEYHWADG | TNIKKPIKCS | APKYIDYLMT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WVQDQLDDET | LFPSKIGVPF | PKNFMSVAKT | ILKRLFRVYA | HIYHQHFDPV | IQLQEEAHLN |
| 190 | 200 | 210 | |||
| TSFKHFIFFV | QEFNLIDRRE | LAPLQELIEK | LTSKDR |