AiPD: Autoinhibited Protein Database

Gene name	Arhgap28 (Kiaa1314)
Protein name	Rho GTPase-activating protein 28
Names	Rho-type GTPase-activating protein 28
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:268970
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

24-105 (Predicted disordered autoinhibitory region) PR

24-105 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BN58-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs221991421	66	N>D	No	EVA
rs224248434	72	D>Y	No	EVA
rs217472608	95	S>A	No	EVA
rs248181508	106	A>T	No	EVA
rs3389484992	184	E>*	No	EVA
rs3389478250	204	K>N	No	EVA
rs3389457093	212	T>R	No	EVA
rs212980699	223	S>N	No	EVA
rs3407917244	247	S>Q	No	EVA
rs3407917228	249	L>P	No	EVA
rs51413453	256	A>P	No	EVA
rs3389457091	260	N>D	No	EVA
rs51326721	300	V>M	No	EVA
rs3389478413	325	I>F	No	EVA
rs3389457081	383	G>E	No	EVA
rs3389444514	387	T>R	No	EVA
rs3412749453	408	K>I	No	EVA
rs3389470058	413	V>SDG*	No	EVA
rs3389425768	418	L>V	No	EVA
rs3412781672	420	S>*	No	EVA
rs3389478300	423	I>M	No	EVA
rs3389470073	459	A>T	No	EVA
rs3389425706	481	P>H	No	EVA
rs3389479190	513	D>G	No	EVA
rs3389492706	599	M>I	No	EVA
rs3389470327	610	K>T	No	EVA
rs3389477502	673	L>Q	No	EVA
rs3389477469	678	Y>F	No	EVA
rs3389470329	699	G>V	No	EVA
rs3389436161	702	I>M	No	EVA

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	159 - 479	IPR000719
active_site	Serine/threonine-protein kinase, active site	283 - 295	IPR008271
binding_site	Protein kinase, ATP binding site	165 - 188	IPR017441
domain	Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain	148 - 484	IPR044131

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

Name	Definition
negative regulation of GTP binding	Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding.
negative regulation of stress fiber assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
regulation of actin filament polymerization	Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A7E300	DLC1	Rho GTPase-activating protein 7	Bos taurus (Bovine)	SS
Q9P2N2	ARHGAP28	Rho GTPase-activating protein 28	Homo sapiens (Human)	PR
Q9R0Z9	Dlc1	Rho GTPase-activating protein 7	Mus musculus (Mouse)	SS
Q63744	Dlc1	Rho GTPase-activating protein 7	Rattus norvegicus (Rat)	SS